{"id":"https://openalex.org/W3215032986","doi":"https://doi.org/10.12047/j.cjap.6062.2021.084","title":"[Effects of Metformin and Sitagliptin on islet cell function in insulin-resistant prediabetic KKay mice].","display_name":"[Effects of Metformin and Sitagliptin on islet cell function in insulin-resistant prediabetic KKay mice].","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3215032986","doi":"https://doi.org/10.12047/j.cjap.6062.2021.084","mag":"3215032986","pmid":"https://pubmed.ncbi.nlm.nih.gov/34821099"},"language":"zh","primary_location":{"id":"pmid:34821099","doi":"https://doi.org/10.12047/j.cjap.6062.2021.084","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34821099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ping Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Li","raw_affiliation_strings":["Department of Rheumatology, the General Hospital of Northern Theater Command, Shenyang 110812"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, the General Hospital of Northern Theater Command, Shenyang 110812","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008381132","display_name":"Linlang Liang","orcid":"https://orcid.org/0000-0002-4710-8153","observed_orcids":["https://orcid.org/0000-0002-4710-8153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin-Lang Liang","raw_affiliation_strings":["Department of Endocrinology, Shenyang 110812, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shenyang 110812, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Department of Endocrinology, Shenyang 110812, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shenyang 110812, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061703923","display_name":"Hou Da","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Da Hou","raw_affiliation_strings":["Department of Endocrinology, Shenyang 110812, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shenyang 110812, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013487786","display_name":"Xin Yang","orcid":"https://orcid.org/0000-0002-7940-714X","observed_orcids":["https://orcid.org/0000-0002-7940-714X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Yang","raw_affiliation_strings":["Department of Endocrinology, Shenyang 110812, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shenyang 110812, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059848235","display_name":"Bo Yang","orcid":"https://orcid.org/0000-0002-1327-8699","observed_orcids":["https://orcid.org/0000-0002-1327-8699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Yang","raw_affiliation_strings":["Department of Endocrinology, Shenyang 110812, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shenyang 110812, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27942503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"6","first_page":"644","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7300000190734863},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.871999979019165},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/kk-ay-mice","display_name":"KK-Ay mice","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mafa","display_name":"MafA","score":0.9390000104904175},{"id":"https://openalex.org/keywords/diabetes-prevention","display_name":"diabetes prevention","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8758807182312012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8209206461906433},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8189353942871094},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.8016780614852905},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6414602994918823},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6065032482147217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6009448766708374},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.5274598598480225},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.510831356048584},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4716814160346985},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.4551314413547516},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.4440954923629761},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.284851998090744}],"mesh":[{"descriptor_ui":"D000068900","descriptor_name":"Sitagliptin Phosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:34821099","doi":"https://doi.org/10.12047/j.cjap.6062.2021.084","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34821099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"Journal Article"},{"id":"mag:3215032986","doi":"https://doi.org/10.12047/j.cjap.6062.2021.084","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34821099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2275415666","https://openalex.org/W7096211395","https://openalex.org/W2039677416","https://openalex.org/W1842144698","https://openalex.org/W2098008729","https://openalex.org/W7099128484","https://openalex.org/W2992864166","https://openalex.org/W7118631933","https://openalex.org/W2127189471","https://openalex.org/W2012953185"],"abstract_inverted_index":{"In":[0],"pre-diabetes":[1],"mellitus":[2],"KKAy":[3],"mice":[4],"with":[5],"insulin":[6,32],"resistance,":[7],"metformin":[8],"can":[9],"maintain":[10],"the":[11,22,28,38],"function":[12],"and":[13,18,36,40],"morphology":[14],"of":[15,24,31,42],"pancreatic":[16],"islets,":[17],"sitagliptin":[19],"may":[20],"promote":[21],"proliferation":[23],"islet":[25],"\u03b2cells,":[26],"improve":[27],"expression":[29],"level":[30],"transcription":[33],"factor":[34],"MafA,":[35],"prevent":[37],"occurrence":[39],"development":[41],"diabetes.":[43]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2021-12-06T00:00:00"}
