{"id":"https://openalex.org/W3215519550","doi":"https://doi.org/10.3389/fcell.2021.784367","title":"Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels","display_name":"Mechanisms of Non-Vesicular Exchange of Lipids at Membrane Contact Sites: Of Shuttles, Tunnels and, Funnels","publication_year":2021,"publication_date":"2021-11-29","ids":{"openalex":"https://openalex.org/W3215519550","doi":"https://doi.org/10.3389/fcell.2021.784367","mag":"3215519550","pmid":"https://pubmed.ncbi.nlm.nih.gov/34912813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8667587"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.784367","doi":"https://doi.org/10.3389/fcell.2021.784367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.784367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.784367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.784367/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008477969","display_name":"Pascal F. Egea","orcid":"https://orcid.org/0000-0003-4432-8625","observed_orcids":["https://orcid.org/0000-0003-4432-8625"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pascal F. Egea","raw_affiliation_strings":["Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008477969"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5992,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.48685857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"784367","last_page":"784367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-contact-sites","display_name":"membrane contact sites","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lipid-transfer-proteins","display_name":"lipid transfer proteins","score":0.968999981880188},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9229999780654907},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lipid-flux","display_name":"lipid flux","score":0.4020000100135803},{"id":"https://openalex.org/keywords/membrane-asymmetry","display_name":"membrane asymmetry","score":0.7289999723434448},{"id":"https://openalex.org/keywords/fat-deposition","display_name":"fat deposition","score":0.5270000100135803},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/organelle-biogenesis","display_name":"organelle biogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/yeast-model","display_name":"yeast model","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.49279025197029114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4264340400695801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41937577724456787},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4041576385498047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30091166496276855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15494391322135925}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2021.784367","doi":"https://doi.org/10.3389/fcell.2021.784367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.784367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.784367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8667587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8667587","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:34912813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34912813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:df8c049d309a45dfa02b6b9946f4976b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/df8c049d309a45dfa02b6b9946f4976b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7p20896t","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7p20896t","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, vol 9","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.784367","doi":"https://doi.org/10.3389/fcell.2021.784367","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.784367","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.784367/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1747320671","display_name":null,"funder_award_id":"R01 GM120173","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000909391","display_name":"ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling","funder_award_id":"R01GM129325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3215519550.pdf","grobid_xml":"https://content.openalex.org/works/W3215519550.grobid-xml"},"referenced_works_count":217,"referenced_works":["https://openalex.org/W1578323460","https://openalex.org/W1803102843","https://openalex.org/W1929336150","https://openalex.org/W1953476296","https://openalex.org/W1963587806","https://openalex.org/W1967042190","https://openalex.org/W1970395441","https://openalex.org/W1972963835","https://openalex.org/W1976421151","https://openalex.org/W1980939512","https://openalex.org/W1981049765","https://openalex.org/W1986477156","https://openalex.org/W1987804473","https://openalex.org/W1988578862","https://openalex.org/W1993084790","https://openalex.org/W1993460406","https://openalex.org/W1994025530","https://openalex.org/W1997527771","https://openalex.org/W1998416648","https://openalex.org/W2000805858","https://openalex.org/W2001956269","https://openalex.org/W2007647318","https://openalex.org/W2012876719","https://openalex.org/W2015115860","https://openalex.org