{"id":"https://openalex.org/W3215865645","doi":"https://doi.org/10.1182/blood-2021-148625","title":"Fractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy Provides Very Good Outcome in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: First Results from the EWALL-INO Study","display_name":"Fractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy Provides Very Good Outcome in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: First Results from the EWALL-INO Study","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3215865645","doi":"https://doi.org/10.1182/blood-2021-148625","mag":"3215865645"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-148625","doi":"https://doi.org/10.1182/blood-2021-148625","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-148625","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036207495","display_name":"Patrice Chevallier","orcid":"https://orcid.org/0000-0003-3142-5581","observed_orcids":["https://orcid.org/0000-0003-3142-5581"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Chevallier","raw_affiliation_strings":["Department of Clinical Hematology, Nantes University Hospital, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Nantes University Hospital, Nantes, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019508950","display_name":"Thibault Leguay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thibault Leguay","raw_affiliation_strings":["Bordeaux University Hospital, Pessac, FRA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bordeaux University Hospital, Pessac, FRA","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042672780","display_name":"Michael Doubek","orcid":"https://orcid.org/0000-0002-1269-6282","observed_orcids":["https://orcid.org/0000-0002-1269-6282"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210102302","display_name":"University Hospital Brno","ror":"https://ror.org/00qq1fp34","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210102302"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michael Doubek","raw_affiliation_strings":["Department of Internal Medicine - Hematology and Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine - Hematology and Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261","https://openalex.org/I4210102302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004066423","display_name":"Fran\u00e7oise Huguet","orcid":"https://orcid.org/0000-0002-9576-8578","observed_orcids":["https://orcid.org/0000-0002-9576-8578","https://orcid.org/0000-0002-5302-5784"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francoise Huguet","raw_affiliation_strings":["Department of Hematology, Institut Universitaire du Cancer-Oncopole CHU de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institut Universitaire du Cancer-Oncopole CHU de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013446879","display_name":"Cyril \u0160\u00e1lek","orcid":"https://orcid.org/0000-0002-0021-3247","observed_orcids":["https://orcid.org/0000-0002-0021-3247"]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Cyril Salek","raw_affiliation_strings":["Institute of Hematology and Blood Transfusion, Prague, CZE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology and Blood Transfusion, Prague, CZE","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086254154","display_name":"Aur\u00e9lie Cabannes\u2010Hamy","orcid":"https://orcid.org/0000-0002-6064-3783","observed_orcids":["https://orcid.org/0000-0002-6064-3783"]},"institutions":[{"id":"https://openalex.org/I4210159263","display_name":"Centre Hospitalier de Versailles","ror":"https://ror.org/053evvt91","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lie Cabannes","raw_affiliation_strings":["Hematology and Oncology department, Centre Hospitalier de Versailles, Le Chesnay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology department, Centre Hospitalier de Versailles, Le Chesnay, France","institution_ids":["https://openalex.org/I4210159263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087038443","display_name":"Ulla Wartiovaara\u2010Kautto","orcid":"https://orcid.org/0000-0002-2803-2712","observed_orcids":["https://orcid.org/0000-0002-2803-2712"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ulla Wartiovaara-Kautto","raw_affiliation_strings":["Helsinki University Hospital, Helsinki University, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Helsinki University, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054012129","display_name":"Colombe Saillard","orcid":"https://orcid.org/0000-0002-3984-5612","observed_orcids":["https://orcid.org/0000-0002-3984-5612"]},"institutions":[{"id":"https://openalex.org/I4210150365","display_name":"Institut Paoli-Calmettes","ror":"https://ror.org/04s3t1g37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210150365"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Colombe