{"id":"https://openalex.org/W324137543","doi":"https://doi.org/10.1182/blood.v81.6.1630.1630","title":"Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia or beta-thalassemia","display_name":"Hydroxyurea increases fetal hemoglobin in cultured erythroid cells derived from normal individuals and patients with sickle cell anemia or beta-thalassemia","publication_year":1993,"publication_date":"1993-03-15","ids":{"openalex":"https://openalex.org/W324137543","doi":"https://doi.org/10.1182/blood.v81.6.1630.1630","mag":"324137543","pmid":"https://pubmed.ncbi.nlm.nih.gov/7680923"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v81.6.1630.1630","doi":"https://doi.org/10.1182/blood.v81.6.1630.1630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v81.6.1630.1630","pdf_url":"https://ashpublications.org/blood/article-pdf/81/6/1630/610113/1630.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/81/6/1630/610113/1630.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015469728","display_name":"Eitan Fibach","orcid":"https://orcid.org/0000-0002-6658-6126","observed_orcids":["https://orcid.org/0000-0002-6658-6126"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Fibach","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037362526","display_name":"LP Burke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"LP Burke","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048178","display_name":"Alan N. Schechter","orcid":"https://orcid.org/0000-0002-6055-6452","observed_orcids":["https://orcid.org/0000-0002-6055-6452","https://orcid.org/0000-0002-5235-9408"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"AN Schechter","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112162882","display_name":"CT Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"CT Noguchi","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063483123","display_name":"GP Rodgers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"GP Rodgers","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799899409"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.0616,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.90748103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"81","issue":"6","first_page":"1630","last_page":"1635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":1.0},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":1.0},{"id":"https://openalex.org/keywords/erythroid-progenitors","display_name":"erythroid progenitor cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/globin-gene-regulation","display_name":"globin gene regulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.652999997138977},{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.5989999771118164},{"id":"https://openalex.org/keywords/predictive-assays","display_name":"predictive assays","score":0.3709999918937683},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.840111255645752},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.5984545350074768},{"id":"https://openalex.org/C2908652662","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Hemoglobin F","level":5,"score":0.5956333875656128},{"id":"https://openalex.org/C2781058662","wikidata":"https://www.wikidata.org/wiki/Q1358504","display_name":"Mean corpuscular volume","level":3,"score":0.5945379137992859},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5582787990570068},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.5260113477706909},{"id":"https://openalex.org/C2780554921","wikidata":"https://www.wikidata.org/wiki/Q1940759","display_name":"Mean corpuscular hemoglobin","level":4,"score":0.5036734938621521},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.4810895621776581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.473969429731369},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46385905146598816},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.4585525691509247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45120182633399963},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.44420522451400757},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.44386807084083557},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.44270920753479004},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.42881518602371216},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.424582302570343},{"id":"https://openalex.org/C2780844101","wikidata":"https://www.wikidata.org/wiki/Q2380264","display_name":"Ineffective erythropoiesis","level":4,"score":0.4185537099838257},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4128565490245819},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4082528054714203},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.40632402896881104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2449871301651001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1861034333705902},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.103314608335495},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08037284016609192}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v81.6.1630.1630","doi":"https://doi.org/10.1182/blood.v81.6.1630.1630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v81.6.1630.1630","pdf_url":"https://ashpublications.org/blood/article-pdf/81/6/1630/610113/1630.