{"id":"https://openalex.org/W324344089","doi":null,"title":"Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.","display_name":"Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W324344089","mag":"324344089","pmid":"https://pubmed.ncbi.nlm.nih.gov/9310957"},"language":"en","primary_location":{"id":"pmid:9310957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9310957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047361567","display_name":"Mohammad A. Vasef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Vasef","raw_affiliation_strings":["Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000027373","display_name":"Leonard Jeffrey Medeiros","orcid":"https://orcid.org/0000-0001-6577-8006","observed_orcids":["https://orcid.org/0000-0001-6577-8006"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L J Medeiros","raw_affiliation_strings":["City of Hope National Med Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope National Med Center","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043080511","display_name":"Lisa S. Yospur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L S Yospur","raw_affiliation_strings":["University of California at Los Angeles**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles**","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N C Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N C Sun","raw_affiliation_strings":["University of California at Los Angeles**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Los Angeles**","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108085839","display_name":"Althea McCourty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A McCourty","raw_affiliation_strings":["City of Hope National Med Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope National Med Center","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112152295","display_name":"RK Brynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R K Brynes","raw_affiliation_strings":["City of Hope National Med Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope National Med Center","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5124,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.92569464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"9","first_page":"927","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/plasmacytoma","display_name":"plasmacytoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plasma-cell-neoplasms","display_name":"plasma cell neoplasms","score":0.9649999737739563},{"id":"https://openalex.org/keywords/plasma-cell-leukemia","display_name":"plasma cell leukemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.5509999990463257},{"id":"https://openalex.org/keywords/paraffin-embedded-tissue","display_name":"paraffin-embedded tissue","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.8621733784675598},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6509729623794556},{"id":"https://openalex.org/C2778964538","wikidata":"https://www.wikidata.org/wiki/Q2090167","display_name":"Plasmacytoma","level":3,"score":0.5616773962974548},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5567643642425537},{"id":"https://openalex.org/C2780353925","wikidata":"https://www.wikidata.org/wiki/Q7201765","display_name":"Plasma cell leukemia","level":3,"score":0.5411194562911987},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5379430055618286},{"id":"https://openalex.org/C2908937092","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Plasma Cell Myeloma","level":3,"score":0.5309381484985352},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5218595266342163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49473831057548523},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43844541907310486},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29682600498199463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23226302862167358},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11193865537643433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007952","descriptor_name":"Leukemia, Plasma Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007952","descriptor_name":"Leukemia, Plasma Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007952","descriptor_name":"Leukemia, Plasma Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010954","descriptor_name":"Plasmacytoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010954","descriptor_name":"Plasmacytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010954","descriptor_name":"Plasmacytoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9310957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9310957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},{"id":"mag:324344089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9310957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995500506","https://openalex.org/W2472147509","https://openalex.org/W4405658129","https://openalex.org/W2585170919","https://openalex.org/W2018397039","https://openalex.org/W2113444305","https://openalex.org/W4242158744","https://openalex.org/W2108761296","https://openalex.org/W2022240615","https://openalex.org/W2062255707"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3,109],"analyzed":[4,111],"69":[5,48],"plasma":[6,17,49,67,146],"cell":[7,18,50,68,147],"neoplasms,":[8,51],"including":[9,52],"54":[10,56],"multiple":[11],"myelomas":[12],"(MMs),":[13],"3":[14],"cases":[15,65,113],"of":[16,25,47,55,61,66,83,87,103,145,154,164,175,189,197],"leukemia,":[19],"and":[20,58,80,96,130,149,157],"12":[21,62],"plasmacytomas,":[22],"for":[23,122],"expression":[24,74,140],"cyclin":[26,115,119,132,138,165,190],"D1":[27,41,73,116,120,133,139,166,191],"protein":[28,192],"using":[29],"an":[30],"immuno-histochemical":[31],"method":[32],"applied":[33],"to":[34],"routinely":[35],"fixed,":[36],"paraffin-embedded":[37],"tissue":[38],"sections.":[39],"Cyclin":[40,72],"was":[42],"expressed":[43,131],"in":[44,142,183],"18":[45],"(26%)":[46],"16":[53,88],"(30%)":[54],"MMs":[57,89],"2":[59],"(17%)":[60],"plasmacytomas.":[63],"Three":[64],"leukemia":[69],"were":[70,97],"negative.":[71],"correlated":[75],"with":[76,151,169],"the":[77,123,128,152,170,176,184,195,201],"cytologic":[78,94,155],"differentiation":[79,156],"histologic":[81,98,158],"stage":[82],"MM.":[84],"Twelve":[85],"(75%)":[86],"had":[90],"intermediate":[91],"or":[92],"immature":[93],"features":[95],"Stage":[99],"III.":[100],"With":[101],"use":[102],"a":[104],"polymerase":[105],"chain":[106],"reaction":[107],"assay,":[108],"also":[110],"six":[112],"(three":[114],"positive,":[117],"three":[118],"negative)":[121],"t(11;14);":[124],"one":[125],"MM":[126],"carried":[127],"t(11;14)":[129,177],"protein.":[134],"We":[135],"conclude":[136],"that":[137,187],"occurs":[141],"approximately":[143],"one-quarter":[144],"neoplasms":[148],"correlates":[150],"degree":[153],"stage.":[159],"The":[160],"relatively":[161],"high":[162],"frequency":[163],"expression,":[167],"compared":[168],"less":[171],"than":[172,200],"5%":[173],"incidence":[174],"detected":[178],"by":[179],"conventional":[180],"cytogenetics":[181],"reported":[182],"literature,":[185],"suggests":[186],"upregulation":[188],"might":[193],"be":[194],"result":[196],"mechanisms":[198],"other":[199],"t(11;14).":[202]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}