{"id":"https://openalex.org/W322088057","doi":null,"title":"The Role of HER-2 in Breast Cancer Bone Metastasis","display_name":"The Role of HER-2 in Breast Cancer Bone Metastasis","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W322088057","mag":"322088057"},"language":"en","primary_location":{"id":"pmh:ADA444250","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA444250","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040450464","display_name":"Dihua Yu","orcid":"https://orcid.org/0000-0001-6231-9381","observed_orcids":["https://orcid.org/0000-0001-6231-9381"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yu, Dihua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040450464"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03776313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteolytic-lesions","display_name":"osteolytic lesions","score":0.843999981880188},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9750000238418579},{"id":"https://openalex.org/keywords/growth-factor-receptors","display_name":"growth factor receptors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.5640000104904175},{"id":"https://openalex.org/keywords/bone-resorption-markers","display_name":"bone resorption markers","score":0.7620000243186951},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8241435289382935},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.7121140956878662},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6859444975852966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6233277916908264},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5445116758346558},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5253514647483826},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.46266674995422363},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4434514343738556},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.4317152202129364},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4277758002281189},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39281371235847473},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36344432830810547},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1447911262512207}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:ADA444250","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA444250","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977016399","https://openalex.org/W1965031685","https://openalex.org/W2954659192","https://openalex.org/W4406671310","https://openalex.org/W7161845878","https://openalex.org/W2885161429","https://openalex.org/W1577525593","https://openalex.org/W4317038976","https://openalex.org/W4397031632","https://openalex.org/W2792433871"],"abstract_inverted_index":{"The":[0,73],"major":[1],"goal":[2],"of":[3,41,45,55,65,78,99,117,125,137,166,181,210,217],"this":[4,167,185,211],"Concept":[5],"award":[6],"is":[7],"to":[8,131,203,213],"define":[9],"the":[10,13,23,34,50,90,97,118,162,169,179,196,215,218],"role":[11],"for":[12,155,205],"growth":[14,21,48],"factor":[15],"receptor,":[16],"HER2,":[17],"in":[18,22,28,49,70,134,173,184],"breast":[19,46,82,102,138,157],"cancer":[20,47,83,103,139,158],"bone":[24,29,56,59,71,84,140,159],"and":[25,58,62,142,192],"its":[26],"involvement":[27],"metastasis.":[30],"To":[31],"achieve":[32],"this,":[33],"authors":[35,91,170],"proposed":[36,197],"three":[37],"tasks:":[38],"(1)":[39],"analysis":[40,54],"an":[42,132],"orthotropic":[43],"model":[44,175],"bone,":[51],"(2)":[52],"immunohistochemical":[53],"resorption":[57,60],"markers,":[61],"(3)":[63],"identification":[64],"potential":[66],"HER2":[67,79,107,128,148],"targets":[68],"involved":[69],"resorption.":[72],"results":[74],"show":[75,146],"that":[76,93,105,111,116,147,177],"overexpression":[77],"could":[80],"enhance":[81],"metastases.":[85,160],"In":[86],"their":[87,174],"pilot":[88],"study,":[89],"found":[92],"when":[94],"injected":[95],"into":[96],"tibia":[98],"nude":[100],"mice,":[101],"cells":[104],"overexpress":[106],"induced":[108],"osteolytic":[109,135],"lesions":[110],"were":[112],"more":[113],"aggressive":[114],"than":[115],"parental":[119],"cell":[120],"line":[121],"expressing":[122],"low":[123],"levels":[124],"HER2.":[126],"Thus,":[127],"may":[129,145,149],"contribute":[130],"increase":[133],"activity":[136],"metastases":[141],"further":[143],"experiments":[144],"serve":[150],"as":[151],"a":[152,206],"therapeutic":[153],"target":[154],"controlling":[156],"During":[161],"1-year":[163,207],"funding":[164],"period":[165],"grant,":[168],"experienced":[171],"setbacks":[172],"system":[176],"hindered":[178],"completion":[180,216],"tasks":[182],"outlined":[183,219],"award.":[186],"They":[187],"have":[188],"remedied":[189],"these":[190],"obstacles":[191],"are":[193],"actively":[194],"pursuing":[195],"experiments.":[198],"Therefore,":[199],"they":[200],"would":[201],"like":[202],"ask":[204],"nonfunded":[208],"extension":[209],"grant":[212],"facilitate":[214],"tasks.":[220]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
