{"id":"https://openalex.org/W3217787707","doi":"https://doi.org/10.3389/fonc.2021.790373","title":"Cost-Effectiveness Analysis of Camrelizumab vs. Placebo Added to Chemotherapy as First-Line Therapy for Advanced or Metastatic Esophageal Squamous Cell Carcinoma in China","display_name":"Cost-Effectiveness Analysis of Camrelizumab vs. Placebo Added to Chemotherapy as First-Line Therapy for Advanced or Metastatic Esophageal Squamous Cell Carcinoma in China","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W3217787707","doi":"https://doi.org/10.3389/fonc.2021.790373","mag":"3217787707","pmid":"https://pubmed.ncbi.nlm.nih.gov/34926306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8671697"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2021.790373","doi":"https://doi.org/10.3389/fonc.2021.790373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.790373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.790373/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.790373/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100756980","display_name":"Qilin Zhang","orcid":"https://orcid.org/0000-0002-4779-3875","observed_orcids":["https://orcid.org/0000-0002-4779-3875"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilin Zhang","raw_affiliation_strings":["Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011123221","display_name":"Pan Wu","orcid":"https://orcid.org/0000-0001-8339-4495","observed_orcids":["https://orcid.org/0000-0001-8339-4495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pan Wu","raw_affiliation_strings":["Department of Pharmacy, Qionglai Maternal & Child Health and Family Planning Service Center, Qionglai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Qionglai Maternal & Child Health and Family Planning Service Center, Qionglai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xucheng He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xucheng He","raw_affiliation_strings":["Department of Pharmacy, Pengzhou Second People's Hospital, Pengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Pengzhou Second People's Hospital, Pengzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101420323","display_name":"Yufeng Ding","orcid":"https://orcid.org/0000-0002-0321-7139","observed_orcids":["https://orcid.org/0000-0002-0321-7139"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufeng Ding","raw_affiliation_strings":["Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037274038","display_name":"Yamin Shu","orcid":"https://orcid.org/0000-0002-1532-8135","observed_orcids":["https://orcid.org/0000-0002-1532-8135"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yamin Shu","raw_affiliation_strings":["Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037274038"],"corresponding_institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":8.3105,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97424573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"790373","last_page":"790373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camrelizumab","display_name":"camrelizumab","score":1.0},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6880000233650208},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.8450000286102295},{"id":"https://openalex.org/keywords/incremental-cost-effectiveness-ratio","display_name":"incremental cost-effectiveness ratio","score":0.9810000061988831},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8460381031036377},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6456363201141357},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5620166063308716},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.5364193916320801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5091137290000916},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.49416258931159973},{"id":"https://openalex.org/C515549039","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost-effectiveness analysis","level":3,"score":0.4479597508907318},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4255495071411133},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07559278607368469},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2021.790373","doi":"https://doi.org/10.3389/fonc.2021.790373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.790373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.790373/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8671697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8671697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:34926306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34926306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4a077a115a5445af8625b899a4d52b71","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a077a115a5445af8625b899a4d52b71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2021.790373","doi":"https://doi.org/10.3389/fonc.2021.790373","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.790373","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.790373/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3288299131","display_name":null,"funder_award_id":"2017YFC0909900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G796532200","display_name":null,"funder_award_id":"82104476","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3217787707.pdf","grobid_xml":"https://content.openalex.org/works/W3217787707.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1942602300","https://openalex.org/W1950620244","https://openalex.org/W2032689844","https://openalex.org/W2044932116","https://openalex.org/W2087108889","https://openalex.org/W2137210918","https://openalex.org/W2272984102","https://openalex.org/W2749884966","https://openalex.org/W2765920214","https://openalex.org/W2792142385","https://openalex.org/W2796582438","https://openalex.org/W2889004312","https://openalex.org/W2889646458","https://openalex.org/W2967566250","https://openalex.org/W2976652879","https://openalex.org/W2982045845","https://openalex.org/W3009892187","https://openalex.org/W3023184521","https://openalex.org/W3025003676","https://openalex.org/W3025967965","https://openalex.org/W3047618013","https://openalex.org/W3092384992","https://openalex.org/W3106005610","https://openalex.org/W3179482610","https://openalex.org/W3200109370"],"related_works":["https://openalex.org/W3179482610","https://openalex.org/W3214098836","https://openalex.org/W4211068861","https://openalex.org/W4376641294","https://openalex.org/W3208578755","https://openalex.org/W4399136090","https://openalex.org/W4385602289","https://openalex.org/W4389180394","https://openalex.org/W4388681234","https://openalex.org/W7131217131"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,148,162],"purpose":[2],"of":[3,12,51,78,124,137,145,155,159,172],"this":[4],"cost-effectiveness":[5,90],"analysis":[6,167],"was":[7,44,66],"to":[8,15,46,68,108,152,174],"estimate":[9],"the":[10,19,48,60,70,79,110,113,119,141,153,165,170],"effects":[11],"adding":[13],"camrelizumab":[14,173],"standard":[16],"chemotherapy":[17,175],"as":[18],"first-line":[20],"treatment":[21],"in":[22,38,59,112,134,180,187],"patients":[23,53,181],"with":[24,54,182],"advanced":[25,55,183],"or":[26,56,184],"metastatic":[27,57,185],"esophageal":[28],"squamous":[29],"cell":[30],"carcinoma":[31],"(ESCC)":[32],"on":[33],"health":[34],"and":[35,74,81,88,102,122,131,157],"economic":[36],"outcomes":[37],"China.":[39,188],"METHODS:":[40],"A":[41],"Markov":[42],"model":[43,65],"developed":[45],"simulate":[47],"clinical":[49],"course":[50],"typical":[52],"ESCC":[58,186],"ESCORT-1st":[61],"trial.":[62],"Weibull":[63],"survival":[64,73,76],"employed":[67],"fit":[69],"Kaplan-Meier":[71],"progression-free":[72],"overall":[75],"probabilities":[77],"camrelizumab-chemotherapy":[80,125],"placebo-chemotherapy":[82,127],"strategy,":[83],"respectively.":[84],"Quality-adjusted":[85],"life-years":[86],"(QALYs)":[87],"incremental":[89,120],"ratios":[91],"(ICER)":[92],"were":[93,106,128,150],"estimated":[94],"over":[95],"a":[96],"5-year":[97],"lifetime":[98],"horizon.":[99],"Meanwhile,":[100],"one-way":[101],"probabilistic":[103],"sensitivity":[104],"analyses":[105],"conducted":[107],"test":[109],"uncertainty":[111],"model.":[114],"RESULTS:":[115],"On":[116],"baseline":[117],"analysis,":[118],"effectiveness":[121],"cost":[123,158],"versus":[126],"0.15":[129],"QALYs":[130],"$7,110.56,":[132],"resulting":[133],"an":[135],"ICER":[136],"$46,671.10/QALY,":[138],"higher":[139],"than":[140],"willingness-to-pay":[142],"(WTP)":[143],"threshold":[144],"China":[146],"($31,498.70/QALY).":[147],"results":[149],"sensitive":[151],"utility":[154],"PFS":[156],"camrelizumab.":[160],"CONCLUSION:":[161],"findings":[163],"from":[164],"present":[166],"suggest":[168],"that":[169],"addition":[171],"might":[176],"not":[177],"be":[178],"cost-effective":[179]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-06T00:00:00"}