{"id":"https://openalex.org/W3215089403","doi":"https://doi.org/10.2147/ott.s340435","title":"The Controversial Role of Polyploidy in Hepatocellular Carcinoma","display_name":"The Controversial Role of Polyploidy in Hepatocellular Carcinoma","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3215089403","doi":"https://doi.org/10.2147/ott.s340435","mag":"3215089403","pmid":"https://pubmed.ncbi.nlm.nih.gov/34866913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8636953"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s340435","doi":"https://doi.org/10.2147/ott.s340435","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s340435","pdf_url":"https://www.dovepress.com/getfile.php?fileID=76233","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=76233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100332779","display_name":"Nan Wang","orcid":"https://orcid.org/0000-0003-0685-4384","observed_orcids":["https://orcid.org/0000-0003-0685-4384"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Wang","raw_affiliation_strings":["Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-0685-4384","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109589503","display_name":"Fengjie Hao","orcid":"https://orcid.org/0000-0002-6734-265X","observed_orcids":["https://orcid.org/0000-0002-6734-265X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengjie Hao","raw_affiliation_strings":["Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088218336","display_name":"Yan Shi","orcid":"https://orcid.org/0000-0001-7341-6945","observed_orcids":["https://orcid.org/0000-0001-7341-6945"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Shi","raw_affiliation_strings":["Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100670158","display_name":"Junqing Wang","orcid":"https://orcid.org/0000-0001-6874-9614","observed_orcids":["https://orcid.org/0000-0001-6874-9614","https://orcid.org/0000-0003-1219-639X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junqing Wang","raw_affiliation_strings":["Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088218336"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.1647,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.22529274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"Volume 14","issue":null,"first_page":"5335","last_page":"5344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7129999995231628},{"id":"https://openalex.org/keywords/chronic-liver-injury","display_name":"chronic liver injury","score":0.8370000123977661},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5429999828338623},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.5669999718666077},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8238003849983215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787090480327606},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37681615352630615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278639316558838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2819156050682068}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ott.s340435","doi":"https://doi.org/10.2147/ott.s340435","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s340435","pdf_url":"https://www.dovepress.com/getfile.php?fileID=76233","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8636953","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8636953","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmid:34866913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34866913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:84ec80b1f4344e158d3a2295e1af8e8d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/84ec80b1f4344e158d3a2295e1af8e8d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoTargets and Therapy, Vol Volume 14, Pp 5335-5344 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/70976","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/the-controversial-role-of-polyploidy-in-hepatocellular-carcinoma-peer-reviewed-fulltext-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ott.s340435","doi":"https://doi.org/10.2147/ott.s340435","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s340435","pdf_url":"https://www.dovepress.com/getfile.php?fileID=76233","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3215089403.pdf","grobid_xml":"https://content.openalex.org/works/W3215089403.