{"id":"https://openalex.org/W3216596398","doi":"https://doi.org/10.5644/ama2006-124.340","title":"Characteristics of Patients with Nonvariceal Upper Gastrointestinal Bleeding - Are We Underestimating Gastroprotection during NSAIDs Therapy?","display_name":"Characteristics of Patients with Nonvariceal Upper Gastrointestinal Bleeding - Are We Underestimating Gastroprotection during NSAIDs Therapy?","publication_year":2021,"publication_date":"2021-11-21","ids":{"openalex":"https://openalex.org/W3216596398","doi":"https://doi.org/10.5644/ama2006-124.340","mag":"3216596398","pmid":"https://pubmed.ncbi.nlm.nih.gov/34847677"},"language":"en","primary_location":{"id":"doi:10.5644/ama2006-124.340","doi":"https://doi.org/10.5644/ama2006-124.340","is_oa":true,"landing_page_url":"https://doi.org/10.5644/ama2006-124.340","pdf_url":"http://www.ama.ba/index.php/ama/article/download/459/pdf","source":{"id":"https://openalex.org/S4210201824","display_name":"Acta Medica Academica","issn_l":"1840-1848","issn":["1840-1848","1840-2879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321207","host_organization_name":"Academy of Sciences and Arts of Bosnia and Herzegovina","host_organization_lineage":["https://openalex.org/P4310321207"],"host_organization_lineage_names":["Academy of Sciences and Arts of Bosnia and Herzegovina"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Academica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.ama.ba/index.php/ama/article/download/459/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053690426","display_name":"Nerma \u010custovi\u0107","orcid":"https://orcid.org/0000-0002-1424-1628","observed_orcids":["https://orcid.org/0000-0002-1424-1628"]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Nerma \u010custovi\u0107","raw_affiliation_strings":["Clinic for gastroenterohepatology, Clinical University Center Sarajevo. zahiragic.nerma@gmail.com","Clinic for gastroenterohepatology, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo. zahiragic.nerma@gmail.com","institution_ids":["https://openalex.org/I4210110851"]},{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033908367","display_name":"Aida Saray","orcid":"https://orcid.org/0000-0002-5436-2424","observed_orcids":["https://orcid.org/0000-0002-5436-2424"]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Aida Saray","raw_affiliation_strings":["Clinic for gastroenterohepatology, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011037080","display_name":"Samra \u0106ato-Mehmedba\u0161i\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Samra \u0106ato-Mehmedba\u0161i\u0107","raw_affiliation_strings":["Clinic for gastroenterohepatology, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054781881","display_name":"Ira Tan\u010dica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Ira Tan\u010dica","raw_affiliation_strings":["Clinic for gastroenterohepatology, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014224781","display_name":"Sanjin Spre\u010dki\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Sanjin Spre\u010dki\u0107","raw_affiliation_strings":["Clinic for gastroenterohepatology, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for gastroenterohepatology, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081434099","display_name":"Nedim Toki\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Nedim Toki\u0107","raw_affiliation_strings":["Clinic for urgent medicine, Cinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for urgent medicine, Cinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081313427","display_name":"Naida Herenda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110851","display_name":"Clinical Center University of Sarajevo","ror":"https://ror.org/019bz1656","country_code":"BA","type":"healthcare","lineage":["https://openalex.org/I4210110851"]}],"countries":["BA"],"is_corresponding":false,"raw_author_name":"Naida Herenda","raw_affiliation_strings":["Clinic for anesthesiology and reanimation, Clinical University Center Sarajevo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for anesthesiology and reanimation, Clinical University Center Sarajevo","institution_ids":["https://openalex.org/I4210110851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210110851"],"apc_list":null,"apc_paid":null,"fwci":0.1762,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43759653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"50","issue":"2","first_page":"244","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-variceal-upper-gastrointestinal-bleeding","display_name":"non-variceal upper gastrointestinal bleeding","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nsaid-induced-gastrointestinal-bleeding","display_name":"NSAID-induced gastrointestinal bleeding","score":0.6449999809265137},{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.9340000152587891},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.5740000009536743},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rebleeding","display_name":"rebleeding","score":0.8360000252723694},{"id":"https://openalex.org/keywords/endoscopic-hemostasis","display_name":"endoscopic hemostasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.871999979019165},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4490000009536743},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9646809101104736},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7288086414337158},{"id":"https://openalex.org/C2776345487","wikidata":"https://www.wikidata.org/wiki/Q3144956","display_name":"Upper gastrointestinal bleeding","level":3,"score":0.6229293942451477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5876008868217468},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.49874067306518555},{"id":"https://openalex.org/C2778080469","wikidata":"https://www.wikidata.org/wiki/Q1495657","display_name":"Gastrointestinal