{"id":"https://openalex.org/W3215186404","doi":"https://doi.org/10.1182/blood-2021-153114","title":"Chromatin Content Capture Reveals Acute Leukaemia Oncogenic Vulnerability Point in Human B Cell Development","display_name":"Chromatin Content Capture Reveals Acute Leukaemia Oncogenic Vulnerability Point in Human B Cell Development","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3215186404","doi":"https://doi.org/10.1182/blood-2021-153114","mag":"3215186404"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-153114","doi":"https://doi.org/10.1182/blood-2021-153114","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-153114","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046490978","display_name":"Reema Baskar","orcid":"https://orcid.org/0000-0002-3872-0164","observed_orcids":["https://orcid.org/0000-0002-3872-0164"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reema Baskar","raw_affiliation_strings":["Stanford School of Medicine, Stanford,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford School of Medicine, Stanford,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134133127","display_name":"Patricia M.B. Favaro","orcid":"https://orcid.org/0000-0002-3764-9538","observed_orcids":["https://orcid.org/0000-0002-3764-9538"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia Favaro","raw_affiliation_strings":["Hematology and Blood Transfusion Center, University of Campinas, Campinas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Blood Transfusion Center, University of Campinas, Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059036898","display_name":"Warren D. Reynolds","orcid":"https://orcid.org/0000-0002-1755-2835","observed_orcids":["https://orcid.org/0000-0002-1755-2835"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren D. Reynolds","raw_affiliation_strings":["Center for Cancer Cell Therapy, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Cell Therapy, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075073583","display_name":"Pablo Domizi","orcid":"https://orcid.org/0000-0003-2903-0337","observed_orcids":["https://orcid.org/0000-0003-2903-0337"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Domizi","raw_affiliation_strings":["Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028268171","display_name":"Albert G. Tsai","orcid":"https://orcid.org/0000-0002-6607-3347","observed_orcids":["https://orcid.org/0000-0002-6607-3347"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert G Tsai","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, Palo Alto, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009700060","display_name":"Kara Lynn Davis","orcid":"https://orcid.org/0000-0002-7182-2592","observed_orcids":["https://orcid.org/0000-0002-7182-2592"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara L. Davis","raw_affiliation_strings":["Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplant, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplant, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045383208","display_name":"Sean C. Bendall","orcid":"https://orcid.org/0000-0003-1341-2453","observed_orcids":["https://orcid.org/0000-0003-1341-2453"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Bendall","raw_affiliation_strings":["Department of Pathology, Stanford University, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"673","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.9559999704360962},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.6470000147819519},{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.8360000252723694},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9660000205039978},{"id":"https://openalex.org/keywords/h2ak119ub","display_name":"H2AK119ub","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mll1","display_name":"MLL1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7385836243629456},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6029714941978455},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5874086022377014},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5824404954910278},