{"id":"https://openalex.org/W3215748489","doi":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","title":"307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel","display_name":"307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel","publication_year":2021,"publication_date":"2021-11-24","ids":{"openalex":"https://openalex.org/W3215748489","doi":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","mag":"3215748489"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000804428.49042.2a","doi":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088588258","display_name":"Jeffrey Harold Lawson","orcid":"https://orcid.org/0000-0001-5603-7070","observed_orcids":["https://orcid.org/0000-0001-5603-7070"]},"institutions":[{"id":"https://openalex.org/I4210117320","display_name":"Humacyte (United States)","ror":"https://ror.org/02dahmt29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210117320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey H. Lawson","raw_affiliation_strings":["Humacyte, Inc., Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humacyte, Inc., Durham, NC, United States","institution_ids":["https://openalex.org/I4210117320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347468","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0003-0219-4200","observed_orcids":["https://orcid.org/0000-0003-0219-4200"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101627852","display_name":"Edward Xu Han","orcid":"https://orcid.org/0000-0002-5989-1747","observed_orcids":["https://orcid.org/0000-0002-5989-1747"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward X. Han","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004204971","display_name":"Mehmet Hamdi Kural","orcid":"https://orcid.org/0000-0002-3748-4593","observed_orcids":["https://orcid.org/0000-0002-3748-4593"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Kural","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072198686","display_name":"Bo Jiang","orcid":"https://orcid.org/0000-0003-1261-7705","observed_orcids":["https://orcid.org/0000-0003-1261-7705"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Jiang","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076368362","display_name":"Katherine L. Leiby","orcid":"https://orcid.org/0000-0003-3409-9371","observed_orcids":["https://orcid.org/0000-0003-3409-9371"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Leiby","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007971790","display_name":"Nazar Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazar Chowdhury","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036202065","display_name":"George Tellides","orcid":"https://orcid.org/0000-0001-7042-8190","observed_orcids":["https://orcid.org/0000-0001-7042-8190"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Tellides","raw_affiliation_strings":["Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085748100","display_name":"Laura E. Niklason","orcid":"https://orcid.org/0000-0002-5156-504X","observed_orcids":["https://orcid.org/0000-0002-5156-504X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210117320","display_name":"Humacyte (United States)","ror":"https://ror.org/02dahmt29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210117320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E. Niklason","raw_affiliation_strings":["Humacyte, Inc., Durham, NC, United States","Yale University, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humacyte, Inc., Durham, NC, United States","institution_ids":["https://openalex.org/I4210117320"]},{"raw_affiliation_string":"Yale University, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28425128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"12S1","first_page":"S26","last_page":"S26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.2175000011920929,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/oxygen-diffusion","display_name":"oxygen diffusion","score":0.7179999947547913},{"id":"https://openalex.org/keywords/fibrin-gel","display_name":"fibrin gel","score":0.8299999833106995},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.42399999499320984},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3919999897480011},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.849320113658905},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.8027002811431885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4989783763885498},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46727240085601807},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.4531855285167694},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4193941354751587},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.37198150157928467},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33395764231681824},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.297249972820282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24596193432807922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23368555307388306},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2151598334312439},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16387531161308289},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000804428.49042.2a","doi":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000804428.49042.2a","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174558844","https://openalex.org/W4399691291","https://openalex.org/W4285555192","https://openalex.org/W1969103692","https://openalex.org/W2315583024","https://openalex.org/W3096335179","https://openalex.org/W4387877475","https://openalex.org/W76701848","https://openalex.org/W4390953221","https://openalex.org/W2032338031"],"abstract_inverted_index":{"Introduction:":[0],"Transplantation":[1],"of":[2,18,24,100,132,211,221,239,266],"pancreatic":[3,267],"islets":[4,25,166,268],"has":[5,82,257],"been":[6,83],"shown":[7],"to":[8,43,65,136,146,185,235,259,269],"be":[9,36,51,115],"effective,":[10],"in":[11,60,153,179,203,222,225,230],"some":[12],"patients,":[13],"for":[14,165,189,264],"the":[15,28,32,86,98,139,147,159,198,209,212,237,247,252],"long-term":[16],"treatment":[17],"type":[19,273],"1":[20,274],"diabetes.":[21,275],"However,":[22],"transplantation":[23,71,244,265],"into":[26],"either":[27],"portal":[29],"vein":[30],"or":[31,271],"subcutaneous":[33],"space":[34],"can":[35,50,113],"limited":[37],"by":[38,251],"insufficient":[39],"oxygen":[40,47,145],"transfer,":[41],"leading":[42],"islet":[44,54,70,170,243],"loss.":[45],"Furthermore,":[46,200],"diffusion":[48],"limitations":[49],"magnified":[52],"when":[53],"numbers":[55],"are":[56,91],"increased":[57],"dramatically,":[58],"as":[59,78,93,107,117,174,261],"translating":[61],"from":[62,197],"rodent":[63],"studies":[64,234],"human-scale":[66],"treatments.":[67],"Methods:":[68],"An":[69],"approach":[72],"using":[73,105],"an":[74,94,101,118,219],"acellular":[75,102],"vascular":[76,80,103],"graft":[77,140],"a":[79,108,130,240,262],"scaffold":[81],"developed,":[84],"termed":[85],"BioVascular":[87],"Pancreas":[88],"(BVP).":[89],"Islets":[90],"seeded":[92],"outer":[95],"coating":[96],"on":[97],"surface":[99],"graft,":[104,122],"fibrin":[106],"hydrogel":[109],"carrier.":[110],"The":[111],"BVP":[112,160],"then":[114],"anastomosed":[116],"arterial":[119,127],"(or":[120],"arteriovenous)":[121],"which":[123,207],"allows":[124],"fully":[125],"oxygenated":[126],"blood":[128],"with":[129],"pO2":[131],"roughly":[133],"100":[134],"mmHg":[135],"flow":[137],"through":[138],"lumen":[141],"and":[142,152,167,192,229],"thereby":[143],"supply":[144],"islets.":[148],"Results:In":[149],"silico":[150,223],"simulations":[151],"vitro":[154,226],"bioreactor":[155,227],"experiments":[156],"show":[157],"that":[158],"design":[161,256],"provides":[162],"adequate":[163],"survivability":[164],"helps":[168],"avoid":[169],"hypoxia.":[171],"When":[172],"implanted":[173],"end-to-end":[175],"abdominal":[176],"aorta":[177],"grafts":[178],"nude":[180],"rats,":[181],"BVPs":[182],"were":[183,205],"able":[184],"restore":[186],"near-normoglycemia":[187],"durably":[188],"90":[190],"days":[191],"developed":[193],"robust":[194],"microvascular":[195],"infiltration":[196],"host.":[199],"pilot":[201],"implantations":[202],"pigs":[204],"performed,":[206],"demonstrated":[208],"scalability":[210],"technology.":[213],"Conclusion:":[214],"Collectively,":[215],"this":[216,254],"work":[217],"represents":[218],"intersection":[220],"modeling,":[224],"testing,":[228],"vivo":[231],"tissue":[232,255],"implantation":[233],"evaluate":[236],"efficacy":[238],"potentially":[241],"improved":[242],"therapy.":[245],"Given":[246],"potential":[248,258],"benefits":[249],"provided":[250],"BVP,":[253],"serve":[260],"solution":[263],"treat":[270],"cure":[272]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-12-06T00:00:00"}
