{"id":"https://openalex.org/W327531441","doi":null,"title":"Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.","display_name":"Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.","publication_year":2008,"publication_date":"2008-10-25","ids":{"openalex":"https://openalex.org/W327531441","mag":"327531441","pmid":"https://pubmed.ncbi.nlm.nih.gov/18958367"},"language":"en","primary_location":{"id":"pmid:18958367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18958367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111536841","display_name":"G. D. Nicol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grant D Nicol","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gnicol@iupui.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gnicol@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111536841"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":1.127,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75013949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"5","first_page":"603","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.07720000296831131,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sphingomyelinase","display_name":"sphingomyelinase","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sensory-neuron-excitability","display_name":"sensory neuron excitability","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.7760000228881836},{"id":"https://openalex.org/keywords/capsaicin-sensitive-neurons","display_name":"capsaicin-sensitive neurons","score":0.8790000081062317},{"id":"https://openalex.org/keywords/potassium-currents","display_name":"potassium currents","score":0.7570000290870667},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8050000071525574},{"id":"https://openalex.org/keywords/membrane-currents","display_name":"membrane currents","score":0.47200000286102295},{"id":"https://openalex.org/keywords/action-potential-firing","display_name":"action potential firing","score":0.5400000214576721},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.8195487260818481},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7259674668312073},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.6348913311958313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.615871250629425},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.5813573598861694},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.5213802456855774},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.5166900157928467},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44983208179473877},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.42932796478271484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4180504083633423},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.4147777855396271},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3459826111793518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2786034047603607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26516762375831604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11227765679359436},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.07955819368362427},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.060744285583496094},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0596432089805603},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099157","descriptor_name":"Sphingosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18958367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18958367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:3149807588","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90118X/200805/28577636.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555152","display_name":"\u751f\u7406\u5b66\u62a5","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7406\u5b66\u62a5","raw_type":null},{"id":"mag:327531441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18958367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2062227896","https://openalex.org/W2082714603","https://openalex.org/W2097482307","https://openalex.org/W2116384871"],"related_works":["https://openalex.org/W2097482307","https://openalex.org/W2116384871","https://openalex.org/W2062227896","https://openalex.org/W2113169063","https://openalex.org/W2073090071","https://openalex.org/W2102130488","https://openalex.org/W2165112648","https://openalex.org/W1817439804","https://openalex.org/W2169933875","https://openalex.org/W1996101006"],"abstract_inverted_index":{"Because":[0],"nerve":[1],"growth":[2],"factor":[3],"(NGF)":[4],"is":[5,19,248,255,334,458,486],"elevated":[6],"during":[7],"inflammation,":[8],"plays":[9],"a":[10,69,82,88,306],"causal":[11],"role":[12],"in":[13,73,87,279,441],"the":[14,23,39,47,74,99,105,121,138,148,155,166,184,188,199,244,258,263,270,276,280,286,290,296,302,313,353,358,383,391,397,405,436,442,449,452,461,471,478,491,512],"initiation":[15],"of":[16,