{"id":"https://openalex.org/W32211017","doi":null,"title":"C-cell hyperplasia and medullary thyroid carcinoma in the rat. An immunohistochemical and ultrastructural analysis.","display_name":"C-cell hyperplasia and medullary thyroid carcinoma in the rat. An immunohistochemical and ultrastructural analysis.","publication_year":1979,"publication_date":"1979-02-01","ids":{"openalex":"https://openalex.org/W32211017","mag":"32211017","pmid":"https://pubmed.ncbi.nlm.nih.gov/431034"},"language":"en","primary_location":{"id":"pmid:431034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/431034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039653395","display_name":"Ronald A. DeLellis","orcid":"https://orcid.org/0000-0002-7137-948X","observed_orcids":["https://orcid.org/0000-0002-7137-948X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A DeLellis","raw_affiliation_strings":["Tufts University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010959385","display_name":"Gretl Nunnemacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Nunnemacher","raw_affiliation_strings":["Tufts University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071272675","display_name":"William Bitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W R Bitman","raw_affiliation_strings":["Tufts University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046671975","display_name":"Robert F. Gagel","orcid":"https://orcid.org/0000-0002-9888-0362","observed_orcids":["https://orcid.org/0000-0002-9888-0362"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F Gagel","raw_affiliation_strings":["Endocrine Neoplasia & HD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Neoplasia & HD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110899131","display_name":"Armen H. Tashjian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Tashjian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Blount","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Blount","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113728113","display_name":"Hubert J. Wolfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Wolfe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3552,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.77281316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"2","first_page":"140","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/c-cell-hyperplasia","display_name":"C-cell hyperplasia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/long-evans-rats","display_name":"Long-Evans rats","score":0.8579999804496765},{"id":"https://openalex.org/keywords/parathyroid-hyperplasia","display_name":"parathyroid hyperplasia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/familial-medullary-thyroid-carcinoma","display_name":"familial medullary thyroid carcinoma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6589999794960022},{"id":"https://openalex.org/keywords/thyroid-ultrastructure","display_name":"thyroid ultrastructure","score":0.5759999752044678},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.802039384841919},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.6649013757705688},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.640335202217102},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5342843532562256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5237764716148376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.518518328666687},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.47795653343200684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44318196177482605},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.44038933515548706},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.35722124576568604}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010280","descriptor_name":"Parathyroid Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:431034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/431034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:32211017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/431034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981830219","https://openalex.org/W1970577657","https://openalex.org/W1989222829","https://openalex.org/W2407956879","https://openalex.org/W1497978643","https://openalex.org/W4246693319","https://openalex.org/W2323916369","https://openalex.org/W1984511658","https://openalex.org/W194707562","https://openalex.org/W2025580041"],"abstract_inverted_index":{"Medullary":[0],"thyroid":[1,177],"carcinoma":[2],"(MTC)":[3],"is":[4,9,231],"a":[5,42,257],"distinctive":[6],"neoplasm":[7],"which":[8,18],"derived":[10],"from":[11,35,55,67,70],"the":[12,94,129,166,175,182,209,218,221,227,254,263,269],"calcitonin-producing":[13],"intrathyroidal":[14],"C-cell":[15,45,63,81,187,223,266],"system":[16,260],"and":[17,102,131,208,251,274],"develops":[19],"commonly":[20,195],"in":[21,33,100,103,148,205,247],"untreated":[22],"rats":[23,31],"of":[24,29,44,75,133,140,157,165,185,201,229,237,265,271],"various":[25],"strains.":[26],"Thyroid":[27],"glands":[28],"Long-Evans":[30],"ranging":[32,69],"age":[34,76],"3":[36,39,73],"months":[37],"to":[38,50,57,72,93,181],"years":[40,74],"showed":[41],"spectrum":[43],"proliferative":[46],"abnormalities.":[47],"As":[48],"compared":[49],"3-month-old":[51],"control":[52],"rats,":[53],"thyroids":[54],"9-":[56],"12-month-old":[58],"animals":[59,68,104,109],"exhibited":[60,77],"mild":[61,106],"diffuse":[62,85,107,112,189],"hyperplasia":[64,193],"(CCH).":[65],"Thyroids":[66],"1":[71],"progressively":[78],"more":[79],"severe":[80,84,111],"abnormalities":[82],"including":[83],"CCH,":[86,88,108,113,115],"nodular":[87,114,141,191],"and/or":[89,190],"MTC.":[90],"In":[91,179],"contrast":[92],"normal":[95,215],"basal":[96,120,168],"serum":[97,121,210],"calcitonin":[98,122],"levels":[99,212],"controls":[101],"with":[105,110,172,244],"or":[116,152],"MTC":[117,160,230,250],"had":[118],"elevated":[119],"values.":[123],"Nodular":[124],"CCH":[125,142],"was":[126,161,194,198],"characterized":[127,144,162],"by":[128,136,145,153,163,170,233],"replacement":[130],"enlargement":[132],"individual":[134,158],"follicles":[135,151],"C-cells.":[137],"Larger":[138],"foci":[139],"were":[143,213],"similar":[146],"changes":[147],"multiple":[149],"adjacent":[150,176],"an":[154],"irregular":[155],"expansion":[156],"follicles.":[159],"penetration":[164],"follicular":[167],"lamina":[169],"C-cells":[171],"extension":[173],"into":[174],"stroma.":[178],"addition":[180],"high":[183],"incidence":[184],"thyroidal":[186],"abnormalities,":[188],"parathyroid":[192],"found.":[196],"There":[197],"no":[199],"evidence":[200],"chronic":[202],"renal":[203],"failure":[204],"these":[206],"animals,":[207],"calcium":[211],"within":[214],"limits.":[216],"Although":[217],"stimulus":[219],"for":[220,261],"initial":[222],"proliferation":[224,267],"remains":[225],"unknown,":[226],"appearance":[228],"preceded":[232],"relatively":[234],"prolonged":[235],"phases":[236],"CCH.":[238],"These":[239],"findings":[240],"are":[241],"essentially":[242],"identical":[243],"those":[245],"noted":[246],"human":[248],"familial":[249],"indicate":[252],"that":[253],"rat":[255],"provides":[256],"useful":[258],"model":[259],"studying":[262],"regulation":[264],"during":[268],"processes":[270],"neoplastic":[272],"development":[273],"progression.":[275]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
