{"id":"https://openalex.org/W3215855692","doi":"https://doi.org/10.1161/circ.144.suppl_1.13781","title":"Abstract 13781: Megakaryocytes Participating in Thrombosis Under Inflammatory Stress and Sepsis: Direct Pathological Evidence in Two Cases","display_name":"Abstract 13781: Megakaryocytes Participating in Thrombosis Under Inflammatory Stress and Sepsis: Direct Pathological Evidence in Two Cases","publication_year":2021,"publication_date":"2021-11-16","ids":{"openalex":"https://openalex.org/W3215855692","doi":"https://doi.org/10.1161/circ.144.suppl_1.13781","mag":"3215855692"},"language":"en","primary_location":{"id":"doi:10.1161/circ.144.suppl_1.13781","doi":"https://doi.org/10.1161/circ.144.suppl_1.13781","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.144.suppl_1.13781","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100408738","display_name":"Hua Zhang","orcid":"https://orcid.org/0000-0003-3501-8385","observed_orcids":["https://orcid.org/0000-0003-3501-8385"]},"institutions":[{"id":"https://openalex.org/I4210105514","display_name":"Capital Institute of Pediatrics","ror":"https://ror.org/00zw6et16","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210105514"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["Capital Institute of Pediatrics, Beijing","Hua Zhang Capital Institute of Pediatrics, Beijing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capital Institute of Pediatrics, Beijing","institution_ids":["https://openalex.org/I4210105514"]},{"raw_affiliation_string":"Hua Zhang Capital Institute of Pediatrics, Beijing","institution_ids":["https://openalex.org/I4210105514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076831147","display_name":"Kuan Zeng","orcid":"https://orcid.org/0000-0003-1411-8707","observed_orcids":["https://orcid.org/0000-0003-1411-8707"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"kuan zeng","raw_affiliation_strings":["Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, Guangzhou","kuan zeng Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, Guangzhou","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"kuan zeng Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, Guangzhou","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420615","display_name":"Liang Li","orcid":"https://orcid.org/0000-0001-5453-3839","observed_orcids":["https://orcid.org/0000-0001-5453-3839"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Li","raw_affiliation_strings":["The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","Liang Li The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Liang Li The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025989976","display_name":"Lu Zhang","orcid":"https://orcid.org/0000-0003-4808-6555","observed_orcids":["https://orcid.org/0000-0003-4808-6555"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Zhang","raw_affiliation_strings":["Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","Lu Zhang Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Lu Zhang Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianfen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfen Li","raw_affiliation_strings":["Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","Jianfen Li Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Jianfen Li Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mo Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo Yang","raw_affiliation_strings":["The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","Mo Yang The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Mo Yang The Seventh Affiliated Hosp, Sun Yat-sen Univ, Shenzhen","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101944067","display_name":"Yanqi Yang","orcid":"https://orcid.org/0000-0002-3582-1277","observed_orcids":["https://orcid.org/0000-0002-3582-1277"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanqi Yang","raw_affiliation_strings":["Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","Yanqi Yang Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Yanqi Yang Sun Yat-sen Memorial Hosp, Sun Yat-sen Univ, GuangZhou","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammatory-stress","display_name":"inflammatory stress","score":0.9700000286102295},{"id":"https://openalex.org/keywords/coronary-thrombus","display_name":"coronary thrombus","score":0.7049999833106995},{"id":"https://openalex.org/keywords/right-atrial-thrombus","display_name":"right atrial thrombus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/heparin-resistance","display_name":"heparin resistance","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8069999814033508},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.5770000219345093},{"id":"https://openalex.org/keywords/fibrin-network","display_name":"fibrin