{"id":"https://openalex.org/W3216856495","doi":"https://doi.org/10.1182/blood-2021-146268","title":"A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)","display_name":"A First-in-Human Study of YTB323, a Novel, Autologous CD19-Directed CAR-T Cell Therapy Manufactured Using the Novel T-Charge TM platform, for the Treatment of Patients (Pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3216856495","doi":"https://doi.org/10.1182/blood-2021-146268","mag":"3216856495"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-146268","doi":"https://doi.org/10.1182/blood-2021-146268","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-146268","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000959540","display_name":"Ian W. Flinn","orcid":"https://orcid.org/0000-0001-6724-290X","observed_orcids":["https://orcid.org/0000-0001-6724-290X"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian W. Flinn","raw_affiliation_strings":["Sarah Cannon Research Institute, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, Nashville, TN","institution_ids":["https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113865605","display_name":"Ulrich Jaeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802328216","display_name":"Vienna General Hospital","ror":"https://ror.org/05f0zr486","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I2802328216"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ulrich Jaeger","raw_affiliation_strings":["Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Vienna General Hospital - Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Vienna General Hospital - Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I2802328216","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088341793","display_name":"Nirav Niranjan Shah","orcid":"https://orcid.org/0000-0002-4336-1071","observed_orcids":["https://orcid.org/0000-0002-4336-1071"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nirav N. Shah","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022161221","display_name":"Didier Blaise","orcid":"https://orcid.org/0000-0002-5684-9447","observed_orcids":["https://orcid.org/0000-0002-5684-9447"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144608","display_name":"Centre de Recherche en Canc\u00e9rologie de Marseille","ror":"https://ror.org/0494jpz02","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]},{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Blaise","raw_affiliation_strings":["D\u00e9partement d'h\u00e9matologie, Programme de transplantation et de th\u00e9rapie Cellulaire, Centre de Recherche en Canc\u00e9rologie de Marseille, Aix-Marseille University, Institut Paoli Calmettes, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'h\u00e9matologie, Programme de transplantation et de th\u00e9rapie Cellulaire, Centre de Recherche en Canc\u00e9rologie de Marseille, Aix-Marseille University, Institut Paoli Calmettes, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210144608","https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053280136","display_name":"Javier Briones","orcid":"https://orcid.org/0000-0003-2750-3735","observed_orcids":["https://orcid.org/0000-0003-2750-3735"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Briones","raw_affiliation_strings":["Department of Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039680248","display_name":"Leyla Osman Shune","orcid":"https://orcid.org/0000-0003-1650-1873","observed_orcids":["https://orcid.org/0000-0003-1650-1873"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leyla Shune","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076973611","display_name":"Nicolas Boissel","orcid":"https://orcid.org/0000-0003-2091-7927","observed_orcids":["https://orcid.org/0000-0003-2091-7927"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Boissel","raw_affiliation_strings":["St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055304980","display_name":"Attilio Bondanza","orcid":"https://orcid.org/0000-0003-3899-9879","observed_orcids":["https://orcid.org/0000-0003-3899-9879"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Attilio Bondanza","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071300503","display_name":"Darlene Lu","orcid":"https://orcid.org/0009-0006-2315-2789","observed_orcids":["https://orcid.org/0009-0006-2315-2789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darlene