{"id":"https://openalex.org/W3215650511","doi":"https://doi.org/10.3390/foods10122959","title":"Enhancement of Anti-Proliferative Activity of the Extracts from Dehulled Adlay by Fermentation with Bacillus subtilis","display_name":"Enhancement of Anti-Proliferative Activity of the Extracts from Dehulled Adlay by Fermentation with Bacillus subtilis","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W3215650511","doi":"https://doi.org/10.3390/foods10122959","mag":"3215650511","pmid":"https://pubmed.ncbi.nlm.nih.gov/34945511","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8701002"},"language":"en","primary_location":{"id":"doi:10.3390/foods10122959","doi":"https://doi.org/10.3390/foods10122959","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods10122959","pdf_url":"https://www.mdpi.com/2304-8158/10/12/2959/pdf?version=1638367762","source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2304-8158/10/12/2959/pdf?version=1638367762","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008035356","display_name":"Anyan Wen","orcid":"https://orcid.org/0000-0002-8311-071X","observed_orcids":["https://orcid.org/0000-0002-8311-071X","https://orcid.org/0000-0002-0018-8889"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anyan Wen","raw_affiliation_strings":["School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0002-8311-071X","affiliations":[{"raw_affiliation_string":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000372210","display_name":"Yong Zhu","orcid":"https://orcid.org/0000-0002-5302-3893","observed_orcids":["https://orcid.org/0000-0002-5302-3893"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]},{"id":"https://openalex.org/I4210144453","display_name":"Guizhou Institute of Plant Protection","ror":"https://ror.org/03zb1qq41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144453"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhu","raw_affiliation_strings":["Plant Protection and Plant Quarantine Station of Guizhou Province, Guiyang 550001, China","School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Protection and Plant Quarantine Station of Guizhou Province, Guiyang 550001, China","institution_ids":["https://openalex.org/I4210144453"]},{"raw_affiliation_string":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034329513","display_name":"Muhammad Saleem Mazhar","orcid":"https://orcid.org/0000-0002-3172-8737","observed_orcids":["https://orcid.org/0000-0002-3172-8737"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muhammad Mazhar","raw_affiliation_strings":["College of Life Sciences, Guizhou University, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007962165","display_name":"Likang Qin","orcid":"https://orcid.org/0000-0002-4156-2937","observed_orcids":["https://orcid.org/0000-0002-4156-2937"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Likang Qin","raw_affiliation_strings":["Key Laboratory of Agricultural and Animal Products Storage and Processing of Guizhou Province, Guiyang 550025, China","National & Local Joint Engineering Center for the Development and Utilization Technology of Drug and Food Resources in Southwest China, Guiyang 550025, China","School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Agricultural and Animal Products Storage and Processing of Guizhou Province, Guiyang 550025, China","institution_ids":[]},{"raw_affiliation_string":"National & Local Joint Engineering Center for the Development and Utilization Technology of Drug and Food Resources in Southwest China, Guiyang 550025, China","institution_ids":[]},{"raw_affiliation_string":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haiying Zeng","orcid":"https://orcid.org/0000-0002-9220-0186","observed_orcids":["https://orcid.org/0000-0002-9220-0186"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Zeng","raw_affiliation_strings":["Key Laboratory of Agricultural and Animal Products Storage and Processing of Guizhou Province, Guiyang 550025, China","School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"],"raw_orcid":"https://orcid.org/0000-0002-9220-0186","affiliations":[{"raw_affiliation_string":"Key Laboratory of Agricultural and Animal Products Storage and Processing of Guizhou Province, Guiyang 550025, China","institution_ids":[]},{"raw_affiliation_string":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044909254","display_name":"Yi Zhu","orcid":"https://orcid.org/0000-0003-2559-5912","observed_orcids":["https://orcid.org/0000-0003-2559-5912"]},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]},{"id":"https://openalex.org/I4210144453","display_name":"Guizhou Institute of Plant Protection","ror":"https://ror.org/03zb1qq41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144453"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhu","raw_affiliation_strings":["Plant Protection and Plant Quarantine Station of Guizhou Province, Guiyang 550001, China","School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Protection and Plant Quarantine Station of Guizhou Province, Guiyang 550001, China","institution_ids":["https://openalex.org/I4210144453"]},{"raw_affiliation_string":"School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China","institution_ids":["https://openalex.org/I178232147"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007962165"],"corresponding_institution_ids":["https://openalex.org/I178232147"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.6159,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62461347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"12","first_page":"2959","last_page":"2959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12385","display_name":"Food Quality and Safety Studies","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12385","display_name":"Food Quality and Safety Studies","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13479","display_name":"Food Science and Nutritional Studies","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis-fermentation","display_name":"Bacillus subtilis fermentation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tetramethylpyrazine","display_name":"tetramethylpyrazine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bcl-2-bax","display_name":"Bcl-2/Bax","score":0.7979999780654907},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.921999990940094},{"id":"https://openalex.org/keywords/bioactive-phenolic-compounds","display_name":"bioactive phenolic