{"id":"https://openalex.org/W32710038","doi":null,"title":"Successful elimination of reflux symptoms does not insure adequate control of acid reflux in patients with Barrett's esophagus.","display_name":"Successful elimination of reflux symptoms does not insure adequate control of acid reflux in patients with Barrett's esophagus.","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W32710038","mag":"32710038","pmid":"https://pubmed.ncbi.nlm.nih.gov/8017396"},"language":"en","primary_location":{"id":"pmid:8017396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8017396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089464953","display_name":"David A. Katzka","orcid":"https://orcid.org/0000-0003-2307-2317","observed_orcids":["https://orcid.org/0000-0003-2307-2317"]},"institutions":[{"id":"https://openalex.org/I2801219303","display_name":"Graduate Hospital","ror":"https://ror.org/0116mdr21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801219303","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Katzka","raw_affiliation_strings":["Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I2801219303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109901205","display_name":"Castell Do","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D O Castell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5797,"has_fulltext":false,"cited_by_count":221,"citation_normalized_percentile":{"value":0.94260761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"89","issue":"7","first_page":"989","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gastroesophageal-reflux","display_name":"gastroesophageal reflux","score":0.9139999747276306},{"id":"https://openalex.org/keywords/heartburn","display_name":"heartburn","score":0.7879999876022339},{"id":"https://openalex.org/keywords/omeprazole","display_name":"omeprazole","score":0.859000027179718},{"id":"https://openalex.org/keywords/acid-suppression","display_name":"acid suppression","score":0.5720000267028809},{"id":"https://openalex.org/keywords/ambulatory-ph-monitoring","display_name":"ambulatory pH monitoring","score":0.7990000247955322},{"id":"https://openalex.org/keywords/reflux-control","display_name":"reflux management","score":0.4320000112056732},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9110071659088135},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.8948113918304443},{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.8939846158027649},{"id":"https://openalex.org/C2776462128","wikidata":"https://www.wikidata.org/wiki/Q537297","display_name":"Heartburn","level":4,"score":0.8678064346313477},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7152692079544067},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.712853729724884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6157381534576416},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.5773266553878784},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5590657591819763},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.5076712369918823},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.46981385350227356},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.46659398078918457},{"id":"https://openalex.org/C2779949763","wikidata":"https://www.wikidata.org/wiki/Q4446828","display_name":"Esophageal pH monitoring","level":5,"score":0.4354018568992615},{"id":"https://openalex.org/C2909576783","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Reflux esophagitis","level":4,"score":0.42853209376335144},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.35292190313339233},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12342751026153564}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8017396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8017396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:32710038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8017396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024689101","https://openalex.org/W2019352812","https://openalex.org/W1963662836","https://openalex.org/W2077689141","https://openalex.org/W2102336468","https://openalex.org/W1975940424","https://openalex.org/W14432231","https://openalex.org/W2030926893","https://openalex.org/W2125451295","https://openalex.org/W2003260173"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Patients":[1],"with":[2,25,52,59,63,94,136],"Barrett's":[3,26,53,137],"metaplasia":[4,27],"of":[5,13,18,56,84,122,142,144,151,158,170],"the":[6,10,123,127,134,140,159],"esophagus":[7,138,160],"often":[8],"lack":[9],"appropriate":[11],"amount":[12],"heartburn":[14,37,145],"for":[15],"their":[16,36],"severity":[17],"gastroesophageal":[19,90],"reflux.":[20,115,153],"Therefore,":[21],"we":[22],"studied":[23],"patients":[24,51,86,97,105],"by":[28,126],"prolonged":[29],"ambulatory":[30,73,155],"pH":[31,72,156],"monitoring":[32,74,157],"after":[33,92],"completely":[34],"suppressing":[35],"symptoms":[38],"to":[39,139,164],"determine":[40],"whether":[41],"acid":[42,124,152],"reflux":[43,91,102,125],"was":[44,75],"underestimated":[45],"in":[46,110],"symptom":[47],"assessment.":[48],"METHODS:":[49],"Five":[50],"esophagus,":[54],"all":[55],"whom":[57],"presented":[58],"heartburn,":[60],"were":[61,69,79],"treated":[62],"omeprazole":[64,128,171],"(20-60":[65],"mg/day)":[66],"until":[67],"they":[68,78],"asymptomatic.":[70],"Twenty-four-hour":[71],"performed":[76],"while":[77],"on":[80],"omeprazole.":[81,95],"RESULTS:":[82],"Four":[83],"five":[85],"showed":[87,98],"persistent":[88],"abnormal":[89,108],"treatment":[93],"Two":[96],"abnormally":[99],"increased":[100],"supine":[101,112],"and":[103,113],"two":[104],"had":[106,119],"an":[107,167],"increase":[109],"both":[111],"upright":[114],"Only":[116],"one":[117],"patient":[118,135],"complete":[120],"inhibition":[121],"(20":[129],"mg":[130],"b.i.d.).":[131],"CONCLUSIONS:":[132],"Treating":[133],"endpoint":[141],"eradication":[143],"does":[146],"not":[147],"insure":[148],"adequate":[149,168],"control":[150],"Prolonged":[154],"should":[161],"be":[162],"conducted":[163],"demonstrate":[165],"that":[166],"dose":[169],"has":[172],"been":[173],"given,":[174],"despite":[175],"symptomatic":[176],"improvement.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}