{"id":"https://openalex.org/W3216936992","doi":"https://doi.org/10.15789/1563-0625-ado-2192","title":"Age-dependent disregulation of the immune response in humans","display_name":"Age-dependent disregulation of the immune response in humans","publication_year":2021,"publication_date":"2021-11-17","ids":{"openalex":"https://openalex.org/W3216936992","doi":"https://doi.org/10.15789/1563-0625-ado-2192","mag":"3216936992"},"language":"en","primary_location":{"id":"doi:10.15789/1563-0625-ado-2192","doi":"https://doi.org/10.15789/1563-0625-ado-2192","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-ado-2192","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2192/1465","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mimmun.ru/mimmun/article/download/2192/1465","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072293863","display_name":"Alexey A. Artemenkov","orcid":"https://orcid.org/0000-0001-7919-3690","observed_orcids":["https://orcid.org/0000-0001-7919-3690"]},"institutions":[{"id":"https://openalex.org/I70053296","display_name":"Cherepovets State University","ror":"https://ror.org/04tav7h44","country_code":"RU","type":"education","lineage":["https://openalex.org/I70053296"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. A. Artemenkov","raw_affiliation_strings":["Cherepovets State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cherepovets State University","institution_ids":["https://openalex.org/I70053296"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072293863"],"corresponding_institution_ids":["https://openalex.org/I70053296"],"apc_list":null,"apc_paid":null,"fwci":0.589,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.51260504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"23","issue":"5","first_page":"1005","last_page":"1016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.164900004863739,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.890999972820282},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8529999852180481},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.6380000114440918},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.6240000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.765999972820282},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8840000033378601},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9100000262260437},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.8100000023841858},{"id":"https://openalex.org/keywords/adrenergic-nerves","display_name":"adrenergic nerves","score":0.9010000228881836},{"id":"https://openalex.org/keywords/peptidergic-nerves","display_name":"peptidergic nerves","score":0.8100000023841858},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6899999976158142},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.734000027179718},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7279999852180481},{"id":"https://openalex.org/keywords/general-adaptation-syndrome","display_name":"general adaptation syndrome","score":0.7089999914169312},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8039753437042236},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5536299347877502},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5386552214622498},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5156475305557251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46490299701690674},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4228579103946686},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.41632938385009766},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41441670060157776},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38231462240219116},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20488247275352478},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.13266053795814514}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.15789/1563-0625-ado-2192","doi":"https://doi.org/10.15789/1563-0625-ado-2192","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-ado-2192","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2192/1465","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b44e76f9130448909e852537d3b910c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b44e76f9130448909e852537d3b910c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0438\u044f, Vol 23, Iss 5, Pp 1005-1016 (2021)","raw_type":"article"},{"id":"mag:3213020517","doi":null,"is_oa":true,"landing_page_url":"https://www.mimmun.ru/mimmun/article/download/2192/1465","pdf_url":null,"source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medical Immunology (Russia)","raw_type":null}],"best_oa_location":{"id":"doi:10.15789/1563-0625-ado-2192","doi":"https://doi.org/10.15789/1563-0625-ado-2192","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-ado-2192","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2192/1465","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216936992.pdf","grobid_xml":"https://content.openalex.org/works/W3216936992.