{"id":"https://openalex.org/W3216616822","doi":"https://doi.org/10.1002/pro.4246","title":"Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 ( Cys216Gly ) that causes very early onset autoimmune enteropathy","display_name":"Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 ( Cys216Gly ) that causes very early onset autoimmune enteropathy","publication_year":2021,"publication_date":"2021-11-22","ids":{"openalex":"https://openalex.org/W3216616822","doi":"https://doi.org/10.1002/pro.4246","mag":"3216616822","pmid":"https://pubmed.ncbi.nlm.nih.gov/34806245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8820110"},"language":"en","primary_location":{"id":"doi:10.1002/pro.4246","doi":"https://doi.org/10.1002/pro.4246","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.4246","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8820110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014315145","display_name":"Qing Nian","orcid":"https://orcid.org/0000-0001-7986-866X","observed_orcids":["https://orcid.org/0000-0001-7986-866X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Qing Nian","raw_affiliation_strings":["Department of Blood Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China and Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China","Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China and Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I19820366","https://openalex.org/I4210118397"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050963640","display_name":"J\u00e9r\u00e9my Berthelet","orcid":"https://orcid.org/0009-0002-9301-5166","observed_orcids":["https://orcid.org/0009-0002-9301-5166"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00e9my Berthelet","raw_affiliation_strings":["Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005685737","display_name":"Marianna Parlato","orcid":"https://orcid.org/0000-0002-8750-082X","observed_orcids":["https://orcid.org/0000-0002-8750-082X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marianna Parlato","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM, Institut Imagine  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, Institut Imagine  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011893335","display_name":"Ariel M\u00e9chaly","orcid":"https://orcid.org/0000-0002-5305-7495","observed_orcids":["https://orcid.org/0000-0002-5305-7495"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387156267","display_name":"Biologie Mol\u00e9culaire Structurale et Processus Infectieux","ror":"https://ror.org/009b91528","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387156267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ariel E. Mechaly","raw_affiliation_strings":["Institut Pasteur, Plate-forme de Cristallographie-C2RT, CNRS UMR 3528, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Plate-forme de Cristallographie-C2RT, CNRS UMR 3528, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387156267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062619351","display_name":"Rongxing Liu","orcid":"https://orcid.org/0000-0002-8773-9064","observed_orcids":["https://orcid.org/0000-0002-8773-9064"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rongxing Liu","raw_affiliation_strings":["Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109558707","display_name":"Jean\u2010Marie Dupret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Marie Dupret","raw_affiliation_strings":["Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010756691","display_name":"Nadine Cerf\u2013Bensussan","orcid":"https://orcid.org/0000-0003-0665-1245","observed_orcids":["https://orcid.org/0000-0003-0665-1245"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nadine Cerf\u2010Bensussan","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM, Institut Imagine  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, Institut Imagine  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075457982","display_name":"Ahmed Haouz","orcid":"https://orcid.org/0000-0003-1196-1635","observed_orcids":["https://orcid.org/0000-0003-1196-1635","https://orcid.org/0000-0002-0843-1580"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387156267","display_name":"Biologie Mol\u00e9culaire Structurale et Processus Infectieux","ror":"https://ror.org/009b91528","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387156267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ahmed Haouz","raw_affiliation_strings":["Institut Pasteur, Plate-forme de Cristallographie-C2RT, CNRS UMR 3528, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Plate-forme de Cristallographie-C2RT, CNRS UMR 3528, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387156267"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086686471","display_name":"Fernando Rodrigues\u2010Lima","orcid":"https://orcid.org/0000-0002-1081-4767","observed_orcids":["https://orcid.org/0000-0002-1081-4767"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210137329","display_name":"Unit of Functional and Adaptive Biology","ror":"https://ror.org/02z0jq636","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210137329"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fernando Rodrigues Lima","raw_affiliation_strings":["Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France"],"raw_orcid":"https://orcid.org/0000-0002-1081-4767","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, CNRS, Unit\u00e9 de Biologie Fonctionnelle et Adaptative  Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5086686471"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210137329"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.6273,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62381333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"31","issue":"2","first_page":"538","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptpn2","display_name":"PTPN2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.871999979019165},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.7829999923706055},{"id":"https://openalex.org/keywords/closed-conformation","display_name":"closed conformation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.9399999976158142},{"id":"https://openalex.org/keywords/enzyme-inactivity","display_name":"enzyme inactivity","score":0.4569999873638153},{"id":"https://openalex.org/keywords/ligand-design","display_name":"ligand design","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.7374241352081299},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6363718509674072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932680368423462},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.49724677205085754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3853034973144531},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3726866841316223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30318334698677063},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2465188205242157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19261795282363892}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054578","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054578","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/pro.4246","doi":"https://doi.org/10.1002/pro.4246","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pro.4246","pdf_url":null,"source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8820110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8820110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:34806245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34806245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:pasteur-03524511v1","doi":null,"is_oa":false,"landing_page_url":"https://pasteur.hal.science/pasteur-03524511","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Science, 2021, ⟨10.1002/pro.4246⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8820110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8820110","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322141","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W125787089","https://openalex.org/W1592311769","https://openalex.org/W1967579340","https://openalex.org/W2002379520","https://openalex.org/W2013355944","https://openalex.org/W2026671374","https://openalex.org/W2044529125","https://openalex.org/W2059286008","https://openalex.org/W2093634504","https://openalex.org/W2122586120","https://openalex.org/W2133718112","https://openalex.org/W2139144434","https://openalex.org/W2252013066","https://openalex.org/W2736476343","https://openalex.org/W2898404101","https://openalex.org/W2909352392","https://openalex.org/W2973860127","https://openalex.org/W2992056665","https://openalex.org/W2996644149","https://openalex.org/W3030415176","https://openalex.org/W3044591597","https://openalex.org/W3175560554"],"related_works":["https://openalex.org/W2166690707","https://openalex.org/W1974601505","https://openalex.org/W4401813484","https://openalex.org/W2938401744","https://openalex.org/W2317996983","https://openalex.org/W4240095529","https://openalex.org/W1592311769","https://openalex.org/W2081439838","https://openalex.org/W2318143376","https://openalex.org/W4400140721"],"abstract_inverted_index":{"PTPN2":[0,21,73,91,136,159],"is":[1],"an":[2,95],"important":[3],"protein":[4],"tyrosine":[5],"phosphatase":[6],"(PTP)":[7],"that":[8,93,102],"plays":[9],"a":[10,87,106,141],"key":[11],"role":[12,32],"in":[13,25,33,100],"cell":[14],"signaling.":[15],"Deletions":[16],"or":[17],"inactivating":[18],"mutations":[19],"of":[20,44,49,54,72,86,90,131,153],"have":[22],"been":[23,77],"described":[24],"different":[26],"pathologies":[27],"and":[28,36,52,122,149],"underline":[29],"its":[30,55,117],"critical":[31],"hematopoiesis,":[34],"autoimmunity,":[35],"inflammation.":[37],"Surprisingly,":[38],"despite":[39],"the":[40,46,82,114,125,150,157],"major":[41],"pathophysiological":[42],"implications":[43],"PTPN2,":[45],"structural":[47,151],"analysis":[48],"this":[50,103],"PTP":[51,65,108,132,147],"notably":[53],"pathogenic":[56,88,154],"mutants":[57],"remains":[58],"poorly":[59],"documented.":[60],"Contrary":[61],"to":[62,67,119,123,144,165],"other":[63],"human":[64],"enzymes,":[66],"date,":[68],"only":[69],"one":[70],"structure":[71,85,137,160],"(wild-type":[74],"form)":[75],"has":[76],"reported.":[78],"Here,":[79],"we":[80],"report":[81],"first":[83],"crystal":[84],"mutant":[89,104,115],"(Cys216Gly)":[92],"causes":[94],"autoimmune":[96],"enteropathy.":[97],"We":[98],"show":[99],"particular":[101],"adopts":[105],"classical":[107],"fold.":[109],"More":[110],"importantly,":[111],"albeit":[112],"inactive,":[113],"retains":[116],"ability":[118],"bind":[120],"substrates":[121],"adopt":[124],"characteristic":[126],"catalytically":[127],"competent":[128],"closed":[129],"form":[130],"enzymes.":[133],"This":[134],"novel":[135],"may":[138],"serve":[139],"as":[140],"new":[142],"tool":[143],"better":[145],"understand":[146],"structures":[148],"impacts":[152],"mutations.":[155],"Moreover,":[156],"C216G":[158],"could":[161],"also":[162],"be":[163],"helpful":[164],"design":[166],"specific":[167],"ligands/inhibitors.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-12-06T00:00:00"}