{"id":"https://openalex.org/W3214972258","doi":"https://doi.org/10.1007/s12672-021-00448-z","title":"microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7","display_name":"microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7","publication_year":2021,"publication_date":"2021-11-27","ids":{"openalex":"https://openalex.org/W3214972258","doi":"https://doi.org/10.1007/s12672-021-00448-z","mag":"3214972258","pmid":"https://pubmed.ncbi.nlm.nih.gov/35201478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8777553"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-021-00448-z","doi":"https://doi.org/10.1007/s12672-021-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-021-00448-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-021-00448-z.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s12672-021-00448-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100456567","display_name":"Liang Wang","orcid":"https://orcid.org/0000-0002-9364-8572","observed_orcids":["https://orcid.org/0000-0002-9364-8572"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Wang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101639455","display_name":"Meijun Li","orcid":"https://orcid.org/0000-0002-5570-4924","observed_orcids":["https://orcid.org/0000-0002-5570-4924"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meijun Li","raw_affiliation_strings":["Department of Blood, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100405417","display_name":"Fei Chen","orcid":"https://orcid.org/0000-0003-0243-2758","observed_orcids":["https://orcid.org/0000-0003-0243-2758"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Chen","raw_affiliation_strings":["Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, No. 2 of the People Street, Gu Ta district, Jinzhou, 121001, Liao Ning, China. ultrasoundchenfei@163.com","Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, No. 2 of the People Street, Gu Ta district, Jinzhou, 121001, Liao Ning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, No. 2 of the People Street, Gu Ta district, Jinzhou, 121001, Liao Ning, China. ultrasoundchenfei@163.com","institution_ids":["https://openalex.org/I85430964"]},{"raw_affiliation_string":"Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, No. 2 of the People Street, Gu Ta district, Jinzhou, 121001, Liao Ning, China","institution_ids":["https://openalex.org/I85430964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100405417"],"corresponding_institution_ids":["https://openalex.org/I85430964"],"apc_list":{"value":1290,"currency":"USD","value_usd":1290},"apc_paid":{"value":1290,"currency":"USD","value_usd":1290},"fwci":0.9454,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67286899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-26a","display_name":"miR-26a","score":0.9200000166893005},{"id":"https://openalex.org/keywords/e2f7","display_name":"E2F7","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8259999752044678},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.824999988079071},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7280473709106445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6184008121490479},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.6081637144088745},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5778290033340454},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5724042057991028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5589971542358398},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5377436280250549},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.46267029643058777},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.45144033432006836},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4361104667186737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33686771988868713},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.3250230550765991},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.15734779834747314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15088051557540894},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.11895021796226501},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10815295577049255}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12672-021-00448-z","doi":"https://doi.org/10.1007/s12672-021-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-021-00448-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-021-00448-z.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},{"id":"pmid:35201478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35201478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8777553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8777553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discov Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:64735ed4c3074fc2af4b6d8c25ef1d72","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/64735ed4c3074fc2af4b6d8c25ef1d72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Oncology, Vol 12, Iss 1, Pp 1-11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s12672-021-00448-z","doi":"https://doi.org/10.1007/s12672-021-00448-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-021-00448-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-021-00448-z.