{"id":"https://openalex.org/W3216632473","doi":"https://doi.org/10.1155/2021/6417658","title":"Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock","display_name":"Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3216632473","doi":"https://doi.org/10.1155/2021/6417658","mag":"3216632473","pmid":"https://pubmed.ncbi.nlm.nih.gov/34840990"},"language":"en","primary_location":{"id":"doi:10.1155/2021/6417658","doi":"https://doi.org/10.1155/2021/6417658","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6417658","pdf_url":"https://downloads.hindawi.com/journals/jir/2021/6417658.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jir/2021/6417658.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752420","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-9523-5296","observed_orcids":["https://orcid.org/0000-0002-9523-5296"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937965","display_name":"Tao Xu","orcid":"https://orcid.org/0000-0003-0153-0815","observed_orcids":["https://orcid.org/0000-0003-0153-0815"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Xu","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439601","display_name":"Cheng Zhang","orcid":"https://orcid.org/0000-0001-8631-4411","observed_orcids":["https://orcid.org/0000-0001-8631-4411"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zhang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109465174","display_name":"Wenqiao Yu","orcid":"https://orcid.org/0000-0003-3940-2237","observed_orcids":["https://orcid.org/0000-0003-3940-2237"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Qiao Yu","raw_affiliation_strings":["Department of Surgical Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101430890","display_name":"Tao Wei","orcid":"https://orcid.org/0000-0002-3818-5675","observed_orcids":["https://orcid.org/0000-0002-3818-5675"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wei","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210145330","display_name":"Shenzhen Luohu People's Hospital","ror":"https://ror.org/04bpt8p43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Department of General Surgery, Shenzhen Luohu People\u2019s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","Department of General Surgery, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shenzhen Luohu People\u2019s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145330"]},{"raw_affiliation_string":"Department of General Surgery, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340189","display_name":"Qi Chen","orcid":"https://orcid.org/0000-0002-8711-155X","observed_orcids":["https://orcid.org/0000-0002-8711-155X","https://orcid.org/0000-0001-7722-0640"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Chen","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073948415","display_name":"Junyu Qiu","orcid":"https://orcid.org/0000-0003-3191-836X","observed_orcids":["https://orcid.org/0000-0003-3191-836X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Yu Qiu","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hai-Jun Li","orcid":"https://orcid.org/0000-0002-5305-1659","observed_orcids":["https://orcid.org/0000-0002-5305-1659"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210145330","display_name":"Shenzhen Luohu People's Hospital","ror":"https://ror.org/04bpt8p43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Jun Li","raw_affiliation_strings":["Department of General Surgery, Shenzhen Luohu People\u2019s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","Department of General Surgery, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-5305-1659","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shenzhen Luohu People\u2019s Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145330"]},{"raw_affiliation_string":"Department of General Surgery, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210145330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101429848","display_name":"Ting\u2010Bo Liang","orcid":"https://orcid.org/0000-0001-6141-0829","observed_orcids":["https://orcid.org/0000-0001-6141-0829"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting-Bo Liang","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-6141-0829","affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":0.4458,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.54878264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr5","display_name":"TLR5","score":0.9789999723434448},{"id":"https://openalex.org/keywords/traumatic-hemorrhagic-shock","display_name":"traumatic hemorrhagic shock","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.8140000104904175},{"id":"https://openalex.org/keywords/regiiigamma","display_name":"RegIII\u03b3","score":0.8259999752044678},{"id":"https://openalex.org/keywords/th1-polarization","display_name":"Th1 polarization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.781000018119812},{"id":"https://openalex.org/keywords/anaerobic-gram-positive-bacteria","display_name":"anaerobic Gram-positive