Saillard","raw_affiliation_strings":["Institut Paoli Calmettes, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Paoli Calmettes, Marseille, France","institution_ids":["https://openalex.org/I4210150365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064103067","display_name":"Emmanuel Raffoux","orcid":"https://orcid.org/0000-0003-3925-7391","observed_orcids":["https://orcid.org/0000-0003-3925-7391"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4405261462","display_name":"Laboratoire d'h\u00e9matologie","ror":"https://ror.org/05b9w4n89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4405261462"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Raffoux","raw_affiliation_strings":["H\u00e9matologie clinique, H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9matologie clinique, H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610","https://openalex.org/I4405261462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080661528","display_name":"Thomas Cluzeau","orcid":"https://orcid.org/0000-0002-6745-1127","observed_orcids":["https://orcid.org/0000-0002-6745-1127"]},"institutions":[{"id":"https://openalex.org/I3018988418","display_name":"Centre Hospitalier Universitaire de Nice","ror":"https://ror.org/05qsjq305","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Cluzeau","raw_affiliation_strings":["Department of Clinical Hematology, CHU De Nice, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, CHU De Nice, Nice, France","institution_ids":["https://openalex.org/I3018988418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045965285","display_name":"St\u00e9phane Lepr\u00eatre","orcid":"https://orcid.org/0000-0003-4282-2160","observed_orcids":["https://orcid.org/0000-0003-4282-2160"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152093","display_name":"Centre Henri Becquerel","ror":"https://ror.org/00whhby07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387152093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Lepr\u00eatre","raw_affiliation_strings":["Inserm U1245 and Department of Hematology, Centre Henri Becquerel and Normandie Univ UNIROUEN, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1245 and Department of Hematology, Centre Henri Becquerel and Normandie Univ UNIROUEN, Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387152093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010632074","display_name":"Marie Balsat","orcid":"https://orcid.org/0000-0003-2973-6751","observed_orcids":["https://orcid.org/0000-0003-2973-6751"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Balsat","raw_affiliation_strings":["Service Hematologie, Centre Hospitalier Lyon Sud, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service Hematologie, Centre Hospitalier Lyon Sud, Lyon, France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065029786","display_name":"Anna Berceanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087978","display_name":"Centre Hospitalier Universitaire de Besan\u00e7on","ror":"https://ror.org/0084te143","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210087978"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anna Berceanu","raw_affiliation_strings":["Department of Clinical Hematology, Besan\u00e7on University Hospital, Besan\u00e7on, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Besan\u00e7on University Hospital, Besan\u00e7on, France","institution_ids":["https://openalex.org/I4210087978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076973611","display_name":"Nicolas Boissel","orcid":"https://orcid.org/0000-0003-2091-7927","observed_orcids":["https://orcid.org/0000-0003-2091-7927"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Boissel","raw_affiliation_strings":["St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023619034","display_name":"Emmanuelle Clappier","orcid":"https://orcid.org/0000-0001-7098-092X","observed_orcids":["https://orcid.org/0000-0001-7098-092X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086835","display_name":"G\u00e9nomes, biologie cellulaire et th\u00e9rapeutiques","ror":"https://ror.org/002fxfq97","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I204730241","https://openalex.org/I4210086835","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Clappier","raw_affiliation_strings":["Hematology Laboratory and INSERM U944, Hopital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Laboratory and INSERM U944, Hopital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210086835","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041625281","display_name":"Laure Morisset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159263","display_name":"Centre Hospitalier de Versailles","ror":"https://ror.org/053evvt91","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laure