{"id":"https://openalex.org/W3214974232","doi":"https://doi.org/10.2139/ssrn.3943615","title":"Spectral Fiber-Photometry Derives Hemoglobin-Absorption Changes for Accurate Measurement of Fluorescent Sensor Activity","display_name":"Spectral Fiber-Photometry Derives Hemoglobin-Absorption Changes for Accurate Measurement of Fluorescent Sensor Activity","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3214974232","doi":"https://doi.org/10.2139/ssrn.3943615","mag":"3214974232"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.3943615","doi":"https://doi.org/10.2139/ssrn.3943615","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3943615","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.3943615","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101707933","display_name":"Weiting Zhang","orcid":"https://orcid.org/0000-0002-7366-9771","observed_orcids":["https://orcid.org/0000-0002-7366-9771"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Ting Zhang","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":"https://orcid.org/0000-0002-7366-9771","affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075663901","display_name":"Tzu-Hao Harry Chao","orcid":"https://orcid.org/0000-0002-0057-6849","observed_orcids":["https://orcid.org/0000-0002-0057-6849"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu-Hao  Harry Chao","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":"https://orcid.org/0000-0002-0057-6849","affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492922","display_name":"Yue Yang","orcid":"https://orcid.org/0000-0002-0470-7244","observed_orcids":["https://orcid.org/0000-0002-0470-7244"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Yang","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086736820","display_name":"Tzu-Wen Winnie Wang","orcid":"https://orcid.org/0000-0003-3413-7817","observed_orcids":["https://orcid.org/0000-0003-3413-7817"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzu-Wen Wang","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402793","display_name":"Sung-Ho Lee","orcid":"https://orcid.org/0000-0003-3553-761X","observed_orcids":["https://orcid.org/0000-0003-3553-761X","https://orcid.org/0009-0001-5753-3516","https://orcid.org/0000-0002-1758-1804"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung-Ho Lee","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042687971","display_name":"Esteban A. Oyarzabal","orcid":"https://orcid.org/0000-0003-2024-243X","observed_orcids":["https://orcid.org/0000-0003-2024-243X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esteban Oyarzabal","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":"https://orcid.org/0000-0003-2024-243X","affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047389903","display_name":"Jingheng Zhou","orcid":"https://orcid.org/0000-0003-0280-6166","observed_orcids":["https://orcid.org/0000-0003-0280-6166"]},"institutions":[{"id":"https://openalex.org/I2800421839","display_name":"Government of the United States of America","ror":"https://ror.org/02rcrvv70","country_code":"US","type":"government","lineage":["https://openalex.org/I2800421839"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingheng Zhou","raw_affiliation_strings":["Government of the United States of America - In Vivo Neurobiology Group, United States","Government of the United States of America - In Vivo Neurobiology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government of the United States of America - In Vivo Neurobiology Group, United States","institution_ids":["https://openalex.org/I2800421839"]},{"raw_affiliation_string":"Government of the United States of America - In Vivo Neurobiology Group","institution_ids":["https://openalex.org/I2800421839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007169487","display_name":"Randy Nonneman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy Nonneman","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026606899","display_name":"Nicolas C. P\u00e9gard","orcid":"https://orcid.org/0000-0003-2868-7118","observed_orcids":["https://orcid.org/0000-0003-2868-7118"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas  C. Pegard","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Department of Applied Physical Sciences, United States","University of North Carolina (UNC) at Chapel Hill - Department of Applied Physical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Department of Applied Physical Sciences, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Department of Applied Physical Sciences","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077961759","display_name":"Hongtu Zhu B","orcid":"https://orcid.org/0000-0002-6781-2690","observed_orcids":["https://orcid.org/0000-0002-6781-2690"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongtu Zhu","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Biomedical Research Imaging Center, NC, United States","University of North Carolina (UNC) at Chapel Hill, 102 Ridge Road, Chapel Hill, NC NC 27514, United States","University of North Carolina (UNC) at Chapel Hill - Biomedical Research Imaging Center"],"raw_orcid":"https://orcid.org/0000-0002-6781-2690","affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Biomedical Research Imaging Center, NC, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill, 102 Ridge Road, Chapel Hill, NC NC 27514, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Biomedical Research Imaging Center","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010542008","display_name":"Guohong Cui","orcid":"https://orcid.org/0000-0002-4555-028X","observed_orcids":["https://orcid.org/0000-0002-4555-028X"]},"institutions":[{"id":"https://openalex.org/I2800421839","display_name":"Government of the United States of America","ror":"https://ror.org/02rcrvv70","country_code":"US","type":"government","lineage":["https://openalex.org/I2800421839"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guohong Cui","raw_affiliation_strings":["Government of the United States of America - In Vivo Neurobiology Group, United States","Government of the United States of America - In Vivo Neurobiology Group"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government of the United States of America - In Vivo Neurobiology Group, United States","institution_ids":["https://openalex.org/I2800421839"]},{"raw_affiliation_string":"Government of the United States of America - In Vivo Neurobiology Group","institution_ids":["https://openalex.org/I2800421839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074818451","display_name":"Yen\u2010Yu Ian Shih","orcid":"https://orcid.org/0000-0001-6529-911X","observed_orcids":["https://orcid.org/0000-0001-6529-911X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yen-Yu Ian Shih","raw_affiliation_strings":["University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI"],"raw_orcid":"https://orcid.org/0000-0001-6529-911X","affiliations":[{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI, United States","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina (UNC) at Chapel Hill - Center for Animal MRI","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074818451"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fiber-photometry","display_name":"fiber photometry","score":0.906000018119812},{"id":"https://openalex.org/keywords/spectrophotometry","display_name":"spectrophotometry","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oxyhemoglobin","display_name":"oxyhemoglobin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/deoxyhemoglobin","display_name":"deoxyhemoglobin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/regional-brain-differences","display_name":"regional brain differences","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C68271606","wikidata":"https://www.wikidata.org/wiki/Q625648","display_name":"Photometry (optics)","level":3,"score":0.752223789691925},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6415324807167053},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5025255680084229},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.41138797998428345},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.37650513648986816},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.339232474565506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3088539242744446},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2911558151245117},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.13322436809539795},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.12876424193382263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10712990164756775},{"id":"https://openalex.org/C150846664","wikidata":"https://www.wikidata.org/wiki/Q7602306","display_name":"Stars","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.3943615","doi":"https://doi.org/10.2139/ssrn.3943615","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3943615","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.3943615","doi":"https://doi.org/10.2139/ssrn.3943615","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3943615","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4286884886","https://openalex.org/W2029599483","https://openalex.org/W4285808507","https://openalex.org/W4283311695","https://openalex.org/W4388662506","https://openalex.org/W2064227068","https://openalex.org/W2545318962","https://openalex.org/W3028968718","https://openalex.org/W7124436855","https://openalex.org/W2782467283"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2021-12-06T00:00:00"}