bacteria","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2777338127","wikidata":"https://www.wikidata.org/wiki/Q14914085","display_name":"TLR5","level":5,"score":0.9886232614517212},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7322710752487183},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.6297999620437622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5968377590179443},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5922946929931641},{"id":"https://openalex.org/C38117629","wikidata":"https://www.wikidata.org/wiki/Q24788421","display_name":"Flagellin","level":3,"score":0.5649164915084839},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.5191311240196228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4545816481113434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36242538690567017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35496461391448975},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.3462742269039154},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.30736270546913147},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3014220595359802},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.21605870127677917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18899807333946228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11477425694465637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08767375349998474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08184337615966797}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051198","descriptor_name":"Toll-Like Receptor 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051198","descriptor_name":"Toll-Like Receptor 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051198","descriptor_name":"Toll-Like Receptor 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/6417658","doi":"https://doi.org/10.1155/2021/6417658","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6417658","pdf_url":"https://downloads.hindawi.com/journals/jir/2021/6417658.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},{"id":"pmid:34840990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34840990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8626180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8626180","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Immunol Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0c448ddbcdab4d2790fec8bf82e9bddf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0c448ddbcdab4d2790fec8bf82e9bddf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology Research, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/6417658","doi":"https://doi.org/10.1155/2021/6417658","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6417658","pdf_url":"https://downloads.hindawi.com/journals/jir/2021/6417658.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1178376988","display_name":null,"funder_award_id":"81801642","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1192738962","display_name":null,"funder_award_id":"LD19H150001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1221957899","display_name":null,"funder_award_id":"81801642","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G1502911995","display_name":null,"funder_award_id":"LY18H150003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1983730130","display_name":null,"funder_award_id":"81871545","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G2182020565","display_name":null,"funder_award_id":"LY21H100003","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2307121031","display_name":null,"funder_award_id":"2019YFC1316000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2328948395","display_name":null,"funder_award_id":"(2019YFC1316000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2739611868","display_name":null,"funder_award_id":"81871545","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2755329152","display_name":null,"funder_award_id":"81801640","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4602198183","display_name":null,"funder_award_id":"81801642","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5362746880","display_name":null,"funder_award_id":"LGF20H160027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5783987878","display_name":null,"funder_award_id":"LY21H100003","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G6897013730","display_name":null,"funder_award_id":"LY18H150003","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G7463023292","display_name":null,"funder_award_id":"LGF20H160027","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7778832444","display_name":null,"funder_award_id":"LY18H150003","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7915668518","display_name":"\u80a0\u4e0a\u76ae\u7ec6\u80deTlr 5\u901a\u8def\u53c2\u4e0e\u6025\u6027\u80f0\u817a\u708e\u81f4\u80a0\u9053\u7ec6\u83cc\u79fb\u4f4d\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"LD19H150001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G7941793514","display_name":null,"funder_award_id":"81801640","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8064978282","display_name":null,"funder_award_id":"LGF20H160027","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8174747940","display_name":null,"funder_award_id":"LY21H100003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8473735199","display_name":null,"funder_award_id":"81871545","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8717775152","display_name":null,"funder_award_id":"2019YFC1316000","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8947424877","display_name":null,"funder_award_id":"LD19H150001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G975352975","display_name":null,"funder_award_id":"81801640","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216632473.pdf","grobid_xml":"https://content.openalex.org/works/W3216632473.