{"id":"https://openalex.org/W327993197","doi":null,"title":"Tissue renin-angiotensin systems. Their role in cardiovascular disease.","display_name":"Tissue renin-angiotensin systems. Their role in cardiovascular disease.","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W327993197","mag":"327993197","pmid":"https://pubmed.ncbi.nlm.nih.gov/8485836"},"language":"en","primary_location":{"id":"pmid:8485836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8485836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066795708","display_name":"M A Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M A Lee","raw_affiliation_strings":["German Institute for High Blood Pressure Research, University of Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute for High Blood Pressure Research, University of Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111638116","display_name":"M B\u00f6hm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B\u00f6hm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110211697","display_name":"M. Paul","orcid":"https://orcid.org/0000-0001-5551-1893","observed_orcids":["https://orcid.org/0000-0001-5551-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Paul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5092173916","display_name":"Detlev Ganten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Ganten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7489,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.94893663,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"87","issue":"5 Suppl","first_page":"IV7","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-renin-angiotensin-system","display_name":"tissue renin-angiotensin system","score":0.9800000190734863},{"id":"https://openalex.org/keywords/local-renin-angiotensin-system","display_name":"local renin-angiotensin system","score":0.9179999828338623},{"id":"https://openalex.org/keywords/autocrine-paracrine-signaling","display_name":"autocrine and paracrine signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.984000027179718},{"id":"https://openalex.org/keywords/angiotensinogen","display_name":"angiotensinogen","score":0.7300000190734863},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9570000171661377},{"id":"https://openalex.org/keywords/angiotensin-receptors","display_name":"angiotensin receptors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pathogenesis-of-hypertension","display_name":"hypertension pathogenesis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":1.0},{"id":"https://openalex.org/keywords/converting-enzyme-inhibitors","display_name":"converting enzyme inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/renal-sodium-excretion","display_name":"renal sodium excretion","score":0.781000018119812},{"id":"https://openalex.org/keywords/cardiovascular-homeostasis","display_name":"cardiovascular homeostasis","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.798048734664917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7485470771789551},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6482862830162048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5559174418449402},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5551966428756714},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5415087342262268},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5185075998306274},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49033069610595703},{"id":"https://openalex.org/C63263939","wikidata":"https://www.wikidata.org/wiki/Q3153691","display_name":"Intracrine","level":4,"score":0.48692572116851807},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4855625331401825},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4701523780822754},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4578702449798584},{"id":"https://openalex.org/C57190642","wikidata":"https://www.wikidata.org/wiki/Q7144839","display_name":"Pathophysiology of hypertension","level":3,"score":0.44769468903541565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43051135540008545},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.42174601554870605},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1827952265739441}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8485836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8485836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:327993197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8485836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076043745","https://openalex.org/W2040418189","https://openalex.org/W1987093417","https://openalex.org/W2332519089","https://openalex.org/W2320384507","https://openalex.org/W2129084782","https://openalex.org/W2018464522","https://openalex.org/W2090374524","https://openalex.org/W1994575805","https://openalex.org/W2028439883"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,116,149],"identification":[2],"of":[3,6,18,40,43,96,118,127,145,152,154,178,186,206,212,229],"the":[4,7,16,30,38,44,63,74,94,128,143,155,179,182,230],"components":[5,126],"renin-angiotensin":[8,20],"system":[9],"(RAS)":[10],"in":[11,80,137,142,181,192],"various":[12],"extrarenal":[13],"tissues":[14,139],"suggested":[15],"existence":[17],"local":[19],"systems":[21],"with":[22],"organ-specific":[23],"functions":[24,42],"that":[25,48,124,140],"may":[26,91],"act":[27],"independently":[28],"from":[29],"plasma":[31,198],"RAS.":[32,232],"These":[33],"findings":[34],"have":[35],"led":[36],"to":[37,68,78,93,174],"hypothesis":[39],"paracrine-autocrine":[41],"RAS,":[45,156],"which":[46,193],"implies":[47],"locally":[49],"generated":[50],"angiotensin":[51,134],"II":[52],"mediates":[53],"effects":[54,171],"within":[55,59],"one":[56,60],"tissue":[57,75,231],"or":[58,195],"cell.":[61],"Whereas":[62],"circulating":[64],"endocrine":[65],"RAS":[66,76,180],"appears":[67],"be":[69],"responsible":[70],"for":[71],"acute":[72],"effects,":[73],"seems":[77],"participate":[79,141],"more":[81],"chronic":[82],"processes":[83],"such":[84,104,157],"as":[85,98,100,105,158,167,169],"secondary":[86],"structural":[87,208],"changes":[88,209],"and":[89,111,133,172,184,210],"therefore":[90],"contribute":[92],"pathogenesis":[95],"hypertension":[97],"well":[99,168],"other":[101],"cardiovascular":[102,146,207],"disorders":[103],"cardiac":[106],"hypertrophy,":[107],"coronary":[108],"artery":[109],"disease,":[110],"atherosclerosis.":[112],"METHODS":[113],"AND":[114],"RESULTS:":[115],"use":[117],"molecular":[119],"biological":[120],"techniques":[121],"has":[122],"demonstrated":[123],"all":[125],"RAS-renin,":[129],"angiotensinogen,":[130],"converting":[131,159,217],"enzyme,":[132],"receptors-are":[135],"expressed":[136],"several":[138],"regulation":[144],"homeostasis.":[147],"CONCLUSIONS:":[148],"therapeutic":[150],"importance":[151],"inhibitors":[153,219],"enzyme":[160,218],"inhibitors,":[161],"is":[162,201],"based":[163],"on":[164],"their":[165],"cardioprotective":[166],"antiproliferative":[170],"points":[173],"a":[175,189,202],"direct":[176],"involvement":[177],"development":[183],"preservation":[185],"primary":[187],"hypertension,":[188],"pathological":[190],"condition":[191],"normal":[194],"even":[196],"low":[197],"renin":[199],"activity":[200],"common":[203],"finding.":[204],"Reversal":[205],"enhancement":[211],"renal":[213],"sodium":[214],"excretion":[215],"by":[216,227],"are":[220],"important":[221],"long-term":[222],"antihypertensive":[223],"actions":[224],"possibly":[225],"mediated":[226],"inhibition":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}