/W2015536770","https://openalex.org/W2017209697","https://openalex.org/W2017828774","https://openalex.org/W2020028771","https://openalex.org/W2020432830","https://openalex.org/W2022144068","https://openalex.org/W2029589437","https://openalex.org/W2031468878","https://openalex.org/W2033488273","https://openalex.org/W2035310767","https://openalex.org/W2039932572","https://openalex.org/W2043312574","https://openalex.org/W2046855017","https://openalex.org/W2046867359","https://openalex.org/W2051965634","https://openalex.org/W2058153670","https://openalex.org/W2059412195","https://openalex.org/W2061267512","https://openalex.org/W2064892346","https://openalex.org/W2066029883","https://openalex.org/W2066821865","https://openalex.org/W2068526264","https://openalex.org/W2078323583","https://openalex.org/W2081253095","https://openalex.org/W2085978470","https://openalex.org/W2089860059","https://openalex.org/W2093883442","https://openalex.org/W2099538852","https://openalex.org/W2105769353","https://openalex.org/W2107099939","https://openalex.org/W2108713843","https://openalex.org/W2111097328","https://openalex.org/W2120156669","https://openalex.org/W2121330845","https://openalex.org/W2125872855","https://openalex.org/W2127538056","https://openalex.org/W2130893307","https://openalex.org/W2133922530","https://openalex.org/W2140687094","https://openalex.org/W2144451488","https://openalex.org/W2147943584","https://openalex.org/W2150368013","https://openalex.org/W2161478881","https://openalex.org/W2163484619","https://openalex.org/W2170942278","https://openalex.org/W2174792969","https://openalex.org/W2182369134","https://openalex.org/W2214704277","https://openalex.org/W2233665003","https://openalex.org/W2250472293","https://openalex.org/W2318022761","https://openalex.org/W2333826650","https://openalex.org/W2334448470","https://openalex.org/W2346561353","https://openalex.org/W2411730198","https://openalex.org/W2411847621","https://openalex.org/W2416594970","https://openalex.org/W2460215877","https://openalex.org/W2490403655","https://openalex.org/W2515920663","https://openalex.org/W2529905170","https://openalex.org/W2549836295","https://openalex.org/W2552567900","https://openalex.org/W2560295811","https://openalex.org/W2582410297","https://openalex.org/W2590568317","https://openalex.org/W2597223015","https://openalex.org/W2600192926","https://openalex.org/W2610538780","https://openalex.org/W2611851783","https://openalex.org/W2613365825","https://openalex.org/W2617190377","https://openalex.org/W2617667835","https://openalex.org/W2618097669","https://openalex.org/W2619431296","https://openalex.org/W2626003366","https://openalex.org/W2655523273","https://openalex.org/W2696341497","https://openalex.org/W2742457004","https://openalex.org/W2743619083","https://openalex.org/W2746038414","https://openalex.org/W2749141699","https://openalex.org/W2753690063","https://openalex.org/W2753791808","https://openalex.org/W2766127467","https://openalex.org/W2766608142","https://openalex.org/W2777157902","https://openalex.org/W2786170680","https://openalex.org/W2787879899","https://openalex.org/W2788633957","https://openalex.org/W2794677524","https://openalex.org/W2805576450","https://openalex.org/W2884082692","https://openalex.org/W2885910759","https://openalex.org/W2888403478","https://openalex.org/W2888527186","https://openalex.org/W2890430608","https://openalex.org/W2890848016","https://openalex.org/W2891007226","https://openalex.org/W2895580902","https://openalex.org/W2896758254","https://openalex.org/W2898224116","https://openalex.org/W2903107073","https://openalex.org/W2904820355","https://openalex.org/W2906366029","https://openalex.org/W2911548071","https://openalex.org/W2911693410","https://openalex.org/W2915920304","https://openalex.org/W2917971401","https://openalex.org/W2923461283","https://openalex.org/W2923686899","https://openalex.org/W2924515523","https://openalex.org/W2924708058","https://openalex.org/W2935116054","https://openalex.org/W2937810045","https://openalex.org/W2938050888","https://openalex.org/W2940177815","https://openalex.org/W2944435823","https://openalex.org/W2950913191","https://openalex.org/W2953771712","https://openalex.org/W2956011757","https://openalex.org/W2969084200","https://openalex.org/W2969438268","https://openalex.org/W2971414127","https://openalex.org/W2972846839","https://openalex.org/W2979472203","https://openalex.org/W2980601854","https://openalex.org/W2981652808","https://openalex.org/W2981916477","https://openalex.org/W2989453214","https://openalex.org/W2996284996","https://openalex.org/W2999528257","https://openalex.org/W3003161086","https://openalex.org/W3004009934","https://openalex.org/W3004533093","https://openalex.org/W3010716147","https://openalex.org/W3011333118","https://openalex.org/W3011374555","https://openalex.org/W3011617625","https://openalex.org/W3013666444","https://openalex.org/W3018756116","https://openalex.org/W3021770362","https://openalex.org/W3023494905","https://openalex.org/W3024644845","https://openalex.org/W3025543874","https://openalex.org/W3029168653","https://openalex.org/W3033485143","https://openalex.org/W3