{"id":"https://openalex.org/W3216469347","doi":"https://doi.org/10.1101/2021.07.09.451632","title":"Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress","display_name":"Dataset on the mass spectrometry-based proteomic profiling of mouse embryonic fibroblasts from a wild type and DYT-TOR1A mouse model of dystonia, basally and during stress","publication_year":2021,"publication_date":"2021-07-11","ids":{"openalex":"https://openalex.org/W3216469347","doi":"https://doi.org/10.1101/2021.07.09.451632","mag":"3216469347"},"language":"en","primary_location":{"id":"doi:10.1101/2021.07.09.451632","doi":"https://doi.org/10.1101/2021.07.09.451632","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.07.09.451632","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/11/2021.07.09.451632.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/11/2021.07.09.451632.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080532306","display_name":"Kunal Shroff","orcid":"https://orcid.org/0000-0002-3803-7517","observed_orcids":["https://orcid.org/0000-0002-3803-7517"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunal Shroff","raw_affiliation_strings":["Department of Neurology, Duke University Medical Center,"],"raw_orcid":"https://orcid.org/0000-0002-3803-7517","affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052358706","display_name":"Zachary F. Caffall","orcid":"https://orcid.org/0000-0003-4601-6799","observed_orcids":["https://orcid.org/0000-0003-4601-6799"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary F. Caffall","raw_affiliation_strings":["Department of Neurology, Duke University Medical Center,"],"raw_orcid":"https://orcid.org/0000-0003-4601-6799","affiliations":[{"raw_affiliation_string":"Department of Neurology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054443109","display_name":"Erik J. Soderblom","orcid":"https://orcid.org/0000-0002-6765-1786","observed_orcids":["https://orcid.org/0000-0002-6765-1786"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik J. Soderblom","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center,","Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,"],"raw_orcid":"https://orcid.org/0000-0002-6765-1786","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007108663","display_name":"Greg M. Waitt","orcid":"https://orcid.org/0000-0003-1306-5885","observed_orcids":["https://orcid.org/0000-0003-1306-5885"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Waitt","raw_affiliation_strings":["Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112746035","display_name":"Tricia Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tricia Ho","raw_affiliation_strings":["Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Metabolomics Core Facility, Duke Center for Genomic and Computational Biology,","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085465113","display_name":"Nicole Calakos","orcid":"https://orcid.org/0000-0002-9918-3294","observed_orcids":["https://orcid.org/0000-0002-9918-3294"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole Calakos","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center,","Department of Neurobiology, Duke University Medical Center,","Department of Neurology, Duke University Medical Center,","Duke Institute for Brain Sciences, Duke University"],"raw_orcid":"https://orcid.org/0000-0002-9918-3294","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Neurology, Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Duke Institute for Brain Sciences, Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085465113"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tor1a","display_name":"TOR1A","score":0.871999979019165},{"id":"https://openalex.org/keywords/torsina","display_name":"torsinA","score":0.984000027179718},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.972000002861023},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.8730000257492065},{"id":"https://openalex.org/keywords/subcellular-proteomics","display_name":"subcellular proteomics","score":0.8880000114440918},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9330000281333923},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.5627993941307068},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5073830485343933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49976611137390137},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4778318405151367},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4715286195278168},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.4589470624923706},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4152892231941223},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.41503381729125977},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.41008543968200684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3794262409210205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30441170930862427},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2788423001766205},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2662097215652466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2308134138584137},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.22532254457473755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18879997730255127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08358511328697205},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.073036789894104},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.07.09.451632","doi":"https://doi.org/10.1101/2021.07.09.451632","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.07.09.451632","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/11/2021.07.09.451632.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.07.09.451632","doi":"https://doi.org/10.1101/2021.07.09.451632","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.07.09.451632","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/07/11/2021.07.09.451632.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3216469347.pdf","grobid_xml":"https://content.openalex.org/works/W3216469347.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1998724633","https://openalex.org/W2013127588","https://openalex.org/W2111073993"],"related_works":["https://openalex.org/W3188425724","https://openalex.org/W2033287980","https://openalex.org/W2527724769","https://openalex.org/W2130566610","https://openalex.org/W1581376189","https://openalex.org/W422463883","https://openalex.org/W2744595098","https://openalex.org/W2118742277","https://openalex.org/W7023883717","https://openalex.org/W4376869185"],"abstract_inverted_index":{"Abstract":[0],"Here,":[1],"we":[2,27],"present":[3],"quantitative":[4],"subcellular":[5,93],"compartment-specific":[6,94],"proteomic":[7,75,95],"data":[8,89,109],"from":[9,30],"wildtype":[10],"and":[11,19,33,66,81,104,126,133,154],"DYT-TOR1A":[12,36,152],"heterozygous":[13,35],"mouse":[14,37],"embryonic":[15],"fibroblasts":[16],"(MEFs)":[17],"basally":[18,103],"following":[20],"thapsigargin":[21,51],"treatment":[22],"[1].":[23],"In":[24,135],"this":[25,140],"experiment,":[26],"generated":[28],"MEFs":[29],"wild":[31],"type":[32],"a":[34,98],"model":[38,100],"of":[39,119,162,165],"dystonia.":[40,166],"Subsequently,":[41],"these":[42],"MEF":[43],"cultures":[44],"were":[45,62],"treated":[46],"with":[47],"either":[48],"1":[49],"\u03bcM":[50],"or":[52],"dimethylsulfoxide":[53],"vehicle":[54],"for":[55],"six":[56],"hours.":[57],"Following":[58],"treatment,":[59],"the":[60,117,121,137,149,155,163],"cells":[61],"fractionated":[63],"into":[64],"nuclear":[65],"cytosolic":[67],"fractions.":[68],"Liquid":[69],"chromatography,":[70],"tandem":[71],"mass":[72],"spectrometry":[73],"(LC/MS/MS)-based":[74],"profiling":[76],"identified":[77],"65,056":[78],"unique":[79,83],"peptides":[80],"4801":[82],"proteins":[84],"across":[85],"all":[86],"samples.":[87],"The":[88],"presented":[90],"here":[91],"provide":[92],"information":[96,138],"within":[97],"dystonia":[99,153],"system":[101],"both":[102],"under":[105],"cellular":[106,156],"stress.":[107],"These":[108],"can":[110,142],"inform":[111,144],"future":[112,145],"experiments":[113],"focused":[114],"on":[115],"studying":[116],"function":[118],"TorsinA,":[120],"protein":[122],"encoded":[123],"by":[124],"TOR1A,":[125],"its":[127],"potential":[128],"role":[129],"in":[130,139],"nucleocytoplasmic":[131],"transport":[132],"proteostasis.":[134],"addition,":[136],"article":[141],"also":[143],"mechanistic":[146],"studies":[147],"investigating":[148],"relationship":[150],"between":[151],"stress":[157],"response":[158],"to":[159],"advance":[160],"understanding":[161],"pathogenesis":[164]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-06T00:00:00"}
