{"id":"https://openalex.org/W3216569747","doi":"https://doi.org/10.1016/j.celrep.2021.110039","title":"Single-cell landscape of peripheral immune responses to fatal SFTS","display_name":"Single-cell landscape of peripheral immune responses to fatal SFTS","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3216569747","doi":"https://doi.org/10.1016/j.celrep.2021.110039","mag":"3216569747","pmid":"https://pubmed.ncbi.nlm.nih.gov/34818556"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2021.110039","doi":"https://doi.org/10.1016/j.celrep.2021.110039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110039","pdf_url":"http://www.cell.com/article/S2211124721015217/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124721015217/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348616","display_name":"Hao Li","orcid":"https://orcid.org/0000-0002-6280-267X","observed_orcids":["https://orcid.org/0000-0002-6280-267X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Li","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China. Electronic address: lihao_1986@126.com","Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","Graduate School of Anhui Medical University, Hefei 230022, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-6280-267X","affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China. Electronic address: lihao_1986@126.com","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Graduate School of Anhui Medical University, Hefei 230022, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628716","display_name":"Xiaokun Li","orcid":"https://orcid.org/0000-0001-8966-4767","observed_orcids":["https://orcid.org/0000-0001-8966-4767"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaokun Li","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-8966-4767","affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029508465","display_name":"Shou\u2010Ming Lv","orcid":"https://orcid.org/0000-0002-7478-5109","observed_orcids":["https://orcid.org/0000-0002-7478-5109"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouming Lv","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China","Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","Graduate School of Anhui Medical University, Hefei 230022, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Graduate School of Anhui Medical University, Hefei 230022, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978519","display_name":"Xue\u2010Fang Peng","orcid":"https://orcid.org/0000-0002-4817-3117","observed_orcids":["https://orcid.org/0000-0002-4817-3117"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuefang Peng","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-4817-3117","affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101658739","display_name":"Ning Cui","orcid":"https://orcid.org/0000-0003-2505-098X","observed_orcids":["https://orcid.org/0000-0003-2505-098X"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Cui","raw_affiliation_strings":["The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103090984","display_name":"Tong Yang","orcid":"https://orcid.org/0000-0002-2276-8534","observed_orcids":["https://orcid.org/0000-0002-2276-8534","https://orcid.org/0000-0003-2402-5854","https://orcid.org/0009-0001-5446-1609","https://orcid.org/0009-0007-0100-6796"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Yang","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101472899","display_name":"Zhen\u2010Dong Yang","orcid":"https://orcid.org/0000-0002-3449-3697","observed_orcids":["https://orcid.org/0000-0002-3449-3697"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhendong Yang","raw_affiliation_strings":["The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103864849","display_name":"Chun Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Yuan","raw_affiliation_strings":["The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 154 Hospital, People's Liberation Army, Xinyang 464000, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101713041","display_name":"Yang Yuan","orcid":"https://orcid.org/0000-0003-4022-0246","observed_orcids":["https://orcid.org/0000-0003-4022-0246"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yuan","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038763072","display_name":"Jiaying Yao","orcid":"https://orcid.org/0000-0003-4607-311X","observed_orcids":["https://orcid.org/0000-0003-4607-311X"]},"institutions":[{"id":"https://openalex.org/I4210132158","display_name":"Annoroad Gene Technology (China)","ror":"https://ror.org/03gyd9q58","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210132158"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaying Yao","raw_affiliation_strings":["Annoroad Gene Technology (Beijing) Co., Ltd, Beijing 100176, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annoroad Gene Technology (Beijing) Co., Ltd, Beijing 100176, P.R. China","institution_ids":["https://openalex.org/I4210132158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084826316","display_name":"Zan Yuan","orcid":"https://orcid.org/0000-0001-5582-5120","observed_orcids":["https://orcid.org/0000-0001-5582-5120"]},"institutions":[{"id":"https://openalex.org/I4210132158","display_name":"Annoroad Gene Technology (China)","ror":"https://ror.org/03gyd9q58","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210132158"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zan Yuan","raw_affiliation_strings":["Annoroad Gene Technology (Beijing) Co., Ltd, Beijing 100176, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-5582-5120","affiliations":[{"raw_affiliation_string":"Annoroad Gene Technology (Beijing) Co., Ltd, Beijing 100176, P.R. China","institution_ids":["https://openalex.org/I4210132158"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiachen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Li","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaolei Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Ye","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053202587","display_name":"Xiao\u2010Ai Zhang","orcid":"https://orcid.org/0000-0002-9505-1307","observed_orcids":["https://orcid.org/0000-0002-9505-1307"]},"institutions":[{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoai Zhang","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014455779","display_name":"Shu Zhu","orcid":"https://orcid.org/0000-0003-2919-5473","observed_orcids":["https://orcid.org/0000-0003-2919-5473"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Zhu","raw_affiliation_strings":["Key Laboratory of Animal Virology of Ministry of Agriculture, Center for Veterinary Sciences, Zhejiang University, Hangzhou 310058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Animal Virology of Ministry of Agriculture, Center for Veterinary Sciences, Zhejiang University, Hangzhou 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081728299","display_name":"Ke Peng","orcid":"https://orcid.org/0000-0003-0172-8725","observed_orcids":["https://orcid.org/0000-0003-0172-8725"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Peng","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100431895","display_name":"Wei Yong Liu","orcid":"https://orcid.org/0000-0002-9302-8170","observed_orcids":["https://orcid.org/0000-0002-9302-8170","https://orcid.org/0009-0001-6937-2430"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4405260518","display_name":"Beijing Institute of Microbiology and Epidemiology","ror":"https://ror.org/03w50ns22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4405260518"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China; School of Public Health, Peking University, Beijing 100083, P.R. China. Electronic address: liuwei@bmi.ac.cn","Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","Graduate School of Anhui Medical University, Hefei 230022, P.R. China","School of Public Health, Peking University, Beijing 100083, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China; Graduate School of Anhui Medical University, Hefei 230022, P.R. China; School of Public Health, Peking University, Beijing 100083, P.R. China. Electronic address: liuwei@bmi.ac.cn","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I20231570","https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China","institution_ids":["https://openalex.org/I4405260518"]},{"raw_affiliation_string":"Graduate School of Anhui Medical University, Hefei 230022, P.R. China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing 100083, P.R. China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100348616","https://openalex.org/A5100431895"],"corresponding_institution_ids":["https://openalex.org/I197869895","https://openalex.org/I20231570","https://openalex.org/I4405260518"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":4.2528,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.95699687,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"8","first_page":"110039","last_page":"110039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-fever-with-thrombocytopenia-syndrome","display_name":"severe fever with thrombocytopenia syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sftsv","display_name":"SFTSV","score":0.8859999775886536},{"id":"https://openalex.org/keywords/peripheral-immune-response","display_name":"peripheral immune response","score":0.7070000171661377},{"id":"https://openalex.org/keywords/intermediate-monocytes","display_name":"intermediate monocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/plasmablasts","display_name":"plasmablasts","score":0.9010000228881836},{"id":"https://openalex.org/keywords/exhausted-t-cells","display_name":"exhausted T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/viremia","display_name":"viremia","score":0.7720000147819519},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2778732662","wikidata":"https://www.wikidata.org/wiki/Q3508725","display_name":"Severe fever with thrombocytopenia syndrome","level":3,"score":0.7743920087814331},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6984063386917114},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6205149292945862},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.5232621431350708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4589693248271942},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3541267514228821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33569827675819397},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2596103549003601}],"mesh":[{"descriptor_ui":"D000085142","descriptor_name":"Severe Fever with Thrombocytopenia Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000085142","descriptor_name":"Severe Fever with