{"id":"https://openalex.org/W3276113","doi":null,"title":"Role of herpes simplex virus-1, cytomegalovirus and Epstein-Barr virus in atherosclerosis.","display_name":"Role of herpes simplex virus-1, cytomegalovirus and Epstein-Barr virus in atherosclerosis.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W3276113","mag":"3276113","pmid":"https://pubmed.ncbi.nlm.nih.gov/22186314"},"language":"en","primary_location":{"id":"pmid:22186314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22186314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111000866","display_name":"Abdullah Ahmed Alghamdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Abdullah Al-Ghamdi","raw_affiliation_strings":["Department of Medical Microbiology, King Abdul-Aziz University, Jeddah, Saudi Arabia. ghonm5000@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, King Abdul-Aziz University, Jeddah, Saudi Arabia. ghonm5000@yahoo.com","institution_ids":["https://openalex.org/I185163786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111000866"],"corresponding_institution_ids":["https://openalex.org/I185163786"],"apc_list":null,"apc_paid":null,"fwci":1.2856,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77033089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"1","first_page":"89","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.15410000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.859000027179718},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":1.0},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.6790000200271606},{"id":"https://openalex.org/keywords/acute-coronary-artery-disease","display_name":"acute coronary artery disease","score":0.7229999899864197},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9309999942779541},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.9150000214576721},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7454478144645691},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7288029193878174},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.7098169326782227},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6389199495315552},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5530734658241272},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49483436346054077},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.4461002051830292},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.41629207134246826},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.41452455520629883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36487260460853577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3593160808086395},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.17357870936393738}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22186314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22186314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},{"id":"mag:3276113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22186314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W77112461","https://openalex.org/W139152919","https://openalex.org/W200679562","https://openalex.org/W1011421942","https://openalex.org/W1509528851","https://openalex.org/W1510281703","https://openalex.org/W1534126065","https://openalex.org/W1590312470","https://openalex.org/W1601263240","https://openalex.org/W1982675479","https://openalex.org/W1986335142","https://openalex.org/W2011075699","https://openalex.org/W2016186842","https://openalex.org/W2017704303","https://openalex.org/W2019627459","https://openalex.org/W2025088281","https://openalex.org/W2028879192","https://openalex.org/W2035248936","https://openalex.org/W2035720710","https://openalex.org/W2038241725","https://openalex.org/W2048538839","https://openalex.org/W2059073706","https://openalex.org/W2061755142","https://openalex.org/W2070702889","https://openalex.org/W2081681953","https://openalex.org/W2089527479","https://openalex.org/W2094768566","https://openalex.org/W2109204050","https://openalex.org/W2114849931","https://openalex.org/W2139656347","https://openalex.org/W2147068092","https://openalex.org/W2148668265","https://openalex.org/W2168514834","https://openalex.org/W2308178561","https://openalex.org/W2319669994","https://openalex.org/W2328908717","https://openalex.org/W2329800128","https://openalex.org/W2331879659","https://openalex.org/W2333119610","https://openalex.org/W2340053228","https://openalex.org/W2340819127","https://openalex.org/W2410560429","https://openalex.org/W2412081482","https://openalex.org/W2416736244","https://openalex.org/W2419979079","https://openalex.org/W2607907810","https://openalex.org/W4213225455","https://openalex.org/W4231320588","https://openalex.org/W4245512005","https://openalex.org/W4251702714","https://openalex.org/W4318963783","https://openalex.org/W6695474964"],"related_works":["https://openalex.org/W2130101056","https://openalex.org/W2060043285","https://openalex.org/W1989958005","https://openalex.org/W2473196435","https://openalex.org/W2006048964","https://openalex.org/W2075185537","https://openalex.org/W1582290606","https://openalex.org/W2094392368","https://openalex.org/W2412554810","https://openalex.org/W4293584892"],"abstract_inverted_index":{"Infectious":[0],"agents":[1],"such":[2],"as":[3,99,175],"herpes":[4],"viruses":[5],"may":[6],"be":[7],"implicated":[8],"in":[9,63],"the":[10,22,48,51,118,141,163,178,197,246,254,266,281,291,300],"inflammatory":[11],"atherosclerotic":[12,42,238],"process.":[13],"The":[14,103,219],"aim":[15],"of":[16,24,53,117,143,162,170,182,221,245,256,268,283,290],"this":[17],"study":[18],"was":[19,154,192,249,307],"to":[20,46,108,160,177,208,213,243],"assess":[21],"levels":[23,52,142,220,255,312],"IgG":[25,132,174,188,204,225,258,285,311],"antibody":[26],"specific":[27,272],"for":[28],"Herpes":[29],"simplex":[30],"virus-1":[31],"(HSV-1),":[32],"Cytomegalovirus":[33],"(CMV)":[34],"and":[35,45,56,87,115,130,147,186,223,230,259,270,280,295,313],"Epstein-Barr":[36],"virus":[37],"(EBV)":[38],"among":[39,157,235,276,299],"patients":[40,68,158,171,183,236,279],"with":[41,70,77,84,89,95,237,288],"vascular":[43,210,239,277],"diseases":[44,240],"examine":[47],"relation":[49],"between":[50,196,253,309],"these":[54,64],"antibodies":[55,133,226,273],"lipid":[57,122,260,314],"profile,":[58,123],"high-sensitive":[59],"C-reactive":[60],"protein":[61],"(hsCRP)":[62],"patients.":[65],"Seventy":[66],"five":[67],"[20":[69],"acute":[71],"coronary":[72,79],"artery":[73,80],"disease":[74,81,92,211,278],"(ACAD),":[75],"20":[76,83],"chronic":[78],"(CCAD),":[82],"cerebral":[85],"stroke":[86],"15":[88,96],"peripheral":[90],"arterial":[91],"(PAD)]":[93],"along":[94],"healthy":[97],"individuals":[98,105],"a":[100],"control":[101],"group.":[102],"studied":[104,301],"were":[106,149,205,227,297],"subjected":[107],"complete":[109],"history":[110],"taking,":[111],"thorough":[112],"physical":[113],"examination,":[114],"assessment":[116],"blood":[119],"glucose":[120],"level,":[121],"creatine":[124],"kinase":[125],"(CK),":[126],"hsCRP":[127,148,296],"by":[128,134],"nephlemetry":[129],"virus-specific":[131,257],"enzyme":[135],"immunoassay":[136],"(EIA).":[137],"Results":[138],"showed":[139],"that":[140,161],"cholesterol,":[144],"triglycerides,":[145],"LDL-c":[146],"significantly":[150,155,166,228],"higher,":[151],"while":[152],"HDL-c":[153],"lower":[156],"compared":[159,176,212,242],"controls.":[164,179,247],"A":[165],"(p<0.05)":[167],"higher":[168],"percentage":[169,181],"had":[172,184,202],"CMV-specific":[173,203,284],"Higher":[180],"HSV-":[185],"EBV-specific":[187,224],"antibodies,":[189],"however,":[190,303],"there":[191],"no":[193,250,304],"significant":[194,251,305],"difference":[195],"2":[198],"groups.":[199],"Individuals":[200],"who":[201],"more":[206],"liable":[207],"have":[209],"those":[214,244],"without":[215],"(OR=4.10,":[216],"CI=":[217],"1.07-15.75).":[218],"CMV-":[222,269],"(P<0.01":[229],"<":[231],"0.05":[232],"respectively)":[233],"elevated":[234,275],"when":[241],"There":[248],"correlation":[252,306],"profile":[261,315],"or":[262,316],"hsCRP.":[263,317],"In":[264],"conclusion,":[265],"level":[267],"EBV-":[271],"are":[274],"presence":[282],"is":[286],"associated":[287],"development":[289],"disease.":[292],"Serum":[293],"lipids":[294],"increased":[298],"patients;":[302],"detected":[308],"antiviral":[310]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}