bleeding","level":2,"score":0.4603002667427063},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.45629429817199707},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42185765504837036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34862738847732544},{"id":"https://openalex.org/C2778451229","wikidata":"https://www.wikidata.org/wiki/Q212809","display_name":"Endoscopy","level":2,"score":0.3181743323802948},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5644/ama2006-124.340","doi":"https://doi.org/10.5644/ama2006-124.340","is_oa":true,"landing_page_url":"https://doi.org/10.5644/ama2006-124.340","pdf_url":"http://www.ama.ba/index.php/ama/article/download/459/pdf","source":{"id":"https://openalex.org/S4210201824","display_name":"Acta Medica Academica","issn_l":"1840-1848","issn":["1840-1848","1840-2879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321207","host_organization_name":"Academy of Sciences and Arts of Bosnia and Herzegovina","host_organization_lineage":["https://openalex.org/P4310321207"],"host_organization_lineage_names":["Academy of Sciences and Arts of Bosnia and Herzegovina"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Academica","raw_type":"journal-article"},{"id":"pmid:34847677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34847677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica academica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5644/ama2006-124.340","doi":"https://doi.org/10.5644/ama2006-124.340","is_oa":true,"landing_page_url":"https://doi.org/10.5644/ama2006-124.340","pdf_url":"http://www.ama.ba/index.php/ama/article/download/459/pdf","source":{"id":"https://openalex.org/S4210201824","display_name":"Acta Medica Academica","issn_l":"1840-1848","issn":["1840-1848","1840-2879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321207","host_organization_name":"Academy of Sciences and Arts of Bosnia and Herzegovina","host_organization_lineage":["https://openalex.org/P4310321207"],"host_organization_lineage_names":["Academy of Sciences and Arts of Bosnia and Herzegovina"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Medica Academica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216596398.pdf","grobid_xml":"https://content.openalex.org/works/W3216596398.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1511326335","https://openalex.org/W1994575625","https://openalex.org/W2118910625","https://openalex.org/W2119376936","https://openalex.org/W2119758634","https://openalex.org/W2121674487","https://openalex.org/W2131921164","https://openalex.org/W2408919963","https://openalex.org/W2606988815","https://openalex.org/W2766436834","https://openalex.org/W2768768110","https://openalex.org/W2773975059","https://openalex.org/W2807806060","https://openalex.org/W2905137072","https://openalex.org/W2927713450","https://openalex.org/W2942244286","https://openalex.org/W2945792041","https://openalex.org/W2972077670","https://openalex.org/W3015066528","https://openalex.org/W3106710358","https://openalex.org/W4299470449"],"related_works":["https://openalex.org/W2339221354","https://openalex.org/W1039990393","https://openalex.org/W4386019624","https://openalex.org/W2350684277","https://openalex.org/W2782746807","https://openalex.org/W4299448365","https://openalex.org/W2618556689","https://openalex.org/W2434239367","https://openalex.org/W2978640379","https://openalex.org/W2237291726"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,94,154,182],"aim":[2],"of":[3,15,42,60,96,105,132,144,152,161,170,179,190,207,227,230,248],"our":[4,122,186],"study":[5,28],"was":[6,148,166],"to":[7,33,49,185],"determine":[8],"the":[9,58,113,246],"etiological":[10],"factors,":[11,81,222],"treatment":[12,89,215],"and":[13,40,64,76,90,109,137,175,203,245],"outcome":[14],"patients":[16,31,53,97,183,217],"with":[17,38,101,188,200,218,223,238],"non-variceal":[18],"bleeding":[19,195],"from":[20,46],"upper":[21,43,193],"gastrointestinal":[22,44,61,194],"tract.":[23],"MATERIALS":[24],"AND":[25],"METHODS:":[26],"This":[27],"enrolled":[29],"200":[30],"admitted":[32,184],"Sarajevo":[34],"University":[35],"Clinical":[36,63],"Center":[37],"signs":[39],"symptoms":[41,189],"bleeding,":[45],"January":[47],"2019":[48],"July":[50],"2020.":[51],"All":[52],"had":[54,127],"undergone":[55],"gastroscopy,":[56],"confirming":[57],"cause":[59],"bleeding.":[62],"laboratory":[65,87],"data":[66],"were":[67,98,112,196],"collected":[68],"retrospectively,":[69],"including":[70],"previous":[71,124],"non-steroid":[72],"antiinflammatory":[73],"drugs":[74],"(NSAIDs)":[75],"anticoagulant":[77],"therapy,":[78,236],"comorbidities,":[79],"risk":[80,221],"as":[82,84],"well":[83],"endoscopic":[85],"findings,":[86,88],"clinical":[91],"follow-up.":[92],"RESULTS:":[93],"majority":[95],"men":[99],"(59%)":[100],"an":[102],"average":[103],"age":[104],"53\u00b16":[106],"years.":[107],"Duodenal":[108],"gastric":[110],"ulcers":[111],"most":[114],"common":[115],"cause,":[116],"followed":[117],"by":[118],"other":[119,219],"etiologies.":[120],"In":[121],"study,":[123],"NSAIDs":[125,233],"therapy":[126],"been":[128],"registered":[129],"in":[130,135,142,150,159,168,173,177,216],"29.5%":[131],"patients,":[133,171],"anticoagulants":[134],"8%,":[136],"proton":[138],"pump":[139],"inhibitors":[140],"(PPI)":[141],"2.9%":[143],"patients.":[145,153,180],"Endoscopic":[146,235],"intervention":[147],"required":[149],"34%":[151],"need":[155],"for":[156],"transfusion":[157],"occurred":[158],"44.5%":[160],"cases.":[162],"Rebleeding":[163],"during":[164,213,232],"hospitalization":[165],"observed":[167],"7.5%":[169],"mortality":[172,244],"1.5%":[174],"surgery":[176],"3%":[178],"CONCLUSION:":[181],"hospital":[187],"acute":[191],"nonvariceal":[192],"elderly,":[197],"predominantly":[198],"males,":[199],"significant":[201],"comorbidities":[202],"a":[204,224],"higher":[205],"incidence":[206],"NSAID":[208,214],"use.":[209],"Gastroprotection":[210],"is":[211],"underutilized":[212],"coexisting":[220],"low":[225],"rate":[226],"concomitant":[228],"use":[229],"PPI":[231],"therapy.":[234],"together":[237],"PPI,":[239],"significantly":[240],"reduces":[241],"rebleeding":[242],"rates,":[243],"number":[247],"emergency":[249],"surgical":[250],"interventions.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}