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W879479010","https://openalex.org/W1968356572","https://openalex.org/W1974092965","https://openalex.org/W1988005096","https://openalex.org/W2001414794","https://openalex.org/W2005203181","https://openalex.org/W2009112167","https://openalex.org/W2015901595","https://openalex.org/W2026528407","https://openalex.org/W2032574604","https://openalex.org/W2044161168","https://openalex.org/W2048512273","https://openalex.org/W2051529467","https://openalex.org/W2063276097","https://openalex.org/W2071203986","https://openalex.org/W2084533450","https://openalex.org/W2086499468","https://openalex.org/W2090488505","https://openalex.org/W2093972125","https://openalex.org/W2094004937","https://openalex.org/W2105221079","https://openalex.org/W2107066107","https://openalex.org/W2107216672","https://openalex.org/W2108246384","https://openalex.org/W2123617326","https://openalex.org/W2134533989","https://openalex.org/W2138801049","https://openalex.org/W2144504039","https://openalex.org/W2156145269","https://openalex.org/W2158820172","https://openalex.org/W2163706356","https://openalex.org/W2165722876","https://openalex.org/W2169415889","https://openalex.org/W2172135635","https://openalex.org/W2197368019","https://openalex.org/W2276961144","https://openalex.org/W2332044667","https://openalex.org/W2335159631","https://openalex.org/W2460079419","https://openalex.org/W2527885929","https://openalex.org/W2528219245","https://openalex.org/W2534977774","https://openalex.org/W2580798654","https://openalex.org/W2615398012","https://openalex.org/W2807724532","https://openalex.org/W2886322630","https://openalex.org/W3000808213","https://openalex.org/W3119184449"],"related_works":["https://openalex.org/W3143455065","https://openalex.org/W1428902317","https://openalex.org/W3175688394","https://openalex.org/W2097783688","https://openalex.org/W1976204225","https://openalex.org/W4366384814","https://openalex.org/W2022374656","https://openalex.org/W101831468","https://openalex.org/W2119453332","https://openalex.org/W1129086792"],"abstract_inverted_index":{"Enterogenous":[0],"infection":[1,231],"is":[2],"a":[3,83,136,175,205],"major":[4],"cause":[5],"of":[6,33,140,152,188,212],"death":[7],"during":[8,163],"traumatic":[9],"hemorrhagic":[10],"shock":[11],"(THS).":[12],"It":[13],"has":[14],"been":[15],"reported":[16],"that":[17,74,98,185,201,235],"Toll-like":[18],"receptor":[19],"5":[20],"(TLR5)":[21],"plays":[22,204],"an":[23],"integral":[24],"role":[25,85,177,207],"in":[26,61,68,86,130,178,193,208],"regulating":[27,209],"mucosal":[28,103],"immunity":[29],"and":[30,46,64,126,135,142,216,229],"intestinal":[31,43,94,119,132,226],"homeostasis":[32],"the":[34,37,102,131,150,161],"microbiota.":[35],"However,":[36],"roles":[38],"played":[39,82],"by":[40,106,155],"TLR5":[41,69,80,99,147,202],"on":[42],"barrier":[44,105],"maintenance":[45],"commensal":[47,88],"bacterial":[48,77,191,227,245],"translocation":[49,192,228,246],"post-THS":[50],"are":[51],"poorly":[52],"understood.":[53],"In":[54,197],"this":[55],"research,":[56],"we":[57,199],"established":[58],"THS":[59,75],"models":[60],"wild-type":[62],"(WT)":[63],"Tlr5\u2212/\u2212":[65],"(genetically":[66],"deficient":[67],"expression)":[70],"mice.":[71,196],"We":[72,115,182],"found":[73,184],"promoted":[76],"translocation,":[78],"while":[79],"deficiency":[81,100,148],"protective":[84],"preventing":[87],"bacteria":[89],"dissemination":[90],"after":[91,232,247],"THS.":[92,164,248],"Furthermore,":[93],"microbiota":[95,241],"analysis":[96],"uncovered":[97],"enhanced":[101],"biological":[104],"decreasing":[107],"RegIII\u03b3-mediated":[108],"bactericidal":[109],"activity":[110],"against":[111],"G+":[112,213],"anaerobic":[113,214],"bacteria.":[114],"then":[116],"sorted":[117],"small":[118],"TLR5+":[120,171],"lamina":[121,133],"propria":[122,134],"dendritic":[123],"cells":[124,162],"(LPDCs)":[125],"analyzed":[127],"TH1":[128,153,180,219],"differentiation":[129,220],"coculture":[137],"system":[138],"consisting":[139],"LPDCs":[141,172,217,238],"na\u00efve":[143],"T":[144],"cells.":[145],"Although":[146],"attenuated":[149],"regulation":[151],"polarization":[154],"LPDCs,":[156],"it":[157],"conferred":[158],"stability":[159],"to":[160],"Moreover,":[165],"retinoic":[166],"acid":[167],"(RA)":[168],"released":[169],"from":[170],"could":[173],"play":[174],"key":[176],"modulating":[179],"polarization.":[181],"also":[183],"gavage":[186],"administration":[187],"RA":[189],"alleviated":[190],"THS-treated":[194],"WT":[195],"summary,":[198],"documented":[200],"signaling":[203],"pivotal":[206],"RegIII\u03b3-induced":[210],"killing":[211],"bacteria,":[215],"mediated":[218],"via":[221],"RA.":[222],"These":[223],"processes":[224],"prevent":[225],"enterogenous":[230],"THS,":[233],"suggesting":[234],"therapeutically":[236],"targeting":[237],"or":[239],"gut":[240],"can":[242],"interfere":[243],"with":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}