Lu","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102679429","display_name":"Xu Zhu","orcid":"https://orcid.org/0009-0003-8647-1320","observed_orcids":["https://orcid.org/0009-0003-8647-1320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu Zhu","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029751531","display_name":"Boris Engels","orcid":"https://orcid.org/0000-0001-9682-2954","observed_orcids":["https://orcid.org/0000-0001-9682-2954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris Engels","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008019757","display_name":"Jennifer L. Brogdon","orcid":"https://orcid.org/0000-0002-2084-832X","observed_orcids":["https://orcid.org/0000-0002-2084-832X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer L Brogdon","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016087125","display_name":"Jennifer Mataraza","orcid":"https://orcid.org/0009-0004-5898-007X","observed_orcids":["https://orcid.org/0009-0004-5898-007X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Mataraza","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007954572","display_name":"Jaclyn Davis","orcid":"https://orcid.org/0009-0006-1879-0057","observed_orcids":["https://orcid.org/0009-0006-1879-0057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaclyn Davis","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, East Hanover, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, East Hanover, NJ","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063794256","display_name":"Anne-Laure Marchal","orcid":"https://orcid.org/0009-0003-8986-7072","observed_orcids":["https://orcid.org/0009-0003-8986-7072"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anne Laure Marchal","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046622402","display_name":"Luisa Mariconti","orcid":"https://orcid.org/0009-0000-2154-2704","observed_orcids":["https://orcid.org/0009-0000-2154-2704"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luisa Mariconti","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059943491","display_name":"Michele Moschetta","orcid":"https://orcid.org/0000-0003-4370-1723","observed_orcids":["https://orcid.org/0000-0003-4370-1723"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michele Moschetta","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059162808","display_name":"Laure Moutouh\u2013de Parseval","orcid":"https://orcid.org/0009-0000-7582-810X","observed_orcids":["https://orcid.org/0009-0000-7582-810X"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laure Moutouh-de Parseval","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040138933","display_name":"Pere Barba","orcid":"https://orcid.org/0000-0001-7076-7969","observed_orcids":["https://orcid.org/0000-0001-7076-7969","https://orcid.org/0000-0003-1038-5197"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pere Barba","raw_affiliation_strings":["Hematology Department, Hospital Universitari Vall d'Hebr\u00f3n, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital Universitari Vall d'Hebr\u00f3n, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210127641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102014552","display_name":"Michael John Dickinson","orcid":"https://orcid.org/0000-0002-1492-5966","observed_orcids":["https://orcid.org/0000-0002-1492-5966"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Dickinson","raw_affiliation_strings":["Peter MacCallum Cancer Centre and Royal Melbourne Hospital and the University of Melbourne, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre and Royal Melbourne Hospital and the University of Melbourne, Melbourne, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":17,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"740","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-refractory-diffuse-large-b-cell-lymphoma","display_name":"relapsed/refractory diffuse large B-cell lymphoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/4-1bb-costimulation","display_name":"4-1BB costimulation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.5419999957084656},{"id":"https://openalex.org/keywords/stem-cell-memory-t-cells","display_name":"stem cell memory T cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.5789999961853027},{"id":"https://openalex.org/keywords/first-in-human","display_name":"first-in-human","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6656994819641113},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4974994957447052},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4697107672691345},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.4499097168445587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4496392607688904},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42141416668891907},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4209331274032593},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.41835087537765503},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3873598575592041},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.34219062328338623},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3377758860588074},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26188546419143677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11404106020927429},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-146268","doi":"https://doi.org/10.1182/blood-2021-146268","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-146268","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2917403768","https://openalex.org/W4381594543","https://openalex.org/W2952260713","https://openalex.org/W3142239825","https://openalex.org/W2969241243","https://openalex.org/W3204328954","https://openalex.org/W3199232787","https://openalex.org/W2977459329","https://openalex.org/W4281961745","https://openalex.org/W4231177780"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Despite":[2],"unprecedented":[3],"efficacy":[4,131,500,523,669],"of":[5,116,132,164,209,242,249,289,303,367,377,470,565,582,601,619,623,680],"existing":[6],"CAR-T":[7,28,104],"cell":[8,29,81,105,171],"therapy,":[9,17],"many":[10],"pts":[11,135,148,254,310,315,362,398,496,519,529,585],"fail":[12],"to":[13,15,60,68,100,201,220,395,448,452,457,468,533,661,703,719,735,750,764,779,794,811,826,841,854,868,885,899,916,937,952,967,982,996,1014,1032,1049,1063,1077,1094,1111,1126,1140,1155,1171,1191,1208,1225,1242,1257,1272,1286,1303,1318,1333,1351,1366,1379],"respond":[14],"the":[16,32,55,70,88,144,214,308,505,583,631],"or":[18,192,571],"relapse":[19],"after":[20,161],"initial":[21],"response.":[22,117],"YTB323":[23,42,133,177,202,534,620,646,653,666,681],"is":[24,43,98,126,655],"an":[25,46,925],"autologous":[26,168],"CD19-directed":[27],"therapy":[30,199,290],"utilizing":[31],"FMC63":[33],"domain":[34],"for":[35,274,312,428,478,486,499,522],"CD19":[36],"recognition":[37],"and":[38,64,79,107,113,129,158,218,244,268,276,291,333,355,383,410,424,434,455,462,480,504,507,537,550,625,640,670,730,789,806,880,911,932,1009,1027,1044,1089,1106,1166,1186,1203,1220,1237,1298],"4-1BB":[39],"costimulatory":[40],"domain.":[41],"manufactured":[44],"with":[45,136,151,255,260,557,588,607],"innovative":[47],"simplified":[48],"process,":[49],"called":[50],"T-Charge":[51,74],"TM,":[52],"which":[53,97,368,419],"reduces":[54],"ex":[56],"vivo":[57],"culture":[58],"time":[59,467],"about":[61],"24":[62],"hours":[63],"takes":[65],"<2":[66],"d":[67,217,474,482,612],"manufacture":[69],"final":[71,89,632],"product.":[72],"The":[73,615],"TM":[75],"platform":[76],"preserves":[77],"naive":[78,649],"stem":[80,170],"memory":[82],"T":[83],"(T":[84,604],"scm)":[85],"cells":[86,570,629],"in":[87,102,108,134,213,431,530,568,630,682],"product":[90,633],"(preclinical":[91],"data":[92,676],"will":[93],"be":[94,579,662],"reported":[95,301,317,344],"separately),":[96],"expected":[99],"result":[101],"longer":[103,114],"persistence,":[106],"turn":[109],"higher":[110],"response":[111,234,490],"rates":[112,509,539],"durability":[115],"Methods:":[118],"This":[119],"Phase":[120,224],"I,":[121],"multicenter,":[122],"dose-escalation":[123],"study":[124,304],"(NCT03960840)":[125],"evaluating":[127],"safety":[128,219,673],"preliminary":[130],"B-cell":[137],"malignancies.":[138],"Results":[139],"presented":[140],"here":[141],"focus":[142],"on":[143,444],"DLBCL":[145,160,257,684],"cohort.":[146],"Eligible":[147],"are":[149,207,230],"adults":[150],"measurable":[152],"disease":[153,453],"at":[154,178,263,266,270,318,327,336,460,464,501,524,563,586,657