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4958136975765228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4801327884197235},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.4655763506889343},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43540048599243164},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4111233353614807},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3816518187522888},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34430456161499023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33315038681030273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31950464844703674},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18872210383415222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1176513135433197}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-153114","doi":"https://doi.org/10.1182/blood-2021-153114","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-153114","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2098958008","https://openalex.org/W4389248130","https://openalex.org/W4403155987","https://openalex.org/W2778290456","https://openalex.org/W2979622933","https://openalex.org/W4310112207","https://openalex.org/W3130068645","https://openalex.org/W4249677598","https://openalex.org/W4310163409","https://openalex.org/W2566311090"],"abstract_inverted_index":{"Abstract":[0],"Human":[1],"B":[2,26,37,43,78,83,143,175,187,207,224,293,350,443,487,500,564,586],"cell":[3,27,44,79,84,144,156,176,188,218,235,242,294,351,412,439,444,478,501,565,587],"development":[4,189,295,566,588],"in":[5,77,93,102,199,226,291,441,458,498,510,524,563,584],"adult":[6,135],"human":[7,174],"bone":[8],"marrow":[9],"(BM)":[10],"is":[11,74,90],"tightly":[12],"regulated":[13,52],"through":[14],"well-defined":[15],"stages":[16,49],"to":[17,60,130,181,190,239,297,339,430,491,506,520,593],"produce":[18,35],"adaptive":[19],"immune":[20],"cells":[21,38,225,488],"with":[22,39,158,362,381,408,452],"assembled":[23],"and":[24,55,68,96,112,116,133,136,154,161,194,213,251,264,305,316,319,321,342,359,392,397,414,461,477,547,551,567,572,611],"functional":[25,40],"antigen":[28],"receptor":[29],"(BCR)(Martin":[30],"et":[31,329,369],"al.,":[32,330,370],"2016).":[33],"To":[34,209,332],"mature":[36],"immunoglobulin":[41],"receptors,":[42],"progenitors":[45,201],"must":[46],"undergo":[47],"multiple":[48],"of":[50,63,121,124,185,222,302,308,384,455,464,485,495,531,539,581],"highly":[51,91],"chromatin":[53,219,252,265,278,340,355,374,459,483,532,570,609],"remodelling":[54],"transcriptional":[56],"reprogramming":[57],"which":[58],"correspond":[59],"unique":[61],"patterns":[62,111],"surface":[64,243],"protein":[65],"expression":[66,463,574],"(Nutt":[67],"Kee,":[69],"2007).":[70],"This":[71,446,518,596],"complex":[72],"process":[73],"frequently":[75],"dysregulated":[76],"neoplasia":[80],"such":[81,107,247,255,387],"as":[82,99,101,108,202,248,256,388,426],"Acute":[85],"Lymphoblastic":[86],"Leukemia":[87],"(B-ALL).":[88],"B-ALL":[89,138,152,474,540,607],"heterogenous":[92],"its":[94,103],"phenotypic":[95,160,193,300],"clinical":[97,162],"presentation,":[98],"well":[100],"underlying":[104,569],"molecular":[105],"features":[106],"DNA":[109,621],"methylation":[110,622],"genetic":[113],"aberrations":[114],"(Cobaleda":[115],"S\u00e1nchez-Garc\u00eda,":[117],"2009).":[118],"The":[119],"lack":[120],"general":[122],"mechanism":[123],"leukemogenesis":[125],"has":[126],"made":[127],"it":[128],"difficult":[129],"identify":[131,558],"when":[132],"where":[134],"pediatric":[137],"blasts":[139,164],"diverge":[140],"from":[141,353,428,504],"normal":[142,186],"development.":[145,177,445],"Here":[146],"we":[147,179,228,280,347,420,470,577],"show":[148],"that":[149,472,589],"across":[150,473,535],"5":[151],"patients":[153,475,541],"3":[155,283],"lines":[157,479],"diverse":[159],"presentations,":[163],"are":[165],"epigenetically":[166],"arrested":[167],"at":[168,395,399],"a":[169,183,230,521,579],"conserved":[170],"point":[171,494,580],"within":[172,550],"healthy":[173,292,442,585],"First,":[178],"sought":[180],"establish":[182],"trajectory":[184],"delineate":[191],"the":[192,373,499,543,600,614],"concomitant":[195],"epigenetic":[196,214,285,548,560,582,617],"changes":[197],"occurring":[198],"BM":[200,349],"they":[203],"differentiate":[204],"into":[205],"na\u00efve":[206],"cells.":[208],"capture":[210],"phenotype,":[211],"function,":[212],"state":[215,425,451],"via":[216],"single":[217,234,275,411],"content":[220,356,610],"(chromotype)":[221],"developing":[223],"BM,":[227,419],"developed":[229],"multiplexed,":[231],"high":[232,314,382,453,462],"throughput,":[233],"proteomic":[236],"method":[237],"(chromotyping)":[238],"simultaneously":[240],"measure":[241],"markers,":[244],"intracellular":[245],"regulators":[246,254,534],"transcription":[249],"factors":[250],"structure":[253,533],"histone":[257],"post-translational":[258],"modifications":[259],"(i.e.":[260,267],"H3K4me3,":[261],"H3K27me3,":[262],"H2AK119ubi)":[263],"re-modelers":[266],"CTCF,":[268],"DNMT1,":[269],"MLL1).":[270],"Using":[271],"these":[272,335,354],"surrogates":[273],"for":[274,602,606,616],"cell,":[276],"global":[277],"content,":[279],"notably":[281],"identified":[282],"coordinated":[284,336,522,529],"inflection":[286],"or":[287],"switch":[288,401,561],"(S)":[289],"points":[290,358,562],"corresponding":[296],"previously":[298],"characterized":[299],"landmarks":[301],"STAT5":[303],"signalling":[304],"active":[306],"re-arrangement":[307],"IgH":[309],"loci":[310],"(S1),":[311],"CD24":[312],"expression-linked":[313,323],"translation":[315],"proliferation":[317],"(S2),":[318],"IgM":[320],"CD20":[322],"BCR":[324],"assembly":[325],"completion":[326],"(S3)":[327],"(Bendall":[328],"2014).":[331],"determine":[333],"how":[334],"chromotypes":[337],"translated":[338],"accessibility":[341,375,484,571],"primed":[343,424],"gene":[344,573],"regulation":[345],"networks,":[346],"isolated":[348],"population":[352],"transition":[357],"analysed":[360],"them":[361],"our":[363,405,511,525,556],"modified":[364],"ATAC-seq":[365],"protocol,":[366],"InTAC-seq":[367,406],"(Baskar":[368],"2021).":[371],"Strikingly,":[372],"landscape":[376],"revealed":[377],"putative":[378],"oncogenic":[379,423,496],"priming":[380],"activity":[383,454],"leukemic":[385,594],"TFs":[386],"PAX5,":[389],"TCF3,":[390],"ZEB1":[391],"ID4":[393],"predominantly":[394],"S2":[396,429,505],"some":[398],"S3":[400,432,509],"points.":[402],"By":[403],"integrating":[404],"data":[407,417],"publicly":[409],"available":[410],"ATAC":[413],"RNA":[415],"seq":[416],"on":[418],"located":[421],"this":[422,450,493],"existing":[427],"before":[431,508],"(IgH":[433],"rearranged,":[434],"late":[435],"pro-":[436],"/":[437],"Pre-B":[438],"stage)":[440],"integration":[447],"further":[448],"associated":[449],"ASCL1":[456],"(role":[457],"remodelling)":[460],"STMN1":[465],"(Leukaemia-associated":[466],"phosphoprotein":[467],"18).":[468],"Finally":[469],"showed":[471],"(n=5)":[476],"(REH,":[480],"NALM6,":[481],"SUBP15),":[482],"neoplastic":[486],"indeed":[489],"continue":[490],"occupy":[492],"vulnerability":[497,583],"developmental":[502],"space":[503],"right":[507],"integrated":[512],"scATAC":[513],"map,":[514],"despite":[515],"variable":[516],"immunophenotypes.":[517],"corresponds":[519],"minima":[523],"chromotyping":[526],"map":[527],"(lowest,":[528],"abundance":[530],"trajectory).":[536],"Further":[537],"analysis":[538],"reinforced":[542],"divergence":[544],"between":[545,552],"immunophenotypic":[546],"heterogeneity":[549],"samples.":[553],"Taken":[554],"together,":[555],"findings":[557],"key":[559],"their":[568],"patterns.":[575],"Consequently,":[576],"reveal":[578],"could":[590,612],"be":[591],"predisposed":[592],"transformation.":[595],"work":[597],"opens":[598],"up":[599],"possibility":[601],"new":[603],"diagnostic":[604],"strategies":[605],"utilizing":[608],"pave":[613],"way":[615],"modulation-based":[618],"treatments":[619],"beyond":[620],"inhibition.":[623],"Disclosures":[624],"Davis:":[625],"Novartis":[626],"Pharmaceuticals:":[627,630],"Honoraria;":[628],"Jazz":[629],"Research":[631],"Funding.":[632]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-12-06T00:00:00"}
