{"id":"https://openalex.org/W32842924","doi":null,"title":"Effects of Age and Immune Dysfunction on the Cardiac Extracellular Matrix and Diastolic Function","display_name":"Effects of Age and Immune Dysfunction on the Cardiac Extracellular Matrix and Diastolic Function","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W32842924","mag":"32842924"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/195581","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195581","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109894291","display_name":"Cory M. Alwardt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cory M. Alwardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109894291"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.7990000247955322},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7960000038146973},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cardiac-extracellular-matrix","display_name":"cardiac extracellular matrix","score":0.9649999737739563},{"id":"https://openalex.org/keywords/left-ventricular-stiffness","display_name":"left ventricular stiffness","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9800000190734863},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9300000071525574},{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":1.0},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.972000002861023},{"id":"https://openalex.org/keywords/murine-aids","display_name":"murine AIDS","score":0.8629999756813049},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.7521039843559265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7003597021102905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5685800313949585},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5275841951370239},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4724807143211365},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4644593894481659},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.4385390877723694},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3641694188117981},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3608652949333191},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3350698947906494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20870700478553772},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13917139172554016}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/195581","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195581","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:32842924","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/195581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7949455086","display_name":"BB/J014516/1","funder_award_id":"BB/J014516/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8221317002","display_name":null,"funder_award_id":"1517063","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W81237463","https://openalex.org/W124502319","https://openalex.org/W137177190","https://openalex.org/W174512763","https://openalex.org/W1521778022","https://openalex.org/W1525577992","https://openalex.org/W1532013290","https://openalex.org/W1540874939","https://openalex.org/W1571553794","https://openalex.org/W1592627182","https://openalex.org/W1615324037","https://openalex.org/W1661544713","https://openalex.org/W1840399502","https://openalex.org/W1911673960","https://openalex.org/W1967015050","https://openalex.org/W1967640021","https://openalex.org/W1968747646","https://openalex.org/W1970079470","https://openalex.org/W1970102552","https://openalex.org/W1970627910","https://openalex.org/W1973942995","https://openalex.org/W1974147494","https://openalex.org/W1976020429","https://openalex.org/W1976236115","https://openalex.org/W1977536303","https://openalex.org/W1978310574","https://openalex.org/W1980084527","https://openalex.org/W1982647397","https://openalex.org/W1983772431","https://openalex.org/W1983996730","https://openalex.org/W1985168335","https://openalex.org/W1985991501","https://openalex.org/W1986889750","https://openalex.org/W1991880130","https://openalex.org/W1995114988","https://openalex.org/W2000091858","https://openalex.org/W2003339493","https://openalex.org/W2007217247","https://openalex.org/W2009142206","https://openalex.org/W2010318153","https://openalex.org/W2011446326","https://openalex.org/W2012115499","https://openalex.org/W2012464391","https://openalex.org/W2013651790","https://openalex.org/W2014552992","https://openalex.org/W2014973914","https://openalex.org/W2015080409","https://openalex.org/W2016671919","https://openalex.org/W2017350962","https://openalex.org/W2018792951","https://openalex.org/W2023394535","https://openalex.org/W2026285106","https://openalex.org/W2029479550","https://openalex.org/W2029954197","https://openalex.org/W2030215482","https://openalex.org/W2032602706","https://openalex.org/W2033651441","https://openalex.org/W2034566257","https://openalex.org/W2036674518","https://openalex.org/W2036966030","https://openalex.org/W2037521168","https://openalex.org/W2038464101","https://openalex.org/W2042836049","https://openalex.org/W2043659211","https://openalex.org/W2044315186","https://openalex.org/W2046412711","https://openalex.org/W2048539374","https://openalex.org/W2048593108","https://openalex.org/W2049235717","https://openalex.org/W2049821905","https://openalex.org/W2051251503","https://openalex.org/W2052978794","https://openalex.org/W2053497293","https://openalex.org/W2053570926","https://openalex.org/W2054190356","https://openalex.org/W2054644728","https://openalex.org/W2055435159","https://openalex.org/W2055746138","https://openalex.org/W2058350561","https://openalex.org/W2058398387","https://openalex.org/W2059289017","https://openalex.org/W2060018075","https://openalex.org/W2060147998","https://openalex.org/W2062093782","https://openalex.org/W2062813847","https://