Morisset","raw_affiliation_strings":["Clinical research department, Centre Hospitalier de Versailles, Le Chesnay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical research department, Centre Hospitalier de Versailles, Le Chesnay, France","institution_ids":["https://openalex.org/I4210159263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054745373","display_name":"Claude Gardin","orcid":"https://orcid.org/0000-0001-9934-3748","observed_orcids":["https://orcid.org/0000-0001-9934-3748"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210129146","display_name":"H\u00f4pital Avicenne","ror":"https://ror.org/03n6vs369","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Gardin","raw_affiliation_strings":["Hematology, Avicenne Hospital, APHP, University Paris XIII, Bobigny, France, Bobigny, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Avicenne Hospital, APHP, University Paris XIII, Bobigny, France, Bobigny, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210129146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000436961","display_name":"Herv\u00e9 Dombret","orcid":"https://orcid.org/0000-0002-5454-6768","observed_orcids":["https://orcid.org/0000-0002-5454-6768","https://orcid.org/0000-0003-4824-3880"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4403386472","display_name":"Recherche clinique appliqu\u00e9e \u00e0 l'h\u00e9matologie","ror":"https://ror.org/01df79331","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386472"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Dombret","raw_affiliation_strings":["Division of Hematology, EA3518 Saint-Louis Institute for Research, H\u00f4pital Saint-Louis, APHP, University of Paris, Paris, France, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, EA3518 Saint-Louis Institute for Research, H\u00f4pital Saint-Louis, APHP, University of Paris, Paris, France, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210144610","https://openalex.org/I4403386472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052564121","display_name":"Philippe H. Rousselot","orcid":"https://orcid.org/0000-0003-3238-4494","observed_orcids":["https://orcid.org/0000-0003-3238-4494"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210159263","display_name":"Centre Hospitalier de Versailles","ror":"https://ror.org/053evvt91","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Rousselot","raw_affiliation_strings":["Department of Hematology and Oncology, Centre Hospitalier de Versailles, INSERM UMR 1184, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Universit\u00e9 Paris Saclay, Le Chesnay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Centre Hospitalier de Versailles, INSERM UMR 1184, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Universit\u00e9 Paris Saclay, Le Chesnay, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210159263"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":25,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"511","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd22","display_name":"CD22","score":0.6970000267028809},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7739999890327454},{"id":"https://openalex.org/keywords/dose-fractionation","display_name":"dose fractionation","score":0.722000002861023},{"id":"https://openalex.org/keywords/low-intensity-chemotherapy","display_name":"low-intensity chemotherapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hyper-cvad","display_name":"hyper-CVAD","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.5809999704360962},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intrathecal-chemotherapy","display_name":"intrathecal chemotherapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hepatic-veno-occlusive-disease","display_name":"veno-occlusive disease","score":0.7580000162124634},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5440000295639038},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.5929999947547913},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7812792658805847},{"id":"https://openalex.org/C2778245361","wikidata":"https://www.wikidata.org/wiki/Q409744","display_name":"Calicheamicin","level":3,"score":0.7690431475639343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5275639891624451},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4507468044757843},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.4395976960659027},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4369763135910034},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4155419170856476},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.41383475065231323},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40112775564193726},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.36126285791397095},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