038998766","https://openalex.org/W3039715058","https://openalex.org/W3042926687","https://openalex.org/W3046894614","https://openalex.org/W3081059968","https://openalex.org/W3085685293","https://openalex.org/W3090513376","https://openalex.org/W3090534531","https://openalex.org/W3093507769","https://openalex.org/W3093562399","https://openalex.org/W3093716916","https://openalex.org/W3094062383","https://openalex.org/W3099323319","https://openalex.org/W3100288276","https://openalex.org/W3108943181","https://openalex.org/W3112768442","https://openalex.org/W3113157624","https://openalex.org/W3118074212","https://openalex.org/W3118542492","https://openalex.org/W3119861749","https://openalex.org/W3120778189","https://openalex.org/W3121121739","https://openalex.org/W3122343234","https://openalex.org/W3126683045","https://openalex.org/W3127669623","https://openalex.org/W3129827786","https://openalex.org/W3133137643","https://openalex.org/W3134360244","https://openalex.org/W3137143246","https://openalex.org/W3137205495","https://openalex.org/W3154074861","https://openalex.org/W3155150351","https://openalex.org/W3155159429","https://openalex.org/W3159278124","https://openalex.org/W3164349593","https://openalex.org/W3177828909","https://openalex.org/W3181271241","https://openalex.org/W3186087156","https://openalex.org/W3193919390","https://openalex.org/W3196586274","https://openalex.org/W3198777442","https://openalex.org/W3200175586","https://openalex.org/W3203857810","https://openalex.org/W3206191144","https://openalex.org/W4212995728","https://openalex.org/W4255907729"],"related_works":["https://openalex.org/W4296063811","https://openalex.org/W2805360837","https://openalex.org/W2619400613","https://openalex.org/W2030530833","https://openalex.org/W4385301629","https://openalex.org/W3114376523","https://openalex.org/W1999698113","https://openalex.org/W3199415429","https://openalex.org/W2987781057","https://openalex.org/W2311178261"],"abstract_inverted_index":{"Eukaryotic":[0],"cells":[1],"are":[2,75],"characterized":[3],"by":[4,143,175],"their":[5,111,239],"exquisite":[6],"compartmentalization":[7],"resulting":[8],"from":[9,72,219],"a":[10,20,264],"cornucopia":[11],"of":[12,16,22,52,67,81,86,92,100,116,137,165,179,193,196,198,202,215,229,238,244,256,267],"membrane-bound":[13,260],"organelles.":[14],"Each":[15,243],"these":[17,245],"compartments":[18],"hosts":[19],"flurry":[21],"biochemical":[23],"reactions":[24],"and":[25,35,38,54,58,109,135,152,156,163,204,234,241,250,275,280],"supports":[26],"biological":[27,166],"functions":[28],"such":[29,270],"as":[30,47,129,182,271],"genome":[31],"storage,":[32,278],"membrane":[33,62,112],"protein":[34],"lipid":[36,154,183,230,277],"biosynthesis/degradation":[37],"ATP":[39],"synthesis,":[40],"all":[41,146],"essential":[42,76,158,262],"to":[43,77,159,211,263],"cellular":[44,78,268],"life.":[45],"Acting":[46],"hubs":[48],"for":[49,132,252],"the":[50,60,82,89,126,130,133,141,160,169,190,199,208,236,253],"transfer":[51,184,231],"matter":[53],"signals":[55],"between":[56,70,258],"organelles":[57,107,261],"throughout":[59,140,168],"cell,":[61],"contacts":[63],"sites":[64,66],"(MCSs),":[65],"close":[68],"apposition":[69,172],"membranes":[71,167],"different":[73,227],"organelles,":[74],"homeostasis.":[79],"One":[80],"now":[83],"well-acknowledged":[84],"function":[85,181],"MCSs":[87,150,218,233],"involves":[88],"non-vesicular":[90,254],"trafficking":[91],"lipids;":[93],"its":[94],"characterization":[95],"answered":[96],"one":[97],"long-standing":[98],"question":[99],"eukaryotic":[101,259],"cell":[102,142],"biology":[103],"revealing":[104],"how":[105],"some":[106,178,197],"receive":[108],"distribute":[110],"lipids":[113,257],"in":[114,123,223],"absence":[115],"vesicular":[117],"trafficking.":[118],"The":[119],"endoplasmic":[120],"reticulum":[121],"(ER)":[122],"synergy":[124],"with":[125],"mitochondria,":[127],"stands":[128],"nexus":[131],"biosynthesis":[134,274],"distribution":[136],"phospholipids":[138],"(PLs)":[139],"contacting":[144],"nearly":[145],"other":[147],"organelle":[148,281],"types.":[149],"create":[151],"maintain":[153],"fluxes":[155],"gradients":[157],"functional":[161],"asymmetry":[162],"polarity":[164],"cell.":[170],"Membrane":[171],"is":[173],"mediated":[174],"proteinaceous":[176],"tethers":[177,205],"which":[180],"proteins":[185],"(LTPs).":[186],"We":[187],"summarize":[188],"here":[189],"current":[191],"state":[192],"mechanistic":[194],"knowledge":[195],"major":[200],"classes":[201],"LTPs":[203],"based":[206],"on":[207],"available":[209],"atomic":[210],"near-atomic":[212],"resolution":[213],"structures":[214],"several":[216],"\"model\"":[217],"yeast":[220],"but":[221],"also":[222],"Metazoans;":[224],"we":[225],"describe":[226],"models":[228],"at":[232,272],"analyze":[235],"determinants":[237],"specificity":[240],"directionality.":[242],"systems":[246],"illustrate":[247],"fundamental":[248],"principles":[249],"mechanisms":[251],"exchange":[255],"wide":[265],"range":[266],"processes":[269],"PL":[273],"distribution,":[276],"autophagy":[279],"biogenesis.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-12-06T00:00:00"}