{"id":"https://openalex.org/W3216775166","doi":"https://doi.org/10.21203/rs.3.rs-1112337/v1","title":"A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang Distributions","display_name":"A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang Distributions","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W3216775166","doi":"https://doi.org/10.21203/rs.3.rs-1112337/v1","mag":"3216775166"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1112337/v1","doi":"https://doi.org/10.21203/rs.3.rs-1112337/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1112337/v1","pdf_url":"https://www.researchsquare.com/article/rs-1112337/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["arxiv","crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1112337/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083596010","display_name":"Giulia Belluccini","orcid":"https://orcid.org/0000-0002-9543-2337","observed_orcids":["https://orcid.org/0000-0002-9543-2337"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Giulia Belluccini","raw_affiliation_strings":["University of Leeds","Los Alamos National Laboratory","University of Leeds Grant Lythe University of Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"University of Leeds Grant Lythe University of Leeds","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087520236","display_name":"Mart\u00edn L\u00f3pez\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0003-3833-8595","observed_orcids":["https://orcid.org/0000-0003-3833-8595"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Martin Lopez-Garcia","raw_affiliation_strings":["University of Leeds","Los Alamos National Laboratory","University of Leeds Grant Lythe University of Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"University of Leeds Grant Lythe University of Leeds","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022689831","display_name":"Grant Lythe","orcid":"https://orcid.org/0000-0001-7966-5571","observed_orcids":["https://orcid.org/0000-0001-7966-5571"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant Lythe","raw_affiliation_strings":["University of Leeds","Department of Applied Mathematics, University of Leeds, LS2 9JT Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Leeds, LS2 9JT Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053760589","display_name":"Carmen Molina-Par\u0131\u0301s","orcid":"https://orcid.org/0000-0001-9828-6737","observed_orcids":["https://orcid.org/0000-0001-9828-6737"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"carmen molina-par\u00eds","raw_affiliation_strings":["Los Alamos National Laboratory","Department of Applied Mathematics, University of Leeds, LS2 9JT Leeds, UK","Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA LA-UR-21-25591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Leeds, LS2 9JT Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA LA-UR-21-25591","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053760589"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I1343871089"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.06719999760389328,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.9419999718666077},{"id":"https://openalex.org/keywords/erlang-distribution","display_name":"Erlang distribution","score":0.9919999837875366},{"id":"https://openalex.org/keywords/exponential-distribution","display_name":"exponential distribution","score":0.6769999861717224},{"id":"https://openalex.org/keywords/stochastic-cell-division","display_name":"stochastic cell division","score":0.4729999899864197},{"id":"https://openalex.org/keywords/lymphocyte-dynamics","display_name":"lymphocyte dynamics","score":0.47999998927116394},{"id":"https://openalex.org/keywords/ot-i-t-cells","display_name":"OT-I T cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8330000042915344},{"id":"https://openalex.org/keywords/approximate-bayesian-computation","display_name":"approximate Bayesian computation","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C82484044","wikidata":"https://www.wikidata.org/wiki/Q334879","display_name":"Erlang (programming language)","level":3,"score":0.867743730545044},{"id":"https://openalex.org/C55350006","wikidata":"https://www.wikidata.org/wiki/Q237193","display_name":"Exponential distribution","level":2,"score":0.6315953731536865},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5681324601173401},{"id":"https://openalex.org/C60798267","wikidata":"https://www.wikidata.org/wiki/Q1226939","display_name":"Division (mathematics)","level":2,"score":0.5362156629562378},{"id":"https://openalex.org/C151376022","wikidata":"https://www.wikidata.org/wiki/Q168698","display_name":"Exponential function","level":2,"score":0.5335633754730225},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5224418044090271},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.49752095341682434},{"id":"https://openalex.org/C149717495","wikidata":"https://www.wikidata.org/wiki/Q117806","display_name":"Gamma