{"id":"https://openalex.org/W32393134","doi":null,"title":"Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART.","display_name":"Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART.","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W32393134","mag":"32393134","pmid":"https://pubmed.ncbi.nlm.nih.gov/16200335"},"language":"en","primary_location":{"id":"pmid:16200335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16200335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110402720","display_name":"Janez Toma\u017ei\u010d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Janez Tomazic","raw_affiliation_strings":["Dept. of Infectious Diseases and febrile Illnesses, University Medical Centre Ljubljana, Japljeva 2, 1000, Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Infectious Diseases and febrile Illnesses, University Medical Centre Ljubljana, Japljeva 2, 1000, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044250964","display_name":"Primo\u017e Karner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Primoz Karner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005858703","display_name":"Ludvik Vidmar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludvik Vidmar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009270009","display_name":"Mojca Mati\u010di\u010d","orcid":"https://orcid.org/0000-0003-4261-0424","observed_orcids":["https://orcid.org/0000-0003-4261-0424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mojca Maticic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021058108","display_name":"Prem M. Sharma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prem M Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002770606","display_name":"Andrej Jane\u017e","orcid":"https://orcid.org/0000-0002-6594-5254","observed_orcids":["https://orcid.org/0000-0002-6594-5254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrej Janez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1332,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.85498122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"3","first_page":"99","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7360000014305115},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7649999856948853},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.7099999785423279},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.6480000019073486},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.5740000009536743},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antiretroviral-therapy-adverse-effects","display_name":"antiretroviral therapy adverse effects","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.4230000078678131},{"id":"https://openalex.org/keywords/type-2-diabetes-prevention","display_name":"type 2 diabetes prevention","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8984119296073914},{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.8707454204559326},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8354527950286865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7297645211219788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6851466298103333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6005089282989502},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5718420147895813},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5038091540336609},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34465622901916504}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16200335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16200335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermatovenerologica Alpina, Pannonica, et Adriatica","raw_type":"Clinical