{"id":"https://openalex.org/W3217568197","doi":"https://doi.org/10.1038/s42003-021-02867-8","title":"A computational exploration of resilience and evolvability of protein\u2013protein interaction networks","display_name":"A computational exploration of resilience and evolvability of protein\u2013protein interaction networks","publication_year":2021,"publication_date":"2021-12-02","ids":{"openalex":"https://openalex.org/W3217568197","doi":"https://doi.org/10.1038/s42003-021-02867-8","mag":"3217568197","pmid":"https://pubmed.ncbi.nlm.nih.gov/34857859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8639913"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-021-02867-8","doi":"https://doi.org/10.1038/s42003-021-02867-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02867-8","pdf_url":"https://www.nature.com/articles/s42003-021-02867-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-021-02867-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034550396","display_name":"Brennan Klein","orcid":"https://orcid.org/0000-0001-8326-5044","observed_orcids":["https://orcid.org/0000-0001-8326-5044"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brennan Klein","raw_affiliation_strings":["Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, MA, USA. b.klein@northeastern.edu","Network Science Institute, Northeastern University, Boston, MA, USA. b.klein@northeastern.edu","Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, MA, USA","Network Science Institute, Northeastern University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-8326-5044","affiliations":[{"raw_affiliation_string":"Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, MA, USA. b.klein@northeastern.edu","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Network Science Institute, Northeastern University, Boston, MA, USA. b.klein@northeastern.edu","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Network Science Institute, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078321161","display_name":"Ludvig Holm\u00e9r","orcid":"https://orcid.org/0000-0003-1416-2222","observed_orcids":["https://orcid.org/0000-0003-1416-2222"]},"institutions":[{"id":"https://openalex.org/I180242103","display_name":"Stockholm School of Economics","ror":"https://ror.org/01s5jzh92","country_code":"SE","type":"education","lineage":["https://openalex.org/I180242103"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ludvig Holm\u00e9r","raw_affiliation_strings":["Center for Data Analytics, Stockholm School of Economics, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Data Analytics, Stockholm School of Economics, Stockholm, Sweden","institution_ids":["https://openalex.org/I180242103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002330647","display_name":"Keith Smith","orcid":"https://orcid.org/0000-0002-4615-9020","observed_orcids":["https://orcid.org/0000-0002-4615-9020"]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Keith M. Smith","raw_affiliation_strings":["Department of Physics and Mathematics, Nottingham Trent University, Nottingham, UK. keith.smith@ntu.ac.uk","Department of Physics and Mathematics, Nottingham Trent University, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0002-4615-9020","affiliations":[{"raw_affiliation_string":"Department of Physics and Mathematics, Nottingham Trent University, Nottingham, UK. keith.smith@ntu.ac.uk","institution_ids":["https://openalex.org/I52590639"]},{"raw_affiliation_string":"Department of Physics and Mathematics, Nottingham Trent University, Nottingham, UK","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073373217","display_name":"Mackenzie M. Johnson","orcid":"https://orcid.org/0000-0002-3915-2023","observed_orcids":["https://orcid.org/0000-0002-3915-2023"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie M. Johnson","raw_affiliation_strings":["Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-3915-2023","affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022774532","display_name":"Anshuman Swain","orcid":"https://orcid.org/0000-0002-9180-2222","observed_orcids":["https://orcid.org/0000-0002-9180-2222"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshuman Swain","raw_affiliation_strings":["Department of Biology, University of Maryland, College Park, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-9180-2222","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007817413","display_name":"Laura Stolp","orcid":"https://orcid.org/0000-0002-0757-4037","observed_orcids":["https://orcid.org/0000-0002-0757-4037"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Laura Stolp","raw_affiliation_strings":["Graduate School of Science, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0757-4037","affiliations":[{"raw_affiliation_string":"Graduate School of Science, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083104513","display_name":"A Teufel","orcid":"https://orcid.org/0000-0003-3613-9517","observed_orcids":["https://orcid.org/0000-0003-3613-9517"]},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I1335518801","display_name":"Texas A&M University \u2013 San Antonio","ror":"https://ror.org/0084njv03","country_code":"US","type":"education","lineage":["https://openalex.org/I1335518801"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley I. Teufel","raw_affiliation_strings":["Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA","Santa Fe Institute, Santa Fe, NM, USA","Texas A&M University, San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, NM, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Texas A&M University, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I1335518801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042694578","display_name":"April Sn\u00f8frid Kleppe","orcid":"https://orcid.org/0000-0001-7866-3056","observed_orcids":["https://orcid.org/0000-0001-7866-3056"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE","DK"],"is_corresponding":true,"raw_author_name":"April S. Kleppe","raw_affiliation_strings":["Department of Clinical Medicine (MOMA), Aarhus