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1144717940","https://openalex.org/W1603039868","https://openalex.org/W1978103330","https://openalex.org/W1992256029","https://openalex.org/W1999298001","https://openalex.org/W2021431505","https://openalex.org/W2027663660","https://openalex.org/W2032693714","https://openalex.org/W2082402714","https://openalex.org/W2145688292","https://openalex.org/W2285204915","https://openalex.org/W2312752147","https://openalex.org/W2321548671","https://openalex.org/W2416950119","https://openalex.org/W2483359327","https://openalex.org/W2518460556","https://openalex.org/W2546703801","https://openalex.org/W2560668196","https://openalex.org/W2563804790","https://openalex.org/W2585306593","https://openalex.org/W2589256120","https://openalex.org/W2589489083","https://openalex.org/W2605727283","https://openalex.org/W2623458911","https://openalex.org/W2742687902","https://openalex.org/W2775503072","https://openalex.org/W2789690147","https://openalex.org/W2794301425","https://openalex.org/W2794844487","https://openalex.org/W2797170123","https://openalex.org/W2802639922","https://openalex.org/W2810952045","https://openalex.org/W2883985466","https://openalex.org/W2886087395","https://openalex.org/W2887700639","https://openalex.org/W2894696369","https://openalex.org/W2909041556","https://openalex.org/W2915067442","https://openalex.org/W2922212539","https://openalex.org/W2922667293","https://openalex.org/W2959252254","https://openalex.org/W2971607590","https://openalex.org/W2976262218","https://openalex.org/W2983462170","https://openalex.org/W3026804200","https://openalex.org/W3028209856","https://openalex.org/W3035996888","https://openalex.org/W3047722112","https://openalex.org/W3084237788","https://openalex.org/W4241152216"],"related_works":["https://openalex.org/W3213020517","https://openalex.org/W4365146071","https://openalex.org/W2144900391","https://openalex.org/W2794301425","https://openalex.org/W22330704","https://openalex.org/W2129524213","https://openalex.org/W1506389172","https://openalex.org/W145940735","https://openalex.org/W2527685045","https://openalex.org/W1991182601"],"abstract_inverted_index":{"The":[0,77,134,214],"review":[1,179],"article":[2,215],"analyzes":[3],"literature":[4],"data":[5,135],"on":[6,125],"the":[7,33,37,46,49,57,70,80,95,118,126,129,149,159,164,172,175,178,189,200,211,239,246,261,271,278,284,300,304,308,320,330],"issues":[8],"of":[9,21,35,48,59,79,103,171,191,202,210,225,245,256,287,307,327,340,342],"immune":[10,25,60,72,150,226,257,295,313],"response":[11,26,73,151,170,227],"dysregulation":[12,228],"during":[13,163,184,297],"aging.":[14,298],"It":[15,108],"has":[16],"been":[17,75],"shown":[18,110],"that":[19,111,140,161,181,217,238,277,303],"impairment":[20],"innate":[22],"and":[23,29,51,65,106,131,144,168,194,243,249,314,325],"adaptive":[24],"in":[27,45,56,85,98,148,205,266,270,283,293],"elderly":[28],"senile":[30],"people":[31],"under":[32,101],"conditions":[34],"spreading":[36],"new":[38],"coronavirus":[39],"infection":[40],"is":[41,83,92,109,229,236,275,290,334],"an":[42],"aggravating":[43],"factor":[44],"course":[47],"disease":[50],"recovery.":[52],"Neuro-immuno-endocrine":[53],"changes":[54,96,160],"occurring":[55,97,263],"organs":[58],"system,":[61],"immunocompetent":[62],"cells,":[63,196],"molecules":[64],"receptor":[66],"formations":[67],"involved":[68,116,147,253,292],"into":[69,117,254,329],"arising":[71],"have":[74],"traced.":[76],"imbalance":[78],"brain-intestine-microbiota":[81],"axis":[82],"considered":[84],"sufficient":[86],"details,":[87],"where":[88],"a":[89,221],"significant":[90],"role":[91],"attributed":[93],"to":[94,122,158,347],"hypothalamic-adrenal":[99],"system":[100,258,289],"participation":[102],"biogenic":[104],"neurotransmitters":[105],"neuromodulators.":[107],"intestinal":[112],"microbiota":[113],"may":[114],"be":[115],"neurodegeneration":[119],"events,":[120],"due":[121],"toxic":[123],"effects":[124],"brain":[127],"via":[128],"neuro-immuno-endocrine":[130],"metabolic":[132],"pathways.":[133],"are":[136,146,252,316],"presented,":[137],"which":[138],"show":[139],"adrenaline,":[141],"norepinephrine,":[142],"dopamine":[143],"serotonin":[145],"dysregulation,":[152],"thus":[153,345],"making":[154],"this":[155,233,332],"process":[156],"similar":[157],"occur":[162],"general":[165],"adaptation":[166],"syndrome":[167],"stress":[169,183],"body.":[173],"On":[174],"other":[176],"hand,":[177],"notes":[180],"chronic":[182],"aging":[185,324],"not":[186,264],"only":[187,265],"alters":[188],"activity":[190],"macrophages,":[192],"lymphocytes":[193],"dendritic":[195],"but":[197,268,322],"also":[198,269,291],"increases":[199],"level":[201],"proinflammatory":[203],"cytokines":[204],"blood,":[206],"thereby":[207],"affecting":[208,260],"permeability":[209],"blood-brain":[212],"barrier.":[213],"emphasizes":[216],"with":[218,323],"body":[219],"aging,":[220],"neuroendocrine":[222],"sensory":[223],"pathway":[224],"gradually":[230],"formed.":[231],"In":[232],"regard,":[234],"it":[235,274],"noted":[237],"afferent":[240],"nerve":[241],"endings":[242],"neurons":[244],"vagus,":[247],"adrenergic":[248],"peptidergic":[250],"nerves":[251],"dysfunction":[255],"by":[259],"processes":[262],"thymus,":[267],"brain.":[272],"However,":[273],"obvious":[276],"pathodynamic":[279],"\u201cdysadapting":[280],"circuit\u201d":[281],"formed":[282],"higher":[285],"compartments":[286],"nervous":[288],"dysregulatory":[294],"responses":[296],"Hence,":[299],"work":[301],"concludes":[302],"signaling":[305],"networks":[306],"body's":[309],"regulatory":[310],"systems":[311],"(nervous,":[312],"endocrine)":[315],"closely":[317],"interconnected":[318],"throughout":[319],"lifetime,":[321],"penetration":[326],"antigens":[328],"body,":[331],"interaction":[333],"easily":[335],"disrupted":[336],"at":[337],"different":[338],"levels":[339],"organization":[341],"living":[343],"matter,":[344],"leading":[346],"dysregulation.":[348]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-06T00:00:00"}
