{"id":"https://openalex.org/W3216436780","doi":"https://doi.org/10.1039/d1fo02932k","title":"Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2","display_name":"Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2","publication_year":2021,"publication_date":"2021-11-23","ids":{"openalex":"https://openalex.org/W3216436780","doi":"https://doi.org/10.1039/d1fo02932k","mag":"3216436780","pmid":"https://pubmed.ncbi.nlm.nih.gov/34881772"},"language":"en","primary_location":{"id":"doi:10.1039/d1fo02932k","doi":"https://doi.org/10.1039/d1fo02932k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1fo02932k","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & Function","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035580389","display_name":"Tingting Huang","orcid":"https://orcid.org/0000-0002-9747-7969","observed_orcids":["https://orcid.org/0000-0002-9747-7969"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting-Ting Huang","raw_affiliation_strings":["Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061813020","display_name":"Pan\u2010Pan Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan-Pan Gu","raw_affiliation_strings":["Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ting Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zheng","raw_affiliation_strings":["Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013155060","display_name":"Lingshan Gou","orcid":"https://orcid.org/0000-0001-6496-7569","observed_orcids":["https://orcid.org/0000-0001-6496-7569"]},"institutions":[{"id":"https://openalex.org/I4210148003","display_name":"Maternal and Child Health Hospital of Xuzhou","ror":"https://ror.org/05nfdhr48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Shan Gou","raw_affiliation_strings":["Center for Genetic Medicine, Xuzhou Maternity and Child Health Care Hospital, Xuzhou 221009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genetic Medicine, Xuzhou Maternity and Child Health Care Hospital, Xuzhou 221009, Jiangsu, China","institution_ids":["https://openalex.org/I4210148003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054533319","display_name":"Yao\u2010Wu Liu","orcid":"https://orcid.org/0000-0002-4203-1943","observed_orcids":["https://orcid.org/0000-0002-4203-1943"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao-Wu Liu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-4203-1943","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054533319"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":null,"apc_paid":null,"fwci":1.2296,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.74490305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"242","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/tas2r14","display_name":"TAS2R14","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bitter-taste-receptors","display_name":"bitter taste receptors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1-secretion","display_name":"glucagon-like peptide-1 secretion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/enteroendocrine-cells","display_name":"enteroendocrine cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8669999837875366},{"id":"https://openalex.org/keywords/phospholipase-c-beta2","display_name":"PLC\u03b22","score":0.8629999756813049},{"id":"https://openalex.org/keywords/trpm5","display_name":"TRPM5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hesperetin","display_name":"hesperetin","score":0.902999997138977},{"id":"https://openalex.org/keywords/flufenamic-acid","display_name":"flufenamic acid","score":0.9039999842643738},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.9204803705215454},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5173856019973755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.504468560218811},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.5017287731170654},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4175166189670563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3479664921760559},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33436378836631775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32313936948776245},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3129578232765198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2785809636116028},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000098706","descriptor_name":"Taste Receptors, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019858","descriptor_name":"Enteroendocrine Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019858","descriptor_name":"Enteroendocrine Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/d1fo02932k","doi":"https://doi.org/10.1039/d1fo02932k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d1fo02932k","pdf_url":null,"source":{"id":"https://openalex.org/S2483688756","display_name":"Food & Function","issn_l":"2042-6496","issn":["2042-6496","2042-650X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & Function","raw_type":"journal-article"},{"id":"pmid:34881772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34881772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & function","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327794","display_name":"Qinglan Project of Jiangsu Province of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1620010871","https://openalex.org/W1945952457","https://openalex.org/W1969104991","https://openalex.org/W1970509678","https://openalex.org/W1986131583","https://openalex.org/W2004813627","https://openalex.org/W2033389722","https://openalex.org/W2043397734","https://openalex.org/W2059117845","https://openalex.org/W2064683678","https://openalex.org/W2066520363","https://openalex.org/W2070578985","https://openalex.org/W2084948079","https://openalex.org/W2086339199","https://openalex.org/W2122168617","https://openalex.org/W2137311570","https://openalex.org/W2193087033","https://openalex.org/W2252903298","https://openalex.org/W2330721994","https://openalex.org/W2340720529","https://openalex.org/W2585049727","https://openalex.org/W2588391494","https://openalex.org/W2607559883","https://openalex.org/W2742044309","https://openalex.org/W2784437722","https://openalex.org/W2801549604","https://openalex.org/W2894181382","https://openalex.org/W2914227154","https://openalex.org/W2937307872","https://openalex.org/W2957879476","https://openalex.org/W2982372586","https://openalex.org/W3033092906","https://openalex.org/W3113198786","https://openalex.org/W3127887955"],"related_works":["https://openalex.org/W4415786232","https://openalex.org/W2784437722","https://openalex.org/W3032377249","https://openalex.org/W4320493437","https://openalex.org/W2396234369","https://openalex.org/W2132706955","https://openalex.org/W7222880226","https://openalex.org/W2193087033","https://openalex.org/W3174694152","https://openalex.org/W3113198786"],"abstract_inverted_index":{"Piperine":[0,67],"is":[1,12],"reported":[2],"to":[3],"ameliorate":[4],"common":[5],"metabolic":[6,241],"diseases,":[7],"however,":[8],"its":[9,124],"molecular":[10],"mechanism":[11],"still":[13],"unclear.":[14],"In":[15,165,209],"the":[16,38,42,84,99,111,120,143,166,177,188,199,217,224,238],"present":[17],"study,":[18],"we":[19],"examined":[20],"whether":[21],"piperine":[22,102,173,215,236],"could":[23],"stimulate":[24],"glucagon-like":[25],"peptide-1":[26],"(GLP-1)":[27],"secretion":[28,161,201,219],"in":[29,58,94,162,202,237],"a":[30,72,134,146,154,168,233],"human":[31,45],"enteroendocrine":[32,221],"cell":[33],"line,":[34],"Caco-2,":[35],"and":[36,65,68,81,103,114,119,133,174,181,193],"explored":[37],"potential":[39,137],"mechanisms":[40],"from":[41,220],"activation":[43,225],"of":[44,91,117,123,191,226,235,240],"bitter":[46],"taste":[47],"receptors":[48],"(TAS2Rs).":[49],"It":[50],"was":[51,55,231],"found":[52],"that":[53,214],"TAS2R14":[54,74,106,185,206,227,230],"highly":[56],"expressed":[57],"Caco-2":[59,95,163,203],"cells,":[60],"far":[61],"more":[62],"than":[63],"TAS2R4":[64],"TAS2R10.":[66],"flufenamic":[69],"acid":[70],"(FA,":[71],"known":[73],"agonist)":[75],"markedly":[76],"increased":[77,112,198],"intracellular":[78,178],"calcium":[79,179],"mobilization":[80,180],"significantly":[82,171],"enhanced":[83],"GLP-1":[85,160,182,200,218],"secretion,":[86],"accompanied":[87],"by":[88,110,205],"elevated":[89],"levels":[90,116],"proglucagon":[92],"mRNA":[93,113],"cells":[96,204,222],"compared":[97],"with":[98],"control.":[100],"Moreover,":[101,229],"FA":[104,175],"activated":[105],"signaling":[107],"as":[108,195,197],"evidenced":[109],"protein":[115,121,148],"TAS2R14,":[118],"expression":[122],"downstream":[125],"key":[126],"molecules":[127],"including":[128],"phospholipase":[129],"C":[130],"\u03b22":[131],"(PLC\u03b22)":[132],"transient":[135],"receptor":[136],"channel":[138],"melastatin":[139],"5":[140],"(TRPM5).":[141],"On":[142],"other":[144],"hand,":[145],"G":[147],"\u03b2\u03b3":[149],"subunit":[150],"inhibitor":[151,156],"Gallein":[152],"or":[153],"PLC":[155],"U73122":[157],"alleviated":[158],"piperine-stimulated":[159],"cells.":[164],"meantime,":[167],"flavanone":[169],"hesperetin":[170],"attenuated":[172],"induced":[176],"secretion.":[183],"Furthermore,":[184],"knockdown":[186],"reversed":[187],"piperine-triggered":[189],"up-regulation":[190],"PLC\u03b22":[192],"TRPM5":[194],"well":[196],"shRNA":[207],"transfection.":[208],"summary,":[210],"our":[211],"findings":[212],"demonstrated":[213],"promoted":[216],"through":[223],"signaling.":[228],"likely":[232],"target":[234],"alleviation":[239],"diseases.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}