compounds","score":0.6669999957084656},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5867400169372559},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5852721929550171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.571204423904419},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.5561310052871704},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.555814802646637},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.518541157245636},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5164309144020081},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4895952343940735},{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.4696604013442993},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.444731742143631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4100741446018219},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.34100064635276794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3372800648212433},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2920095920562744},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20999398827552795},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/foods10122959","doi":"https://doi.org/10.3390/foods10122959","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods10122959","pdf_url":"https://www.mdpi.com/2304-8158/10/12/2959/pdf?version=1638367762","source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},{"id":"pmid:34945511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34945511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8701002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8701002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0955aa13ecbf4272907a5717824936a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0955aa13ecbf4272907a5717824936a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Foods, Vol 10, Iss 12, p 2959 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/foods10122959","doi":"https://doi.org/10.3390/foods10122959","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods10122959","pdf_url":"https://www.mdpi.com/2304-8158/10/12/2959/pdf?version=1638367762","source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6895183550","display_name":null,"funder_award_id":"(2019) 1111","funder_id":"https://openalex.org/F4320323236","funder_display_name":"Natural Science Foundation of Guizhou Province"}],"funders":[{"id":"https://openalex.org/F4320323236","display_name":"Natural Science Foundation of Guizhou Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3215650511.pdf","grobid_xml":"https://content.openalex.org/works/W3215650511.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W590717829","https://openalex.org/W1967853390","https://openalex.org/W1969237487","https://openalex.org/W1970733769","https://openalex.org/W1971781746","https://openalex.org/W1972326829","https://openalex.org/W1973193612","https://openalex.org/W1974210580","https://openalex.org/W2001971521","https://openalex.org/W2018423228","https://openalex.org/W2036562545","https://openalex.org/W2046145131","https://openalex.org/W2113443131","https://openalex.org/W2132155980","https://openalex.org/W2280301286","https://openalex.org/W2299047657","https://openalex.org/W2397486580","https://openalex.org/W2471217257","https://openalex.org/W2504846665","https://openalex.org/W2510439456","https://openalex.org/W2522734760","https://openalex.org/W2548768463","https://openalex.org/W2555008719","https://openalex.org/W2573121869","https://openalex.org/W2589635315","https://openalex.org/W2591989326","https://openalex.org/W2594157316","https://openalex.org/W2615509606","https://openalex.org/W2738418239","https://openalex.org/W2789361718","https://openalex.org/W2807312646","https://openalex.org/W2809830291","https://openalex.org/W2890728046","https://openalex.org/W2952335887","https://openalex.org/W2973705628","https://openalex.org/W2980160737","https://openalex.org/W2986407680","https://openalex.org/W3008841699","https://openalex.org/W3012018489","https://openalex.org/W3018338716","https://openalex.org/W3092842475","https://openalex.org/W3109750604","https://openalex.org/W3133971484","https://openalex.org/W6712400500"],"related_works":["https://openalex.org/W3195786073","https://openalex.org/W2151467517","https://openalex.org/W2966125918","https://openalex.org/W2152399944","https://openalex.org/W2327211576","https://openalex.org/W4283274371","https://openalex.org/W2385969892","https://openalex.org/W2091147414","https://openalex.org/W3215133916","https://openalex.org/W4410360006"],"abstract_inverted_index":{"Dehulled":[0],"adlay":[1,17,48,52,118,184],"was":[2,122,127],"fermented":[3,15,116,185],"with":[4,20,86,186],"Bacillus":[5],"subtilis":[6,188],"BJ3-2,":[7],"the":[8,12,28,32,42,68,88,112,145,158,168,173],"anti-proliferative":[9,33,65,96,113],"activities":[10,66,97],"of":[11,23,44,67,75,91,115,148,170,175],"extracts":[13,43,69],"from":[14,70],"dehulled":[16,47,51,117,183],"were":[18,35,78],"investigated":[19],"six":[21,73],"types":[22,74],"tumor":[24,76],"cells,":[25],"and":[26,31,50,103,141,150,165,172,177,197],"then":[27],"bioactive":[29],"components":[30],"mechanism":[34],"primarily":[36],"explored.":[37],"Results":[38],"showed":[39],"that":[40,182],"all":[41],"B.":[45,187],"subtilis-fermented":[46],"(BDA)":[49],"(DA)":[53],"had":[54],"no":[55],"inhibition":[56,147],"effect":[57],"on":[58],"human":[59,99,104],"embryonic":[60],"kidney":[61],"239T":[62],"cells.":[63,110],"The":[64],"BDA":[71,92],"against":[72,98,119],"cells":[77,102,121,152],"almost":[79],"always":[80],"significantly":[81],"higher":[82],"than":[83],"DA.":[84],"Compared":[85],"others,":[87],"n-butanol":[89],"extract":[90],"(BDA-Nb)":[93],"exhibited":[94],"stronger":[95],"leukemia":[100,196],"K562":[101,120,149],"non-small":[105],"cell":[106,156,160],"lung":[107,198],"cancer":[108],"A549":[109,151],"Importantly,":[111],"activity":[114],"firstly":[123],"discovered.":[124],"Meanwhile,":[125],"BDA-Nb":[126,143],"rich":[128],"in":[129,162],"tetramethylpyrazine,":[130],"\u03b3-aminobutyric":[131],"acid,":[132],"protocatechuic,":[133],"2,3,4-trihydroxybenzoic,":[134],"chlorogenic,":[135],"p-hydroxybenzoic,":[136],"caffeic,":[137],"trans-cinnamic,":[138],"ferulic":[139],"acids,":[140],"rutin.":[142],"induced":[144],"proliferative":[146],"due":[153],"to":[154],"abnormal":[155],"morphology,":[157],"increased":[159],"population":[161],"G1":[163],"phase":[164],"apoptosis":[166],"rate,":[167],"downregulation":[169],"Bcl-2,":[171],"upregulation":[174],"Bax":[176],"caspase-3/8/9.":[178],"These":[179],"results":[180],"indicate":[181],"could":[189],"be":[190],"a":[191],"potential":[192],"therapeutic":[193],"agent":[194],"for":[195],"cancer.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}