],"enrollment,":[155],"ECOG":[156],"0-1,":[157],"r/r":[159,256,683],"\u22652":[162],"lines":[163,288],"prior":[165,200,287,295,532],"therapies,":[166],"including":[167,405,527],"hematopoietic":[169],"transplantation":[172],"(aHSCT).":[173],"Pts":[174],"received":[175,285],"single-dose":[176],"dose":[179,226],"level":[180],"1":[181,269,411,435,463,691],"(DL1;":[182],"1-2.5\u00d710":[183],"6":[184,189,195,325],"CAR+":[185,190,196,567],"cells),":[186,191],"DL2":[187,564,587],"(5-12.5\u00d710":[188],"DL3":[193,271],"(25-40\u00d710":[194],"cells).":[197],"Bridging":[198],"was":[203,280,472,491,553],"optional.":[204],"Primary":[205],"endpoints":[206,229],"rate":[208,235],"dose-limiting":[210],"toxicities":[211],"(DLTs)":[212],"first":[215],"28":[216],"determine":[221],"a":[222,648,671,1179],"recommended":[223],"II":[225],"(RP2D).":[227],"Secondary":[228],"cellular":[231],"kinetics,":[232],"overall":[233,245],"(ORR)":[236],"by":[237,596,636],"local":[238],"investigator":[239],"assessment,":[240],"duration":[241],"response,":[243],"survival.":[246],"Results:":[247],"As":[248],"April":[250],"16,":[251],"2021,":[252],"15":[253,309],"were":[258,300,348,372,426,497,510,520,540],"infused":[259],"YTB323:":[261,449],"4":[262,292,314,331,414,442,495],"DL1,":[264,494],"10":[265],"DL2,":[267,517,665],"(Fig,":[272],"n=14":[273],"DL1":[275,461,479],"DL2).":[277],"Median":[278,466],"age":[279],"65":[281],"years;":[282],"most":[283],"(60%)":[284],"2":[286,334,369,385,432,450,456,528],"(27%)":[293,316,399],"had":[294,364,592],"aHSCT.":[296],"All":[297,698,715,728,745,759,775,787,804,821,837,849,863,878,894,909,930,947,962,977,991,1007,1025,1042,1058,1072,1087,1104,1121,1135,1151,1164,1184,1201,1218,1235,1252,1267,1281,1296,1313,1328,1346,1362,1375],"adverse":[298],"events":[299,370],"regardless":[302],"drug":[305],"relationship.":[306],"Of":[307],"evaluable":[311,498,521],"safety,":[313],"least":[319,328,337],"one":[320,329,338],"Grade":[321,392],"(Gr)":[322],"3":[323,379,406,503,591],"AE,":[324,332],"(40%)":[326],"Gr":[330,339,345,378,384,408,413],"(13%)":[335,371,433],"5":[340],"AE.":[341],"Most":[342],"commonly":[343],"3/4":[346],"AEs":[347],"thrombocytopenia":[349],"(n=2,":[350],"13%),":[351],"neutropenia":[352],"(n=3,":[353,359],"20%),":[354],"decreased":[356],"neutrophil":[357],"count":[358],"20%).":[360],"Seven":[361],"(47%)":[363],"neurological":[365],"AEs,":[366],"considered":[373],"serious-1":[374],"event":[375],"each":[376],"peripheral":[380],"neuropathy":[381],"(unrelated)":[382],"seizure":[386],"(immune":[387],"effector":[388],"cell-associated":[389],"neurotoxicity":[390],"syndrome":[391,403],"3,":[393,526],"related":[394],"treatment).":[396],"Four":[397],"experienced":[400],"cytokine":[401,609],"release":[402],"(CRS),":[404],"(20%)":[407],"1/2":[409],"(7%)":[412,436],"(Lee":[415],"et":[416],"al,":[417],"2014),":[418],"met":[420],"DLT":[421],"criteria.":[422],"Tocilizumab":[423],"corticosteroids":[425],"administered":[427],"CRS":[429,471],"management":[430],"pts,":[437],"respectively.":[438],"There":[439],"have":[440],"been":[441],"deaths":[443],"trial,":[445],"all":[446],"unrelated":[447],"due":[451],"progression":[454],"sepsis":[458],"(1":[459],"DL3).":[465],"onset":[469],"9":[473],"(range,":[475,483],"9-9":[476],"d)":[477,485],"11":[481],"8-17":[484],"DL2.":[487],"Preliminary":[488],"dose-dependent":[489],"observed.":[492],"At":[493,516,664],"Mo":[502,525],"ORR":[506,536],"CR":[508,531,538],"both":[511,541],"25%":[512],"(95%":[513,543],"CI,":[514,544],"0.6%-80.6%).":[515],"8":[518,584],"infusion;":[535],"75%":[542],"34.9%-96.8%).":[545],"Dose-dependent":[546],"expansion":[547,560,603],"(C":[548,561],"max":[549],"AUC":[551],"0-28d)":[552],"observed":[554],"following":[555],"infusion":[556],"mean":[558],"peak":[559,602,608],"max)":[562,605],"13.6%":[566],"CD3+":[569],"32,100":[572],"copies/\u00b5g":[573],"DNA.":[574],"Although":[575],"long-term":[576],"persistence":[577],"cannot":[578],"evaluated":[580],"yet,":[581],"3-mo":[589],"follow-up,":[590],"detectable":[593],"CAR":[594],"expression":[595],"flow":[597,637],"cytometry":[598],"(\u22651%).":[599],"Time":[600],"coincided":[606],"levels":[610],"(~16":[611],"post":[613],"infusion).":[614],"novel":[616],"manufacturing":[617],"methodology":[618],"allowed":[621],"preservation":[622],"CD4":[624],"