{"id":"https://openalex.org/W3215495703","doi":"https://doi.org/10.1161/circ.144.suppl_1.11898","title":"Abstract 11898: KLF10 Deficiency in CD4+ T Cells Exacerbates Angiotensin II-Induced Perivascular Fibrosis","display_name":"Abstract 11898: KLF10 Deficiency in CD4+ T Cells Exacerbates Angiotensin II-Induced Perivascular Fibrosis","publication_year":2021,"publication_date":"2021-11-16","ids":{"openalex":"https://openalex.org/W3215495703","doi":"https://doi.org/10.1161/circ.144.suppl_1.11898","mag":"3215495703"},"language":"en","primary_location":{"id":"doi:10.1161/circ.144.suppl_1.11898","doi":"https://doi.org/10.1161/circ.144.suppl_1.11898","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.144.suppl_1.11898","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024294938","display_name":"Rulin Zhuang","orcid":"https://orcid.org/0000-0003-4557-4289","observed_orcids":["https://orcid.org/0000-0003-4557-4289"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rulin Zhuang","raw_affiliation_strings":["Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","Rulin Zhuang Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Rulin Zhuang Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042366766","display_name":"Jingshu Chen","orcid":"https://orcid.org/0000-0003-4813-3569","observed_orcids":["https://orcid.org/0000-0003-4813-3569","https://orcid.org/0009-0000-1738-562X","https://orcid.org/0000-0002-2656-7625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingshu Chen","raw_affiliation_strings":["Jingshu Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jingshu Chen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081199563","display_name":"Henry S. Cheng","orcid":"https://orcid.org/0000-0002-4254-962X","observed_orcids":["https://orcid.org/0000-0002-4254-962X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Cheng","raw_affiliation_strings":["Brigham and Women's Hosp, Boston, MA","Henry Cheng Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Henry Cheng Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040157771","display_name":"Carmel Rebecca Assa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmel Assa","raw_affiliation_strings":["Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","Carmel Assa Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Carmel Assa Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007435338","display_name":"Anurag Jamaiyar","orcid":"https://orcid.org/0000-0002-8731-2394","observed_orcids":["https://orcid.org/0000-0002-8731-2394"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anurag Jamaiyar","raw_affiliation_strings":["Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","Anurag Jamaiyar Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Anurag Jamaiyar Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003593543","display_name":"Arvind Kant Pandey","orcid":"https://orcid.org/0000-0001-7890-4665","observed_orcids":["https://orcid.org/0000-0001-7890-4665"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvind Pandey","raw_affiliation_strings":["Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","Arvind Pandey Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Arvind Pandey Dept of Medicine, Cardiovascular Div, Brigham and Women's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025247079","display_name":"Akm Khyrul Wara","orcid":"https://orcid.org/0000-0002-1468-6053","observed_orcids":["https://orcid.org/0000-0002-1468-6053"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akm Wara","raw_affiliation_strings":["Brigham and Women's Hosp, Boston, MA","Akm Wara Brigham and Women's Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Akm Wara Brigham and Women's Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026476092","display_name":"Mark W. Feinberg","orcid":"https://orcid.org/0000-0001-9523-3859","observed_orcids":["https://orcid.org/0000-0001-9523-3859"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W Feinberg","raw_affiliation_strings":["BRIGHAM AND WOMENS HOSPITAL, Boston, MA","Mark W Feinberg BRIGHAM AND WOMENS HOSPITAL, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BRIGHAM AND WOMENS HOSPITAL, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Mark W Feinberg BRIGHAM AND WOMENS HOSPITAL, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klf10","display_name":"KLF10","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-9","display_name":"IL-9","score":0.847000002861023},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.6309999823570251},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.48500001430511475},{"id":"https://openalex.org/keywords/aortic-fibrosis","display_name":"aortic fibrosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6872881650924683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6650522351264954},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.621283769607544},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.45783427357673645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40544483065605164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33838921785354614},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1465347409248352}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.144.suppl_1.11898","doi":"https://doi.org/10.1161/circ.144.suppl_1.11898","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.144.suppl_1.11898","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4224234813","https://openalex.org/W2912994870","https://openalex.org/W4224936676","https://openalex.org/W2899103191","https://openalex.org/W4387621044","https://openalex.org/W2889070728","https://openalex.org/W2123034349","https://openalex.org/W3007173220","https://openalex.org/W3166276626","https://openalex.org/W2267324633"],"abstract_inverted_index":{"Introduction:":[0],"Perivascular":[1],"fibrosis,":[2,47],"characterized":[3],"by":[4,137,161,232],"increased":[5,186,197],"amount":[6],"of":[7,39,45,73,104,230,237,254,269,285],"connective":[8],"tissue":[9],"around":[10],"vessels,":[11],"is":[12,58],"a":[13,59],"hallmark":[14],"for":[15,282],"vascular":[16,24,81,286],"disease.":[17],"Angiotensin":[18],"II":[19,106,209,245,266],"(Ang":[20],"II)":[21],"contributes":[22],"to":[23,69,101,134,153,264],"disease":[25],"via":[26,267],"promoting":[27],"T-cell":[28],"activation":[29],"and":[30,93,99,123,144,163,179,183,192,259],"end-organ":[31],"damage.":[32],"Despite":[33],"recent":[34],"data":[35],"suggesting":[36],"the":[37,43,48,71,141,283],"role":[38,72],"T":[40,64,77,202,212,251,275],"cells":[41,78,213,276],"in":[42,63,75,79,83,140,174,187,198,207,214,243,262,274],"progression":[44],"perivascular":[46,131,241,257],"underlying":[49],"mechanisms":[50],"are":[51],"poorly":[52],"understood.":[53],"Objective:":[54],"Kruppel-like":[55],"Factor":[56],"10":[57],"transcription":[60,224],"factor":[61],"expressed":[62],"cell":[65,252],"subsets.":[66],"We":[67],"sought":[68],"investigate":[70],"KLF10":[74,90,221],"CD4+":[76,201,250],"regulating":[80],"damage":[82],"an":[84],"AngII":[85],"mouse":[86],"model.":[87],"Methods:":[88],"CD4-targeted":[89],"deficient":[91],"(TKO)":[92],"CD4-Cre":[94],"(WT)":[95],"mice":[96,128,136,147],"were":[97,185,195],"generated":[98],"subjected":[100],"28":[102],"days":[103],"Ang":[105,208,244,265],"infusion.":[107],"Endpoint":[108],"characterization":[109],"included":[110],"fibrotic":[111,288],"organ":[112],"transcriptomic":[113],"analysis,":[114,120],"multi-organ":[115,260],"histology,":[116],"flow":[117],"cytometry,":[118],"cytokine":[119],"myograph":[121],"vasoreactivity,":[122],"cardiac":[124],"echocardiography.":[125],"Results:":[126],"TKO":[127,146,178,188,200,247],"showed":[129],"enhanced":[130,151],"fibrosis":[132,242,258],"compared":[133],"WT":[135],"histological":[138],"analysis":[139],"aorta,":[142],"heart,":[143],"kidney.":[145],"had":[148],"vessels":[149],"with":[150,156,165,227],"vasoconstriction":[152],"phenylephrine,":[154],"hearts":[155],"impaired":[157],"global":[158],"longitudinal":[159],"strain":[160],"echo,":[162],"kidneys":[164],"elevated":[166],"albumin/creatinine":[167],"ratio.":[168],"However,":[169],"no":[170],"change":[171],"was":[172],"found":[173],"blood":[175],"pressure":[176],"between":[177],"WT.":[180],"Plasma":[181],"IL-9":[182,190,273],"IL-15":[184],"mice.":[189,248],"mRNA":[191],"secreted":[193],"protein":[194],"also":[196],"activated":[199],"cells,":[203],"as":[204,206],"well":[205],"treated":[210],"WT-CD4+":[211],"vitro":[215],".":[216],"Mechanistic":[217],"studies":[218],"revealed":[219],"that":[220],"regulated":[222],"Il9":[223,231],"through":[225],"interaction":[226],"promoter":[228],"region":[229],"ChIP":[233],"assay.":[234],"Notably,":[235],"injection":[236],"anti-IL9":[238],"antibody":[239],"reversed":[240],"infused":[246],"Conclusion:":[249],"deficiency":[253],"Klf10":[255,271],"exacerbated":[256],"dysfunction":[261],"response":[263],"upregulation":[268],"IL-9.":[270],"or":[272,287],"might":[277],"represent":[278],"novel":[279],"therapeutic":[280],"targets":[281],"treatment":[284],"diseases.":[289]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2021-12-06T00:00:00"}
