{"id":"https://openalex.org/W3216615504","doi":"https://doi.org/10.1002/adbi.202101020","title":"Remodeling of Membrane Shape and Topology by Curvature Elasticity and Membrane Tension","display_name":"Remodeling of Membrane Shape and Topology by Curvature Elasticity and Membrane Tension","publication_year":2021,"publication_date":"2021-12-03","ids":{"openalex":"https://openalex.org/W3216615504","doi":"https://doi.org/10.1002/adbi.202101020","mag":"3216615504","pmid":"https://pubmed.ncbi.nlm.nih.gov/34859961"},"language":"en","primary_location":{"id":"doi:10.1002/adbi.202101020","doi":"https://doi.org/10.1002/adbi.202101020","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202101020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202101020","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202101020","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023067075","display_name":"Reinhard Lipowsky","orcid":"https://orcid.org/0000-0001-8417-8567","observed_orcids":["https://orcid.org/0000-0001-8417-8567"]},"institutions":[{"id":"https://openalex.org/I4210092306","display_name":"Max Planck Institute of Colloids and Interfaces","ror":"https://ror.org/00pwgnh47","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210092306"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Reinhard Lipowsky","raw_affiliation_strings":["Theory &amp; Biosystems Max Planck Institute of Colloids and Interfaces Science Park Golm  Potsdam Germany","Theory & Biosystems, Max Planck Institute of Colloids and Interfaces, Science Park Golm, Potsdam, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8417-8567","affiliations":[{"raw_affiliation_string":"Theory &amp; Biosystems Max Planck Institute of Colloids and Interfaces Science Park Golm  Potsdam Germany","institution_ids":["https://openalex.org/I4210092306"]},{"raw_affiliation_string":"Theory & Biosystems, Max Planck Institute of Colloids and Interfaces, Science Park Golm, Potsdam, Germany","institution_ids":["https://openalex.org/I4210092306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023067075"],"corresponding_institution_ids":["https://openalex.org/I4210092306"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":1.3,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.8052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"e2101020","last_page":"e2101020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-remodeling","display_name":"membrane remodeling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.7179999947547913},{"id":"https://openalex.org/keywords/curvature-elasticity","display_name":"curvature elasticity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/membrane-tension","display_name":"membrane tension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membrane-protein-topology","display_name":"membrane topology","score":0.7360000014305115},{"id":"https://openalex.org/keywords/giant-vesicles","display_name":"giant vesicles","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nanovesicles","display_name":"nanovesicles","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tubules","display_name":"tubules","score":0.5009999871253967},{"id":"https://openalex.org/keywords/membrane-fission","display_name":"membrane fission","score":0.7360000014305115},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vesicle-division","display_name":"vesicle division","score":0.734000027179718},{"id":"https://openalex.org/keywords/synthetic-membranes","display_name":"synthetic membranes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8079451322555542},{"id":"https://openalex.org/C2777278457","wikidata":"https://www.wikidata.org/wiki/Q6815124","display_name":"Membrane curvature","level":4,"score":0.7498743534088135},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6400439143180847},{"id":"https://openalex.org/C121854251","wikidata":"https://www.wikidata.org/wiki/Q62932","display_name":"Elasticity (physics)","level":2,"score":0.4628670811653137},{"id":"https://openalex.org/C534586","wikidata":"https://www.wikidata.org/wiki/Q6815143","display_name":"Membrane topology","level":4,"score":0.4226074814796448},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39190924167633057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3903317451477051},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3889088034629822},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34496480226516724},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2429952323436737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21648108959197998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07659643888473511},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0759848952293396},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/adbi.202101020","doi":"https://doi.org/10.1002/adbi.202101020","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202101020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202101020","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},{"id":"pmid:34859961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34859961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adbi.202101020","doi":"https://doi.org/10.1002/adbi.202101020","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202101020","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202101020","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216615504.pdf","grobid_xml":"https://content.openalex.org/works/W3216615504.