University, Aarhus, Denmark. kleppe@clin.au.dk","Institute for Evolution and Biodiversity, University of M\u00fcnster, M\u00fcnster, Germany. kleppe@clin.au.dk","Department of Clinical Medicine (MOMA), Aarhus University, Aarhus, Denmark","Institute for Evolution and Biodiversity, University of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7866-3056","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine (MOMA), Aarhus University, Aarhus, Denmark. kleppe@clin.au.dk","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Institute for Evolution and Biodiversity, University of M\u00fcnster, M\u00fcnster, Germany. kleppe@clin.au.dk","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Department of Clinical Medicine (MOMA), Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Institute for Evolution and Biodiversity, University of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5002330647","https://openalex.org/A5034550396","https://openalex.org/A5042694578"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I204337017","https://openalex.org/I22465464","https://openalex.org/I52590639"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":0.8389,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.67381279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"1352","last_page":"1352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":1.0},{"id":"https://openalex.org/keywords/network-resilience","display_name":"network resilience","score":0.9980000257492065},{"id":"https://openalex.org/keywords/evolvability","display_name":"evolvability","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/preferential-attachment","display_name":"preferential attachment","score":0.921999990940094},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.5059999823570251},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8140000104904175},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.921999990940094},{"id":"https://openalex.org/keywords/phenotypic-traits","display_name":"phenotypic traits","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.9173427820205688},{"id":"https://openalex.org/C2779585090","wikidata":"https://www.wikidata.org/wiki/Q3457762","display_name":"Resilience (materials science)","level":2,"score":0.721764087677002},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4960354268550873},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46392545104026794},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4535851776599884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2830721139907837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21289783716201782},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.104106605052948},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s42003-021-02867-8","doi":"https://doi.org/10.1038/s42003-021-02867-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02867-8","pdf_url":"https://www.nature.com/articles/s42003-021-02867-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.07.02.184325","doi":"https://doi.org/10.1101/2020.07.02.184325","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.02.184325","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/27/2020.07.02.184325.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:34857859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34857859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8639913","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8639913/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmh:oai:irep.ntu.ac.uk:45103","doi":null,"is_oa":false,"landing_page_url":"http://irep.ntu.ac.uk/id/eprint/45103/1/1502606_Smith.pdf","pdf_url":"http://irep.ntu.ac.uk/id/eprint/45103/1/1502606_Smith.pdf","source":{"id":"https://openalex.org/S4306400559","display_name":"Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52590639","host_organization_name":"Nottingham Trent University","host_organization_lineage":["https://openalex.org/I52590639"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:strathprints.strath.ac.uk:87331","doi":null,"is_oa":true,"landing_page_url":"https://strathprints.strath.ac.uk/view/author/1501626.html>","pdf_url":"https://strathprints.strath.ac.uk/87331/1/Klein-etal-CB-2021-A-computational-exploration-of-resilience-and-evolvability-of-protein_protein-interaction-networks.pdf","source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:29445a7751234166a604ff210360f209","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29445a7751234166a604ff210360f209","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/9a14ad7f-5ffc-45f1-91e3-d6d12e597e28","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/9a14ad7f-5ffc-45f1-91e3-d6d12e597e28","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Klein, B, Holm\u00e9r, L, Smith, K M, Johnson, M M, Swain, A, Stolp, L, Teufel, A I & Kleppe, A S 2021, 'A computational exploration of resilience and evolvability of protein\u2013protein interaction networks', Communications Biology, vol. 4, no. 1, 1352. https://doi.org/10.1038/s42003-021-02867-8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s42003-021-02867-8","doi":"https://doi.org/10.1038/s42003-021-02867-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-021-02867-8","pdf_url":"https://www.nature.com/articles/s42003-021-02867-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3849505775","display_name":"Toward a teleology of complex networks","funder_award_id":"61780","funder_id":"https://openalex.org/F4320306193","funder_display_name":"John Templeton Foundation"},{"id":"https://openalex.org/G7706097911","display_name":"PREDOCTORAL TRAINING IN BIOMEDICAL BIG DATA SCIENCE","funder_award_id":"T32LM012414","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G7949604535","display_name":"NRT-DESE: Network Biology: From Data to Information to Insights","funder_award_id":"1632976","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8491872559","display_name":null,"funder_award_id":"DGE-1632976","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306193","display_name":"John Templeton Foundation","ror":"https://ror.org/035tnyy05"},{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320322572","display_name":"Studienstiftung des Deutschen Volkes","ror":"https://ror.org/05xwwfy96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333566","display_name":"National Defense Science and Engineering Graduate","ror":null},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F7757660664","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3217568197.pdf","grobid_xml":"https://content.openalex.org/works/W3217568197.