{"id":"https://openalex.org/W3217022345","doi":"https://doi.org/10.3389/fchem.2021.773981","title":"Synthesis, Structure Elucidation, Antibacterial Activities, and Synergistic Effects of Novel Juglone and Naphthazarin Derivatives Against Clinical Methicillin-Resistant Staphylococcus aureus Strains","display_name":"Synthesis, Structure Elucidation, Antibacterial Activities, and Synergistic Effects of Novel Juglone and Naphthazarin Derivatives Against Clinical Methicillin-Resistant Staphylococcus aureus Strains","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3217022345","doi":"https://doi.org/10.3389/fchem.2021.773981","mag":"3217022345","pmid":"https://pubmed.ncbi.nlm.nih.gov/34869221","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8640087"},"language":"en","primary_location":{"id":"doi:10.3389/fchem.2021.773981","doi":"https://doi.org/10.3389/fchem.2021.773981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2021.773981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.773981/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.773981/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083152224","display_name":"Valentin Duvauchelle","orcid":"https://orcid.org/0000-0003-1227-0262","observed_orcids":["https://orcid.org/0000-0003-1227-0262"]},"institutions":[{"id":"https://openalex.org/I4405261603","display_name":"N\u00eemes Universit\u00e9","ror":"https://ror.org/05jhv1f87","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentin Duvauchelle","raw_affiliation_strings":["UNIV. NIMES, UPR CHROME, N\u00eemes, France","CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV. NIMES, UPR CHROME, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)","institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084237995","display_name":"Chaimae Majdi","orcid":"https://orcid.org/0000-0002-6556-3598","observed_orcids":["https://orcid.org/0000-0002-6556-3598"]},"institutions":[{"id":"https://openalex.org/I4405261603","display_name":"N\u00eemes Universit\u00e9","ror":"https://ror.org/05jhv1f87","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chaimae Majdi","raw_affiliation_strings":["UNIV. NIMES, UPR CHROME, N\u00eemes, France","CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV. NIMES, UPR CHROME, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)","institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017502533","display_name":"David B\u00e9nim\u00e8lis","orcid":"https://orcid.org/0000-0002-3493-8553","observed_orcids":["https://orcid.org/0000-0002-3493-8553"]},"institutions":[{"id":"https://openalex.org/I4405261603","display_name":"N\u00eemes Universit\u00e9","ror":"https://ror.org/05jhv1f87","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David B\u00e9nim\u00e9lis","raw_affiliation_strings":["UNIV. NIMES, UPR CHROME, N\u00eemes, France","CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV. NIMES, UPR CHROME, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)","institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015350827","display_name":"Catherine Dunyach\u2010Remy","orcid":"https://orcid.org/0000-0001-6884-470X","observed_orcids":["https://orcid.org/0000-0001-6884-470X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210104607","display_name":"Centre Hospitalier Universitaire de N\u00eemes","ror":"https://ror.org/0275ye937","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210104607"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Dunyach-Remy","raw_affiliation_strings":["VBIC, INSERM U1047, Service de Microbiologie et Hygi\u00e8ne Hospitali\u00e8re, Universit\u00e9 de Montpellier, CHU N\u00eemes, N\u00eemes, France","CHU N\u00eemes - H\u00f4pital Universitaire Car\u00e9meau [N\u00eemes] (Place du Professeur Robert Debr\u00e9, 30900 N\u00eemes - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VBIC, INSERM U1047, Service de Microbiologie et Hygi\u00e8ne Hospitali\u00e8re, Universit\u00e9 de Montpellier, CHU N\u00eemes, N\u00eemes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307"]},{"raw_affiliation_string":"CHU N\u00eemes - H\u00f4pital Universitaire Car\u00e9meau [N\u00eemes] (Place du Professeur Robert Debr\u00e9, 30900 N\u00eemes - France)","institution_ids":["https://openalex.org/I4210104607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011875128","display_name":"Patrick R. Meffre","orcid":"https://orcid.org/0000-0002-6189-9860","observed_orcids":["https://orcid.org/0000-0002-6189-9860"]},"institutions":[{"id":"https://openalex.org/I4405261603","display_name":"N\u00eemes Universit\u00e9","ror":"https://ror.org/05jhv1f87","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Meffre","raw_affiliation_strings":["UNIV. NIMES, UPR CHROME, N\u00eemes, France","CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV. NIMES, UPR