{"id":"https://openalex.org/W326784262","doi":null,"title":"miR-21 and miR-375 microRNAs as candidate diagnostic biomarkers in squamous cell carcinoma of the larynx: association with patient survival.","display_name":"miR-21 and miR-375 microRNAs as candidate diagnostic biomarkers in squamous cell carcinoma of the larynx: association with patient survival.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W326784262","mag":"326784262","pmid":"https://pubmed.ncbi.nlm.nih.gov/25360224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212934"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3179270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030550171","display_name":"An Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151530","display_name":"Shanghai Pudong New Area Gongli Hospital","ror":"https://ror.org/04v5gcw55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151530"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"An Hu","raw_affiliation_strings":["Department of Otolaryngology, Gongli Hospita Pudong New Area, Miaopu Road 219, Shanghai 200135, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Gongli Hospita Pudong New Area, Miaopu Road 219, Shanghai 200135, China","institution_ids":["https://openalex.org/I4210151530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070752239","display_name":"Jingjuan Huang","orcid":"https://orcid.org/0000-0003-1172-7056","observed_orcids":["https://orcid.org/0000-0003-1172-7056"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Juan Huang","raw_affiliation_strings":["Department of Gerontology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Kongjiang Road 1665, Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerontology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Kongjiang Road 1665, Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039224280","display_name":"Weihua Xu","orcid":"https://orcid.org/0000-0002-2570-5897","observed_orcids":["https://orcid.org/0000-0002-2570-5897"]},"institutions":[{"id":"https://openalex.org/I4210151530","display_name":"Shanghai Pudong New Area Gongli Hospital","ror":"https://ror.org/04v5gcw55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151530"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Hua Xu","raw_affiliation_strings":["Department of Otolaryngology, Gongli Hospita Pudong New Area, Miaopu Road 219, Shanghai 200135, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Gongli Hospita Pudong New Area, Miaopu Road 219, Shanghai 200135, China","institution_ids":["https://openalex.org/I4210151530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057097309","display_name":"Xiaojie Jin","orcid":"https://orcid.org/0000-0002-1467-6269","observed_orcids":["https://orcid.org/0000-0002-1467-6269"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Jie Jin","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine Pudong New Area, Dongfang Road 1630, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine Pudong New Area, Dongfang Road 1630, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612777","display_name":"Jiping Li","orcid":"https://orcid.org/0009-0002-8323-1770","observed_orcids":["https://orcid.org/0009-0002-8323-1770"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Ping Li","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine Pudong New Area, Dongfang Road 1630, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine Pudong New Area, Dongfang Road 1630, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110718057","display_name":"Yuanjia Tang","orcid":"https://orcid.org/0000-0002-2044-5424","observed_orcids":["https://orcid.org/0000-0002-2044-5424"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-Jia Tang","raw_affiliation_strings":["Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I2800570007","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112686515","display_name":"Xinfang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Fang Huang","raw_affiliation_strings":["Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I2800570007","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024548083","display_name":"Huijuan Cui","orcid":"https://orcid.org/0000-0002-0308-1550","observed_orcids":["https://orcid.org/0000-0002-0308-1550","https://orcid.org/0000-0002-3489-1097"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Juan Cui","raw_affiliation_strings":["Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Molecular Rheumatology Laboratory of The Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shandong(M) Road 145, Shanghai 200001, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I2800570007","https://openalex.org/I4210106477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114238551","display_name":"Guang-Bin Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Bin Sun","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Shanghai Fudan University School of Medicine Wurumuqi Road 12, Shanghai 200040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Shanghai Fudan University School of Medicine Wurumuqi Road 12, Shanghai 200040, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2618,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.9303857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"604","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mir-375","display_name":"miR-375","score":1.0},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9480000138282776},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.7950000166893005},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8673481345176697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.63642418384552},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.5871157050132751},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5572347640991211},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5151997208595276},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49598392844200134},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.45309972763061523},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.45008131861686707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4490051865577698},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4465767443180084},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4453229308128357},{"id":"https://openalex.org/C2910049883","wikidata":"https://www.wikidata.org/wiki/Q852423","display_name":"Laryngeal