{"id":"https://openalex.org/W322809319","doi":null,"title":"[Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinoma A431 xenograft in nude mice].","display_name":"[Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinoma A431 xenograft in nude mice].","publication_year":2013,"publication_date":"2013-02-05","ids":{"openalex":"https://openalex.org/W322809319","mag":"322809319","pmid":"https://pubmed.ncbi.nlm.nih.gov/23660270"},"language":"zh","primary_location":{"id":"pmid:23660270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23660270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083572935","display_name":"Yuqin Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098299","display_name":"Third Affiliated Hospital of Inner Mongolia Medical College","ror":"https://ror.org/00ymd9k36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098299"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-qin Hao","raw_affiliation_strings":["Department of Dermatology, Third Affiliated Hospital of Inner Mongolian Medical University, Baotou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Third Affiliated Hospital of Inner Mongolian Medical University, Baotou, China","institution_ids":["https://openalex.org/I4210098299"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei-xing Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-xing Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102320360","display_name":"Hongxia Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-xia Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629247","display_name":"Guohui Zhang","orcid":"https://orcid.org/0000-0001-6905-0637","observed_orcids":["https://orcid.org/0000-0001-6905-0637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo-hui Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103473307","display_name":"Xiaohong Ning","orcid":"https://orcid.org/0009-0002-2092-246X","observed_orcids":["https://orcid.org/0009-0002-2092-246X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-hong Ning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045732910","display_name":"Heng-gui Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heng-gui Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063147519","display_name":"Chunguang Hao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-guang Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103101880","display_name":"Zhe-hai Li","orcid":"https://orcid.org/0000-0003-4676-3532","observed_orcids":["https://orcid.org/0000-0003-4676-3532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhe-hai Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.483,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70680687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"93","issue":"6","first_page":"464","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/a431-xenografts","display_name":"A431 xenografts","score":0.925000011920929},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.7580000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/anti-tumor-effect","display_name":"anti-tumor effect","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tunel-staining","display_name":"TUNEL staining","score":0.5809999704360962},{"id":"https://openalex.org/keywords/tumor-cell-morphology","display_name":"tumor cell morphology","score":0.37400001287460327},{"id":"https://openalex.org/keywords/apoptosis-sensitization","display_name":"apoptosis sensitization","score":0.34299999475479126},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.7452597618103027},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6462725400924683},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6082319021224976},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.532454788684845},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5095179677009583},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4456009268760681},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.43310999870300293},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4167094826698303},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.411434143781662},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38584959506988525},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38008755445480347},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3427429497241974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32325053215026855},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32225537300109863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1974036693572998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17519119381904602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08791971206665039}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23660270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23660270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