35607200860977173},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3522590398788452},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-148625","doi":"https://doi.org/10.1182/blood-2021-148625","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-148625","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310117799","https://openalex.org/W4403508383","https://openalex.org/W3044484405","https://openalex.org/W2560689199","https://openalex.org/W2907228074","https://openalex.org/W4310107744","https://openalex.org/W2212861725","https://openalex.org/W4385667205","https://openalex.org/W4241421077","https://openalex.org/W3095861981"],"abstract_inverted_index":{"Abstract":[0],"On":[1],"behalf":[2],"of":[3,22,52,94,102,138,200,218,245,273,309,327,343,428,433,447,489,520,543,590,612],"the":[4,7,12,17,50,62,76,95,100,104,134,179,230,431,434,473,670,693],"GRAALL":[5],"group,":[6,11],"Czech":[8],"Republic":[9],"ALL":[10,14],"Finland":[13],"group":[15],"and":[16,136,193,224,235,261,281,324,332,352,358,377,385,399,406,456,482,530,546,552,561,576,578,609,624,643,684,701,733],"EWALL":[18,180],"group.":[19,181],"Introduction.":[20],"Treatment":[21,555],"older":[23,83,154,739],"patients":[24,740],"(pts)":[25],"with":[26,67,89,147,156,270,296,498,726,741],"B-cell":[27,873],"precursor":[28,874],"acute":[29,875],"lymphoblastic":[30,876],"leukemia":[31,877],"(BCP-ALL)":[32],"remains":[33],"an":[34,41],"unmet":[35],"medical":[36],"need.":[37],"Inotuzumab":[38,861],"ozogamicin":[39,719,862],"(INO),":[40],"anti-CD22":[42],"antibody":[43],"conjugated":[44],"to":[45,99,132,178,289,318,339,348,381,454,507,516,586,616,638,680],"calicheamicin,":[46],"is":[47,164,468,729],"approved":[48],"for":[49,112,153,513,533,738],"treatment":[51],"relapsed/refractory":[53],"BCP-ALL":[54,205],"in":[55,78,87,145,174,237,291,335,665,867],"adults,":[56],"sinusoidal":[57],"obstruction":[58],"syndrome":[59],"(SOS)":[60],"being":[61],"major":[63],"adverse":[64,704],"event":[65],"associated":[66],"INO.":[68,448],"A":[69],"previous":[70],"first":[71,502,864],"line":[72,865],"study":[73,172,467,671],"conducted":[74,173],"by":[75,116,409,451,583],"MDACC":[77],"pts":[79,155,185,290,440,462,487,497,505,535,548,580,598,626,631,667,674,690],"60":[80],"years":[81,538],"or":[82,188,198,293,303,369],"successfully":[84],"used":[85],"INO":[86,140,274,328,613,681],"combination":[88,146],"a":[90,142,165,212,225,410,518,587,730],"lower":[91],"intensity":[92],"version":[93],"hyper-CVAD":[96],"(mini-hyper-CVD).":[97],"Due":[98],"occurrence":[101],"SOS,":[103,677],"total":[105],"doses":[106,722],"were":[107,184,337,450,493,511,581,614,632],"fixed":[108],"at":[109,119,141,424,430,443,470,720],"1.3":[110],"mg/m\u00b2":[111,121,276,279,316,330,389,393,402],"cycle":[113],"1":[114,120,357,368,445,746],"followed":[115,408],"3":[117,271,405,426,607,673],"cycles":[118,356,383,404],"(Kantarjian":[122],"H":[123],"et":[124],"al.":[125],"Lancet":[126],"Oncol,":[127],"2018).":[128],"Here,":[129],"we":[130],"aimed":[131],"assess":[133],"activity":[135],"safety":[137],"fractionated":[139],"reduced":[143,721],"dosage":[144],"low-intensity":[148,727],"chemotherapy":[149,728],"as":[150,304,863],"frontline":[151,736],"therapy":[152,737,866],"CD22+":[157,196,742,870],"Philadelphia":[158,871],"chromosome-negative":[159,872],"(Ph-neg)":[160],"BCP-ALL.":[161,744],"Methods.":[162],"EWALL-INO":[163],"single":[166,226],"arm":[167],"prospective":[168],"phase":[169],"2":[170,238,251,325,370,384,617,622,678],"multicentric":[171],"European":[175],"centers":[176],"belonging":[177],"Eligibility":[182],"criteria":[183],"aged":[186],"55y":[187],"older,":[189],"performance":[190],"status":[191],"\u22642,":[192],"newly":[194,868],"diagnosed":[195,869],"(20%":[197],"more":[199],"positive":[201],"blast":[202],"cells)":[203],"Ph-neg":[204,743],"without":[206],"central":[207],"nervous":[208],"system":[209],"involvement.":[210],"After":[211],"prephase":[213],"including":[214,495,672,709],"5":[215,579,610],"days":[216],"(D)":[217],"dexamethasone":[219],"(DEX)":[220],"10mg":[221],"per":[222],"D":[223],"intrathecal":[227],"injection":[228],"(IT),":[229],"induction":[231],"regimen":[232],"was":[233,287,421,439,526,536,558,564,636,646,653,663],"begun":[234],"split":[236],"parts.":[239],"Induction":[240,283],"part":[241,284],"I":[242],"(Induc1)":[243],"consisted":[244,308],"one":[246,320,373,395,685,710],"triple":[247,321,374,396],"IT,":[248],"vincristine":[249],"(VCR)":[250],"mg":[252,254,264,371],"(1":[253],"over":[255,364],"70y)":[256],"D1":[257,317,331,380],"D8":[258,280],"D15":[259],"D22":[260],"DEX":[262,310,353],"20":[263],"D1D2":[265,351],"D8D9":[266],"D15D16":[267],"D22D23":[268],"combined":[269,725],"injections":[272,326,611],"(0.8":[275],"D1,":[277,366,372,403],"0.5":[278],"D15).":[282],"II":[285],"(Induc2)":[286],"offered":[288