{"id":"https://openalex.org/W32400621","doi":null,"title":"beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids.","display_name":"beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids.","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W32400621","mag":"32400621","pmid":"https://pubmed.ncbi.nlm.nih.gov/8917388"},"language":"en","primary_location":{"id":"pmid:8917388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8917388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016850242","display_name":"Atif B. Awad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Awad","raw_affiliation_strings":["Nutrition Program, State University of New York at Buffalo 14214, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Program, State University of New York at Buffalo 14214, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004993844","display_name":"Y C Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y C Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037617915","display_name":"Carol S. Fink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Fink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006793394","display_name":"Todd M. Hennessey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hennessey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2846,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.7849596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"16","issue":"5A","first_page":"2797","last_page":"804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":1.0},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.949999988079071},{"id":"https://openalex.org/keywords/membrane-cholesterol","display_name":"membrane cholesterol","score":0.8090000152587891},{"id":"https://openalex.org/keywords/membrane-lipid-composition","display_name":"membrane lipid composition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phosphatidylinositol","display_name":"phosphatidylinositol","score":1.0},{"id":"https://openalex.org/keywords/fatty-acid-unsaturation","display_name":"fatty acid unsaturation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cholesterol-to-phospholipid-ratio","display_name":"cholesterol/phospholipid ratio","score":0.8640000224113464},{"id":"https://openalex.org/keywords/dietary-sterols","display_name":"dietary sterols","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2779718769","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Phytosterol","level":2,"score":0.7493083477020264},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7287765741348267},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.7272382974624634},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6736195087432861},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.6627655625343323},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.5646129250526428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49577316641807556},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4802175462245941},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46677011251449585},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.41399693489074707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40170547366142273},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3549214005470276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33828163146972656},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8917388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8917388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:32400621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8917388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2069443390","https://openalex.org/W2071567004","https://openalex.org/W2139941978","https://openalex.org/W2781927843","https://openalex.org/W2157747044","https://openalex.org/W2295213297","https://openalex.org/W2002670808"],"related_works":["https://openalex.org/W2016776899","https://openalex.org/W2409792149","https://openalex.org/W2143145004","https://openalex.org/W1996784811","https://openalex.org/W2083071024","https://openalex.org/W2115985987","https://openalex.org/W2093359030","https://openalex.org/W2151721022","https://openalex.org/W2043987112","https://openalex.org/W2069560379"],"abstract_inverted_index":{"The":[0,75,89,94,104],"purpose":[1],"of":[2,11,20,33,47,85,145,151,201,217,220,236,242,276],"the":[3,9,13,18,31,44,48,80,83,125,181,213,234,248,258,264,274],"present":[4],"study":[5,105],"was":[6,92,100,141,155,169,193,238],"to":[7,72,79,96,121,124,185],"examine":[8],"effect":[10,154,241],"beta-sitosterol,":[12],"main":[14],"dietary":[15],"phytosterol":[16,35],"on":[17,157,247],"growth":[19,117,140,266],"HT-29":[21],"cells,":[22,223],"a":[23,177,194],"human":[24],"colon":[25],"cancer":[26],"cell":[27,139],"line.":[28],"In":[29],"addition,":[30],"incorporation":[32,252],"this":[34,41],"into":[36],"cellular":[37],"membranes":[38,49],"and":[39,61,109,229],"how":[40],"might":[42],"influence":[43,275],"lipid":[45],"composition":[46,216],"were":[50,54,77,113,210],"investigated.":[51],"Tumor":[52],"cells":[53,146,189,202],"grown":[55,203],"in":[56,82,176,180,197,204,212,233,254,257],"DMEM":[57],"containing":[58],"10%":[59],"FBS":[60],"supplemented":[62,147,188,222],"with":[63,132,148],"sterols":[64,76],"(cholesterol":[65],"or":[66,123,190],"beta-sitosterol)":[67],"at":[68,102,115],"final":[69],"concentrations":[70],"up":[71],"16":[73,110,133,163,205],"microM.":[74],"supplied":[78],"media":[81],"form":[84],"sterol":[86,95,128],"cyclodextrin":[87,90,97],"complexes.":[88],"used":[91],"2-hydroxypropyl-beta-cyclodextrin.":[93],"molar":[98],"ratio":[99,183],"maintained":[101],"1:300.":[103],"indicated":[106],"that":[107,144,263,280],"8":[108],"microM":[111,134,164,206],"beta-sitosterol":[112,135,165,187,221,251,269],"effective":[114],"cel":[116],"inhibition":[118,267],"as":[119,225],"compared":[120,184],"cholesterol":[122,168],"control":[126],"(no":[127],"supplementation).":[129],"After":[130],"supplementation":[131,174],"for":[136],"9":[137],"days,":[138],"only":[142],"one-third":[143],"equimolar":[149],"concentration":[150],"cholesterol.":[152],"No":[153],"observed":[156,211,265],"total":[158],"membrane":[159,167,198,282],"phospholipid":[160],"concentration.":[161],"At":[162],"supplementation,":[166],"reduced":[170],"by":[171,268],"26%.":[172],"Cholesterol":[173],"resulted":[175,253],"significant":[178],"increase":[179,256],"cholesterol/phospholipid":[182],"either":[186],"controls.":[191],"There":[192],"50%":[195],"reduction":[196],"sphingomyelin":[199],"(SM)":[200],"beta-sitosterol.":[207],"Additional":[208],"changes":[209,246],"fatty":[214,244],"acid":[215,245],"minor":[218],"phospholipids":[219],"such":[224],"SM,":[226],"phosphatidylserine":[227],"(PS),":[228],"phosphatidylinositol":[230],"(PI).":[231],"Only":[232],"case":[235],"PI,":[237],"there":[239],"an":[240,255],"these":[243],"unsaturation":[249],"index,":[250],"U.I.":[259],"It":[260],"is":[261],"possible":[262],"may":[270],"be":[271],"mediated":[272],"through":[273],"signal":[277],"transduction":[278],"pathways":[279],"involve":[281],"phospholipids.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}