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W607690890","https://openalex.org/W1544573343","https://openalex.org/W1557564805","https://openalex.org/W1613315412","https://openalex.org/W1618719257","https://openalex.org/W1915536483","https://openalex.org/W1963573377","https://openalex.org/W1968209548","https://openalex.org/W1970081203","https://openalex.org/W1972438943","https://openalex.org/W1977004640","https://openalex.org/W1982792659","https://openalex.org/W1984680345","https://openalex.org/W1985365711","https://openalex.org/W1988578938","https://openalex.org/W1990937760","https://openalex.org/W1993745463","https://openalex.org/W1995950736","https://openalex.org/W1999303422","https://openalex.org/W2009037673","https://openalex.org/W2010953792","https://openalex.org/W2014405796","https://openalex.org/W2017805495","https://openalex.org/W2018151716","https://openalex.org/W2021907819","https://openalex.org/W2022758871","https://openalex.org/W2025680762","https://openalex.org/W2027302175","https://openalex.org/W2030467666","https://openalex.org/W2032145912","https://openalex.org/W2032495947","https://openalex.org/W2034214429","https://openalex.org/W2035512416","https://openalex.org/W2036082158","https://openalex.org/W2037316488","https://openalex.org/W2039025686","https://openalex.org/W2042035425","https://openalex.org/W2046505197","https://openalex.org/W2052881002","https://openalex.org/W2054352933","https://openalex.org/W2054803640","https://openalex.org/W2055447928","https://openalex.org/W2057410872","https://openalex.org/W2059571424","https://openalex.org/W2062337964","https://openalex.org/W2063089197","https://openalex.org/W2064230582","https://openalex.org/W2075504000","https://openalex.org/W2084141366","https://openalex.org/W2086709935","https://openalex.org/W2089156200","https://openalex.org/W2093853070","https://openalex.org/W2096474273","https://openalex.org/W2100869615","https://openalex.org/W2107008239","https://openalex.org/W2115202121","https://openalex.org/W2115514498","https://openalex.org/W2120841396","https://openalex.org/W2125872855","https://openalex.org/W2127811731","https://openalex.org/W2128441806","https://openalex.org/W2134723427","https://openalex.org/W2137639709","https://openalex.org/W2138402450","https://openalex.org/W2140690761","https://openalex.org/W2140810026","https://openalex.org/W2142760412","https://openalex.org/W2144528091","https://openalex.org/W2146439388","https://openalex.org/W2149509209","https://openalex.org/W2163585561","https://openalex.org/W2165035054","https://openalex.org/W2165068711","https://openalex.org/W2166840071","https://openalex.org/W2167911253","https://openalex.org/W2178102917","https://openalex.org/W2211940871","https://openalex.org/W2238367175","https://openalex.org/W2264936970","https://openalex.org/W2316292148","https://openalex.org/W2320071942","https://openalex.org/W2328871929","https://openalex.org/W2476257205","https://openalex.org/W2479447708","https://openalex.org/W2499715294","https://openalex.org/W2513151331","https://openalex.org/W2526003217","https://openalex.org/W2526225111","https://openalex.org/W2526579288","https://openalex.org/W2541068854","https://openalex.org/W2587850954","https://openalex.org/W2590568317","https://openalex.org/W2590648968","https://openalex.org/W2607864406","https://openalex.org/W2617667835","https://openalex.org/W2787997548","https://openalex.org/W2790646261","https://openalex.org/W2791050980","https://openalex.org/W2794771344","https://openalex.org/W2796334734","https://openalex.org/W2799956708","https://openalex.org/W2801571069","https://openalex.org/W2884865116","https://openalex.org/W2886012836","https://openalex.org/W2888001771","https://openalex.org/W2893523239","https://openalex.org/W2895545887","https://openalex.org/W2897132139","https://openalex.org/W2905463864","https://openalex.org/W2944053555","https://openalex.org/W2946962120","https://openalex.org/W2975833843","https://openalex.org/W2994810555","https://openalex.org/W2996602764","https://openalex.org/W3005591085","https://openalex.org/W3083852952","https://openalex.org/W3116211898","https://openalex.org/W3119750544","https://openalex.org/W3144494114","https://openalex.org/W4231361868","https://openalex.org/W4234543249","https://openalex.org/W4237719707","https://openalex.org/W6600062020","https://openalex.org/W6600362149","https://openalex.org/W6606897792","https://openalex.org/W6631945018","https://openalex.org/W6634411789"],"related_works":["https://openalex.org/W2991629347","https://openalex.org/W4396782354","https://openalex.org/W3119750544","https://openalex.org/W4214938227","https://openalex.org/W2974897185","https://openalex.org/W7154867041","https://openalex.org/W2067755276","https://openalex.org/W2790321934","https://openalex.org/W2008818095","https://openalex.org/W2906779604"],"abstract_inverted_index":{"Cellular":[0],"membranes":[1,100],"exhibit":[2],"a":[3,39],"fascinating":[4],"variety":[5],"of":[6,15,68,77,98,105,114,136,151,160,180,192],"different":[7],"morphologies,":[8],"which":[9,121,154],"are":[10,56,130],"continuously":[11],"remodeled":[12],"by":[13,84,149,164],"transformations":[14],"membrane":[16,46,69,106,115,137,140,152,166,184,187],"shape":[17],"and":[18,34,41,61,87,101,125,142,163,183,189,194],"topology.":[19],"This":[20,92],"remodeling":[21,135],"is":[22],"essential":[23,132],"for":[24,81,133,170,174],"important":[25],"biological":[26],"processes":[27,196],"(cell":[28],"division,":[29],"intracellular":[30],"vesicle":[31],"trafficking,":[32],"endocytosis)":[33],"can":[35,122,146],"be":[36,147],"elucidated":[37],"in":[38,90],"systematic":[40],"quantitative":[42],"manner":[43],"using":[44],"synthetic":[45,54],"systems.":[47],"Here,":[48],"recent":[49],"insights":[50],"obtained":[51],"from":[52,74],"such":[53],"systems":[55],"reviewed,":[57],"integrating":[58],"experimental":[59],"observations":[60],"molecular":[62],"dynamics":[63],"simulations":[64],"with":[65],"the":[66,75,95,103,134,157,178,190],"theory":[67],"elasticity.":[70],"The":[71,112],"study":[72],"starts":[73],"polymorphism":[76,93],"biomembranes":[78],"as":[79,168],"observed":[80,169],"giant":[82,161],"vesicles":[83],"optical":[85],"microscopy":[86],"small":[88,171],"nanovesicles":[89],"simulations.":[91],"reflects":[94],"unusual":[96],"elasticity":[97,182],"fluid":[99,109],"includes":[102],"formation":[104],"necks":[107,116,129],"or":[108],"'worm":[110],"holes'.":[111],"proliferation":[113],"generates":[117],"stable":[118],"multi-spherical":[119],"shapes,":[120],"form":[123],"tubules":[124],"tubular":[126],"junctions.":[127],"Membrane":[128],"also":[131],"topology":[138],"via":[139],"fission":[141,145,193],"fusion.":[143],"Neck":[144],"induced":[148],"fine-tuning":[150],"curvature,":[153],"leads":[155],"to":[156],"controlled":[158],"division":[159],"vesicles,":[162],"adhesion-induced":[165],"tension":[167,185],"nanovesicles.":[172],"Challenges":[173],"future":[175],"research":[176],"include":[177],"interplay":[179],"curvature":[181],"during":[186],"fusion":[188,195],"localization":[191],"within":[197],"intramembrane":[198],"domains.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-06T00:00:00"}