openalex.org/W2063701256","https://openalex.org/W2065784560","https://openalex.org/W2067423036","https://openalex.org/W2069923609","https://openalex.org/W2071251073","https://openalex.org/W2071365066","https://openalex.org/W2071748316","https://openalex.org/W2073463648","https://openalex.org/W2073539437","https://openalex.org/W2074307991","https://openalex.org/W2074565414","https://openalex.org/W2075522000","https://openalex.org/W2076466972","https://openalex.org/W2076547061","https://openalex.org/W2076904453","https://openalex.org/W2077997754","https://openalex.org/W2083544543","https://openalex.org/W2084485021","https://openalex.org/W2085500539","https://openalex.org/W2086140631","https://openalex.org/W2086291645","https://openalex.org/W2088963943","https://openalex.org/W2091019625","https://openalex.org/W2095712197","https://openalex.org/W2097890124","https://openalex.org/W2098548916","https://openalex.org/W2101076761","https://openalex.org/W2105050893","https://openalex.org/W2105582667","https://openalex.org/W2106513436","https://openalex.org/W2112670248","https://openalex.org/W2113945548","https://openalex.org/W2124694949","https://openalex.org/W2124778306","https://openalex.org/W2125088647","https://openalex.org/W2134286592","https://openalex.org/W2137421304","https://openalex.org/W2141228550","https://openalex.org/W2145199466","https://openalex.org/W2145450205","https://openalex.org/W2145779624","https://openalex.org/W2147005862","https://openalex.org/W2151339600","https://openalex.org/W2152214582","https://openalex.org/W2154295247","https://openalex.org/W2155235164","https://openalex.org/W2155395456","https://openalex.org/W2156655309","https://openalex.org/W2159070515","https://openalex.org/W2159968699","https://openalex.org/W2159979637","https://openalex.org/W2161474870","https://openalex.org/W2162277599","https://openalex.org/W2166357118","https://openalex.org/W2166975456","https://openalex.org/W2168595038","https://openalex.org/W2169350806","https://openalex.org/W2204611425","https://openalex.org/W2281019573","https://openalex.org/W2314819106","https://openalex.org/W2317845988","https://openalex.org/W2319160135","https://openalex.org/W2400389908","https://openalex.org/W2405582279","https://openalex.org/W2407369318","https://openalex.org/W2412835465","https://openalex.org/W3143276943"],"related_works":["https://openalex.org/W1963767129","https://openalex.org/W2025950953","https://openalex.org/W4409100026","https://openalex.org/W2146034808","https://openalex.org/W2122993849","https://openalex.org/W2403360916","https://openalex.org/W3174704904","https://openalex.org/W6903246591","https://openalex.org/W2576118788","https://openalex.org/W2783025516"],"abstract_inverted_index":{"Cardiomyopathies":[0],"are":[1,285],"often":[2],"initiated":[3],"by":[4,251],"diastolic":[5,10,28,55,88,245,272],"dysfunction,":[6,84],"and":[7,27,32,49,57,68,76,87,118,130,215,234,243,282],"treatment":[8],"of":[9,25,66,126,141,154,167,178,187,213,222,231,253,256],"dysfunction":[11,29,51,56,224,246,273],"remains":[12],"empirical":[13],"with":[14,123,205,229],"an":[15,97],"emphasis":[16],"on":[17,22,70,147,180],"prevention.":[18],"This":[19],"dissertation":[20],"focuses":[21],"the":[23,64,71,138,158,176,194,211,254,257,293],"mechanism":[24,174],"cardiomyopathy":[26,209],"during":[30,47,201,274],"aging":[31,48,67],"immune":[33,50,83,155,195,223,258,275],"dysfunction.":[34,89,276],"The":[35],"governing":[36],"hypothesis":[37],"is":[38,165],"that":[39,45,93,163,220,247,280],"altered":[40,124],"cytokine":[41],"release":[42],"such":[43],"as":[44,266],"seen":[46],"can":[52,248],"lead":[53],"to":[54,103,184,191,270],"myocardial":[58,85,232],"fibrosis.":[59],"Our":[60],"first":[61],"study":[62],"examined":[63],"role":[65],"immunosenescence":[69],"cardiac":[72,148,170,181],"extracellular":[73,289],"matrix":[74,127,290],"(ECM)":[75],"left":[77],"ventricular":[78,235],"stiffness.":[79,236],"We":[80,90,133,218,277],"demonstrated":[81,219,241],"age-related":[82],"fibrosis,":[86],"also":[91,278],"found":[92,162,279],"exogenous":[94],"dehydroepiandrosterone":[95],"(DHEA),":[96],"adrenal":[98],"steroid":[99],"hormone":[100],"popular":[101],"due":[102],"its":[104,119],"anti-aging":[105],"effects,":[106],"partially":[107],"reversed":[108,250],"these":[109],"pathologies":[110],"in":[111,210,225,288,292,296],"aged":[112],"mice.":[113],"In":[114,157,237],"this":[115,297],"model,":[116],"fibrosis":[117,233],"reversal":[120,221,230],"were":[121],"associated":[122,228],"regulation":[125,291],"metalloproteinases":[128],"(MMP)":[129],"collagen":[131,283],"cross-linking.":[132],"propose":[134],"two":[135],"mechanisms":[136],"for":[137,175],"protective":[139],"effects":[140,153,177,186],"DHEA:":[142],"(1)":[143],"a":[144,173,267],"direct":[145],"effect":[146],"fibroblasts,":[149,171],"or":[150],"(2)":[151],"downstream":[152],"modulation.":[156],"subsequent":[159],"study,":[160],"we":[161,189,239],"DHEA":[164,179],"capable":[166],"directly":[168],"altering":[169],"suggesting":[172],"function.":[182],"Due":[183],"pleiotropic":[185],"DHEA,":[188],"decided":[190],"specifically":[192],"target":[193,269],"system":[196],"using":[197],"T-cell":[198],"receptor":[199],"peptides":[200],"murine":[202],"AIDS(mAIDS).":[203],"Mice":[204],"mAIDS":[206,226],"suffer":[207],"from":[208],"absence":[212],"myocarditis":[214],"opportunistic":[216],"pathogens.":[217],"was":[227],"conclusion,":[238],"have":[240],"age-":[242],"immune-related":[244],"be":[249,263],"modulation":[252,261],"T-cells":[255],"system.":[259],"Immune":[260],"should":[262],"further":[264],"investigated":[265],"therapeutic":[268],"treat":[271],"MMPs":[281],"cross-linking":[284],"highly":[286],"involved":[287],"models":[294],"used":[295],"dissertation.":[298]},"counts_by_year":[],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}
