{"id":"https://openalex.org/W32368148","doi":null,"title":"Abstract 16287: Genetic Deletion of Pim Causes Premature Cardiac Senescence","display_name":"Abstract 16287: Genetic Deletion of Pim Causes Premature Cardiac Senescence","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W32368148","mag":"32368148"},"language":"en","primary_location":{"id":"mag:32368148","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.a16287","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002159498","display_name":"Shabana Din","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shabana Din","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043155983","display_name":"Michael McGregor","orcid":"https://orcid.org/0000-0001-5281-5736","observed_orcids":["https://orcid.org/0000-0001-5281-5736"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael McGregor","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0001-5281-5736","affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071693038","display_name":"Brandi Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi Bailey","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017026968","display_name":"Sadia Mohsin","orcid":"https://orcid.org/0000-0002-2106-1094","observed_orcids":["https://orcid.org/0000-0002-2106-1094"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadia Mohsin","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0002-2106-1094","affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047688436","display_name":"Daniele Avitabile","orcid":"https://orcid.org/0000-0002-1360-2700","observed_orcids":["https://orcid.org/0000-0002-1360-2700"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniele Avitabile","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0002-1360-2700","affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069093849","display_name":"Natalie A. Gude","orcid":"https://orcid.org/0000-0002-2297-1954","observed_orcids":["https://orcid.org/0000-0002-2297-1954"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Gude","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0002-2297-1954","affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003393607","display_name":"Mark Alan Sussman","orcid":"https://orcid.org/0000-0002-0104-4799","observed_orcids":["https://orcid.org/0000-0002-0104-4799"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Sussman","raw_affiliation_strings":["Biology, SDSU, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0002-0104-4799","affiliations":[{"raw_affiliation_string":"Biology, SDSU, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pim-1","display_name":"PIM-1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cardiac-senescence","display_name":"cardiac senescence","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.7850000262260437},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.7170000076293945},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.675000011920929},{"id":"https://openalex.org/keywords/id2","display_name":"Id2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.8399999737739563},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.5210000276565552},{"id":"https://openalex.org/keywords/adenoviral-overexpression","display_name":"adenoviral overexpression","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8201426267623901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6002224683761597},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5558432936668396},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.492317795753479},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4590342044830322},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4414832293987274},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4287208020687103},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4229012131690979},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.418687641620636},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.407683402299881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37716513872146606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3620656132698059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35127609968185425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34148794412612915},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2904994487762451},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.24015748500823975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1273578405380249},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0781976580619812},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:32368148","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.a16287","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2286156688","https://openalex.org/W2413600435"],"related_works":["https://openalex.org/W2738130264","https://openalex.org/W2156372445","https://openalex.org/W2613661613","https://openalex.org/W4397007730","https://openalex.org/W3208981743","https://openalex.org/W2147605880","https://openalex.org/W4404148143","https://openalex.org/W4404246050","https://openalex.org/W4415486386","https://openalex.org/W4224299791"],"abstract_inverted_index":{"Rationale:":[0],"Cardiac":[2,270],"aging":[3,26,34,58,99],"is":[4,28,37,85,171,306],"defined":[5],"as":[6,160,252,282,320],"increased":[7],"cellular":[8,329],"senescence":[9,84,145,281,304],"and":[10,17,44,51,70,91,103,112,144,165,195,265,305,326,331],"loss":[11,92],"of":[12,42,56,74,93,100,125,134,139,152,158,176,193,200,208,223,229,237,249,260,280,287,315],"survival":[13],"signaling":[14,90],"within":[15],"cardiomyocytes":[16,240],"the":[18,32,72,101,140,201,232,278,292],"cardiac":[19,65,107,187,215,226,303,310],"stem":[20],"cell":[21,202],"population.":[22],"To":[23],"prevent":[24],"myocardial,":[25],"it":[27],"important":[29,307],"to":[30,48,61,97,324],"reverse":[31],"characteristic":[33],"phenotype.":[35,234],"Pim-1":[36,53,88,94,243,256,271,301,316],"a":[38,62,178,275,321],"cardioprotective":[39],"kinase":[40],"downstream":[41],"AKT,":[43],"has":[45],"been":[46],"shown":[47],"be":[49,318],"pro-proliferative":[50],"anti-apoptotic.":[52],"mediated":[54,89],"antagonism":[55],"myocardial":[57,83,135,328],"will":[59],"lead":[60],"decrease":[63],"in":[64,106,120,150,185,206,217,247,277,291],"senescence,":[66],"maintain":[67],"contractile":[68],"performance,":[69],"prolong":[71],"lifespan":[73,330],"an":[75],"organism.":[76],"Objective:":[79],"Demonstrate":[81],"that":[82,181],"antagonized":[86],"by":[87,162,189,254,284,294],"activity":[95],"leads":[96],"premature":[98,131],"myocardium":[102,293],"associated":[104],"decline":[105],"performance.":[108],"Methods":[111],"Results:":[113],"Pim":[115,126],"Triple":[116],"KnockOut":[117],"(PTKO)":[118],"mice,":[119],"which":[121],"all":[122],"three":[123],"isoforms":[124],"are":[127,148,204],"genetically":[128],"deleted,":[129],"develop":[130],"phenotypic":[132],"hallmarks":[133],"senescence.":[136,269],"Elevated":[137],"levels":[138],"tumor":[141],"suppressor":[142],"p53":[143],"marker":[146],"p16":[147,169,183,250,267,288],"present":[149],"hearts":[151,207],"PTKO":[153,186,209,218],"mice":[154,219,273],"at":[155,220],"two":[156,221],"months":[157,222],"age":[159],"seen":[161,253],"western":[163,190],"blot":[164],"confocal":[166,295],"microscopy.":[167,296],"Increased":[168],"expression":[170,259],"consistent":[172],"with":[173,242],"observed":[174],"induction":[175],"Ets-1,":[177],"transcription":[179,184],"factor":[180],"activates":[182],"samples":[188],"blot.":[191],"Levels":[192],"Id1":[194],"Id2,":[196],"positive":[197,289],"transcriptional":[198],"regulators":[199],"cycle,":[203],"decreased":[205,285],"mice.":[210],"Hemodynamic":[211],"analyses":[212],"reveal":[213],"impaired":[214],"function":[216],"age.":[224],"Conversely,":[225],"specific":[227],"overexpression":[228,257],"Pim1-kinase":[230],"attenuates":[231],"senescent":[233],"Hypoxia":[235],"treatment":[236],"neonatal":[238],"rat":[239],"infected":[241],"encoding":[244],"adenovirus":[245],"results":[246],"reduction":[248],"accumulation":[251],"qRT-PCR.":[255],"increases":[258],"c-myc,":[261],"thereby":[262],"upregulating":[263],"Id2":[264],"inhibits":[266,302],"induced":[268],"transgenic":[272],"show":[274],"delay":[276],"onset":[279],"evidenced":[283],"frequency":[286],"cells":[290],"Conclusion:":[299],"for":[308],"maintaining":[309],"function.":[311,332],"Therefore,":[312],"selective":[313],"manipulation":[314],"should":[317],"pursued":[319],"therapeutic":[322],"target":[323],"promote":[325],"extend":[327]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
