{"id":"https://openalex.org/W321537221","doi":null,"title":"Mechanism, Efficacy, and Safety of an Ephedrine, Caffeine, and Aspirin Combination in the Treatment of Obesity","display_name":"Mechanism, Efficacy, and Safety of an Ephedrine, Caffeine, and Aspirin Combination in the Treatment of Obesity","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W321537221","mag":"321537221"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6zh730fw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6zh730fw","pdf_url":"https://escholarship.org/uc/item/6zh730fw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition Bytes, vol 7, iss 1","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/6zh730fw","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031613696","display_name":"Nadir Yehya","orcid":"https://orcid.org/0000-0002-2996-217X","observed_orcids":["https://orcid.org/0000-0002-2996-217X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nadir Yehya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031613696"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.03775711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ephedrine","display_name":"ephedrine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":1.0},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.7450000047683716},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sympathetic-activation","display_name":"sympathetic activation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8840000033378601},{"id":"https://openalex.org/keywords/muscle-mass-preservation","display_name":"muscle mass preservation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.7933250665664673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7071458101272583},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.6572269797325134},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.5395269989967346},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5207683444023132},{"id":"https://openalex.org/C2778984665","wikidata":"https://www.wikidata.org/wiki/Q219626","display_name":"Ephedrine","level":2,"score":0.5084409117698669},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.5025107860565186},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4976222813129425},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49627596139907837},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47550708055496216},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4691765606403351},{"id":"https://openalex.org/C2779952866","wikidata":"https://www.wikidata.org/wiki/Q6746705","display_name":"Management of obesity","level":4,"score":0.45270463824272156},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.4514996111392975},{"id":"https://openalex.org/C2780557958","wikidata":"https://www.wikidata.org/wiki/Q211036","display_name":"Stimulant","level":2,"score":0.4102019667625427},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3716046214103699},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3555331826210022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34426453709602356},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.20326825976371765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12239792943000793},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0932314395904541},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt6zh730fw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6zh730fw","pdf_url":"https://escholarship.org/uc/item/6zh730fw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition Bytes, vol 7, iss 1","raw_type":"article"},{"id":"pmh:qt6zh730fw","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/6zh730fw","pdf_url":"http://www.escholarship.org/uc/item/6zh730fw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yehya, Nadir. (2001). Mechanism, Efficacy, and Safety of an Ephedrine, Caffeine, and Aspirin Combination in the Treatment of Obesity. Nutrition Bytes, 7(1). Retrieved from: http://www.escholarship.org/uc/item/6zh730fw","raw_type":"article"},{"id":"mag:321537221","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6zh730fw/qt6zh730fw.pdf?t=krne5g","pdf_url":null,"source":{"id":"https://openalex.org/S2764528077","display_name":"Nutrition bytes","issn_l":"1548-4327","issn":["1548-4327"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nutrition bytes","raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6zh730fw","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6zh730fw","pdf_url":"https://escholarship.org/uc/item/6zh730fw","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition Bytes, vol 7, iss 1","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W321537221.pdf","grobid_xml":"https://content.openalex.org/works/W321537221.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290920852","https://openalex.org/W3501369","https://openalex.org/W67149165","https://openalex.org/W121949149","https://openalex.org/W1842153225","https://openalex.org/W2133101055","https://openalex.org/W2130969282","https://openalex.org/W2331366182","https://openalex.org/W36044457","https://openalex.org/W7096117412"],"abstract_inverted_index":{"The":[0],"field":[1],"of":[2,11,22,76,88,119,135,161,168,174],"obesity":[3],"management":[4],"is":[5,99],"coming":[6],"to":[7,72,108,148],"appreciate":[8],"the":[9,15,19,42,45,49,73,80,86,116,120,133,158,162,166,172],"efficacy":[10,118,160],"pharmacological":[12],"treatments.":[13],"For":[14],"past":[16],"twenty":[17],"years":[18],"thermogenic":[20],"effects":[21,138,167],"sympathetic":[23,142],"stimulation":[24],"have":[25,32,114,130,145],"been":[26,70,91],"known":[27],"and":[28,48,57,96,144,151,165],"described.":[29],"Recent":[30],"studies":[31,125,129,154],"demonstrated":[33,115,132],"that":[34],"treating":[35],"patients":[36],"with":[37,140],"a":[38,104],"drug":[39],"combination":[40],"including":[41],"sympathomimetic":[43],"ephedrine,":[44],"stimulant":[46],"caffeine,":[47],"analgesic":[50],"aspirin":[51],"(ECA":[52],"combination)":[53],"will":[54],"stimulate":[55],"thermogenesis":[56],"result":[58],"in":[59,94,102],"lowered":[60],"weight":[61],"but":[62,123],"maintained":[63],"muscle":[64],"mass.":[65],"This":[66],"protein-sparing":[67],"lipolysis":[68],"has":[69,90],"attributed":[71],"elevated":[74],"levels":[75],"cAMP":[77],"generated":[78],"by":[79],"ECA":[81,121,163],"combination.":[82],"In":[83],"rat":[84],"studies,":[85],"mechanism":[87,106],"action":[89],"well":[92],"characterized":[93],"vitro":[95],"although":[97],"there":[98],"some":[100],"discrepancy":[101],"humans,":[103],"similar":[105],"seems":[107],"be":[109,149],"active.":[110],"Randomized":[111],"placebo-controlled":[112],"trials":[113],"short-term":[117,136],"combination,":[122,164],"long-term":[124,159],"are":[126],"lacking.":[127],"Most":[128],"also":[131],"incidence":[134],"side":[137],"associated":[139],"excessive":[141],"stimulation,":[143],"shown":[146],"them":[147],"transient":[150],"mild.":[152],"Future":[153],"should":[155],"focus":[156],"on":[157,171],"stopping":[169],"treatment":[170],"maintenance":[173],"fat":[175],"loss.":[176]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