"},{"id":"mag:322809319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23660270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998298282","https://openalex.org/W2912954983","https://openalex.org/W2352208339","https://openalex.org/W3032664339","https://openalex.org/W2371394452","https://openalex.org/W2388342914","https://openalex.org/W2488793792","https://openalex.org/W2368138195","https://openalex.org/W2391530182","https://openalex.org/W2375495491"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,22,46,85,122,127,156,160,235,282,308,389,402,414,427,441,460,480,486,491],"anti-tumor":[4],"effects":[5],"of":[6,25,32,97,124,130,143,158,163,199,233,240,250,264,281,306,311,318,333,335,360,362,387,392,394,401,417,419,426,444,462,482,488,493],"resveratrol":[7],"(Res)":[8],"upon":[9,126],"human":[10,33,463],"skin":[11,34,464],"squamous":[12,35,465],"cell":[13,36,99,109,466,484],"carcinoma":[14,37,467],"A431":[15,468],"xenograft":[16,39,469],"in":[17,40,134,470],"nude":[18,41,471],"mice":[19,42,75],"and":[20,27,61,63,84,106,132,145,171,196,207,238,253,268,274,321,405,430,446,490],"elucidate":[21],"regulatory":[23],"mechanisms":[24],"survivin":[26,131,393,445,489],"caspase-3.":[28,494],"METHODS:":[29],"The":[30,78,94,261,278,330,357],"model":[31],"(A431)":[38],"was":[43,82,111,137,397],"established.":[44],"And":[45,413,473],"animals":[47],"were":[48,76,102,148,175,246,271,285,314,338,365,422],"randomly":[49],"divided":[50],"into":[51],"saline-negative":[52,169,205,251,319,403,428],"control,":[53,57],"cyclophosphamide":[54],"(CTX)":[55],"positive":[56],"Res":[58,86,125,165,201,241,265,312,395,420,458],"high-,":[59,166,202,242,266],"medium-":[60,267],"low-dosage":[62,244,269],"blank":[64,172,208,254,322,406,431],"control":[65,170,173,206,209,252,255,320,323,404,407,429,432],"groups":[66,101,174,210,245,256,270,284,313,324,396,408,421],"(n":[67],"=":[68,452],"10":[69],"each).":[70],"After":[71],"drug":[72],"intervention,":[73],"tumor-bearing":[74],"sacrificed.":[77],"tumor":[79,92,98,135,161,197,236,483],"growth":[80,461],"curve":[81],"plotted":[83],"inhibition":[87,262],"rate":[88,263],"calculated":[89],"by":[90,104,113,139],"terminal":[91,114],"weight.":[93],"morphological":[95],"changes":[96],"among":[100],"observed":[103,138],"hematoxylin":[105],"eosin":[107],"staining;":[108],"apoptosis":[110,279,309,481],"detected":[112],"deoxynucleotidyl":[115],"transferase":[116],"dUTP":[117],"nick":[118],"end":[119,157],"labeling":[120],"TUNEL;":[121],"impact":[123],"protein":[128,331,358,390,415,442],"expressions":[129],"caspase-3":[133,418,447],"issues":[136],"Western":[140],"blot.":[141],"Analysis":[142],"variance":[144],"Pearson's":[146,439],"correlation":[147,450],"employed":[149],"for":[150],"statistical":[151],"analyses.":[152],"RESULTS:":[153],"(1)":[154],"By":[155],"treatment,":[159],"volume":[162,237],"CTX,":[164,200],"medium-,":[167,203,243],"low-dosage,":[168,204],"(1154":[176],"\u00b1":[177,180,183,186,189,192,212,215,218,221,224,227,287,290,293,296,299,302,340,343,346,349,352,355,367,370,373,376,379,382],"255),":[178],"(1002":[179],"115),":[181],"(1207":[182],"176),":[184],"(1342":[185],"211),":[187],"(1642":[188],"226),":[190],"(1564":[191],"156)":[193],"mm(3)":[194],"respectively,":[195],"weight":[198,239],"(1.84":[211],"0.30),":[213],"(1.72":[214],"0.39),":[216],"(1.96":[217],"0.40),":[219],"(2.67":[220],"0.73),":[222],"(3.16":[223],"0.52),":[225],"(3.33":[226],"0.59)":[228],"g":[229],"respectively.":[230,276,384],"Through":[231,304,385,438],"analysis":[232,305,386],"variance,":[234,307,388],"smaller":[247],"than":[248,316,399,424],"those":[249,317,400,425],"(all":[257,325,409,434],"P":[258,326,410,435,454],"<":[259,327,411,436],"0.05).":[260,328,412,437,456],"45.57%,":[272],"37.97%":[273],"15.51%":[275],"(2)":[277],"index":[280,310],"above":[283],"36.79%":[286],"8.86%,":[288],"33.15%":[289],"6.00%,":[291],"18.09%":[292],"3.92%,":[294],"10.53%":[295],"4.20%,":[297],"3.87%":[298],"1.63%,":[300],"2.73%":[301],"1.61%.":[303],"higher":[315,423],"(3)":[329],"expression":[332,359,391,416,443],"survivin/\u03b2-actin":[334],"each":[336,363],"group":[337,364,433],"0.48":[339],"0.20,":[341],"0.19":[342],"0.11,":[344],"0.22":[345,375],"0.12,":[347],"0.28":[348],"0.24,":[350],"0.98":[351],"0.41,":[353],"0.85":[354],"0.34.":[356],"caspase-3/\u03b2-actin":[361],"0.42":[366],"0.09,":[368],"0.31":[369,372],"0.10,":[371],"0.07,":[374],"0.08,":[377],"0.14":[378],"0.04,":[380],"0.13":[381],"0.05":[383],"lower":[398],"analysis,":[440],"had":[448],"no":[449],"(r":[451],"-0.279,":[453],">":[455],"CONCLUSIONS:":[457],"inhibits":[459],"mice.":[472],"its":[474],"mechanism":[475],"may":[476],"be":[477],"associated":[478],"with":[479],"through":[485],"depression":[487],"activation":[492]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
