{"id":"https://openalex.org/W32577797","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","title":"Abstract 615: LKB1 is Required for Statin-induced Activation of the AMP-activated Protein Kinase","display_name":"Abstract 615: LKB1 is Required for Statin-induced Activation of the AMP-activated Protein Kinase","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W32577797","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","mag":"32577797"},"language":"en","primary_location":{"id":"doi:10.1161/circ.116.suppl_16.ii_112-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052568474","display_name":"Hyoung Chul Choi","orcid":"https://orcid.org/0000-0002-1367-0797","observed_orcids":["https://orcid.org/0000-0002-1367-0797"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyoung Chul Choi","raw_affiliation_strings":["OUHSC, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OUHSC, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405272","display_name":"Miao Zhang","orcid":"https://orcid.org/0000-0003-4912-2570","observed_orcids":["https://orcid.org/0000-0003-4912-2570"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miao Zhang","raw_affiliation_strings":["OUHSC, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OUHSC, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111167888","display_name":"Zhonglin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhonglin Xie","raw_affiliation_strings":["OUHSC, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OUHSC, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055937253","display_name":"Ming\u2010Hui Zou","orcid":"https://orcid.org/0000-0002-3913-0617","observed_orcids":["https://orcid.org/0000-0002-3913-0617"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Hui Zou","raw_affiliation_strings":["OUHSC, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OUHSC, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"suppl_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9620000123977661},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8920000195503235},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fluvastatin","display_name":"fluvastatin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7089999914169312},{"id":"https://openalex.org/keywords/camkk","display_name":"CaMKK","score":0.7689999938011169},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/diabetic-liver","display_name":"diabetic liver","score":0.4129999876022339},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.45899999141693115},{"id":"https://openalex.org/keywords/kinase-cascade","display_name":"kinase cascade","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8491655588150024},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6855854988098145},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6630887985229492},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.6317691206932068},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5806690454483032},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.5369486808776855},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4783341884613037},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4412633776664734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4110386371612549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4048081934452057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38481462001800537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27127131819725037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.116.suppl_16.ii_112-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_112-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968743698","https://openalex.org/W2135083563","https://openalex.org/W94683223","https://openalex.org/W2021020436","https://openalex.org/W7097425682","https://openalex.org/W1967501240","https://openalex.org/W2098947405","https://openalex.org/W2025166615","https://openalex.org/W7095109336","https://openalex.org/W2131477555"],"abstract_inverted_index":{"Statins,":[0],"lipid-lowering":[1],"drugs,":[2],"exert":[3,22],"many":[4],"beneficial":[5],"effects":[6,25],"on":[7],"the":[8,28,37,44,49,91,193,203,214,243,254],"cardiovascular":[9],"system.":[10],"Recent":[11],"studies":[12],"have":[13],"demonstrated":[14],"that":[15,162,190,272],"clinically":[16],"relevant":[17],"concentrations":[18],"of":[19,43,73,83,93,109,138,153,173,184,196,205,218,227,245,258,267],"statins":[20,54,273],"might":[21],"their":[23],"therapeutic":[24],"by":[26,52,277],"activating":[27],"AMP-activated":[29],"kinase":[30,101,141,142],"(AMPK)":[31],"in":[32,213,235,253,284],"cultured":[33],"endothelial":[34,60],"cells,":[35],"but":[36,115],"mechanism":[38,51],"remains":[39],"elusive.":[40],"The":[41],"aim":[42],"study":[45],"was":[46,210],"to":[47,65,69,75,200],"determine":[48],"molecular":[50],"which":[53],"activate":[55],"AMPK.":[56],"Confluent":[57],"bovine":[58],"aortic":[59],"cells":[61],"(BAEC)":[62],"were":[63],"exposed":[64],"simvastatins":[66,76,88],"for":[67,131,167,238],"1":[68],"24":[70],"h.":[71],"Exposure":[72],"BAEC":[74],"caused":[77],"a":[78,148],"time-dependent":[79],"and":[80,99,187,208,216,256],"dose-dependent":[81],"increase":[82,274],"AMPK-Thr172":[84,125,207,251],"phosphorylation.":[85,269],"In":[86,261],"parallel,":[87],"significantly":[89,211,241,264],"increased":[90,242,265],"phosphorylation":[92,183,204,252,281],"both":[94,185,206],"LKB1":[95,110,128,280],"at":[96,104,282],"serine":[97],"428":[98],"protein":[100],"C":[102],"(PKC)-\u03b6":[103],"Thr410/403.":[105],"Further,":[106],"adenoviral":[107],"overexpression":[108,172],"kinase-dead":[111],"(LKB1":[112],"D194A)":[113],"mutants,":[114],"not":[116,165],"adenoviruses":[117],"encoding":[118],"green":[119],"fluorescence":[120],"proteins":[121],"(GFP),":[122],"ablated":[123],"simvastatin-induced":[124],"phosphorylation,":[126,160],"suggesting":[127,161],"is":[129,164,192],"required":[130,166],"statin-enhanced":[132,168],"AMPK":[133,158,169,247,275],"activation.":[134,170],"Conversely,":[135],"neither":[136],"inhibition":[137],"calcium":[139],"calmodulin-dependent":[140],"(CaMKK)":[143],"with":[144,231],"STO609":[145],"(1":[146],"\u03bcM),":[147],"CaMKK-specific":[149,154],"inhibitor,":[150],"nor":[151],"transfection":[152],"siRNA":[155,180],"altered":[156],"simvastatin-enhanced":[157,182],"Thr172":[159],"CaMKK":[163],"Moreover,":[171],"PKC-\u03b6":[174,191],"dominant":[175],"negative":[176],"mutants":[177],"or":[178,223],"PKC-\u03b6-specific":[179],"abolished":[181],"LKB1-Ser428":[186,209,268],"AMPK-Thr172,":[188],"implying":[189],"upstream":[194],"enzyme":[195],"LKB1.":[197],"Finally,":[198],"compared":[199],"lean":[201],"mice,":[202],"suppressed":[212],"hearts":[215,257],"livers":[217,255],"diabetic":[219,228],"DB/DB":[220,229,259],"mice":[221,230],"(n=4":[222],"6,":[224],"p<0.05).":[225],"Treatment":[226],"fluvastatin":[232,263],"(22.5":[233],"mg/kg/day":[234],"drinking":[236],"water)":[237],"4":[239],"months":[240],"levels":[244],"total":[246],"as":[248,250],"well":[249],"mice.":[260],"addition,":[262],"detection":[266],"We":[270],"conclude":[271],"activation":[276],"increasing":[278],"PKC-\u03b6-dependent":[279],"Ser428":[283],"vivo":[285],".":[286]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}