],"CR":[292],"CRp":[294],"(CR":[295],"platelets":[297],"<":[298],"100":[299],"G/l)":[300],"after":[301,423,569,595,687],"Induc1":[302],"salvage":[305],"therapy.":[306],"Induc2":[307],"20mg":[311],"D1D8,":[312],"cyclophosphamide":[313],"(CY)":[314],"300":[315],"D3,":[319],"IT":[322,375,397],"D2":[323,376,398],"(0.5":[329],"D8).":[333],"Pts":[334],"CR/CRp":[336,562,588],"programmed":[338],"receive":[340],"6":[341,496,567,630],"blocks":[342,427],"consolidation":[344,429],"(Ara-C":[345],"1.5g/m\u00b2/12h":[346],"adapted":[347],"renal":[349],"clearance":[350],"10mg/12h":[354],"D1D2,":[355,390,394],"4;":[359],"Methotrexate":[360],"(MTX)":[361],"1.5":[362],"g/m\u00b2":[363],"24h":[365],"VCR":[367],"6-mercaptopurin":[378],"(6-MP)":[379],"D7,":[382],"5;":[386],"CY":[387],"500":[388],"VP16":[391],"75":[392],"MTX":[400],"25":[401],"6)":[407],"POMP":[411],"maintenance":[412],"(VCR,":[413],"6-MP,":[414],"MTX,":[415],"DEX)":[416],"during":[417,603,669,682,692,714],"18":[418],"months.":[419],"Allograft":[420],"allowed":[422],"least":[425,444],"discretion":[432],"investigators.":[435],"The":[436,466,501],"evaluable":[437],"population":[438],"who":[441],"received":[442],"dose":[446],"Analyses":[449],"modified":[452],"intention":[453],"treat":[455],"performed":[457],"JUN":[458,483],"28,":[459],"2021.":[460],"All":[461],"gave":[463],"informed":[464],"consent.":[465],"registered":[469],"ClinicalTrials.gov":[471],"under":[472],"NCT":[474],"number:":[475],"NCT03249870.":[476],"Results.":[477],"Between":[478],"DEC":[479],"29,":[480],"2017":[481],"22,":[484],"2021,":[485],"115":[486],"(out":[488],"130":[490],"planned":[491],"pts)":[492],"enrolled":[494],"screen":[499],"failure.":[500],"90":[503,545],"eligible":[504],"(up":[506],"MAR":[508],"1,":[509],"2021)":[510],"considered":[512],"this":[514],"analysis":[515],"obtain":[517],"minimum":[519],"4":[521,608],"months":[522],"follow-up.":[523],"Median":[524],"age":[525],"69y":[527],"(range":[528,539],"55-84)":[529],"median":[531,644],"follow-up":[532],"alive":[534],"1.18":[537],"0.3-3.5).":[540],"At":[541],"time":[542],"analysis,":[544],"88":[547],"had":[549],"started":[550],"induc1":[551,575,683],"induc2,":[553],"respectively.":[554,628],"related":[556,679],"mortality":[557],"2.2%":[559],"(2/90)":[560],"rate":[563,589],"85.5%":[565],"(77/90,":[566],"CRp)":[568,594],"induc1.":[570],"Three":[571],"cases":[572],"relapsed":[573],"between":[574],"induc2":[577,584],"salvaged":[582],"allowing":[585],"87.7%":[591],"(79/90,":[592],"8":[593,666],"induc2.":[596,604],"One":[597],"died":[599,691],"from":[600,696,703],"refractory":[601],"disease":[602],"One,":[605],"2,":[606],"administered":[615],"(2.2%),":[618],"2(2.2%),":[619],"11":[620],"(12.2%),":[621],"(2.2%)":[623],"73":[625],"(81.1%)":[627],"Only":[629],"allografted.":[633],"One-year":[634,649],"OS":[635,645],"estimated":[637],"be":[639],"78.5%":[640],"(95%CI":[641],"68-85.9)":[642],"not":[647],"reached.":[648],"relapse":[650],"free":[651],"survival":[652],"74.5%":[654],"(95CI":[655],"63.5-82.6)":[656],"(Figure":[657],"1).":[658],"Grade":[659],"3-4":[660],"liver":[661],"toxicity":[662],"observed":[664],"(8.8%)":[668],"(3.3%)":[675],"developing":[676],"occurred":[686],"transplant.":[688],"Twenty-nine":[689],"follow-up,":[694],"16":[695],"relapses":[697],"(overall":[698,706],"incidence":[699,707],"18%)":[700],"13":[702],"events":[705],"14.4%),":[708],"COVID19":[711],"fatal":[712],"infection":[713],"consolidation.":[715],"Conclusion.":[716],"Fractionated":[717],"inotuzumab":[718],"(0.8/0.5/0.5/0.5":[723],"mg/m\u00b2)":[724],"very":[731],"active":[732],"well":[734],"tolerated":[735],"Figure":[745,747],"1.":[748],"Disclosures":[749],"Doubek:":[750],"Janssen-Cilag,":[751],"AbbVie,":[752],"AstraZeneca,":[753],"Amgen,":[754],"Gilead,":[755],"Novartis:":[756,761,802,836],"Honoraria,":[757,799,804,809,817,824,828,833,840],"Research":[758,800,805,810,818,825,829,834,837,841,844,857],"Funding.":[759,858],"Huguet:":[760],"Other:":[762,766,769,772,775,778],"Advisor;":[763,767,770,773,776],"Jazz":[764,831],"Pharmaceuticals:":[765,832],"Celgene:":[768],"BMS:":[771],"Amgen:":[774,797,823],"Pfizer:":[777,839,855],"Advisor.":[779],"Raffoux:":[780],"ABBVIE:":[781],"Consultancy;":[782,784,786],"PFIZER:":[783,812],"CELGENE/BMS:":[785],"ASTELLAS:":[787],"Consultancy.":[788],"Boissel:":[789],"CELGENE:":[790],"Honoraria;":[791,794,796,814,847,849],"Servier:":[792,843],"Consultancy,":[793,798,803,813,856],"Incyte:":[795,827],"Funding;":[801,806,811,819,826,830,835,838,842,845],"Bristol-Myers":[807],"Squibb:":[808],"JAZZ":[815],"Pharma:":[816],"SANOFI:":[820],"Honoraria.":[821,852],"Dombret:":[822],"Abbvie:":[846],"BMS-Celgene:":[848],"Daiichi":[850],"Sankyo:":[851],"Rousselot:":[853],"Incyte,":[854],"OffLabel":[859],"Disclosure:":[860]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-06T00:00:00"}