network","score":0.671999990940094},{"id":"https://openalex.org/keywords/mitral-annuloplasty","display_name":"mitral annuloplasty","score":0.7350000143051147},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.753000020980835},{"id":"https://openalex.org/keywords/mitral-valve-replacement","display_name":"mitral valve replacement","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.7540000081062317},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585598707199097},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.7068777680397034},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.706276535987854},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.690643846988678},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5207397937774658},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39450663328170776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2889140248298645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.144.suppl_1.13781","doi":"https://doi.org/10.1161/circ.144.suppl_1.13781","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.144.suppl_1.13781","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2461197548","https://openalex.org/W2883557920","https://openalex.org/W2322077740","https://openalex.org/W2911850239","https://openalex.org/W2809430926","https://openalex.org/W4313585900","https://openalex.org/W4233959222","https://openalex.org/W4225129542","https://openalex.org/W2124327952","https://openalex.org/W3161799164"],"abstract_inverted_index":{"Introduction:":[0],"Megakarycytes":[1],"(MKs)":[2],"produce":[3],"platelets":[4],"(PLTs)":[5],"which":[6],"enter":[7,258],"the":[8,53,116,151,175,216,222,242],"circulation":[9,65],"and":[10,16,51,66,70,77,92,103,138,163,185,194,225,235,253,261,271,273],"play":[11],"its":[12],"roles":[13],"in":[14,25,31,39,46,48,52,69,150,212,215,238,266],"hemostasis":[15],"thrombosis.":[17],"However,":[18],"direct":[19,37],"pathological":[20,190],"evidence":[21],"that":[22],"MKs":[23,43,60,206,256],"participate":[24,68,265],"thrombosis":[26,47,72,149,267],"has":[27],"not":[28],"been":[29],"reported":[30],"clinical":[32],"practice.":[33],"We":[34],"describe":[35],"here":[36],"observations":[38],"two":[40,129],"cases":[41],"where":[42],"were":[44,187,210],"found":[45],"coronary":[49,90,98,144,228],"artery":[50,99],"right":[54,117,223],"atrium":[55,118,224],"under":[56,73,106,125,268],"open-heart":[57],"surgery.":[58],"Hypothesis:":[59],"might":[61],"be":[62,274],"mobilized":[63],"into":[64],"directly":[67],"magnify":[71],"sepsis,":[74,272],"inflammatory":[75,249,269],"stress":[76,270],"full":[78,126,281],"heparinization.":[79,127,282],"Methods:":[80],"Case":[81,128],"one":[82],"was":[83,112,123,130,171,230,245],"a":[84,131,178],"51-year-old":[85],"male":[86,133],"with":[87,134,167,192],"ischemic":[88],"cardiomyopathy,":[89],"stenoses":[91],"severe":[93],"mitral":[94,104,136,164],"insufficiency":[95],"who":[96],"underwent":[97,159],"bypass":[100,108],"grafting":[101],"(CABG)":[102],"annuloplasty":[105],"cardiopulmonary":[107],"(CPB).":[109],"A":[110],"thrombus":[111,170,229],"pulled":[113],"out":[114],"from":[115,174,221,278],"when":[119],"an":[120],"atrial":[121],"cannula":[122],"removed":[124,173],"53-year-old":[132],"known":[135],"endocarditis":[137],"acute":[139],"anterior":[140,153],"myocardial":[141],"infarction.":[142],"Acute":[143],"angiogram":[145],"after":[146],"admission":[147],"showed":[148],"left":[152],"descending":[154],"(LAD)":[155],"branch.":[156],"The":[157,169,227],"patient":[158],"emergency":[160],"thrombectomy,":[161],"CABG":[162],"valve":[165,183],"replacement":[166],"CPB.":[168],"completely":[172],"LAD":[176],"through":[177],"small":[179],"incision.":[180],"Both":[181],"thrombi,":[182],"tissue":[184],"vegetation":[186,244],"sent":[188],"for":[189],"examination":[191],"HE":[193],"CD41-IHC":[195],"staining":[196],"on":[197],"paraffin":[198],"sections.":[199],"Results:":[200],"Large":[201],"number":[202],"of":[203,218,232,248,276,280],"giant":[204],"polyploidy":[205],"surrounded":[207],"by":[208],"PLTs":[209,234],"seen":[211],"different":[213],"areas":[214],"thrombi":[217],"MKs-PLTs-fibrin":[219],"networks":[220,240],"LAD.":[226],"consisted":[231,246],"MKs,":[233],"red":[236],"cells":[237],"fibrin":[239],"while":[241],"infected":[243],"dominantly":[247],"cells,":[250],"bacterial":[251],"legions":[252],"fibrin.":[254],"Conclusions:":[255],"may":[257],"both":[259],"venous":[260],"arterial":[262],"circulation,":[263],"actively":[264],"capable":[275],"escaping":[277],"inhibition":[279]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-12-06T00:00:00"}