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v81.6.1630.bloodjournal8161630","doi":"https://doi.org/10.1182/blood.v81.6.1630.bloodjournal8161630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v81.6.1630.bloodjournal8161630","pdf_url":"https://ashpublications.org/blood/article-pdf/81/6/1630/228374/1630.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:7680923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v81.6.1630.1630","doi":"https://doi.org/10.1182/blood.v81.6.1630.1630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v81.6.1630.1630","pdf_url":"https://ashpublications.org/blood/article-pdf/81/6/1630/610113/1630.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W324137543.pdf","grobid_xml":"https://content.openalex.org/works/W324137543.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W130020229","https://openalex.org/W137255699","https://openalex.org/W176375325","https://openalex.org/W206006204","https://openalex.org/W331976407","https://openalex.org/W1516165231","https://openalex.org/W1979704489","https://openalex.org/W1994004378","https://openalex.org/W1994347885","https://openalex.org/W1996043889","https://openalex.org/W2005752061","https://openalex.org/W2010616085","https://openalex.org/W2012901225","https://openalex.org/W2015794428","https://openalex.org/W2025259610","https://openalex.org/W2039820478","https://openalex.org/W2053084472","https://openalex.org/W2068065077","https://openalex.org/W2087482716","https://openalex.org/W2154187040","https://openalex.org/W2167948291","https://openalex.org/W2318281771","https://openalex.org/W2323938126","https://openalex.org/W2339459511","https://openalex.org/W2341675267","https://openalex.org/W2397578269","https://openalex.org/W2463162634","https://openalex.org/W2504899707","https://openalex.org/W3093093377"],"related_works":["https://openalex.org/W2161933079","https://openalex.org/W2554840160","https://openalex.org/W2027948486","https://openalex.org/W206006204","https://openalex.org/W2555302365","https://openalex.org/W2555435665","https://openalex.org/W2542104306","https://openalex.org/W1972148557","https://openalex.org/W2302470898","https://openalex.org/W1971500497"],"abstract_inverted_index":{"Hydroxyurea":[0],"(HU),":[1],"an":[2,104,125,138],"inhibitor":[3],"of":[4,46,58,67,109,121,148,159,189,230,250,255,286,289,301,304],"DNA":[5],"synthesis,":[6],"has":[7],"been":[8,34],"shown":[9,241],"to":[10,95,119,153,163,174,183,193,199,201,244,265,309],"increase":[11,105,126,139,185,213,246],"fetal":[12],"hemoglobin":[13,128,134],"(HbF)":[14],"levels":[15],"in":[16,23,36,53,81,106,115,127,140,186,197,205,214,223,247,279],"patients":[17,25,235,259,306],"with":[18,26,236,260,307],"sickle":[19,237],"cell":[20,116,122,131,141,164,224,238,273],"anemia":[21,239],"and":[22,49,90,136,157,208,283,291,311],"some":[24],"beta-thalassemia.":[27],"However,":[28],"until":[29],"now":[30],"there":[31],"have":[32,96,240],"not":[33],"good":[35],"vitro":[37],"model":[38],"systems":[39],"that":[40,270],"simulate":[41],"this":[42,271],"effect":[43],"for":[44,299],"study":[45],"the":[47,55,59,64,107,154,187,248,281,302],"molecular":[48,284],"cellular":[50,65,282],"mechanism(s)":[51],"involved":[52],"perturbing":[54],"normal":[56,167],"ontogeny":[57],"globin":[60],"genes.":[61],"We":[62,268],"analyzed":[63],"effects":[66,98,150],"HU":[68,92,155,179,256,310],"using":[69],"a":[70,113,181,209,218,242,263,294],"two-phase":[71],"liquid":[72],"culture":[73,274],"procedure":[74,275],"(Fibach":[75],"et":[76],"al:":[77],"Blood":[78],"73:100,":[79],"1989)":[80],"which":[82],"human":[83],"peripheral":[84],"blood-derived":[85],"progenitor":[86],"cells":[87,231],"undergo":[88],"proliferation":[89],"differentiation.":[91],"was":[93,151],"found":[94],"multiple":[97],"on":[99,226],"these":[100,149],"cultured":[101],"cells:":[102],"(1)":[103],"proportion":[108,188],"HbF":[110,290],"produced;":[111],"(2)":[112],"decrease":[114,222],"number":[117,225],"due":[118],"inhibition":[120],"proliferation;":[123],"(3)":[124],"content":[129],"per":[130],"(mean":[132,143,195,203],"corpuscular":[133,144],"[MCH]);":[135],"(4)":[137],"size":[142],"volume).":[145],"The":[146],"extent":[147],"related":[152],"dose":[156],"time":[158],"addition.":[160],"When":[161],"added":[162],"cultures":[165,207],"from":[166,191,233],"individuals,":[168],"4":[169],"days":[170],"following":[171,253],"their":[172],"exposure":[173],"erythropoietin":[175],"(EPO),":[176],"100":[177],"mumol/L":[178],"caused":[180],"1.3-":[182,264],"3.5-fold":[184],"HbF,":[190],"0.4%":[192],"5.2%":[194],"1.6)":[196],"untreated":[198],"1.5%":[200],"8.2%":[202],"3.1)":[204],"HU-treated":[206],"45%":[210],"+/-":[211,220],"10%":[212],"MCH":[215],"but":[216],"only":[217],"25%":[219],"7%":[221],"day":[227],"13.":[228],"Cultures":[229],"derived":[232],"five":[234],"twofold":[243],"fivefold":[245],"percentage":[249],"Hb":[251],"F":[252],"addition":[254],"while":[257],"four":[258],"beta-thalassemia":[261],"showed":[262],"6.2-fold":[266],"increase.":[267],"believe":[269],"primary":[272],"should":[276],"prove":[277],"useful":[278],"studying":[280],"mechanisms":[285],"pharmacologic":[287],"induction":[288],"might":[292],"provide":[293],"valuable":[295],"predictive":[296],"assay":[297],"system":[298],"evaluation":[300],"response":[303],"individual":[305],"hemoglobinopathies":[308],"similar":[312],"agents.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}