{"id":"https://openalex.org/W32439334","doi":null,"title":"Role of wax ester fatty alcohols in chronic blepharitis.","display_name":"Role of wax ester fatty alcohols in chronic blepharitis.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W32439334","mag":"32439334","pmid":"https://pubmed.ncbi.nlm.nih.gov/8258508"},"language":"en","primary_location":{"id":"pmid:8258508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8258508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109904402","display_name":"Ward E. Shine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W E Shine","raw_affiliation_strings":["Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas 75235-9057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas 75235-9057","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035682572","display_name":"James P. McCulley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P McCulley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0505,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.75345327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"34","issue":"13","first_page":"3515","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-blepharitis","display_name":"chronic blepharitis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/meibomian-gland-secretion","display_name":"meibomian gland secretion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/meibum","display_name":"meibum","score":0.8650000095367432},{"id":"https://openalex.org/keywords/fatty-alcohols","display_name":"fatty alcohols","score":0.7239999771118164},{"id":"https://openalex.org/keywords/alpha-oxidation","display_name":"alpha-oxidation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/epoxy-fatty-acids","display_name":"epoxy fatty acids","score":0.8610000014305115},{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2777165675","wikidata":"https://www.wikidata.org/wiki/Q1425513","display_name":"Meibomian gland","level":3,"score":0.775597333908081},{"id":"https://openalex.org/C2776288157","wikidata":"https://www.wikidata.org/wiki/Q3010324","display_name":"Wax ester","level":3,"score":0.7674839496612549},{"id":"https://openalex.org/C2779704304","wikidata":"https://www.wikidata.org/wiki/Q378871","display_name":"Fatty alcohol","level":2,"score":0.7290917634963989},{"id":"https://openalex.org/C153033020","wikidata":"https://www.wikidata.org/wiki/Q124695","display_name":"Wax","level":2,"score":0.6659666299819946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6417427659034729},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6412729620933533},{"id":"https://openalex.org/C2991667435","wikidata":"https://www.wikidata.org/wiki/Q334951","display_name":"Carbon chain","level":2,"score":0.5348189473152161},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.4660070538520813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44035691022872925},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3726162314414978},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.37034547328948975},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2890758812427521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1644822657108307},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12463074922561646},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.10102775692939758}],"mesh":[{"descriptor_ui":"D001762","descriptor_name":"Blepharitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008537","descriptor_name":"Meibomian Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8258508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8258508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:32439334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8258508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G719102954","display_name":"MEIBOMIAN KERATOCONJUNCTIVITIS","funder_award_id":"5r01ey003650-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W19732103","https://openalex.org/W22001082","https://openalex.org/W37688013","https://openalex.org/W61312561","https://openalex.org/W83803278","https://openalex.org/W113565865","https://openalex.org/W119819385","https://openalex.org/W152407597","https://openalex.org/W177996137","https://openalex.org/W590926286","https://openalex.org/W1497958401","https://openalex.org/W1528921211","https://openalex.org/W1607249944","https://openalex.org/W1645641966","https://openalex.org/W1728949843","https://openalex.org/W1912594835","https://openalex.org/W1970652710","https://openalex.org/W1980346504","https://openalex.org/W1980757441","https://openalex.org/W1995395866","https://openalex.org/W2021675427","https://openalex.org/W2021990339","https://openalex.org/W2036078158","https://openalex.org/W2042357295","https://openalex.org/W2056614096","https://openalex.org/W2071692620","https://openalex.org/W2071910562","https://openalex.org/W2081874991","https://openalex.org/W2085111147","https://openalex.org/W2108042842","https://openalex.org/W2153695113","https://openalex.org/W2158003662","https://openalex.org/W2165339855","https://openalex.org/W2298664769","https://openalex.org/W2417419148","https://openalex.org/W2419530189","https://openalex.org/W2575116520","https://openalex.org/W2808474807","https://openalex.org/W2926452721","https://openalex.org/W2954832731","https://openalex.org/W2958112249","https://openalex.org/W2960490797","https://openalex.org/W2974311392"],"related_works":["https://openalex.org/W152407597","https://openalex.org/W46753378","https://openalex.org/W37688013","https://openalex.org/W1988108903","https://openalex.org/W19732103","https://openalex.org/W2037693991","https://openalex.org/W2025625688","https://openalex.org/W2620150846","https://openalex.org/W2409189030","https://openalex.org/W4366001908"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2],"was":[3,170],"performed":[4],"to":[5,29,160,204,223],"determine":[6,30],"the":[7,10,50,71,93,110,148,189],"difference":[8],"in":[9,82,119,188,221],"composition":[11],"of":[12,56,70,76,150,225],"wax":[13,51],"ester":[14,54],"fatty":[15],"alcohols":[16,124,178],"from":[17,21,49,141,157],"meibomian":[18,197],"gland":[19,198],"secretions":[20],"normal":[22,111,127,181],"people":[23],"and":[24,28,52,68,113,134,210],"those":[25],"with":[26,36,92],"blepharitis,":[27],"which":[31],"lipids":[32,78],"are":[33],"associated":[34],"significantly":[35,171,203],"specific":[37],"chronic":[38,206],"blepharitis":[39,207],"disease":[40,115,208],"groups.":[41,73,122,175],"METHODS:":[42],"Fatty":[43],"alcohols,":[44,144],"isolated":[45],"by":[46,61,89],"thin-layer":[47],"chromatography":[48],"sterol":[53],"fraction":[55],"human":[57],"meibum,":[58],"were":[59,86,117,179,186],"analyzed":[60,87],"gas":[62],"chromatography-mass":[63],"spectroscopy":[64],"after":[65],"oxidative":[66],"ozonolysis":[67],"silylation":[69],"alcohol":[72,121,190],"Relative":[74],"amounts":[75],"individual":[77],"or":[79,215],"lipid":[80,199,227],"groupings":[81],"each":[83],"patient":[84],"group":[85,112,130,137,153],"statistically":[88],"Dunnett's":[90],"comparison,":[91],"overall":[94],"significance":[95],"level":[96],"adjusted":[97],"for":[98,173],"multiple":[99],"testing":[100],"(Bonferroni":[101],"adjustment).":[102],"RESULTS:":[103],"Significant":[104],"differences":[105,200],"(P":[106],"<":[107],"0.05)":[108],"between":[109],"five":[114],"groups":[116],"found":[118],"certain":[120,126,174],"These":[123,193],"included":[125],"(straight":[128],"chain-methyl":[129],"on":[131,138,154],"chain":[132,142,158],"end)":[133,143,159],"anteiso":[135,161],"(methyl":[136,152],"second":[139],"carbon":[140,156],"as":[145,147],"well":[146],"ratio":[149],"iso":[151],"first":[155],"alcohols.":[162,182],"The":[163,176],"results":[164],"also":[165,185,211],"suggested":[166],"that":[167,196,213],"alpha-oxidation":[168],"activity":[169],"different":[172],"unsaturated":[177],"primarily":[180],"Epoxy-fatty":[183],"acids":[184],"present":[187],"fraction.":[191],"CONCLUSIONS:":[192],"data":[194],"suggest":[195,212],"may":[201,219],"contribute":[202,220],"some":[205,224],"signs":[209],"peroxisomal":[214],"endoplasmic":[216],"reticulum":[217],"abnormalities":[218],"part":[222],"these":[226],"differences.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}