Trial"},{"id":"mag:32393134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16200335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2911314010","https://openalex.org/W2908610976","https://openalex.org/W2115832251","https://openalex.org/W2362897081","https://openalex.org/W4210662453","https://openalex.org/W2900123337","https://openalex.org/W2005104404","https://openalex.org/W1976611079","https://openalex.org/W2726316632"],"related_works":["https://openalex.org/W2111211095","https://openalex.org/W2018396104","https://openalex.org/W2058856372","https://openalex.org/W1524777272","https://openalex.org/W2037490408","https://openalex.org/W1490891702","https://openalex.org/W2011652299","https://openalex.org/W92959768","https://openalex.org/W7095676021","https://openalex.org/W3012780629"],"abstract_inverted_index":{"AIMS:":[0],"Insulin":[1],"resistance":[2],"may":[3],"be":[4,289],"the":[5,9,26,42,48,79,119,229,234,247,265,270,278,293,310,323,361],"primary":[6,150],"event":[7],"in":[8,58,177,233,246,269,277,285,309,322,364,371],"protease":[10,63,110],"inhibitor-associated":[11],"metabolic":[12],"syndrome.":[13],"Treatment":[14,211],"with":[15,87,212,341],"insulin":[16,22,88,93,161,267,286,296,337],"sensitizers":[17],"(metformin,":[18],"rosiglitazone)":[19],"can":[20],"ameliorate":[21],"resistance.":[23,338],"So":[24],"far,":[25],"effects":[27,49],"of":[28,41,50,227,263,295],"these":[29,365],"agents":[30],"on":[31,55,103,218,254,346,360,381],"blood":[32],"lipids":[33],"have":[34],"not":[35],"been":[36],"well":[37],"determined.":[38],"The":[39,122,149,173,330],"aim":[40],"present":[43],"study":[44,80,120,331],"was":[45,257],"to":[46,118,127,184,195,206,240,306,319],"evaluate":[47],"metformin":[51,131,213,235,279,324,342],"and":[52,99,159,166,200,221,276,316,349,375],"rosiglitazone":[53,138,178,248,271,311],"treatment":[54,145,170,264,340],"lipid":[56,362],"metabolism":[57],"HIV":[59,70],"infected":[60,71],"patients":[61,73,123],"receiving":[62],"inhibitors":[64],"containing":[65],"HAART.":[66],"DESIGN":[67],"AND":[68],"METHODS:":[69],"male":[72],"(>18":[74],"years)":[75],"were":[76,102,124,153,303],"eligible":[77],"for":[78,112],"if":[81,100],"they":[82,101],"had":[83,214],"impaired":[84],"glucose":[85,157,300],"tolerance":[86,301],"resistance,":[89],"characterized":[90],"by":[91,169,274,281],"fasting":[92,154,160,230,266],"concentration":[94,176,232,268],"greater":[95],"then":[96],"20":[97],"mIU/L":[98],"stable":[104],"antiretroviral":[105],"therapy":[106],"regimen":[107],"including":[108],"a":[109],"inhibitor":[111],"at":[113],"least":[114],"12":[115],"months":[116],"prior":[117],"enrolment.":[121],"randomly":[125],"assigned":[126],"receive":[128],"either":[129],"1g/day":[130],"(metformin":[132],"group,":[133,141,147],"n=30)":[134,142],"or":[135,143],"4":[136],"mg/day":[137],"maleate":[139],"(rosiglitazone":[140],"no":[144,215,250,344,379],"(control":[146],"n=30).":[148],"efficacy":[151],"parameters":[152],"plasma":[155,255],"lipids,":[156],"levels":[158,162,191,202],"compared":[163],"between":[164],"baseline":[165],"week":[167],"48,":[168],"groups.":[171],"RESULTS:":[172],"total":[174,372],"cholesterol":[175],"group":[179,236,249,272,280,312,325],"increased":[180,192,203],"from":[181,193,204,238,317],"5.76":[182],"-/+1.2":[183],"7.1-/+1.6":[185],"mmol/l":[186,242],"(23%":[187],"increase,":[188,198,209],"p<0.05),":[189],"HDL":[190,220,348,374],"0.91-/+0.44":[194],"1.3-/+0.2":[196],"(38%":[197],"p<0.01)":[199,315],"LDL":[201,222,350],"3.5-/+0.98":[205],"4.5-/+1.0":[207],"(28%":[208],"p<0.05).":[210],"significant":[216,252,369],"effect":[217,253,345,359,380],"total,":[219,347],"cholesterol.":[223],"After":[224],"48":[225,261],"weeks":[226,262],"treatment,":[228],"triglycerides":[231,256,382],"declined":[237,273],"4.1-/+1.6":[239],"3.2-/+1.3":[241],"(22%":[243],"decrease,p<0.05)":[244],"but":[245,352,377],"statistically":[251],"noted.":[258],"Furthermore,":[259],"after":[260,298],"49%":[275],"28%.":[282],"This":[283],"improvement":[284],"secretion":[287],"could":[288],"clearly":[290],"demonstrated":[291],"when":[292],"sums":[294],"concentrations":[297],"oral":[299],"test":[302],"compared:":[304],"548-/+13":[305],"345-/+11.8":[307],"mIU/l":[308,321],"(37%":[313],"decrease,":[314,327],"552-/+15":[318],"420-/+12":[320],"(24%":[326],"p<0.01).":[328],"CONCLUSIONS:":[329],"demonstrates":[332],"that":[333],"both":[334],"therapies":[335],"improve":[336],"However,":[339],"has":[343,357,378],"cholesterol,":[351,373],"significantly":[353],"reduces":[354],"triglycerides,":[355],"which":[356],"beneficial":[358],"status":[363],"patients.":[366],"Rosiglitazone":[367],"causes":[368],"increases":[370],"LDL,":[376],"concentrations.":[383]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}