{"id":"https://openalex.org/W3216675981","doi":"https://doi.org/10.1016/j.jbior.2021.100840","title":"Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53","display_name":"Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of WT-TP53","publication_year":2021,"publication_date":"2021-11-23","ids":{"openalex":"https://openalex.org/W3216675981","doi":"https://doi.org/10.1016/j.jbior.2021.100840","mag":"3216675981","pmid":"https://pubmed.ncbi.nlm.nih.gov/34866036"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbior.2021.100840","doi":"https://doi.org/10.1016/j.jbior.2021.100840","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbior.2021.100840","pdf_url":null,"source":{"id":"https://openalex.org/S2764887616","display_name":"Advances in Biological Regulation","issn_l":"2212-4926","issn":["2212-4926","2212-4934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biological Regulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.sciencedirect.com/science/article/abs/pii/S2212492621000567?via=ihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010041881","display_name":"Stephen Lee Abrams","orcid":"https://orcid.org/0000-0003-2326-6672","observed_orcids":["https://orcid.org/0000-0003-2326-6672"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Abrams","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071016461","display_name":"Shaw M. Akula","orcid":"https://orcid.org/0000-0001-7990-7307","observed_orcids":["https://orcid.org/0000-0001-7990-7307"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaw M. Akula","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113837598","display_name":"Linda S. Steelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda S. Steelman","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026240711","display_name":"Matilde L. Follo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matilde L. Follo","raw_affiliation_strings":["Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019461184","display_name":"Lucio Cocco","orcid":"https://orcid.org/0000-0002-9206-8277","observed_orcids":["https://orcid.org/0000-0002-9206-8277"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucio Cocco","raw_affiliation_strings":["Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035689520","display_name":"Stefano Ratti","orcid":"https://orcid.org/0000-0002-6258-5345","observed_orcids":["https://orcid.org/0000-0002-6258-5345"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Ratti","raw_affiliation_strings":["Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037164805","display_name":"Alberto Maria Martelli","orcid":"https://orcid.org/0000-0001-5196-7260","observed_orcids":["https://orcid.org/0000-0001-5196-7260"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto M. Martelli","raw_affiliation_strings":["Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche e Neuromotorie, Universit\u00e0 di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015437100","display_name":"Massimo Libra","orcid":"https://orcid.org/0000-0002-7232-7737","observed_orcids":["https://orcid.org/0000-0002-7232-7737"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Libra","raw_affiliation_strings":["Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024701147","display_name":"Luca Falzone","orcid":"https://orcid.org/0000-0001-7349-6826","observed_orcids":["https://orcid.org/0000-0001-7349-6826"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Falzone","raw_affiliation_strings":["Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076971405","display_name":"Saverio Candido","orcid":"https://orcid.org/0000-0003-1255-6666","observed_orcids":["https://orcid.org/0000-0003-1255-6666"]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Saverio Candido","raw_affiliation_strings":["Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Research Center for Prevention, Diagnosis and Treatment of Cancer (PreDiCT), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082733849","display_name":"Giuseppe Montalto","orcid":"https://orcid.org/0000-0002-8731-8577","observed_orcids":["https://orcid.org/0000-0002-8731-8577"]},"institutions":[{"id":"https://openalex.org/I4210130743","display_name":"Institute for Biomedical Research and Innovation","ror":"https://ror.org/03byxpq91","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210130743"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Montalto","raw_affiliation_strings":["Department of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy","Department of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy","Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy","institution_ids":["https://openalex.org/I4210130743","https://openalex.org/I4210155236","https://openalex.org/I900890020"]},{"raw_affiliation_string":"Department of Health Promotion, Maternal and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy","institution_ids":["https://openalex.org/I4210130743","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070243247","display_name":"Melchiorre Cervello","orcid":"https://orcid.org/0000-0003-4923-7220","observed_orcids":["https://orcid.org/0000-0003-4923-7220"]},"institutions":[{"id":"https://openalex.org/I4210130743","display_name":"Institute for Biomedical Research and Innovation","ror":"https://ror.org/03byxpq91","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210130743"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Melchiorre Cervello","raw_affiliation_strings":["Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy","institution_ids":["https://openalex.org/I4210130743","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027603108","display_name":"Paolo Lombardi","orcid":"https://orcid.org/0000-0002-7971-7404","observed_orcids":["https://orcid.org/0000-0002-7971-7404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Lombardi","raw_affiliation_strings":["Naxospharma, Via Giuseppe di Vittorio 70, Novate Milanese, 20026, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naxospharma, Via Giuseppe di Vittorio 70, Novate Milanese, 20026, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030391285","display_name":"James Andrew McCubrey","orcid":"https://orcid.org/0000-0001-6027-3156","observed_orcids":["https://orcid.org/0000-0001-6027-3156"]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. McCubrey","raw_affiliation_strings":["Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA. Electronic address: