{"id":"https://openalex.org/W3217048993","doi":null,"title":"Expression and effects of social defeat on histamine receptor expression in wild-type and hdc \u2013/\u2013 zebrafish gut and brain","display_name":"Expression and effects of social defeat on histamine receptor expression in wild-type and hdc \u2013/\u2013 zebrafish gut and brain","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3217048993","mag":"3217048993"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/330570","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/330570","pdf_url":"http://hdl.handle.net/10138/330570","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"pro gradu -tutkielmat"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/330570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089402055","display_name":"Serena Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Serena Lewis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089402055"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.1670999974012375,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histidine-decarboxylase","display_name":"histidine decarboxylase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/social-defeat","display_name":"social defeat","score":0.7080000042915344},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intestine","display_name":"intestine","score":0.3089999854564667},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.984000027179718},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.621999979019165},{"id":"https://openalex.org/keywords/social-dominance","display_name":"social dominance","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8187069296836853},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.6376149654388428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.555649995803833},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4950851500034332},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48321616649627686},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.45772087574005127},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.42051059007644653},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.389566034078598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38809677958488464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36768725514411926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30269575119018555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30017590522766113},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07184037566184998},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/330570","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/330570","pdf_url":"http://hdl.handle.net/10138/330570","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"pro gradu -tutkielmat"},{"id":"mag:3217048993","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/330570","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/330570","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/330570","pdf_url":"http://hdl.handle.net/10138/330570","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"pro gradu -tutkielmat"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3217048993.pdf","grobid_xml":"https://content.openalex.org/works/W3217048993.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1707228","https://openalex.org/W1515700816","https://openalex.org/W1541708163","https://openalex.org/W1686333409","https://openalex.org/W1964922357","https://openalex.org/W1975411923","https://openalex.org/W1977593923","https://openalex.org/W1987969211","https://openalex.org/W1990809315","https://openalex.org/W1992116689","https://openalex.org/W1997929515","https://openalex.org/W2009570194","https://openalex.org/W2017629598","https://openalex.org/W2025887442","https://openalex.org/W2041937465","https://openalex.org/W2047929399","https://openalex.org/W2053188090","https://openalex.org/W2059270078","https://openalex.org/W2063125566","https://openalex.org/W2074949244","https://openalex.org/W2076133248","https://openalex.org/W2077687762","https://openalex.org/W2098574165","https://openalex.org/W2105728643","https://openalex.org/W2112673542","https://openalex.org/W2122479540","https://openalex.org/W2128664680","https://openalex.org/W2130433101","https://openalex.org/W2150829524","https://openalex.org/W2151269325","https://openalex.org/W2151454086","https://openalex.org/W2158148601","https://openalex.org/W2258309671","https://openalex.org/W2263337119","https://openalex.org/W2283607587","https://openalex.org/W2319173734","https://openalex.org/W2408873968","https://openalex.org/W2414258824","https://openalex.org/W2464957792","https://openalex.org/W2485902480","https://openalex.org/W2514553841","https://openalex.org/W2588657333","https://openalex.org/W2752849791","https://openalex.org/W2886800621","https://openalex.org/W2979697055","https://openalex.org/W3153711360"],"related_works":["https://openalex.org/W3212941616","https://openalex.org/W2039581723","https://openalex.org/W1982819656","https://openalex.org/W2017629598","https://openalex.org/W2066671873","https://openalex.org/W3047177028","https://openalex.org/W4414548878","https://openalex.org/W2914492418","https://openalex.org/W2136860890","https://openalex.org/W2567350953"],"abstract_inverted_index":{"Histamine":[0,75],"receptors":[1,57,76,95,136,228],"are":[2,13,52,151,229],"known":[3,53],"to":[4,41,54,225],"be":[5,66],"expressed":[6,152,230],"throughout":[7],"the":[8,17,31,47,89,128,143,216,222,241,250],"peripheral":[9],"nervous":[10,33],"system":[11,34],"and":[12,19,35,43,61,85,138,156,160,179,184,211,234],"involved":[14],"in":[15,46,58,82,96,153,158,166,196,215,231],"regulating":[16],"gut":[18,39,60,98,117,129,155],"immune":[20],"system.":[21],"The":[22],"gut-brain":[23,71,242],"axis,":[24,243],"which":[25,64],"consists":[26],"of":[27,93,181,252],"bidirectional":[28],"signaling":[29],"between":[30],"central":[32],"gastrointestinal":[36],"tract,":[37],"links":[38],"functions":[40],"emotional":[42],"cognitive":[44],"controls":[45],"brain.":[48],"Many":[49],"animal":[50],"models":[51],"express":[55],"histamine":[56,94,120,135,182,227],"their":[59,105,123],"brain":[62,157],"tissue":[63,99],"can":[65,239],"altered":[67],"by":[68],"a":[69],"compromised":[70],"axis":[72],"like":[73],"stress.":[74,111],"also":[77,108],"play":[78],"an":[79],"important":[80],"role":[81,124],"many":[83],"gastric":[84],"intestinal":[86],"disorders.":[87],"However,":[88,202],"precise":[90],"expression":[91,106],"pattern":[92],"zebrafish":[97,116,154,164,174,232],"is":[100,103],"unknown,":[101],"as":[102,140,142],"whether":[104],"levels":[107,187],"change":[109],"with":[110],"Here,":[112],"I":[113,132],"show":[114],"that":[115,134,145,208,235],"contains":[118],"several":[119],"receptors,":[121],"but":[122],"involving":[125],"stress":[126,238],"within":[127],"remains":[130],"unknown.":[131],"found":[133],"hrh1":[137],"hrh3":[139],"well":[141],"enzyme":[144],"synthesizes":[146],"histamine,":[147],"histidine":[148],"decarboxylase":[149],"(hdc),":[150],"wildtype":[159,172],"hdc":[161,185,212],"knockout":[162],"adult":[163,217],"using":[165,188],"situ":[167],"hybridization.":[168],"Stress":[169],"induction":[170],"on":[171],"male":[173],"through":[175,249],"chronic":[176],"social":[177],"defeat":[178],"analysis":[180],"receptor":[183],"mRNA":[186,213],"quantitative":[189,206],"real":[190],"time":[191],"PCR":[192],"showed":[193],"no":[194],"differences":[195],"subordinate,":[197],"dominate,":[198],"or":[199],"control":[200],"fish.":[201],"it":[203,244],"did":[204],"provide":[205],"data":[207,224],"hrh1,":[209],"hrh2,":[210],"expresses":[214],"gut.":[218],"My":[219],"results":[220],"demonstrate":[221],"first":[223],"suggest":[226],"gut,":[233],"even":[236],"though":[237],"alter":[240],"may":[245],"not":[246],"do":[247],"so":[248],"regulation":[251],"these":[253],"receptors.":[254]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2021-12-06T00:00:00"}