{"id":"https://openalex.org/W3216936197","doi":"https://doi.org/10.1183/13993003.congress-2021.pa461","title":"Recombinant human pentraxin-2 for idiopathic pulmonary fibrosis: Design of STARSCAPE-OLE, a Phase III open label extension study","display_name":"Recombinant human pentraxin-2 for idiopathic pulmonary fibrosis: Design of STARSCAPE-OLE, a Phase III open label extension study","publication_year":2021,"publication_date":"2021-09-05","ids":{"openalex":"https://openalex.org/W3216936197","doi":"https://doi.org/10.1183/13993003.congress-2021.pa461","mag":"3216936197"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2021.pa461","doi":"https://doi.org/10.1183/13993003.congress-2021.pa461","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2021.pa461","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019441565","display_name":"Luca Richeldi","orcid":"https://orcid.org/0000-0001-8594-1448","observed_orcids":["https://orcid.org/0000-0001-8594-1448"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Richeldi","raw_affiliation_strings":["Fondazione Policlinico A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Policlinico A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071968251","display_name":"Kevin Joseph Anstrom","orcid":"https://orcid.org/0000-0001-6452-2172","observed_orcids":["https://orcid.org/0000-0001-6452-2172"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Anstrom","raw_affiliation_strings":["Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010735856","display_name":"J\u00fcrgen Behr","orcid":"https://orcid.org/0000-0001-8782-4456","observed_orcids":["https://orcid.org/0000-0001-8782-4456"]},"institutions":[{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Behr","raw_affiliation_strings":["Department of Internal Medicine V, LMU and Asklepios Fachkliniken Gauting, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V, LMU and Asklepios Fachkliniken Gauting, Comprehensive Pneumology Center, Member of the German Center for Lung Research, Munich, Germany","institution_ids":["https://openalex.org/I4210125421","https://openalex.org/I4210129183","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013400592","display_name":"Tamera Jo Corte","orcid":"https://orcid.org/0000-0002-5076-8929","observed_orcids":["https://orcid.org/0000-0002-5076-8929","https://orcid.org/0000-0002-7096-9365"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tamera J. Corte","raw_affiliation_strings":["Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia and University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia and University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014703126","display_name":"Vincent Cottin","orcid":"https://orcid.org/0000-0002-5591-0955","observed_orcids":["https://orcid.org/0000-0002-5591-0955"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210136143","display_name":"H\u00f4pital Louis Pradel","ror":"https://ror.org/0396v4y86","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Cottin","raw_affiliation_strings":["National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, Claude Bernard University Lyon, INRAE, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, Claude Bernard University Lyon, INRAE, Lyon, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025077014","display_name":"Gisli R. Jenkins","orcid":"https://orcid.org/0000-0002-7929-2119","observed_orcids":["https://orcid.org/0000-0002-7929-2119","https://orcid.org/0000-0002-7415-258X"]},"institutions":[{"id":"https://openalex.org/I4210146512","display_name":"Nottingham Biomedical Research Centre","ror":"https://ror.org/046cr9566","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210146512"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gisli Jenkins","raw_affiliation_strings":["NIHR, Nottingham Biomedical Research Centre, Nottingham University Hospitals, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR, Nottingham Biomedical Research Centre, Nottingham University Hospitals, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I4210146512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034130497","display_name":"Nikhil Kamath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113058","display_name":"Roche (United Kingdom)","ror":"https://ror.org/024tgbv41","country_code":"GB","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210113058"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nikhil Kamath","raw_affiliation_strings":["Roche Products Ltd, Welwyn Garden City, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Products Ltd, Welwyn Garden City, United Kingdom","institution_ids":["https://openalex.org/I4210113058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002422862","display_name":"Yoshikazu Inoue","orcid":"https://orcid.org/0000-0003-3994-874X","observed_orcids":["https://orcid.org/0000-0003-3994-874X","https://orcid.org/0000-0002-4618-2669"]},"institutions":[{"id":"https://openalex.org/I4210160708","display_name":"NHO Kinki Chuo Chest Medical Center","ror":"https://ror.org/05jp74k96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210160708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Inoue","raw_affiliation_strings":["Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210160708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000008374","display_name":"Lutaf Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113058","display_name":"Roche (United Kingdom)","ror":"https://ror.org/024tgbv41","country_code":"GB","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210113058"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lutaf Islam","raw_affiliation_strings":["Roche Products Ltd, Welwyn Garden City, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Products Ltd, Welwyn Garden City, United Kingdom","institution_ids":["https://openalex.org/I4210113058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052485494","display_name":"Steven D. Nathan","orcid":"https://orcid.org/0000-0002-6270-1617","observed_orcids":["https://orcid.org/0000-0002-6270-1617"]},"institutions":[{"id":"https://openalex.org/I2800468613","display_name":"Inova Fairfax Hospital","ror":"https://ror.org/0212h5y77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I116530498","https://openalex.org/I2800468613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Nathan","raw_affiliation_strings":["Inova Heart and Vascular Institute, Inova Fairfax Hospital, Falls Church, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inova