mccubreyj@ecu.edu","Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA"],"raw_orcid":"https://orcid.org/0000-0001-6027-3156","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA. Electronic address: mccubreyj@ecu.edu","institution_ids":["https://openalex.org/I186335123"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, 27858, USA","institution_ids":["https://openalex.org/I186335123"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030391285"],"corresponding_institution_ids":["https://openalex.org/I186335123"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":1.0221,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72713371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"83","issue":null,"first_page":"100840","last_page":"100840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.49799999594688416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.49799999594688416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutlin-3a","display_name":"Nutlin-3a","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.7379999756813049},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.5170000195503235},{"id":"https://openalex.org/keywords/mia-paca-2-cells","display_name":"MIA PaCa-2 cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.7804458737373352},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7391501665115356},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6618921160697937},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6525236368179321},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5831924676895142},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5243316292762756},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.503701388835907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4799087941646576},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4797557592391968},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45976749062538147},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.43034815788269043},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42544788122177124},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4229004979133606},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4157070517539978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3688194453716278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29966872930526733},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26924264430999756},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.26849424839019775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1645735800266266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11188393831253052}],"mesh":[{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jbior.2021.100840","doi":"https://doi.org/10.1016/j.jbior.2021.100840","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbior.2021.100840","pdf_url":null,"source":{"id":"https://openalex.org/S2764887616","display_name":"Advances in Biological Regulation","issn_l":"2212-4926","issn":["2212-4926","2212-4934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biological Regulation","raw_type":"journal-article"},{"id":"pmid:34866036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34866036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biological regulation","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/868891","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/abs/pii/S2212492621000567?via=ihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:cris.unibo.it:11585/868891","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/abs/pii/S2212492621000567?via=ihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G389751425","display_name":null,"funder_award_id":"#111110-668715-0000","funder_id":"https://openalex.org/F4320310571","funder_display_name":"East Carolina University"},{"id":"https://openalex.org/G464037143","display_name":null,"funder_award_id":"#111104","funder_id":"https://openalex.org/F4320310571","funder_display_name":"East Carolina University"},{"id":"https://openalex.org/G745740194","display_name":null,"funder_award_id":"111104 and 111110-668715-0000","funder_id":"https://openalex.org/F4320310571","funder_display_name":"East Carolina University"}],"funders":[{"id":"https://openalex.org/F4320310571","display_name":"East Carolina University","ror":"https://ror.org/01vx35703"},{"id":"https://openalex.org/F4320310616","display_name":"Brody School of Medicine","ror":"https://ror.org/01vx35703"},{"id":"https://openalex.org/F4320322848","display_name":"Fondazione del Monte di Bologna e Ravenna","ror":"https://ror.org/04gmrm344"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1489777708","https://openalex.org/W1969279156","https://openalex.org/W1970064578","https://openalex.org/W1986249544","https://openalex.org/W1991917274","https://openalex.org/W2001536256","https://openalex.org/W2005521356","https://openalex.org/W2015619266","https://openalex.org/W2029865335","https://openalex.org/W2030738890","https://openalex.org/W2141202224","https://openalex.org/W2142548608","https://openalex.org/W2161817637","https://openalex.org/W2168992025","https://openalex.org/W2428928278","https://openalex.org/W2539120393","https://openalex.org/W2626525318","https://openalex.org/W2729108853","https://openalex.org/W2764283066","https://openalex.org/W2771729549","https://openalex.org/W2782917551","https://openalex.org/W2790680781","https://openalex.org/W2792904491","https://openalex.org/W2800408677","https://openalex.org/W2810328235","https://openalex.org/W2921099017","https://openalex.org/W2942176421","https://openalex.org/W2981374542","https://openalex.org/W2990470129","https://openalex.org/W3028690387","https://openalex.org/W3036630705","https://openalex.org/W3041100082","https://openalex.org/W3088183393","https://openalex.org/W3091421761","https://openalex.org/W3106680483","https://openalex.org/W3119758269","https://openalex.org/W3131928636","https://openalex.org/W3144862558","https://openalex.org/W3173008405"],"related_works":["https://openalex.org/W2921099017","https://openalex.org/W2810328235","https://openalex.org/W3119758269","https://openalex.org/W2891422277","https://openalex.org/W4211225342","https://openalex.org/W4406847197","https://openalex.org/W2314570919","https://openalex.org/W1969546668","https://openalex.org/W4225092354","https://openalex.org/W2065016142"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-06T00:00:00"}