Thrombocytopenia Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.celrep.2021.110039","doi":"https://doi.org/10.1016/j.celrep.2021.110039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110039","pdf_url":"http://www.cell.com/article/S2211124721015217/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:34818556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34818556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2021.110039","doi":"https://doi.org/10.1016/j.celrep.2021.110039","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.110039","pdf_url":"http://www.cell.com/article/S2211124721015217/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G455562370","display_name":null,"funder_award_id":"81825019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6676805235","display_name":null,"funder_award_id":"81722041","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G941506852","display_name":null,"funder_award_id":"2018YFE0200401","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3216569747.pdf"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W88999550","https://openalex.org/W1822172142","https://openalex.org/W1834185773","https://openalex.org/W1965251603","https://openalex.org/W1975852576","https://openalex.org/W1976249816","https://openalex.org/W1983566307","https://openalex.org/W1986802512","https://openalex.org/W2006286994","https://openalex.org/W2017405972","https://openalex.org/W2018822911","https://openalex.org/W2019731276","https://openalex.org/W2020173029","https://openalex.org/W2022339063","https://openalex.org/W2026578487","https://openalex.org/W2033300352","https://openalex.org/W2035509260","https://openalex.org/W2035618305","https://openalex.org/W2040653543","https://openalex.org/W2047340788","https://openalex.org/W2059859812","https://openalex.org/W2078646756","https://openalex.org/W2100203916","https://openalex.org/W2102300839","https://openalex.org/W2102978013","https://openalex.org/W2103612325","https://openalex.org/W2109493286","https://openalex.org/W2122137575","https://openalex.org/W2128349139","https://openalex.org/W2146073039","https://openalex.org/W2146112506","https://openalex.org/W2172081451","https://openalex.org/W2256319867","https://openalex.org/W2267114896","https://openalex.org/W2301913135","https://openalex.org/W2345987069","https://openalex.org/W2418219898","https://openalex.org/W2571989765","https://openalex.org/W2574522581","https://openalex.org/W2586264365","https://openalex.org/W2592599340","https://openalex.org/W2594688214","https://openalex.org/W2735891807","https://openalex.org/W2759977828","https://openalex.org/W2790212385","https://openalex.org/W2794480084","https://openalex.org/W2805767265","https://openalex.org/W2817838603","https://openalex.org/W2884660022","https://openalex.org/W2884802662","https://openalex.org/W2886417795","https://openalex.org/W2890671991","https://openalex.org/W2891323347","https://openalex.org/W2897945399","https://openalex.org/W2902652978","https://openalex.org/W2906918014","https://openalex.org/W2915401456","https://openalex.org/W2927565072","https://openalex.org/W2945164644","https://openalex.org/W2949177718","https://openalex.org/W2969900355","https://openalex.org/W2973861007","https://openalex.org/W2975881654","https://openalex.org/W2997364400","https://openalex.org/W3013062213","https://openalex.org/W3013093478","https://openalex.org/W3014758727","https://openalex.org/W3017290399","https://openalex.org/W3030537287","https://openalex.org/W3032995094","https://openalex.org/W3036681929","https://openalex.org/W3041278562","https://openalex.org/W3042444233","https://openalex.org/W3043659257","https://openalex.org/W3047564875","https://openalex.org/W3047880178","https://openalex.org/W3113032581","https://openalex.org/W3128961456","https://openalex.org/W3133178690","https://openalex.org/W3178786080"],"related_works":["https://openalex.org/W4409710234","https://openalex.org/W4416985942","https://openalex.org/W2738093214","https://openalex.org/W4312179817","https://openalex.org/W7131673482","https://openalex.org/W3133178690","https://openalex.org/W7155495724","https://openalex.org/W3094069203","https://openalex.org/W4285591512","https://openalex.org/W7084026743"],"abstract_inverted_index":{"Severe":[0],"fever":[1],"with":[2,11,21,30,62,76],"thrombocytopenia":[3],"syndrome":[4],"(SFTS)":[5],"is":[6,48],"an":[7,58],"emerging":[8],"infectious":[9],"disease":[10],"high":[12,102],"fatality.":[13],"Poor":[14],"prognosis":[15],"of":[16,44,66,83,115,144],"SFTS":[17,33,51,135],"has":[18],"been":[19],"associated":[20,29],"dysregulated":[22],"host":[23],"immunity;":[24],"however,":[25],"the":[26,41,81,124,141,145],"immune":[27,46,89],"patterns":[28],"pathophysiology":[31],"involving":[32],"exacerbation":[34],"remain":[35],"unclear.":[36],"Here,":[37],"we":[38],"show":[39],"that":[40],"single-cell":[42],"landscape":[43],"peripheral":[45],"responses":[47],"reprogrammed":[49],"in":[50,117,148],"and":[52,69,104,127,138,151],"characterized":[53],"by":[54],"monocyte":[55],"shift":[56],"to":[57,99,130],"intermediate":[59,125],"type":[60],"along":[61],"complement":[63],"activation,":[64],"perturbation":[65],"plasmablast":[67],"composition,":[68],"highly":[70],"exhausted":[71],"T":[72],"cells,":[73],"all":[74],"correlated":[75],"lethal":[77,152],"consequences.":[78],"We":[79],"identify":[80],"overexpression":[82],"interferon":[84],"(IFN)-stimulated":[85],"genes":[86],"across":[87],"most":[88],"cell":[90],"types":[91],"after":[92],"SFTSV":[93],"infection,":[94,137],"which":[95],"are":[96],"simultaneously":[97],"related":[98],"older":[100],"age,":[101],"viremia,":[103],"a":[105],"hyperinflammatory":[106],"response.":[107],"A":[108],"retrospective":[109],"clinical":[110],"study":[111],"reveals":[112],"no":[113],"efficiency":[114],"IFN-\u03b1":[116],"treating":[118],"SFTS.":[119,153],"These":[120],"data":[121],"collectively":[122],"support":[123],"monocytes":[126],"IFN-I-inducible":[128],"plasmablasts":[129],"be":[131],"major":[132],"targets":[133],"for":[134],"virus":[136],"they":[139],"indicate":[140],"pivotal":[142],"role":[143],"IFN-I":[146],"response":[147],"exacerbating":[149],"hyperinflammation":[150]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-06T00:00:00"}