{"id":"https://openalex.org/W32174453","doi":null,"title":"Antagonism of fentanyl-induced respiratory depression with nalmefene.","display_name":"Antagonism of fentanyl-induced respiratory depression with nalmefene.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W32174453","mag":"32174453","pmid":"https://pubmed.ncbi.nlm.nih.gov/2314151"},"language":"en","primary_location":{"id":"pmid:2314151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061468032","display_name":"Lindsay Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L R Moore","raw_affiliation_strings":["University of Miami, Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Department of Anesthesiology","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058335049","display_name":"George B. Bikhazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G B Bikhazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077405489","display_name":"Ronald R. Tuttle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Tuttle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111914500","display_name":"D.J. Weidler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Weidler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1416,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.34126673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"29","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.24390000104904175,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.24390000104904175,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.16429999470710754,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.14219999313354492,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nalmefene","display_name":"nalmefene","score":0.972000002861023},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.9850000143051147},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.9399999976158142},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.8730000257492065},{"id":"https://openalex.org/keywords/respiratory-inductance-plethysmography","display_name":"respiratory inductance plethysmography","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.9290000200271606},{"id":"https://openalex.org/keywords/breathing-pattern","display_name":"breathing pattern","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2778836221","wikidata":"https://www.wikidata.org/wiki/Q4353252","display_name":"Nalmefene","level":5,"score":0.921570897102356},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.8733837604522705},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7254987955093384},{"id":"https://openalex.org/C2775962371","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Opioid antagonist","level":5,"score":0.6913133859634399},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6874791979789734},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.653448760509491},{"id":"https://openalex.org/C2776768635","wikidata":"https://www.wikidata.org/wiki/Q3427301","display_name":"Volunteer","level":2,"score":0.5902398228645325},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5679986476898193},{"id":"https://openalex.org/C3019590667","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Narcotic antagonist","level":5,"score":0.4918091595172882},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.48913270235061646},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.40795010328292847},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.3539145588874817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24086859822273254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010991","descriptor_name":"Plethysmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2314151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Clinical Trial"},{"id":"mag:32174453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2314151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1966104788","https://openalex.org/W1968483660","https://openalex.org/W1980801167","https://openalex.org/W1988665553","https://openalex.org/W1994367518","https://openalex.org/W1995119224","https://openalex.org/W1995510727","https://openalex.org/W2001187841","https://openalex.org/W2001944696","https://openalex.org/W2017736138","https://openalex.org/W2017764040","https://openalex.org/W2018928802","https://openalex.org/W2058203122","https://openalex.org/W2060514161","https://openalex.org/W2067498763","https://openalex.org/W2072316294","https://openalex.org/W2089235229","https://openalex.org/W2102368840","https://openalex.org/W2108367829","https://openalex.org/W2112481771","https://openalex.org/W2117386204","https://openalex.org/W2120436172","https://openalex.org/W2156788262","https://openalex.org/W2236504019","https://openalex.org/W2256756668","https://openalex.org/W2401644992","https://openalex.org/W2405362382","https://openalex.org/W2461208141","https://openalex.org/W2474251565","https://openalex.org/W2508794604","https://openalex.org/W2517370544","https://openalex.org/W2546914187","https://openalex.org/W2588560321","https://openalex.org/W2746326653","https://openalex.org/W2791065293","https://openalex.org/W2791347300","https://openalex.org/W2895861302","https://openalex.org/W2901730326","https://openalex.org/W2910286519","https://openalex.org/W2913937735","https://openalex.org/W2953799504","https://openalex.org/W2961890940","https://openalex.org/W3003280167","https://openalex.org/W3003957783"],"related_works":["https://openalex.org/W2157212836","https://openalex.org/W4402985322","https://openalex.org/W2352803117","https://openalex.org/W2406680204","https://openalex.org/W2110115380","https://openalex.org/W1566003636","https://openalex.org/W4413112682","https://openalex.org/W3029960483","https://openalex.org/W2350771903","https://openalex.org/W2348164636"],"abstract_inverted_index":{"We":[0],"determined":[1],"the":[2,27,40,52,80,83,112,126,141,166,170],"ability":[3],"of":[4,62,70,93,128,152],"a":[5,107],"new":[6],"opioid":[7,212,224],"antagonist,":[8,213],"naimefene,":[9],"to":[10,39,135,148,189],"prevent":[11],"fentanyl-induced":[12],"respiratory":[13,28,118],"depression":[14,119],"in":[15,75,106,111,220],"8":[16],"healthy":[17],"male":[18],"volunteers.":[19],"Ventilation":[20],"and":[21,35,116,169,196,214],"pulmonary":[22],"function":[23],"were":[24,85,103,143,155],"measured":[25],"with":[26,121,145],"inductive":[29],"plethysmograph":[30],"(RIP),":[31],"which":[32,161],"is":[33,208],"non-invasive":[34],"requires":[36],"no":[37],"connection":[38],"airway.":[41],"Each":[42],"volunteer":[43,56],"was":[44,57,96],"tested":[45],"two":[46],"times":[47],"on":[48],"different":[49],"days.":[50],"During":[51],"first":[53,113],"session,":[54,82],"each":[55],"monitored":[58,86],"for":[59,87],"one":[60,88],"hour":[61,89],"baseline":[63],"measurement":[64],"followed":[65],"by":[66,223],"4":[67],"hourly":[68],"injections":[69],"fentanyl":[71,99,122,130,149],"(1":[72],"microgram/kg)":[73],"administered":[74],"an":[76,136,209],"open-label":[77],"manner.":[78],"In":[79,125],"second":[81],"subjects":[84,142],"after":[90],"1":[91],"mg":[92],"intravenous":[94],"nalmefene":[95,146,207],"administered.":[97],"Intravenous":[98],"or":[100],"identical":[101],"placebo":[102],"then":[104],"given":[105],"double-blind":[108],"manner":[109],"as":[110],"session.":[114],"Progressive":[115],"profound":[117],"occurred":[120],"administration":[123],"alone.":[124],"absence":[127],"nalmefene,":[129],"converted":[131],"normal":[132],"breathing":[133,138],"pattern":[134],"irregular":[137],"pattern.":[139],"When":[140],"treated":[144],"prior":[147],"administration,":[150],"all":[151],"these":[153],"changes":[154,219],"almost":[156],"completely":[157],"prevented.":[158],"Pulmonary":[159],"variables":[160],"reflected":[162],"this":[163],"difference":[164],"between":[165],"fentanyl-alone":[167],"group":[168],"nalmefene-pretreated":[171],"groups":[172],"included":[173],"frequency":[174],"(p":[175,181,192,199],"less":[176,182,193,200],"than":[177,183,194,201],"0.001),":[178,184],"tidal":[179,190],"volume":[180,191],"percent":[185],"rib":[186],"cage":[187],"contribution":[188],"0.001)":[195],"expiratory":[197],"time":[198],"0.001).":[202],"This":[203],"study":[204],"showed":[205],"that":[206,215],"effective":[210],"long-acting":[211],"RIP":[216],"accurately":[217],"measures":[218],"respiration":[221],"caused":[222],"administration.":[225]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}