CHROME, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)","institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032707646","display_name":"Zohra Benfodda","orcid":"https://orcid.org/0000-0001-7574-4977","observed_orcids":["https://orcid.org/0000-0001-7574-4977"]},"institutions":[{"id":"https://openalex.org/I4405261603","display_name":"N\u00eemes Universit\u00e9","ror":"https://ror.org/05jhv1f87","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603"]},{"id":"https://openalex.org/I66456633","display_name":"Universit\u00e9 de N\u00eemes","ror":"https://ror.org/044t4x544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Zohra Benfodda","raw_affiliation_strings":["UNIV. NIMES, UPR CHROME, N\u00eemes, France","CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV. NIMES, UPR CHROME, N\u00eemes, France","institution_ids":["https://openalex.org/I66456633"]},{"raw_affiliation_string":"CHROME - D\u00e9tection, \u00e9valuation, gestion des risques CHROniques et \u00e9MErgents (CHROME) / Universit\u00e9 de N\u00eemes (Rue du docteur Georges Salan\r\n30021 N\u00eemes cedex 01 - France)","institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032707646"],"corresponding_institution_ids":["https://openalex.org/I4405261603","https://openalex.org/I66456633"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2542,"currency":"EUR","value_usd":2741},"fwci":0.9434,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79243547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"9","issue":null,"first_page":"773981","last_page":"773981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.16750000417232513,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juglone-derivatives","display_name":"juglone derivatives","score":0.9959999918937683},{"id":"https://openalex.org/keywords/naphthazarin-derivatives","display_name":"naphthazarin derivatives","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.996999979019165},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8069999814033508},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.6639999747276306},{"id":"https://openalex.org/keywords/eskape-pathogens","display_name":"ESKAPE pathogens","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/synergistic-antibacterial-activity","display_name":"synergistic antibacterial activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cloxacillin","display_name":"cloxacillin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.5870000123977661},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2780408477","wikidata":"https://www.wikidata.org/wiki/Q422219","display_name":"Cloxacillin","level":4,"score":0.9396932125091553},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6968348026275635},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6876115202903748},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6743988394737244},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5816419124603271},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.5166847705841064},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.47502070665359497},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4447602331638336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3675617575645447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32278382778167725},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.06991887092590332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fchem.2021.773981","doi":"https://doi.org/10.3389/fchem.2021.773981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2021.773981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.773981/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8640087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8640087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Chem","raw_type":"Text"},{"id":"pmid:34869221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34869221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03446358v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03446358","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Chemistry, 2021, 9, &#x27E8;10.3389/fchem.2021.773981&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8a5769c4666044809f579752a3b6d679","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8a5769c4666044809f579752a3b6d679","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Chemistry, Vol 9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fchem.2021.773981","doi":"https://doi.org/10.3389/fchem.2021.773981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fchem.2021.773981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fchem.2021.773981/pdf","source":{"id":"https://openalex.org/S2764970645","display_name":"Frontiers in Chemistry","issn_l":"2296-2646","issn":["2296-2646"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328356","display_name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","ror":"https://ror.org/05mzwwx48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3217022345.pdf","grobid_xml":"https://content.openalex.org/works/W3217022345.