{"id":"https://openalex.org/W325734366","doi":null,"title":"Synth\u00e8se et \u00e9valuation biologique de moutardes \u00e0 l'azote \u00e0 motifs pyrimidiques, puriques et triazoliques :","display_name":"Synth\u00e8se et \u00e9valuation biologique de moutardes \u00e0 l'azote \u00e0 motifs pyrimidiques, puriques et triazoliques :","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W325734366","mag":"325734366"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/1021036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/1021036","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/1021036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049714850","display_name":"Benjamin Bo\u00ebns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin Bo\u00ebns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049714850"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.38109999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.38109999895095825,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.1639000028371811,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroso-compounds","display_name":"nitroso compounds","score":0.7390000224113464},{"id":"https://openalex.org/keywords/uracil-derivatives","display_name":"uracil derivatives","score":0.8799999952316284},{"id":"https://openalex.org/keywords/direct-amidation","display_name":"direct amidation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/noncovalent-interactions","display_name":"non-covalent interactions","score":0.753000020980835},{"id":"https://openalex.org/keywords/copper-catalyzed-azide-alkyne-cycloaddition","display_name":"copper-catalyzed azide-alkyne cycloaddition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6873898506164551},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43820449709892273},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3632422685623169},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.32247474789619446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09823861718177795}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/1021036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/1021036","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:325734366","doi":null,"is_oa":false,"landing_page_url":"http://epublications.unilim.fr/theses/index.php?id=8730","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/1021036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/1021036","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6996894329","https://openalex.org/W793759040","https://openalex.org/W828298522","https://openalex.org/W7148487843","https://openalex.org/W183397534","https://openalex.org/W7148290712","https://openalex.org/W7143474133","https://openalex.org/W6999434492","https://openalex.org/W7006383970","https://openalex.org/W7052871940"],"abstract_inverted_index":{"Au":[0],"travers":[1],"de":[2,9,35,40,48,57,81,88,98,102,120,132,135,158,172,179,196],"ce":[3],"manuscrit,":[4],"nous":[5,24,77,109,110,137,167],"d\u00e9crivons":[6,78],"la":[7,26,79,96,103,133,149,152],"synth\u00e8se":[8,27,80,153],"moutardes":[10,121,159],"\u00e0":[11,14,31,52,83,86,95,113,122,125,129,151,160],"l":[12,32,36,41,64,84,114,123,130,161,169],"azote":[13,33,85,124,162],"motifs":[15,126,164],"pyrimidiques,":[16],"puriques":[17],"ou":[18],"triazoliques.":[19,127],"Dans":[20,73,105],"un":[21],"premier":[22],"temps,":[23],"\u00e9tudions":[25,168],"d":[28,43,116,154],"une":[29,74,106,117,155],"moutarde":[30,82],"d\u00e9riv\u00e9e":[34],"uracile.":[37],"L":[38],"\u00e9tude":[39,56],"\u00e9tape":[42],"amidation":[44],"directe":[45],"a":[46,60,93],"permis":[47],"g\u00e9n\u00e9raliser":[49],"cette":[50,71],"m\u00e9thode":[51],"diverses":[53],"amines.":[54],"Une":[55],"mod\u00e9lisation":[58],"mol\u00e9culaire":[59],"mis":[61],"en":[62,185],"\u00e9vidence":[63],"importance":[65],"des":[66,174,192],"interactions":[67],"non":[68],"liantes":[69],"dans":[70],"r\u00e9action.":[72],"seconde":[75],"partie,":[76,108],"partir":[87],"bases":[89],"puriques.":[90],"Cette":[91,145],"strat\u00e9gie":[92,147],"conduit":[94],"formation":[97],"compos\u00e9s":[99,175,188],"tricycliques,":[100],"d\u00e9riv\u00e9s":[101],"purine.":[104],"troisi\u00e8me":[107],"sommes":[111],"int\u00e9ress\u00e9s":[112],"\u00e9laboration":[115],"nouvelle":[118,156],"famille":[119,157],"Gr\u00e2ce":[128],"utilisation":[131],"r\u00e9action":[134],"CuAAC,":[136],"avons":[138],"synth\u00e9tis\u00e9":[139],"huit":[140],"mol\u00e9cules":[141],"aux":[142,163],"structures":[143],"innovantes.":[144],"derni\u00e8re":[146],"ouvre":[148],"voie":[150],"vari\u00e9s.":[165],"Enfin,":[166],"activit\u00e9":[170],"biologique":[171],"certains":[173],"synth\u00e9tis\u00e9s":[176],"par":[177,183],"test":[178],"viabilit\u00e9":[180],"cellulaire,":[181],"puis":[182],"cytom\u00e9trie":[184],"flux.":[186],"Deux":[187],"obtenus":[189],"ont":[190],"pr\u00e9sent\u00e9":[191],"r\u00e9sultats":[193],"encourageants":[194],"vis-\u00e0-vis":[195],"quatre":[197],"lign\u00e9es":[198],"canc\u00e9reuses.":[199]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
