{"id":"https://openalex.org/W3215972790","doi":"https://doi.org/10.1002/cpdd.1042","title":"Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS\u20105 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip","display_name":"Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS\u20105 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip","publication_year":2021,"publication_date":"2021-12-02","ids":{"openalex":"https://openalex.org/W3215972790","doi":"https://doi.org/10.1002/cpdd.1042","mag":"3215972790","pmid":"https://pubmed.ncbi.nlm.nih.gov/34859612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9299907"},"language":"en","primary_location":{"id":"doi:10.1002/cpdd.1042","doi":"https://doi.org/10.1002/cpdd.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.1042","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.1042","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.1042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087087882","display_name":"Ellen van der Aar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85459889","display_name":"Galapagos (Belgium)","ror":"https://ror.org/04e4j5d46","country_code":"BE","type":"company","lineage":["https://openalex.org/I85459889"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ellen van der Aar","raw_affiliation_strings":["Galapagos NV, Mechelen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos NV, Mechelen, Belgium","institution_ids":["https://openalex.org/I85459889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031100965","display_name":"Henri Deckx","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85459889","display_name":"Galapagos (Belgium)","ror":"https://ror.org/04e4j5d46","country_code":"BE","type":"company","lineage":["https://openalex.org/I85459889"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Henri Deckx","raw_affiliation_strings":["Galapagos NV, Mechelen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos NV, Mechelen, Belgium","institution_ids":["https://openalex.org/I85459889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064792387","display_name":"Sonia Dupont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112084","display_name":"Galapagos (France)","ror":"https://ror.org/023bt3h76","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210112084","https://openalex.org/I85459889"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sonia Dupont","raw_affiliation_strings":["Galapagos SASU, Romainville, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos SASU, Romainville, France","institution_ids":["https://openalex.org/I4210112084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000608047","display_name":"Ann M. Fieuw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85459889","display_name":"Galapagos (Belgium)","ror":"https://ror.org/04e4j5d46","country_code":"BE","type":"company","lineage":["https://openalex.org/I85459889"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ann Fieuw","raw_affiliation_strings":["Galapagos NV, Mechelen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos NV, Mechelen, Belgium","institution_ids":["https://openalex.org/I85459889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007151550","display_name":"Stephane Delage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112084","display_name":"Galapagos (France)","ror":"https://ror.org/023bt3h76","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210112084","https://openalex.org/I85459889"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephane Delage","raw_affiliation_strings":["Galapagos SASU, Romainville, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos SASU, Romainville, France","institution_ids":["https://openalex.org/I4210112084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082334117","display_name":"Staffan Larsson","orcid":"https://orcid.org/0000-0001-8626-9892","observed_orcids":["https://orcid.org/0000-0001-8626-9892"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Staffan Larsson","raw_affiliation_strings":["Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007044951","display_name":"Andr\u00e9 Struglics","orcid":"https://orcid.org/0000-0003-4289-1393","observed_orcids":["https://orcid.org/0000-0003-4289-1393"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Struglics","raw_affiliation_strings":["Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040064633","display_name":"Stefan L. Lohmander","orcid":"https://orcid.org/0000-0002-5424-9448","observed_orcids":["https://orcid.org/0000-0002-5424-9448"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Stefan Lohmander","raw_affiliation_strings":["Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Agnes Lalande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Agnes Lalande","raw_affiliation_strings":["Institut de Recherches Internationales Servier (I.R.I.S.), Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier (I.R.I.S.), Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059684532","display_name":"Emilie Leroux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Leroux","raw_affiliation_strings":["Institut de Recherches Internationales Servier (I.R.I.S.), Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier (I.R.I.S.), Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029640760","display_name":"David Amantini","orcid":"https://orcid.org/0000-0002-6758-1861","observed_orcids":["https://orcid.org/0000-0002-6758-1861"]},"institutions":[{"id":"https://openalex.org/I4210112084","display_name":"Galapagos (France)","ror":"https://ror.org/023bt3h76","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210112084","https://openalex.org/I85459889"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Amantini","raw_affiliation_strings":["Galapagos SASU, Romainville, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos SASU, Romainville, France","institution_ids":["https://openalex.org/I4210112084"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051130571","display_name":"Paul C. C. M. Passier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112084","display_name":"Galapagos (France)","ror":"https://ror.org/023bt3h76","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210112084","https://openalex.org/I85459889"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Paul Passier","raw_affiliation_strings":["Galapagos SASU, Romainville, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos SASU, Romainville, France","institution_ids":["https://openalex.org/I4210112084"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051130571"],"corresponding_institution_ids":["https://openalex.org/I4210112084"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":2.8135,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91757433,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"112","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hip-osteoarthritis","display_name":"hip osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7829999923706055},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8694375157356262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8479857444763184},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7778481245040894},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7621117830276489},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6042764782905579},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5639674067497253},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5358826518058777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45428135991096497},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4365174174308777},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.42004820704460144},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4161824584007263},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.14966338872909546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06744891405105591},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071116","descriptor_name":"ADAMTS5 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cpdd.1042","doi":"https://doi.org/10.1002/cpdd.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.1042","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.1042","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},{"id":"pmid:34859612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34859612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology in drug development","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9299907","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9299907/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Pharmacol Drug Dev","raw_type":"Text"},{"id":"pmh:oai:lup.lub.lu.se:5c1bddfb-908e-42ed-b2fc-cb945bc606dc","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/5c1bddfb-908e-42ed-b2fc-cb945bc606dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2160-763X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/cpdd.1042","doi":"https://doi.org/10.1002/cpdd.1042","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.1042","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.1042","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3215972790.pdf","grobid_xml":"https://content.openalex.org/works/W3215972790.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1550771087","https://openalex.org/W1564232667","https://openalex.org/W1973897421","https://openalex.org/W1975459324","https://openalex.org/W1985608961","https://openalex.org/W1999589417","https://openalex.org/W2009387483","https://openalex.org/W2010404343","https://openalex.org/W2011227409","https://openalex.org/W2012899141","https://openalex.org/W2041173066","https://openalex.org/W2048045857","https://openalex.org/W2064288407","https://openalex.org/W2065039443","https://openalex.org/W2105603468","https://openalex.org/W2122751744","https://openalex.org/W2155436317","https://openalex.org/W2163757047","https://openalex.org/W2209192783","https://openalex.org/W2481203471","https://openalex.org/W2607492135","https://openalex.org/W3138848014","https://openalex.org/W3202319164"],"related_works":["https://openalex.org/W2807978322","https://openalex.org/W2799901656","https://openalex.org/W3153974659","https://openalex.org/W3020658774","https://openalex.org/W2607492135","https://openalex.org/W3036792044","https://openalex.org/W3035112410","https://openalex.org/W3138848014","https://openalex.org/W3202319164","https://openalex.org/W2754254319"],"abstract_inverted_index":{"GLPG1972/S201086":[0],"is":[1],"a":[2,45,182],"disintegrin":[3],"and":[4,24,53,57,98,118,142,158,179,228],"metalloproteinase":[5],"with":[6,101,160,162,181,200],"thrombospondin":[7],"motif-5":[8],"(ADAMTS-5)":[9],"inhibitor":[10],"in":[11,35,72,96,139],"development":[12],"as":[13],"an":[14],"osteoarthritis":[15,102],"disease-modifying":[16],"therapy.":[17],"We":[18],"report":[19],"the":[20,220],"safety,":[21],"tolerability,":[22],"pharmacokinetics,":[23],"pharmacodynamics":[25],"(turnover":[26],"of":[27,33,48,87,137,151,188,198,209,241],"plasma/serum":[28],"ARGS-aggrecan":[29],"neoepitope":[30],"fragments":[31],"[ARGS])":[32],"GLPG1972":[34,71,88,138,152,168,210,242,265],"3":[36],"randomized,":[37],"double-blind,":[38],"placebo-controlled":[39],"phase":[40],"1":[41],"trials.":[42],"Study":[43,79,107],"A,":[44],"first-in-human":[46],"trial":[47],"single":[49,110],"(\u22642100":[50],"mg":[51,55,60,90,116,122,127,208],"[fasted]":[52],"300":[54,115,126,207],"[fed])":[56],"multiple":[58,82,119],"(\u22641050":[59],"once":[61,91,123,128],"daily":[62,92,129],"[fed];":[63,93,130],"14":[64,131],"days)":[65,132],"ascending":[66,83,133],"oral":[67,84,134],"(solution)":[68],"doses,":[69],"investigated":[70,81,109],"healthy":[73,140,156],"men":[74,144],"(N":[75,103,145],"=":[76,104,146],"41;":[77],"NCT02612246).":[78],"B":[80],"(tablet)":[85,135],"doses":[86,136,262],"(\u2264300":[89],"4":[94,177],"weeks)":[95],"male":[97],"female":[99],"participants":[100,157,159],"30;":[105],"NCT03311009).":[106],"C":[108],"(Japanese:":[111],"\u22641500":[112],"mg;":[113],"White:":[114],"[fasted])":[117],"(Japanese,":[120],"\u22641050":[121],"daily;":[124],"White,":[125],"Japanese":[141],"White":[143],"88).":[147],"The":[148],"pharmacokinetic":[149],"profile":[150],"was":[153,169,193,245,266],"similar":[154,236],"between":[155,216,237],"osteoarthritis,":[161],"low":[163,246],"to":[164,174,230],"moderate":[165],"interindividual":[166],"variability.":[167],"rapidly":[170],"absorbed":[171],"(median":[172],"time":[173,229,258],"maximum":[175,231],"concentration,":[176],"hours),":[178],"eliminated":[180],"mean":[183],"apparent":[184],"terminal":[185],"elimination":[186],"half-life":[187],"\u224810":[189],"hours.":[190],"Steady":[191],"state":[192],"achieved":[194],"within":[195],"2":[196],"days":[197],"dosing,":[199],"minimal":[201],"accumulation.":[202],"Steady-state":[203],"plasma":[204,221],"exposure":[205],"after":[206],"showed":[211],"no":[212],"or":[213],"minor":[214],"differences":[215],"populations.":[217],"Area":[218],"under":[219],"concentration-time":[222],"curve":[223],"(56.8-67.6":[224],"\u03bcg":[225],"\u00b7":[226],"h/mL)":[227],"concentration":[232],"(4":[233],"hours)":[234,244],"were":[235],"studies.":[238],"Urinary":[239],"excretion":[240],"(24":[243],"(<11%).":[247],"Multiple":[248],"dosing":[249],"significantly":[250],"reduced":[251],"ARGS":[252],"levels":[253],"vs":[254,263],"baseline":[255],"at":[256,270],"all":[257,261,271],"points":[259],"for":[260],"placebo.":[264],"generally":[267],"well":[268],"tolerated":[269],"doses.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}