CD8":[626],"naive/T":[627],"scm":[628],"as":[634],"ascertained":[635],"cytometry.":[638],"Bulk":[639],"single-cell":[641],"RNAseq":[642],"analysis":[643],"demonstrated":[644],"that":[645],"retained":[647],"stem-like":[650],"phenotype.":[651],"Conclusions:":[652],"recruitment":[654],"ongoing":[656],"DL3;":[658],"RP2D":[659],"remains":[660],"identified.":[663],"showed":[667],"promising":[668],"favorable":[672],"profile.":[674],"Current":[675],"support":[677],"continued":[678],"development":[679],"pts.":[685],"Clinical":[686],"trial":[687],"information:":[688],"CYTB323A12101":[689],"Figure":[690,692],"1.":[693],"Disclosures":[694],"Flinn:":[695],"ArQule:":[696],"Other:":[697,714,727,744,758,774,786,803,820,836,848,862,877,893,908,929,946,961,976,990,1006,1024,1041,1057,1071,1086,1103,1120,1134,1150,1163,1183,1200,1217,1234,1251,1266,1280,1295,1312,1327,1345,1361,1374],"research":[699,731,746,760,790,822,850,864,881,895,912,933,948,963,978,992,1010,1028,1045,1059,1073,1090,1107,1122,1136,1167,1187,1204,1221,1238,1253,1268,1282,1299,1314,1329,1347],"funding":[700,732,747,761,791,823,851,865,882,896,913,934,949,964,979,993,1011,1029,1046,1060,1074,1091,1108,1123,1137,1168,1188,1205,1222,1239,1254,1269,1283,1300,1315,1330,1348],"payments":[701,717,733,748,762,777,792,809,824,839,852,866,883,897,914,935,950,965,980,994,1012,1030,1047,1061,1075,1092,1109,1124,1138,1153,1169,1189,1206,1223,1240,1255,1270,1284,1301,1316,1331,1349,1364,1377],"made":[702,718,734,749,763,778,793,810,825,840,853,867,884,898,915,936,951,966,981,995,1013,1031,1048,1062,1076,1093,1110,1125,1139,1154,1170,1190,1207,1224,1241,1256,1271,1285,1302,1317,1332,1350,1365,1378],"Sarah":[704,720,736,751,765,780,795,812,827,842,855,869,886,900,917,938,953,968,983,997,1015,1033,1050,1064,1078,1095,1112,1127,1141,1156,1172,1192,1209,1226,1243,1258,1273,1287,1304,1319,1334,1352,1367,1380],"Cannon":[705,721,737,752,766,781,796,813,828,843,856,870,887,901,918,939,954,969,984,998,1016,1034,1051,1065,1079,1096,1113,1128,1142,1157,1173,1193,1210,1227,1244,1259,1274,1288,1305,1320,1335,1353,1368,1381],"Research":[706,708,722,738,740,753,755,767,769,782,797,799,807,814,816,829,831,844,857,859,871,873,888,890,902,904,919,921,940,942,955,957,970,972,985,987,999,1001,1017,1019,1035,1037,1052,1054,1066,1068,1080,1082,1097,1099,1114,1116,1129,1131,1143,1145,1158,1174,1176,1194,1196,1211,1213,1228,1230,1245,1247,1260,1262,1275,1277,1289,1291,1306,1308,1321,1323,1336,1338,1341,1354,1356,1369,1382],"Institute,":[707,739,754,768,798,815,830,858,872,889,903,920,941,956,971,986,1000,1018,1036,1053,1067,1081,1098,1115,1130,1144,1175,1195,1212,1229,1246,1261,1276,1290,1307,1322,1337,1355],"Funding;":[709,741,756,770,800,817,832,860,874,891,905,922,943,958,973,988,1002,1020,1038,1055,1069,1083,1100,1117,1132,1146,1177,1197,1214,1231,1248,1263,1278,1292,1309,1324,1339,1357],"Great":[710],"Point":[711],"Partners:":[712],"Consultancy,":[713,726,773,785,802,835,876,907,928,1005,1023,1040,1085,1102,1149,1162,1182,1199,1216,1233,1294,1360,1373],"consultancy":[716,729,776,788,838,879,910,931,1008,1026,1043,1088,1105,1152,1165,1185,1202,1219,1236,1297,1363,1376],"Institute;":[723,783,845,1159,1370,1383],"Gilead":[724,1180],"Sciences:":[725],"Constellation":[742],"Pharmaceuticals:":[743,819,834,1119,1265],"Teva:":[757],"Nurix":[771],"Therapeutics:":[772,847,975,1004,1022,1148,1161,1326,1359],"Roche:":[784],"AbbVie:":[801],"Consultancy":[805],"Funding":[808],"Infinity":[818],"Yingli":[833],"Forma":[846],"Celgene:":[861],"Genentech:":[875],"Agios:":[892],"AstraZeneca:":[906],"Pharmacyclics":[923],"LLC,":[924],"AbbVie":[926],"Company:":[927,1181],"Acerta":[944],"Pharma:":[945,1385],"Forty":[959],"Seven:":[960],"Karyopharm":[974],"Incyte:":[989],"Unum":[1003],"TG":[1021],"Takeda:":[1039],"Loxo:":[1056],"Pfizer:":[1070],"Janssen:":[1084],"BeiGene:":[1101],"Portola":[1118],"Merck:":[1133],"Iksuda":[1147],"Juno":[1160],"Kite,":[1178],"MorphoSys:":[1198],"Seagen:":[1215],"Verastem:":[1232],"IGM":[1249],"Biosciences:":[1250,1311],"Rhizen":[1264],"Curis:":[1279],"Novartis:":[1293],"Calithera":[1310],"Trillium":[1325],"Triphase":[1340],"&":[1342],"Development":[1343],"Corp.:":[1344],"Century":[1358],"Hutchison":[1371],"MediPharma:":[1372],"Vincerx":[1384],"Consulta":[1386]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
