{"id":"https://openalex.org/W326500998","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","title":"Neuroprotective Mechanisms of Methylene Blue","display_name":"Neuroprotective Mechanisms of Methylene Blue","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W326500998","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","mag":"326500998"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.27.1_supplement.691.9","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065322806","display_name":"Myoung\u2010Gwi Ryou","orcid":"https://orcid.org/0000-0002-4494-7007","observed_orcids":["https://orcid.org/0000-0002-4494-7007"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myoung\u2010Gwi Ryou","raw_affiliation_strings":["Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058129833","display_name":"Gourav Roy Choudhury","orcid":"https://orcid.org/0000-0001-8664-7638","observed_orcids":["https://orcid.org/0000-0001-8664-7638"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gourav Roy Choudhury","raw_affiliation_strings":["Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074682486","display_name":"Robert T. Mallet","orcid":"https://orcid.org/0000-0001-7388-9419","observed_orcids":["https://orcid.org/0000-0001-7388-9419"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T Mallet","raw_affiliation_strings":["Integrative Physiology UNT Health Science Center Fort Worth TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Physiology UNT Health Science Center Fort Worth TX","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102898337","display_name":"Shao\u2010Hua Yang","orcid":"https://orcid.org/0000-0002-0405-0887","observed_orcids":["https://orcid.org/0000-0002-0405-0887"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaohua Yang","raw_affiliation_strings":["Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Neuroscience UNT Health Science Center Fort Worth TX","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02650331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation-injury","display_name":"hypoxia/reoxygenation injury","score":0.953000009059906},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation","display_name":"oxygen-glucose deprivation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7940000295639038},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6230000257492065},{"id":"https://openalex.org/keywords/phenothiazine-dyes","display_name":"phenothiazine dyes","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7514649629592896},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7346426248550415},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7223883867263794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6030682921409607},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.5908955931663513},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.5684993267059326},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5600728988647461},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5382604002952576},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46589788794517517},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3978463411331177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3726447820663452},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31482458114624023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29546016454696655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24432745575904846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21916475892066956},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.27.1_supplement.691.9","doi":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.27.1_supplement.691.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W567021032","https://openalex.org/W2290953750","https://openalex.org/W7098366829","https://openalex.org/W2072445126","https://openalex.org/W1979786394","https://openalex.org/W7095698589","https://openalex.org/W4295957254","https://openalex.org/W2094541549","https://openalex.org/W2060786853","https://openalex.org/W2951875748"],"abstract_inverted_index":{"Background":[0],"The":[1],"phenothiazine":[2],"dye":[3],"methylene":[4],"blue":[5],"(MB)":[6],"has":[7],"antioxidant":[8],"properties":[9],"and":[10,14,37,68,77,83,109,132,142,160],"augments":[11],"ATP":[12,35,84,124,158],"production,":[13],"is":[15],"selectively":[16],"internalized":[17],"by":[18,33,58,102,145,155],"neurons":[19,28],"after":[20],"systemic":[21],"injection":[22],"into":[23],"rats.":[24],"Hypothesis":[25],"MB":[26,112,118,135,151],"protects":[27,152],"against":[29],"hypoxia\u2010reoxygenation":[30],"(H/R)":[31],"injury":[32],"enhancing":[34,157],"production":[36,159],"activating":[38,161],"the":[39],"Akt/mTOR":[40,74],"signaling":[41],"pathway.":[42],"Methods":[43],"HT22":[44,153],"cells":[45,154],"were":[46,88,93],"subjected":[47],"to":[48],"3h":[49],"oxygen\u2010glucose":[50],"deprivation":[51],"(OGD;":[52],"0.5%":[53],"O":[54],"2":[55],")":[56],"followed":[57],"24":[59],"h":[60],"reoxygenation":[61],"(H/R":[62],"protocol).":[63],"Cell":[64],"viability":[65,101],"(Calcein":[66],"AM),":[67],"contents":[69],"of":[70],"hypoxia":[71],"inducible":[72],"factor\u20101\u03b1,":[73],"pathway":[75],"components,":[76],"actin":[78],"(immunoblot),":[79],"erythropoietin":[80],"(EPO;":[81],"immunocytochemistry)":[82],"content":[85,131],"(microplate":[86],"assay)":[87],"analyzed.":[89],"P":[90],"values":[91],"<0.05":[92],"considered":[94],"statistically":[95],"different.":[96],"Results":[97],"OGD":[98],"reduced":[99],"cell":[100,116],"40%":[103],"vs":[104],".":[105],"normoxia,":[106],"but":[107],"50":[108],"100":[110],"nM":[111],"prevented":[113],"H/R":[114,148],"induced":[115],"death.":[117],"(10\u20131000":[119],"nM)":[120],"concentration\u2010dependently":[121],"increased":[122,129,138],"cellular":[123],"content,":[125],"in":[126],"parallel":[127],"with":[128],"HIF\u20101\u03b1":[130],"EPO":[133],"expression.":[134],"(500":[136],"\u03bcM)":[137],"Akt":[139],"phosphorylation":[140,144],"fourfold":[141],"mTOR":[143],"45%":[146],"vs.":[147],"control.":[149],"Conclusion":[150],"both":[156],"EPO's":[162],"anti\u2010apoptotic":[163],"signaling.":[164]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}