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1969360633","https://openalex.org/W1984186490","https://openalex.org/W1990043601","https://openalex.org/W1996764065","https://openalex.org/W2016562927","https://openalex.org/W2018847378","https://openalex.org/W2023744543","https://openalex.org/W2026799139","https://openalex.org/W2057569612","https://openalex.org/W2066309187","https://openalex.org/W2079315046","https://openalex.org/W2085172798","https://openalex.org/W2094626158","https://openalex.org/W2101547779","https://openalex.org/W2102336590","https://openalex.org/W2111020219","https://openalex.org/W2111618348","https://openalex.org/W2155589717","https://openalex.org/W2336373035","https://openalex.org/W2336750273","https://openalex.org/W2432128750","https://openalex.org/W2489596030","https://openalex.org/W2492312488","https://openalex.org/W2512611538","https://openalex.org/W2558941103","https://openalex.org/W2593436234","https://openalex.org/W2898419488","https://openalex.org/W2908874869","https://openalex.org/W2934656438","https://openalex.org/W2943050692","https://openalex.org/W2943885243","https://openalex.org/W2998218278","https://openalex.org/W4242372416"],"related_works":["https://openalex.org/W4400481457","https://openalex.org/W3096799045","https://openalex.org/W2940656992","https://openalex.org/W2935031269","https://openalex.org/W7008082563","https://openalex.org/W7168360986","https://openalex.org/W7167608977","https://openalex.org/W3198040769","https://openalex.org/W2900007841","https://openalex.org/W2951336257"],"abstract_inverted_index":{"Infections":[0],"caused":[1],"by":[2,27],"drug-resistant":[3],"bacteria":[4,81],"are":[5,89],"a":[6],"serious":[7],"threat":[8],"to":[9,36,43,96,147,191,198,227],"human":[10],"and":[11,25,38,60,69,76,78,84,102,109,115,126,137,165,172,200,222,245,269],"global":[12],"public":[13],"health.":[14],"Moreover,":[15,239],"in":[16],"recent":[17],"years,":[18],"very":[19],"few":[20],"antibiotics":[21],"have":[22],"been":[23],"discovered":[24],"developed":[26],"pharmaceutical":[28],"companies.":[29],"Therefore,":[30],"there":[31],"is":[32,267],"an":[33,234],"urgent":[34],"need":[35],"discover":[37],"develop":[39],"new":[40],"antibacterial":[41,64,203],"agents":[42],"combat":[44],"multidrug-resistant":[45],"bacteria.":[46],"In":[47,212,257],"this":[48],"study,":[49],"two":[50],"novel":[51],"series":[52],"of":[53,90,149,158,195,205,215,220,229,237,260],"juglone/naphthazarin":[54],"derivatives":[55],"(43":[56],"compounds)":[57],"were":[58,145,167,209,224],"synthesized":[59],"evaluated":[61,168],"for":[62,265,271],"their":[63],"properties":[65],"against":[66,107,118,151],"various":[67],"clinical":[68,73,77,91,108,119,152,196],"reference":[70,79,110,170],"Gram-positive":[71,74],"MSSA,":[72],"MRSA,":[75],"Gram-negative":[80],"E.":[82],"coli":[83],"P.":[85],"aeruginosa.":[86],"These":[87],"strains":[88],"importance":[92],"because":[93],"they":[94,208],"belong":[95],"ESKAPE":[97],"pathogens.":[98],"Compounds":[99],"3al,":[100,161,241],"5ag,":[101,162,242],"3bg":[103],"showed":[104],"promising":[105,268],"activity":[106,130,204,251],"MSSA":[111,133],"(MIC:":[112,121,134,139],"1\u20138":[113],"\u00b5g/ml)":[114,123,136,141],"good":[116],"efficacy":[117],"MRSA":[120,138,153,197],"2\u20138":[122],"strains.":[124,142,154],"5am":[125],"3bm":[127,166,181,188,246,266],"demonstrated":[128],"better":[129],"on":[131,252],"both":[132],"0.5":[135],"2":[140],"Their":[143],"MICs":[144],"similar":[146],"those":[148],"cloxacillin":[150,199,223],"The":[155],"synergistic":[156],"effects":[157],"active":[159],"compounds":[160,240],"5am,":[163,243],"3bg,":[164,244],"with":[169,180,233],"antibiotics,":[171],"it":[173],"was":[174,189],"found":[175,190],"that":[176],"the":[177,184,193,202,213,217,230],"antibiotic":[178],"combination":[179],"efficiently":[182],"enhanced":[183,201],"antimicrobial":[185],"activity.":[186],"Compound":[187],"restore":[192],"sensitivity":[194],"vancomycin":[206,221],"when":[207],"added":[210],"together.":[211],"presence":[214],"3bm,":[216],"MIC":[218,232],"values":[219],"lowered":[225],"up":[226],"1/16th":[228],"original":[231],"FIC":[235],"index":[236],"0.313.":[238],"did":[247],"not":[248],"present":[249],"hemolytic":[250],"sheep":[253],"red":[254],"blood":[255],"cells.":[256],"silico":[258],"prediction":[259],"ADME":[261],"profile":[262],"parameter":[263],"results":[264],"encouraging":[270],"further":[272],"development.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-06T00:00:00"}