Heart and Vascular Institute, Inova Fairfax Hospital, Falls Church, Virginia, United States of America","institution_ids":["https://openalex.org/I2800468613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021656163","display_name":"Ganesh Raghu","orcid":"https://orcid.org/0000-0001-7506-6643","observed_orcids":["https://orcid.org/0000-0001-7506-6643","https://orcid.org/0000-0001-8746-3507"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganesh Raghu","raw_affiliation_strings":["Univ of Washington Medical Ctr, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Washington Medical Ctr, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2801852214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109898050","display_name":"Jessie Randhawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113058","display_name":"Roche (United Kingdom)","ror":"https://ror.org/024tgbv41","country_code":"GB","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210113058"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jessie Randhawa","raw_affiliation_strings":["Roche Products Ltd, Welwyn Garden City, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Products Ltd, Welwyn Garden City, United Kingdom","institution_ids":["https://openalex.org/I4210113058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112547034","display_name":"Simon L. F. Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon L.F. Walsh","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100767595","display_name":"Fernando J. Mart\u00ednez","orcid":"https://orcid.org/0000-0002-2412-3182","observed_orcids":["https://orcid.org/0000-0002-2412-3182","https://orcid.org/0000-0003-4957-8869","https://orcid.org/0000-0001-8298-2703"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando J. Martinez","raw_affiliation_strings":["Weill Cornell Medical College, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, New York, United States of America","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA461","last_page":"PA461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.7609999775886536},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.9509999752044678},{"id":"https://openalex.org/keywords/forced-vital-capacity","display_name":"forced vital capacity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6710000038146973},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/retreatment","display_name":"retreatment","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9232656955718994},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.7267630100250244},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5711437463760376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5667396783828735},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48574477434158325},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.4663606882095337},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46173393726348877},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4376108646392822},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3410426378250122},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2559514045715332},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17556968331336975},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2021.pa461","doi":"https://doi.org/10.1183/13993003.congress-2021.pa461","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2021.pa461","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174708393","https://openalex.org/W4281250546","https://openalex.org/W2945737656","https://openalex.org/W2804909402","https://openalex.org/W2279123099","https://openalex.org/W2971335951","https://openalex.org/W3217531095","https://openalex.org/W4391809394","https://openalex.org/W2312377772","https://openalex.org/W4400322024"],"abstract_inverted_index":{"Introduction:":[0],"Pentraxin-2":[1],"plays":[2],"an":[3],"important":[4],"role":[5],"in":[6,22,25,108,115,126,181,187,189,197,205,228,246],"wound":[7],"repair":[8],"and":[9,44,76,133,149,154,159,224,241],"prevention":[10],"of":[11,59,78,156,162,164,183,244,249],"fibrosis.":[12],"Recombinant":[13],"human":[14],"pentraxin-2":[15],"(rhPTX-2;":[16],"PRM-151)":[17],"has":[18],"demonstrated":[19],"clinical":[20],"benefit":[21],"IPF":[23,82,231],"patients":[24,123,188,213,229],"a":[26,35,45,66],"phase":[27,36,46,69,89,110,199],"II":[28,90],"trial":[29],"(NCT02550873).":[30],"The":[31],"STARSCAPE":[32],"program":[33],"includes":[34],"III":[37,47,70,99,111,200],"52-week":[38],"pivotal,":[39],"placebo":[40,196],"controlled":[41],"study":[42,52,71,91,100,106,112,170],"(NCT04552899)":[43],"open":[48],"label":[49],"extension":[50],"(OLE)":[51],"(NCT04594707).":[53],"Here":[54],"we":[55],"report":[56],"the":[57,60,88,96,127,238,247],"design":[58],"OLE":[61],"study.":[62,128],"Methods:":[63],"STARSCAPE-OLE":[64,235],"is":[65],"global,":[67],"open-label":[68],"to":[72,80,195],"evaluate":[73],"long-term":[74,203,225,239],"safety":[75,148,240],"efficacy":[77,150,242],"rhPTX-2":[79,138,177,245],"treat":[81],"patients,":[83],"who":[84,214],"have":[85],"previously":[86],"completed":[87,95],"(Cohort":[92,101,118,178,222,232],"A),":[93],"or":[94],"pivotal":[97,201],"Phase":[98],"B).":[102],"Patients":[103,129],"that":[104,192],"discontinue":[105],"treatment":[107,145,248],"either":[109],"may":[113],"participate":[114],"survival":[116,226],"follow-up":[117],"C).":[119,233],"We":[120],"anticipate":[121],"600-700":[122],"will":[124,135,171,236],"enroll":[125],"within":[130],"Cohorts":[131],"A":[132],"B":[134],"receive":[136],"intravenous":[137],"every":[139],"four":[140],"weeks,":[141],"with":[142,176,230],"background":[143],"anti-fibrotic":[144],"permitted.":[146],"Key":[147],"endpoints":[151],"are":[152],"incidence":[153],"severity":[155],"adverse":[157],"events,":[158],"annual":[160,220],"rate":[161,182],"decline":[163,186],"FVC":[165],"[mL].":[166],"Additionally,":[167],"this":[168],"novel":[169],"enable":[172],"evaluation":[173],"of:":[174],"re-treatment":[175],"A);":[179],"change":[180],"lung":[184],"function":[185],"cohort":[190],"B,":[191],"were":[193],"randomized":[194],"prior":[198],"study;":[202],"changes":[204],"HRCT":[206,217],"computer":[207],"based":[208],"quantitative":[209],"imaging":[210],"analysis":[211],"for":[212],"had":[215],"baseline":[216],"followed":[218],"by":[219],"scans":[221],"B);":[223],"outcomes":[227],"Conclusions:":[234],"establish":[237],"profile":[243],"IPF.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-12-06T00:00:00"}