distribution","level":2,"score":0.4682997763156891},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.4466512203216553},{"id":"https://openalex.org/C145437242","wikidata":"https://www.wikidata.org/wiki/Q762448","display_name":"Erlang distribution","level":3,"score":0.4317014217376709},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32767125964164734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3253863453865051},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3244985342025757},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24455076456069946},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1983817219734192},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.13961482048034668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08619874715805054},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.08361193537712097},{"id":"https://openalex.org/C42383842","wikidata":"https://www.wikidata.org/wiki/Q193076","display_name":"Functional programming","level":2,"score":0.0},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21203/rs.3.rs-1112337/v1","doi":"https://doi.org/10.21203/rs.3.rs-1112337/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1112337/v1","pdf_url":"https://www.researchsquare.com/article/rs-1112337/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:arXiv.org:2112.00371","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2112.00371","pdf_url":"https://arxiv.org/pdf/2112.00371","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2112.00371","doi":"https://doi.org/10.48550/arxiv.2112.00371","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2112.00371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1112337/v1","doi":"https://doi.org/10.21203/rs.3.rs-1112337/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1112337/v1","pdf_url":"https://www.researchsquare.com/article/rs-1112337/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4300000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G100785649","display_name":"Quantitative T cell Immunology and Immunotherapy","funder_award_id":"764698","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2001806450","display_name":null,"funder_award_id":"H2020-MSCA-ITN","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3345895242","display_name":null,"funder_award_id":"H2020-MSCA","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G529674484","display_name":null,"funder_award_id":"764698","funder_id":"https://openalex.org/F4320320298","funder_display_name":"University of Leeds"},{"id":"https://openalex.org/G7147191618","display_name":null,"funder_award_id":"H2020-MSCA-ITN-2017","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7169169914","display_name":null,"funder_award_id":"764698","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7984235579","display_name":null,"funder_award_id":"H2020-MSCA-ITN","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8512683158","display_name":null,"funder_award_id":"H2020-MSCA","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8591720154","display_name":null,"funder_award_id":"H2020-MSCA-ITN-2017","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320298","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216775166.pdf","grobid_xml":"https://content.openalex.org/works/W3216775166.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W160380472","https://openalex.org/W633278723","https://openalex.org/W1518539840","https://openalex.org/W1534336889","https://openalex.org/W1566106175","https://openalex.org/W1971670219","https://openalex.org/W1976831998","https://openalex.org/W1991216151","https://openalex.org/W1996676269","https://openalex.org/W2013638924","https://openalex.org/W2033712965","https://openalex.org/W2039045791","https://openalex.org/W2041309454","https://openalex.org/W2042321087","https://openalex.org/W2065652450","https://openalex.org/W2067136705","https://openalex.org/W2069043306","https://openalex.org/W2076061482","https://openalex.org/W2077068404","https://openalex.org/W2077496900","https://openalex.org/W2078387120","https://openalex.org/W2083000330","https://openalex.org/W2086021900","https://openalex.org/W2104205011","https://openalex.org/W2106565812","https://openalex.org/W2107002267","https://openalex.org/W2125255512","https://openalex.org/W2129211984","https://openalex.org/W2145261392","https://openalex.org/W2152246075","https://openalex.org/W2155418451","https://openalex.org/W2160837236","https://openalex.org/W2162342191","https://openalex.org/W2167568565","https://openalex.org/W2199004907","https://openalex.org/W2230661433","https://openalex.org/W2617921759","https://openalex.org/W2626808986","https://openalex.org/W2894812063","https://openalex.org/W2921461465","https://openalex.org/W2969950545"],"related_works":["https://openalex.org/W2613997428","https://openalex.org/W830184964","https://openalex.org/W2102235500","https://openalex.org/W2761481563","https://openalex.org/W2033105159","https://openalex.org/W2171382235","https://openalex.org/W2950297123","https://openalex.org/W2994053111","https://openalex.org/W4248932111","https://openalex.org/W1997459874"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}