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3214972258.pdf","grobid_xml":"https://content.openalex.org/works/W3214972258.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W254111596","https://openalex.org/W1970760326","https://openalex.org/W1996348049","https://openalex.org/W2004042953","https://openalex.org/W2014946489","https://openalex.org/W2015003540","https://openalex.org/W2017989710","https://openalex.org/W2026936876","https://openalex.org/W2059117644","https://openalex.org/W2076872714","https://openalex.org/W2101140619","https://openalex.org/W2111277851","https://openalex.org/W2111471857","https://openalex.org/W2115093090","https://openalex.org/W2118819514","https://openalex.org/W2124756133","https://openalex.org/W2155774029","https://openalex.org/W2163106706","https://openalex.org/W2341695670","https://openalex.org/W2402899397","https://openalex.org/W2411769793","https://openalex.org/W2415018300","https://openalex.org/W2491393351","https://openalex.org/W2506143146","https://openalex.org/W2549509036","https://openalex.org/W2579147068","https://openalex.org/W2587210114","https://openalex.org/W2588025094","https://openalex.org/W2590389170","https://openalex.org/W2606188254","https://openalex.org/W2606615337","https://openalex.org/W2608087858","https://openalex.org/W2617630610","https://openalex.org/W2620744966","https://openalex.org/W2751701466","https://openalex.org/W2763367287","https://openalex.org/W2771918297","https://openalex.org/W2772578036","https://openalex.org/W2774559197","https://openalex.org/W2774807260","https://openalex.org/W2795823701","https://openalex.org/W2800233132","https://openalex.org/W2809253370","https://openalex.org/W2890668221","https://openalex.org/W2937513126","https://openalex.org/W2945755627","https://openalex.org/W2953961829","https://openalex.org/W2955378726","https://openalex.org/W2968071550","https://openalex.org/W2980665364","https://openalex.org/W2985771661","https://openalex.org/W2989908245","https://openalex.org/W2991007821","https://openalex.org/W2997687096","https://openalex.org/W3005738728","https://openalex.org/W3006819270","https://openalex.org/W3026896214","https://openalex.org/W3038124608","https://openalex.org/W4237654651"],"related_works":["https://openalex.org/W4248278899","https://openalex.org/W1996348049","https://openalex.org/W3083438981","https://openalex.org/W3004269364","https://openalex.org/W2101140619","https://openalex.org/W2029614054","https://openalex.org/W2154830487","https://openalex.org/W3036805819","https://openalex.org/W2983299555","https://openalex.org/W4327994012"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,10,62,75,90,102,109,124,141,148,159],"microRNAs":[2],"(miRNAs)":[3],"exerts":[4],"key":[5,132],"roles":[6],"in":[7,20,38,79,92,134,161],"the":[8,54,71,100,107,122,139,146,156],"development":[9],"pancreatic":[11],"cancer":[12],"(PCa).":[13],"miR-26a":[14,24,35,41,64,78,91,114,143,164],"is":[15,28,58],"reportedly":[16],"a":[17,59,131,165],"tumor":[18,49],"suppressor":[19],"cancers.":[21],"However,":[22],"whether":[23],"modulates":[25],"PCa":[26,43,80,93,110,169],"progression":[27],"poorly":[29],"understood.":[30],"Here,":[31],"we":[32],"found":[33],"that":[34,119],"was":[36,82],"down-regulated":[37],"PCa.":[39],"Overexpressed":[40],"suppressed":[42],"cell":[44,51],"proliferation,":[45],"colony":[46],"formation,":[47],"and":[48,136],"stem":[50],"properties.":[52],"Mechanically,":[53],"transcription":[55],"factor":[56,128,133],"E2F7":[57,66,97,103,120,149],"downstream":[60],"target":[61,167],"miR-26a.":[63],"decreased":[65],"expression":[67,140],"through":[68],"binding":[69],"to":[70],"3'-untranslated":[72],"region":[73],"(UTR)":[74],"E2F7.":[76,86],"Decreased":[77],"tissues":[81],"inversely":[83],"correlated":[84],"with":[85,113],"The":[87],"inhibitory":[88],"effects":[89,147],"were":[94],"reversed":[95],"by":[96],"overexpression.":[98,115],"Consistently,":[99],"knockout":[101],"further":[104],"significantly":[105],"inhibited":[106],"growth":[108,127],"cells":[111],"combined":[112],"Further":[116],"study":[117],"revealed":[118],"bound":[121],"promoter":[123],"vascular":[125],"endothelial":[126],"A":[129],"(VEGFA),":[130],"angiogenesis,":[135],"transcriptionally":[137],"activated":[138],"VEGFA.":[142],"overexpression":[144],"attenuated":[145],"on":[150],"VEGFA":[151],"promotion.":[152],"Our":[153],"results":[154],"uncovered":[155],"novel":[157],"function":[158],"miR-26a/E2F7/VEGFA":[160],"PCa,":[162],"making":[163],"possible":[166],"for":[168],"treatment.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}