41,53,76,84,101,107,116,124,131,140,150,158,162,168,187,226,282,304,339,342,393,407,413,427,438,444,454,464,480,490],"hyperalgesia,":[17],"and":[18,31,142,172,181,197,208,324,416],"known":[20],"to":[21,57,201,230,311,321,326,356,373,456,507],"activate":[22],"sphingomyelin":[24,343,492],"signalling":[25,309,349,493],"pathway,":[26],"we":[27],"examined":[28],"whether":[29,251,357],"NGF":[30,61,171,180,207,293,363],"its":[32],"putative":[33,307],"second":[34,505],"messenger,":[35],"ceramide,":[36,173,305,415,500],"could":[37],"modulate":[38],"excitability":[40,360,385,479,518],"capsaicin-sensitive":[42],"adult":[43],"sensory":[44,55,481],"neurons.":[45,482],"Using":[46],"whole-cell":[48],"patch-clamp":[49],"recording":[50],"technique,":[51],"exposure":[52,229],"isolated":[54,174],"neurons":[56],"either":[58],"100":[59],"ng/mL":[60],"or":[62,262,369],"1":[63],"mmol/L":[64],"N-acetyl":[65],"sphingosine":[66,322,327,331,428],"(C2-ceramide)":[67],"produced":[68,222,361],"3-4":[70],"fold":[71],"increase":[72,278],"number":[75,100,149,281,392,406,437],"action":[77,157,412],"potentials":[78],"(APs)":[79],"evoked":[80,151,284,395,408,439],"by":[81,194,216,257,285,292,319,330,362,367,396,422,488],"ramp":[83],"depolarizing":[85,398],"current":[86,191,214,287],"time-dependent":[89],"manner.":[90],"Intracellular":[91],"perfusion":[92],"with":[93,269],"bacterial":[94],"sphingomyelinase":[95],"(SMase)":[96],"also":[97],"increased":[98],"APs":[102,283,394,440],"suggesting":[103,233],"that":[104,154,234,337,451,470],"release":[106],"native":[108],"ceramide":[109,145,159,182,209,231,368],"enhanced":[110,147,359,404,435],"neuronal":[111,384],"excitability.":[112,314,465],"Glutathione,":[113],"an":[114,129,211,223,425,503],"inhibitor":[115,130,426],"neutral":[117],"SMase,":[118,133],"completely":[119,274],"blocked":[120],"NGF-induced":[122,253,277,484],"augmentation":[123],"AP":[125],"firing,":[126],"whereas":[127,386],"dithiothreitol,":[128],"acidic":[132],"was":[134,160,294,364],"without":[135],"effect.":[136],"In":[137,205,430],"presence":[139,443],"glutathione":[141],"NGF,":[143,414,474],"exogenous":[144],"still":[146],"APs,":[152],"indicating":[153],"sensitizing":[156,411],"downstream":[161,308],"NGF.":[163],"To":[164],"investigate":[165],"mechanisms":[167],"actions":[169],"for":[170,460],"membrane":[175,509],"currents":[176],"were":[177,420],"examined.":[178],"Both":[179],"facilitated":[183],"peak":[185],"amplitude":[186],"TTX-resistant":[189],"sodium":[190],"(TTX-R":[192],"I(Na))":[193],"approximately":[195],"1.5-fold":[196],"shifted":[198],"activation":[200,489],"more":[202],"hyperpolarized":[203],"voltages.":[204],"addition,":[206],"suppressed":[210],"outward":[212],"potassium":[213],"(I(K))":[215],"~35%.":[217],"The":[218],"inflammatory":[219],"prostaglandin,":[220],"PGE2,":[221],"additional":[224,371],"suppression":[225],"I(K)":[227],"after":[228],"(~35%),":[232],"these":[235,340],"agents":[236],"might":[237],"act":[238,346],"on":[239,243,301],"different":[240],"targets.":[241],"Based":[242],"existing":[245],"literature,":[246],"it":[247],"not":[249,381],"clear":[250],"this":[252],"sensitization":[254,291,485],"mediated":[256,365,487],"high-affinity":[259],"TrkA":[260],"receptor":[261],"low-affinity":[264],"p75":[265,271],"neurotrophin":[266],"receptor.":[267],"Pretreatment":[268],"blocking":[272],"antibody":[273,297],"prevents":[275],"ramp.":[288,399],"Although":[289],"blocked,":[295],"had":[298],"no":[299],"effect":[300],"capacity":[303],"molecule,":[310],"enhance":[312,477],"Ceramide":[315],"can":[316,345,475],"be":[317],"metabolized":[318],"ceramidase":[320],"(Sph)":[323],"Sph":[325,374,377,389],"1-phosphate":[328],"(S1P)":[329],"kinase.":[332,429],"It":[333],"well":[335],"established":[336],"each":[338],"products":[341],"metabolism":[344,372,453],"as":[347,355,502],"intracellular":[348,496],"molecules.":[350],"This":[351,410,483],"raises":[352],"question":[354],"directly":[366],"required":[370],"and/or":[375],"S1P.":[376],"applied":[378],"externally":[379],"did":[380],"affect":[382],"internally":[387,401,417,432],"perfused":[388,402,418,433],"augmented":[390],"Furthermore,":[400],"S1P":[403,434,457,497,516],"APs.":[409],"Sph,":[419],"abolished":[421],"dimethylsphingosine":[423],"(DMS),":[424],"contrast,":[431],"DMS.":[445],"These":[446],"observations":[447],"support":[448],"idea":[450],"ceramide/Sph":[455],"critical":[459],"sphingolipid-induced":[462],"modulation":[463],"Thus,":[466],"our":[467],"findings":[468],"indicate":[469],"pro-inflammatory":[472],"agent,":[473],"rapidly":[476],"pathway":[494],"wherein":[495],"derived":[498],"from":[499],"acts":[501],"internal":[504],"messenger":[506],"regulate":[508],"excitability,":[510],"however,":[511],"effector":[513],"system":[514],"whereby":[515],"modulates":[517],"remains":[519],"undetermined.":[520]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}