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W168063310","https://openalex.org/W1971248187","https://openalex.org/W1972126834","https://openalex.org/W1976059748","https://openalex.org/W1976714996","https://openalex.org/W1979685062","https://openalex.org/W1981232236","https://openalex.org/W1985342348","https://openalex.org/W2004008931","https://openalex.org/W2004954151","https://openalex.org/W2007944586","https://openalex.org/W2023204965","https://openalex.org/W2038850847","https://openalex.org/W2052599626","https://openalex.org/W2055250853","https://openalex.org/W2067278779","https://openalex.org/W2068278990","https://openalex.org/W2071411183","https://openalex.org/W2079019214","https://openalex.org/W2080594397","https://openalex.org/W2107190139","https://openalex.org/W2107840687","https://openalex.org/W2108877086","https://openalex.org/W2116142842","https://openalex.org/W2120881348","https://openalex.org/W2121212012","https://openalex.org/W2124957911","https://openalex.org/W2128950990","https://openalex.org/W2130802358","https://openalex.org/W2134590240","https://openalex.org/W2152112932","https://openalex.org/W2161673895","https://openalex.org/W2164721923","https://openalex.org/W2303133052","https://openalex.org/W2580260118","https://openalex.org/W2616374949","https://openalex.org/W2626298693","https://openalex.org/W2738618087","https://openalex.org/W2765801445","https://openalex.org/W2780234747","https://openalex.org/W2782188584","https://openalex.org/W2796435583","https://openalex.org/W2801995218","https://openalex.org/W2884903585","https://openalex.org/W2884971698","https://openalex.org/W2888336740","https://openalex.org/W2892870770","https://openalex.org/W2940095741","https://openalex.org/W2946183559","https://openalex.org/W2996555649","https://openalex.org/W3000126395","https://openalex.org/W3002896662","https://openalex.org/W3014731797","https://openalex.org/W3106842458","https://openalex.org/W3115990586","https://openalex.org/W3124588927","https://openalex.org/W3125877452","https://openalex.org/W3128646645","https://openalex.org/W3139219703","https://openalex.org/W3162447445","https://openalex.org/W3205938154"],"related_works":["https://openalex.org/W3205938154","https://openalex.org/W4293777887","https://openalex.org/W3014731797","https://openalex.org/W2946183559","https://openalex.org/W6924998755","https://openalex.org/W168063310","https://openalex.org/W1984034083","https://openalex.org/W4249820588","https://openalex.org/W4388713261","https://openalex.org/W7166116428"],"abstract_inverted_index":{"Polyploidy,":[0],"a":[1,58],"physiological":[2],"phenomenon":[3],"in":[4,17,25,34,50,98,130],"which":[5,64],"cells":[6,30],"contain":[7],"more":[8],"than":[9],"two":[10],"sets":[11],"of":[12,60,63,112,133,139,150,162,173,183,214,219,225],"homologous":[13],"chromosomes,":[14],"commonly":[15,33],"exists":[16],"plants,":[18],"fish,":[19],"and":[20,43,86,107,135,142,147,160,202,205],"amphibians":[21],"but":[22],"is":[23,55,117],"rare":[24],"mammals.":[26],"In":[27,165,186],"humans,":[28],"polyploid":[29,69,76,105,128,174,184,200,215],"are":[31,65,78],"detected":[32],"specific":[35,180],"organs":[36],"or":[37,222],"tissues":[38],"including":[39],"the":[40,46,51,53,92,110,131,140,148,156,170,179,197,212],"heart,":[41],"marrow,":[42],"liver.":[44],"As":[45],"largest":[47],"solid":[48],"organ":[49],"body,":[52],"liver":[54,81,115],"responsible":[56],"for":[57],"myriad":[59],"functions,":[61],"most":[62,113],"closely":[66],"related":[67,79],"to":[68,80,195],"hepatocytes.":[70,185],"It":[71],"has":[72,125],"been":[73],"confirmed":[74],"that":[75,127,192,210],"hepatocytes":[77,89,106,146,175,201,216],"regeneration,":[82],"homeostasis,":[83],"terminal":[84],"differentiation,":[85],"aging.":[87],"Polyploid":[88],"accumulate":[90],"during":[91],"aging":[93],"process":[94,132],"as":[95,97,217,223],"well":[96],"chronically":[99],"injured":[100],"livers.":[101],"The":[102,137],"relationship":[103,143],"between":[104,144,199],"hepatocellular":[108,151,163,203,220],"carcinoma,":[109],"endpoint":[111],"chronic":[114],"diseases,":[116],"not":[118],"yet":[119],"fully":[120],"understood.":[121],"Recently,":[122],"accumulated":[123],"evidence":[124],"revealed":[126],"involves":[129],"tumorigenesis":[134],"development.":[136],"study":[138],"correlation":[141],"polyploidy":[145],"development":[149],"carcinoma":[152,204,221],"can":[153],"potentially":[154],"promote":[155],"prevention,":[157],"early":[158],"diagnosis,":[159],"treatment":[161],"carcinoma.":[164],"this":[166],"review,":[167],"we":[168,188],"conclude":[169],"potential":[171],"mechanisms":[172],"formation,":[176],"focusing":[177],"on":[178],"biological":[181],"significance":[182],"addition,":[187],"examine":[189],"recent":[190,207],"discoveries":[191],"have":[193],"begun":[194],"clarify":[196],"relevance":[198],"discuss":[206],"excellent":[208],"findings":[209],"reveal":[211],"role":[213],"resisters":[218],"promoters":[224],"hepatocarcinogenesis.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-12-06T00:00:00"}