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1607969426","https://openalex.org/W1641544182","https://openalex.org/W1971421925","https://openalex.org/W1990406293","https://openalex.org/W1995996823","https://openalex.org/W2016666153","https://openalex.org/W2020541351","https://openalex.org/W2023432555","https://openalex.org/W2030794394","https://openalex.org/W2031915653","https://openalex.org/W2032516423","https://openalex.org/W2037721945","https://openalex.org/W2039790548","https://openalex.org/W2040204840","https://openalex.org/W2044988896","https://openalex.org/W2046797733","https://openalex.org/W2055441291","https://openalex.org/W2068855150","https://openalex.org/W2069860553","https://openalex.org/W2080473579","https://openalex.org/W2083034544","https://openalex.org/W2095293504","https://openalex.org/W2097484079","https://openalex.org/W2103731920","https://openalex.org/W2105557836","https://openalex.org/W2115148114","https://openalex.org/W2116332911","https://openalex.org/W2121821841","https://openalex.org/W2122581451","https://openalex.org/W2127673162","https://openalex.org/W2136088806","https://openalex.org/W2144880743","https://openalex.org/W2145633859","https://openalex.org/W2146749911","https://openalex.org/W2149242848","https://openalex.org/W2158196690","https://openalex.org/W2167766017","https://openalex.org/W2171501215","https://openalex.org/W2271389098","https://openalex.org/W2276689003","https://openalex.org/W2415452881","https://openalex.org/W2463525684","https://openalex.org/W2520983251","https://openalex.org/W2537262399","https://openalex.org/W2550720082","https://openalex.org/W2608157918","https://openalex.org/W2753467283","https://openalex.org/W2765725484","https://openalex.org/W2766955181","https://openalex.org/W2776644290","https://openalex.org/W2779168350","https://openalex.org/W2803164879","https://openalex.org/W2806000513","https://openalex.org/W2886462699","https://openalex.org/W2897805491","https://openalex.org/W2900569176","https://openalex.org/W2921769766","https://openalex.org/W2945066961","https://openalex.org/W2945102084","https://openalex.org/W2945570991","https://openalex.org/W2948489253","https://openalex.org/W2950411297","https://openalex.org/W2951271819","https://openalex.org/W2953298003","https://openalex.org/W2962538444","https://openalex.org/W2972343718","https://openalex.org/W2981175235","https://openalex.org/W2998119497","https://openalex.org/W3002680333","https://openalex.org/W3041691674","https://openalex.org/W3119938933","https://openalex.org/W3129442943","https://openalex.org/W3136918052","https://openalex.org/W3153061243","https://openalex.org/W3162645014","https://openalex.org/W3182443470","https://openalex.org/W6893876675","https://openalex.org/W7095682847"],"related_works":["https://openalex.org/W4319778010","https://openalex.org/W3156197387","https://openalex.org/W7118701539","https://openalex.org/W7100129812","https://openalex.org/W2950411297","https://openalex.org/W1997978177","https://openalex.org/W1996540294","https://openalex.org/W2039291375","https://openalex.org/W2009660640","https://openalex.org/W3015155718"],"abstract_inverted_index":{"Protein-protein":[0],"interaction":[1],"(PPI)":[2],"networks":[3,111],"represent":[4],"complex":[5],"intra-cellular":[6,59],"protein":[7],"interactions,":[8],"and":[9,74,93,118,154],"the":[10,45,69,110,123,126,131,157,186,194],"presence":[11],"or":[12,56,151,172],"absence":[13],"of":[14,47,71,86,125,133,160,168,181,189,196],"such":[15],"interactions":[16],"can":[17,61,155],"lead":[18],"to":[19,36,41,109,149],"biological":[20],"changes":[21,99],"in":[22,44,100,163,192],"an":[23],"organism.":[24],"Recent":[25],"network-based":[26],"approaches":[27],"have":[28],"shown":[29],"that":[30,140],"a":[31,178],"phenotype's":[32],"PPI":[33,78,161],"network's":[34],"resilience":[35,102,124,159],"environmental":[37],"perturbations":[38],"is":[39],"related":[40],"its":[42],"placement":[43],"tree":[46],"life;":[48],"though":[49],"we":[50,67,97,129],"still":[51],"do":[52],"not":[53],"know":[54],"how":[55],"why":[57],"certain":[58],"factors":[60],"bring":[62],"about":[63],"this":[64],"resilience.":[65,80],"Here,":[66],"explore":[68],"influence":[70],"gene":[72,169],"expression":[73,170],"network":[75,101,162,173,190],"properties":[76],"on":[77],"networks'":[79],"We":[81,138],"use":[82],"publicly":[83],"available":[84],"data":[85],"PPIs":[87],"for":[88],"E.":[89],"coli,":[90],"S.":[91],"cerevisiae,":[92],"H.":[94],"sapiens,":[95],"where":[96],"compute":[98],"as":[103],"new":[104],"nodes":[105,142],"(proteins)":[106],"are":[107],"added":[108],"under":[112],"three":[113,165],"node":[114,135],"addition":[115,136],"mechanisms-random,":[116],"degree-based,":[117],"gene-expression-based":[119,144],"attachments.":[120],"By":[121],"calculating":[122],"resulting":[127],"networks,":[128],"estimate":[130],"effectiveness":[132],"these":[134],"mechanisms.":[137],"demonstrate":[139],"adding":[141],"with":[143],"preferential":[145],"attachment":[146],"(as":[147],"opposed":[148],"random":[150],"degree-based)":[152],"preserves":[153],"increase":[156],"original":[158],"all":[164],"species,":[166],"regardless":[167],"distribution":[171],"structure.":[174],"These":[175],"findings":[176],"introduce":[177],"general":[179],"notion":[180],"prospective":[182],"resilience,":[183],"which":[184],"highlights":[185],"key":[187],"role":[188],"structures":[191],"understanding":[193],"evolvability":[195],"phenotypic":[197],"traits.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}