{"id":"https://openalex.org/W32287508","doi":null,"title":"Matrix degrading proteinases from human granulocytes: type I, II, III collagenase, gelatinase and type IV, V-collagenase. A survey of recent findings and inhibition by gamma-anticollagenase.","display_name":"Matrix degrading proteinases from human granulocytes: type I, II, III collagenase, gelatinase and type IV, V-collagenase. A survey of recent findings and inhibition by gamma-anticollagenase.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W32287508","mag":"32287508","pmid":"https://pubmed.ncbi.nlm.nih.gov/3021541"},"language":"en","primary_location":{"id":"pmid:3021541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3021541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086288738","display_name":"Harald Tschesche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Tschesche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071467526","display_name":"Jutta Fedrowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Fedrowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021705933","display_name":"Ulrich Kohnert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Kohnert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054550500","display_name":"Jurgen Michaelis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Michaelis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051020502","display_name":"Henry W. MACARTNEY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H W Macartney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2433,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.45243704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"24","issue":"2","first_page":"125","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8700000047683716},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.6470000147819519},{"id":"https://openalex.org/keywords/type-i-collagenase","display_name":"type I collagenase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/type-iv-collagenase","display_name":"type IV collagenase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/latent-enzyme-activation","display_name":"latent enzyme activation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/organomercury-compounds","display_name":"organomercury compounds","score":0.9269999861717224},{"id":"https://openalex.org/keywords/trypsin-activation","display_name":"trypsin activation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.9439268708229065},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.7818303108215332},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.737585186958313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6400982141494751},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5912015438079834},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.572180986404419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5093463659286499},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46960553526878357},{"id":"https://openalex.org/C2776223131","wikidata":"https://www.wikidata.org/wiki/Q13033733","display_name":"Gelatinase A","level":3,"score":0.41872918605804443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19556614756584167}],"mesh":[{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009941","descriptor_name":"Organomercury Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:3021541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3021541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Comparative Study"},{"id":"pmh:oai:pub.librecat.org:1656221","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/1656221","pdf_url":null,"source":{"id":"https://openalex.org/S4306401671","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tschesche H, FEDROWITZ J, KOHNERT U, MICHAELIS J, MACARTNEY HW. MATRIX DEGRADING PROTEINASES FROM HUMAN-GRANULOCYTES - TYPE-I, TYPE-II, TYPE-III COLLAGENASE, GELATINASE AND TYPE-IV, TYPE-V-COLLAGENASE - A SURVEY OF RECENT FINDINGS AND INHIBITION BY GAMMA-ANTICOLLAGENASE. &lt;em&gt;FOLIA HISTOCHEMICA ET CYTOBIOLOGICA&lt;/em&gt;. 1986;24(2):125-131.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pub.uni-bielefeld.de:1656221","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/1656221","pdf_url":null,"source":{"id":"https://openalex.org/S4306401624","display_name":"Publikationen an der Universit\u00e4t Bielefeld (Universit\u00e4t Bielefeld)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tschesche H, FEDROWITZ J, KOHNERT U, MICHAELIS J, MACARTNEY HW. MATRIX DEGRADING PROTEINASES FROM HUMAN-GRANULOCYTES - TYPE-I, TYPE-II, TYPE-III COLLAGENASE, GELATINASE AND TYPE-IV, TYPE-V-COLLAGENASE - A SURVEY OF RECENT FINDINGS AND INHIBITION BY GAMMA-ANTICOLLAGENASE. &lt;em&gt;FOLIA HISTOCHEMICA ET CYTOBIOLOGICA&lt;/em&gt;. 1986;24(2):125-131.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:32287508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3021541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1499462259","https://openalex.org/W1968479649","https://openalex.org/W1995366538","https://openalex.org/W2006155853","https://openalex.org/W2025918211","https://openalex.org/W2043965523","https://openalex.org/W2084198009","https://openalex.org/W2103569861","https://openalex.org/W2319815586"],"related_works":["https://openalex.org/W7011475867","https://openalex.org/W2280523751","https://openalex.org/W196211547","https://openalex.org/W35430847","https://openalex.org/W2402260991","https://openalex.org/W4388324739","https://openalex.org/W959177553","https://openalex.org/W2410616310","https://openalex.org/W2088708369","https://openalex.org/W2022078198"],"abstract_inverted_index":{"Three":[0],"human":[1,79],"matrix":[2],"degrading":[3],"leukocyte":[4,83],"proteinases,":[5],"type":[6,13,46,71,84,92,105],"I":[7,72,85,106],"collagenase,":[8,107],"gelatinase":[9],"and":[10,20,125],"a":[11,54,123],"new":[12],"IV":[14,93],"collagenase":[15,73,86,94],"were":[16],"isolated":[17],"in":[18],"latent":[19,27,45,59,110],"active":[21,70],"form.":[22],"Activation":[23],"of":[24,122,130],"all":[25],"three":[26],"enzymes":[28],"could":[29,48,61],"be":[30,49,62],"achieved":[31],"by":[32,51,76],"treatment":[33],"with":[34,38,64,67,104],"either":[35],"organomercurials":[36,65],"or":[37,66],"trypsin.":[39,68],"In":[40],"addition":[41],"the":[42,82,89,131,143],"90":[43],"kDa":[44,58],"I-collagenase":[47],"activated":[50,63],"disulfides,":[52],"while":[53,88],"newly":[55,90],"discovered":[56],"70":[57],"form":[60],"The":[69,99,118],"was":[74,95],"inhibited":[75,96],"gamma-anticollagenase":[77,103],"from":[78,102],"serum":[80],"(and":[81],"inhibitor,":[87],"found":[91],"only":[97],"partially.":[98],"complexes":[100],"formed":[101],"i.":[108],"e.":[109],"enzyme,":[111],"are":[112],"not":[113,121],"reactive":[114],"site":[115],"associated":[116],"complexes.":[117],"binding":[119],"is":[120,140],"substrate-like":[124],"competitive":[126],"manner.":[127],"After":[128],"inhibition":[129],"enzyme":[132],"though":[133],"inactive":[134],"against":[135],"its":[136],"natural":[137],"substrates":[138],"it":[139],"still":[141],"hydrolyzing":[142],"synthetic":[144],"low":[145],"molecular":[146],"weight":[147],"octapeptide":[148],"DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH.":[149]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