Neoplasm","level":3,"score":0.43812400102615356},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41733619570732117},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4136219620704651},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4120580554008484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2406984269618988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1913807988166809},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06559151411056519},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3179270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25360224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25360224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4212934","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4212934/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:326784262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25360224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3179270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W168414953","https://openalex.org/W1530269273","https://openalex.org/W1913502161","https://openalex.org/W1971847988","https://openalex.org/W1972755526","https://openalex.org/W1990645475","https://openalex.org/W2004246503","https://openalex.org/W2006797972","https://openalex.org/W2017714432","https://openalex.org/W2020080445","https://openalex.org/W2020830322","https://openalex.org/W2033389149","https://openalex.org/W2035213975","https://openalex.org/W2039606711","https://openalex.org/W2047895710","https://openalex.org/W2050079849","https://openalex.org/W2071264564","https://openalex.org/W2073803015","https://openalex.org/W2077390683","https://openalex.org/W2078058751","https://openalex.org/W2079251691","https://openalex.org/W2081617695","https://openalex.org/W2096573862","https://openalex.org/W2104610341","https://openalex.org/W2105260398","https://openalex.org/W2109567968","https://openalex.org/W2111990378","https://openalex.org/W2124268899","https://openalex.org/W2124603636","https://openalex.org/W2125071712","https://openalex.org/W2128770040","https://openalex.org/W2130728096","https://openalex.org/W2130808338","https://openalex.org/W2135836598","https://openalex.org/W2137649483","https://openalex.org/W2138934177","https://openalex.org/W2140847299","https://openalex.org/W2142310248","https://openalex.org/W2145187069","https://openalex.org/W2145750430","https://openalex.org/W2151428158","https://openalex.org/W2154551754","https://openalex.org/W2161693225","https://openalex.org/W2163578933","https://openalex.org/W2163655902","https://openalex.org/W2165460739","https://openalex.org/W2171201030","https://openalex.org/W2263783608"],"related_works":["https://openalex.org/W2242147159","https://openalex.org/W2063880557","https://openalex.org/W6964824681","https://openalex.org/W2753030235","https://openalex.org/W2514331548","https://openalex.org/W4290769356","https://openalex.org/W4411665794","https://openalex.org/W2302029001","https://openalex.org/W4394828964","https://openalex.org/W2413618440"],"abstract_inverted_index":{"The":[0,17,63,174],"dismal":[1],"outcome":[2],"of":[3,19,28,57,65,103,172,177,189,250,260],"laryngeal":[4,46,83,137,180,255],"squamous":[5,84],"cell":[6],"carcinoma":[7],"(SCC)":[8],"patients":[9,194,221],"highlights":[10],"the":[11,98,101,106,113,136,142,169,190,230,248,261,281],"need":[12],"for":[13,241],"novel":[14],"prognostic":[15],"biomarkers.":[16],"involvement":[18],"microRNAs":[20,40],"in":[21,45,112,135,179,192,213,253,271,280],"cancer":[22],"and":[23,30,48,69,81,87,105,121,125,131,148,165,168,198,238,264,267],"their":[24],"potential":[25,276],"as":[26,160,275],"biomarkers":[27,277],"diagnosis":[29],"prognosis":[31],"are":[32],"becoming":[33],"increasingly":[34],"appreciated.":[35],"We":[36,95],"sought":[37],"to":[38,49,141,184,220],"identify":[39],"that":[41,247,265],"exhibit":[42],"altered":[43],"expression":[44,54,64,102,115,170,176,212,232,252,269],"SCC":[47,138,181,256],"determine":[50],"whether":[51],"microRNA":[52,114,251],"(miRNA)":[53],"is":[55,258],"predictive":[56],"disease":[58,242,262],"progression":[59],"and/or":[60],"patient":[61],"survival.":[62],"two":[66],"miRNAs,":[67],"miR-21":[68,208,224,266],"miR-375,":[70],"was":[71,117,154,182,234],"evaluated":[72],"using":[73],"total":[74],"RNA":[75],"isolated":[76],"from":[77],"freshly-frozen":[78],"primary":[79,254],"tumors":[80,120],"non-cancerous":[82,122],"epithelial":[85],"tissues":[86,215,257],"quantitative":[88],"real-time":[89],"polymerase":[90],"chain":[91],"reaction":[92],"(qRT-PCR)":[93],"analysis.":[94],"further":[96],"analyzed":[97],"association":[99],"between":[100,119,157],"miRNAs":[104],"clinicopathological":[107],"features.":[108],"A":[109],"marked":[110],"difference":[111],"pattern":[116,249],"observed":[118],"tissue.":[123],"MiR-21":[124],"miR-375":[126,211,227,268],"were":[127],"expressed":[128],"at":[129],"higher":[130,226],"lower":[132,223],"levels,":[133,270],"respectively,":[134],"samples,":[139],"compared":[140,219],"normal":[143],"samples":[144],"(p":[145,195,202],"<":[146,150,203],"0.01":[147],"p":[149],"0.001,":[151],"respectively).":[152],"There":[153],"no":[155],"correlation":[156],"characteristics":[158],"such":[159],"age,":[161],"sex,":[162],"clinical":[163,282],"stage,":[164],"alcohol":[166,200],"use,":[167],"level":[171],"mir-21.":[173],"relative":[175],"mir-375":[178],"shown":[183],"be":[185],"associated":[186],"with":[187,199,206,222,278],"localization":[188],"tumor":[191,214],"these":[193],"=":[196],"0.037)":[197],"use":[201],"0.05).":[204],"Patients":[205],"high":[207],"or":[209,225],"low":[210],"had":[216],"poorer":[217],"prognoses":[218],"expression.":[228],"Furthermore,":[229],"miR-21/miR-375":[231],"ratio":[233],"highly":[235],"sensitive":[236],"(0.94)":[237,240],"specific":[239],"prediction.":[243],"These":[244],"data":[245],"suggest":[246],"reflective":[259],"status":[263],"particular,":[272],"may":[273],"serve":[274],"applications":[279],"setting.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}