{"id":"https://openalex.org/W323245490","doi":null,"title":"Expression of a neural type of intermediate filament as a distinguishing feature between oat cell carcinoma and other lung cancers.","display_name":"Expression of a neural type of intermediate filament as a distinguishing feature between oat cell carcinoma and other lung cancers.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W323245490","mag":"323245490","pmid":"https://pubmed.ncbi.nlm.nih.gov/6297305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916148"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1916148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916148","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111339191","display_name":"V.-P. Lehto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V P Lehto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091755656","display_name":"Sebastian Stenman","orcid":"https://orcid.org/0000-0001-5780-0285","observed_orcids":["https://orcid.org/0000-0001-5780-0285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Stenman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024934444","display_name":"Markku Miettinen","orcid":"https://orcid.org/0000-0002-3282-8107","observed_orcids":["https://orcid.org/0000-0002-3282-8107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Miettinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111653643","display_name":"D. R. Dahl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Dahl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113159885","display_name":"Ismo Virtanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Virtanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.2384,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.99439397,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"110","issue":"2","first_page":"113","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.14399999380111694,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.777999997138977},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.8899999856948853},{"id":"https://openalex.org/keywords/keratin","display_name":"keratin","score":0.6990000009536743},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/anaplastic-carcinoma","display_name":"anaplastic carcinoma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/bronchioloalveolar-carcinoma","display_name":"bronchioloalveolar carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.5270000100135803},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6010000109672546},{"id":"https://openalex.org/keywords/diagnostic-antibodies","display_name":"diagnostic antibodies","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.9105724096298218},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.861803412437439},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.7456541657447815},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.7352859377861023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7045273184776306},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.693983793258667},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5145372748374939},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5000715255737305},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4748827815055847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4715074598789215},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4535183012485504},{"id":"https://openalex.org/C2909370275","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate Filament Protein","level":5,"score":0.45078033208847046},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.441893607378006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32954108715057373},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2860136032104492},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20188871026039124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12026521563529968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0693228542804718}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002282","descriptor_name":"Adenocarcinoma, Bronchiolo-Alveolar","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1916148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:6297305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:323245490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6297305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1916148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W292580981","https://openalex.org/W1430202253","https://openalex.org/W1583233593","https://openalex.org/W1600674439","https://openalex.org/W1969023545","https://openalex.org/W1971856205","https://openalex.org/W1975764634","https://openalex.org/W1979024960","https://openalex.org/W1995789984","https://openalex.org/W2013797850","https://openalex.org/W2018725952","https://openalex.org/W2020425695","https://openalex.org/W2023758640","https://openalex.org/W2027321010","https://openalex.org/W2035349174","https://openalex.org/W2043073430","https://openalex.org/W2044442979","https://openalex.org/W2060542911","https://openalex.org/W2067949392","https://openalex.org/W2069024721","https://openalex.org/W2076635413","https://openalex.org/W2085449372","https://openalex.org/W2158265468","https://openalex.org/W2398103039","https://openalex.org/W2414284603","https://openalex.org/W2418902419","https://openalex.org/W2472222025"],"related_works":["https://openalex.org/W4234071375","https://openalex.org/W1963743012","https://openalex.org/W1524111232","https://openalex.org/W2409988105","https://openalex.org/W9179897","https://openalex.org/W1698194686","https://openalex.org/W1505229765","https://openalex.org/W2122578681","https://openalex.org/W1993694887","https://openalex.org/W2170193630"],"abstract_inverted_index":{"Expression":[0],"of":[1,26,48,68,79,106,119,152],"intermediate":[2,40,62,80,121],"filaments":[3,41,122],"was":[4,55,72],"studied":[5],"immunohistologically":[6],"in":[7,102,147],"oat-cell":[8,49,129],"(6":[9],"cases),":[10,13,16,20,25],"epidermoid":[11],"(9":[12],"adeno-":[14],"(7":[15],"large-cell":[17],"anaplastic":[18],"(3":[19,24],"and":[21,37,91,131,135],"bronchioalveolar":[22,92],"carcinoma":[23],"lung.":[27],"Affinity-purified":[28],"antibodies":[29,59,75,101,139],"against":[30,60,76],"epithelial":[31],"(anti-keratin),":[32],"neural":[33,61,120],"(anti-neurofilament),":[34],"muscle":[35],"(anti-desmin)":[36],"mesenchymal":[38],"(anti-vimentin)":[39],"were":[42],"used.":[43],"In":[44],"indirect":[45],"immunofluorescence":[46],"microscopy":[47],"carcinomas":[50,93,130],"a":[51,96,103,124,144],"positive":[52],"cytoplasmic":[53],"fluorescence":[54],"seen":[56],"only":[57],"with":[58,74,99,111],"filaments,":[63],"neurofilaments,":[64],"while":[65],"no":[66,109],"staining":[67],"the":[69,83,87,148],"tumor":[70],"cells":[71,107],"observed":[73],"other":[77,84,132],"types":[78],"filaments.":[81],"On":[82],"hand,":[85],"all":[86],"epidermoid,":[88],"adeno,":[89],"anaplastic,":[90],"showed":[94],"constantly":[95],"strong":[97],"reaction":[98],"anti-keratin":[100],"varying":[104],"number":[105],"but":[108],"decoration":[110],"anti-neurofilament":[112,138],"antibodies.":[113],"The":[114],"results":[115],"show":[116],"that":[117,137],"expression":[118],"is":[123],"major":[125],"distinguishing":[126],"feature":[127],"between":[128],"lung":[133],"cancers":[134],"suggest":[136],"can":[140],"be":[141],"used":[142],"as":[143],"diagnostic":[145],"aid":[146],"surgical":[149],"pathologic":[150],"study":[151],"pulmonary":[153],"neoplasms.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}